MA DM DSc MRCP(UK) FRCR
Friends of ANCHOR Clinical Chair in Oncology
- About
-
- Email Address
- anne.kiltie@abdn.ac.uk
- Office Address
Room 5.053
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I qualified in medicine from the Universities of Cambridge and Oxford and trained in Clinical Oncology at the Christie Hospital, Manchester, and Cookridge Hospital, Leeds. I undertook my DM at the Paterson Institute, University of Manchester and was a Clinical Research Fellow at ICRF Clare Hall before taking up a Senior Lecturer/Honorary Consultant Clinical Oncologist appointment at the University of Leeds in 2001. I moved to the Department of Oncology, University of Oxford in 2009, and obtained my DSc and personal chair in 2016.
I took up my appointment as Friends of ANCHOR Clinical Chair of Oncology at the University of Aberdeen in June 2021.
My research focusses on exploiting dietary fibre manipulation and its effects on the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.
Qualifications
- DSc Medical Sciences2016 - University of Oxford
- DM Medical Sciences1999 - University of Oxford
- BM BCh Medicine1988 - University of Oxford
- BA Medical Sciences1985 - University of Cambridge
- MRCP(UK) General Medicine1992 - Royal College of Physicians of England
- FRCR Clinical Oncology1995 - Royal College of Radiologists
- MA Medicine1989 - University of Cambridge
- MA Medicine1999 - University of Oxford
Memberships and Affiliations
- Internal Memberships
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Jul 2021 - present Member of the Rowett Institute Ethics Panel
Oct 2021 - present Member of Friends of ANCHOR Research Advisory Group
Oct 2024 - present Elected member Senatus Academicus
- External Memberships
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Apr 2024 - present Chair, Scottish Radiation Research Forum (ScoRRF)
Jun 2023 - present Member of RAIDER TrialTranslational Working Group
Jan 2022 - present Member of Scientific Review Group BCAN Bladder Cancer Research Innovation Award 2022
Jan 2022 - present Member of Scottish Radiotherapy Research Forum Committee
Oct 2018 - present Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Research Network Management Committee
Dec 2017 - present Member of Editorial Board of European Urology Oncology
Oct 2016 - present Associate Editor of Bladder Cancer
2014 - present Grant reviewer for Italian Association for Cancer Research (AIRC)
Sept 2012 - present British Uro-oncology Group Executive Committee Trustee
Jan 2012 - present Royal College of Radiologists representative on Advisory Appointments Committees
- Research
-
Research Overview
Tumours in the pelvis, including bladder, prostate and colorectal cancer and gynaecological cancers may be treated by surgical removal or organ-preserving radiotherapy-based treatments. Current organ-preservation standard of care for most tumour sites includes addition of radiosensitising chemotherapy to improve tumour control. However, this often comes at the expense of increased radiotherapy-induced side effects to the surrounding normal tissues, including the intestines. Furthermore, such combined treatments are often not tolerated by elderly patients. With the proportion of over 75-year olds set to double by 2050, there is an urgent need to find alternative approaches to radiosensitisation.
Having worked on histone deacetylase inhibitors, which we showed to be effective tumour radiosensitisers without additional acute and late small intestinal toxicity in in vivo models, we are now working to exploit dietary fibre manipulation and the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.
Research Areas
Applied Health Sciences
Biomedical Sciences
Nutrition and Health
Research Specialisms
- Medicine
- Food Science
- Bacteriology
- Oncology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Teaching
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Teaching Responsibilities
ME3013 MBChB SSC2: supervisor
BM4501 BSc Honours project: supervisor
RN5504 Nutrition and Health through the Life Stages: lecture
RN5505 Clinical Nutrition: lecture and seminar
RN5503 Clinical Nutrition for Disease Prevention: lecture
Non-course Teaching Responsibilities
I am a Regent for the MB ChB Regent Scheme.
- Publications
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Page 2 of 2 Results 51 to 96 of 96
Using gene polymorphisms to assess bladder cancer risk: Progress and challenges
Journal of Urology, vol. 187, no. 2, pp. 379-380Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1016/j.juro.2011.11.002
- [ONLINE] View publication in Scopus
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene
Human Molecular Genetics, vol. 20, no. 21, pp. 4268-4281Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/hmg/ddr303
- [ONLINE] View publication in Scopus
Radiotherapy for node positive penile cancer: Experience of the leeds teaching hospitals
Journal of Urology, vol. 186, no. 2, pp. 524-529Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.juro.2011.03.117
- [ONLINE] View publication in Scopus
Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients
BMC Medical Genetics, vol. 12, 84Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2350-12-84
- [ONLINE] View publication in Scopus
In vitro functional effects of XPC gene rare variants from bladder cancer patients
Carcinogenesis, vol. 32, no. 4, pp. 516-521Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/carcin/bgr005
- [ONLINE] View publication in Scopus
Phase II study of conformal hypofractionated radiotherapy with concurrent gemcitabine in muscle-invasive bladder cancer
Journal of Clinical Oncology, vol. 29, no. 6, pp. 733-738Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1200/JCO.2010.31.5721
- [ONLINE] View publication in Scopus
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Nature Genetics, vol. 42, no. 11, pp. 978-984Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.687
- [ONLINE] View publication in Scopus
MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer
Cancer Research, vol. 70, no. 18, pp. 7017-7026Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/0008-5472.CAN-10-1202
- [ONLINE] View publication in Scopus
Common predisposition alleles for moderately common cancers: Bladder cancer
Current Opinion in Genetics and Development, vol. 20, no. 3, pp. 218-224Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.gde.2010.01.002
- [ONLINE] View publication in Scopus
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
Nature Genetics, vol. 42, no. 5, pp. 415-419Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.558
- [ONLINE] View publication in Scopus
Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer
Cancer Research, vol. 69, no. 17, pp. 6857-6864Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/0008-5472.CAN-09-1091
- [ONLINE] View publication in Scopus
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
Nature Genetics, vol. 41, no. 9, pp. 991-995Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.421
- [ONLINE] View publication in Scopus
Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities
Genes Chromosomes and Cancer, vol. 48, no. 4, pp. 310-321Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/gcc.20641
- [ONLINE] View publication in Scopus
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types
Nature Genetics, vol. 41, no. 2, pp. 221-227Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.296
- [ONLINE] View publication in Scopus
Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
Molecular Cancer Therapeutics, vol. 8, no. 1, pp. 203-213Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1535-7163.MCT-08-0959
- [ONLINE] View publication in Scopus
Cancer biomarkers associated with damage response genes
The DNA Damage Response: Implications on Cancer Formation and Treatment. Springer Netherlands, pp. 307-330, 24 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-90-481-2561-6_14
- [ONLINE] View publication in Scopus
Molecular epidemiology of DNA repair genes in bladder cancer
Cancer Epidemiology: Volume II: Modifiable Factors. Verma, M. (ed.), pp. 281-306, 26 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-1-60327-492-0_12
- [ONLINE] View publication in Scopus
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Nature Genetics, vol. 40, no. 11, pp. 1307-1312Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ng.229
- [ONLINE] View publication in Scopus
In Reply to Dr. Rosario et al.
International Journal of Radiation Oncology Biology Physics, vol. 71, no. 5, pp. 1602Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/j.ijrobp.2008.03.038
- [ONLINE] View publication in Scopus
Analysis of variants in DNA damage signalling genes in bladder cancer
BMC Medical Genetics, vol. 9, 69Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2350-9-69
- [ONLINE] View publication in Scopus
Similar Treatment Outcomes for Radical Cystectomy and Radical Radiotherapy in Invasive Bladder Cancer Treated at a United Kingdom Specialist Treatment Center
International Journal of Radiation Oncology Biology Physics, vol. 70, no. 2, pp. 456-463Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ijrobp.2007.06.030
- [ONLINE] View publication in Scopus
DNA repair gene XRCC1 polymorphisms and bladder cancer risk
BMC Genetics, vol. 8, 13Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2156-8-13
- [ONLINE] View publication in Scopus
Comprehensive analysis of 22 XPC polymorphisms and bladder cancer risk
Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 12, pp. 2537-2541Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1055-9965.EPI-06-0288
- [ONLINE] View publication in Scopus
APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer
Clinical Cancer Research, vol. 11, no. 17, pp. 6205-6211Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-05-0045
- [ONLINE] View publication in Scopus
The polyAT, intronic IVSII-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder
British Journal of Cancer, vol. 92, no. 12, pp. 2262-2265Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjc.6602616
- [ONLINE] View publication in Scopus
Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts
Nucleic Acids Research, vol. 33, no. 8, pp. 2531-2539Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/gki528
- [ONLINE] View publication in Scopus
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining
Nucleic Acids Research, vol. 32, no. 17, pp. 5249-5259Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/gkh842
- [ONLINE] View publication in Scopus
Double strand break repair by non-homologous end joining in bladder cancer
European Urology, Supplements, vol. 2, no. 6, pp. 90Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S1569-9056(03)90451-9
- [ONLINE] View publication in Scopus
Development of a rapid, small-scale DNA repair assay for use on clinical samples.
Nucleic Acids Research, vol. 31, no. 15, pp. e83Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/gng083
- [ONLINE] View publication in Scopus
Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer
Radiotherapy and Oncology, vol. 55, no. 2, pp. 179-186Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0167-8140(99)00158-9
- [ONLINE] View publication in Scopus
Detection of individual differences in radiation-induced apoptosis of peripheral blood lymphocytes in normal individuals, ataxia telangiectasia homozygotes and heterozygotes, and breast cancer patients after radiotherapy
Radiation Research, vol. 153, no. 5 I, pp. 570-578Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1667/0033-7587(2000)153[0570:DOIDIR]2.0.CO;2
- [ONLINE] View publication in Scopus
Iridium-192 implantation for node-negative carcinoma of the penis: The Cookridge Hospital experience
Clinical Oncology, vol. 12, no. 1, pp. 25-31Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1053/clon.2000.9106
- [ONLINE] View publication in Scopus
The need for the moving junction in craniospinal irradiation
British Journal of Radiology, vol. 73, no. 870, pp. 650-654Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1259/bjr.73.870.10911789
- [ONLINE] View publication in Scopus
A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients
Radiotherapy and Oncology, vol. 51, no. 1, pp. 55-65Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0167-8140(99)00030-4
- [ONLINE] View publication in Scopus
Lack of correlation between residual radiation-induced DNA damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients
International Journal of Radiation Oncology Biology Physics, vol. 43, no. 3, pp. 481-487Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0360-3016(98)00392-7
- [ONLINE] View publication in Scopus
Fibroblast radiosensitivity measured using the comet DNA-damage assay correlates with clonogenic survival parameters
British Journal of Cancer, vol. 79, no. 9-10, pp. 1366-1371Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bjc.6690219
- [ONLINE] View publication in Scopus
Training to treat cancer: Future developments
Hospital Medicine, vol. 60, no. 7, pp. 519-521Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.12968/hosp.1999.60.7.1160
- [ONLINE] View publication in Scopus
DNA damage assays in normal tissue radiosensitivity testing
British Journal of Radiology, vol. 71, no. JAN., pp. 103Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Radiation-induced micronuclei in human fibroblasts in relation to clonogenic radiosensitivity
British Journal of Cancer, vol. 78, no. 12, pp. 1559-1563Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.1998.723
- [ONLINE] View publication in Scopus
A correlation between residual dna double-strand breaks and clonogenic measurements of radiosensitivity in fibroblasts from preradiotherapy cervix cancer patients
International Journal of Radiation Oncology Biology Physics, vol. 39, no. 5, pp. 1137-1144Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0360-3016(97)00545-2
- [ONLINE] View publication in Scopus
Ondansetron versus a chlorpromazine and dexamethasone combination for the prevention of nausea and vomiting: A prospective, randomised study to assess efficacy, cost effectiveness and quality of life following single- fraction radiotherapy
Supportive Care in Cancer, vol. 5, no. 6, pp. 500-503Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s005200050119
- [ONLINE] View publication in Scopus
SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cells
Nucleic Acids Research, vol. 25, no. 14, pp. 2945-2946Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/nar/25.14.2945
- [ONLINE] View publication in Scopus
Relapse of intracranial germinoma 23 years postirradiation in a patient given growth hormone replacement
Medical and Pediatric Oncology, vol. 29, no. 1, pp. 41-44Contributions to Journals: ArticlesSurvival and late effects in medulloblastoma patients treated with craniospinal irradiation under three years old
Medical and Pediatric Oncology, vol. 28, no. 5, pp. 348-354Contributions to Journals: ArticlesSurvival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972–1993
Medical and Pediatric Oncology, vol. 25, no. 6, pp. 450-456Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mpo.2950250606
- [ONLINE] View publication in Scopus
Army Cardiac Unit -- cardiac catheter patients, 1991--a review.
Journal of the Royal Army Medical Corps, vol. 140, no. 2, pp. 79-85Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jramc-140-02-06
- [ONLINE] View publication in Scopus