FREIA is an EU-funded project that aims to improve identification of chemicals that affect women’s health via disruption of the hormone system. Our project is called FREIA – Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach, after the Nordic Goddess of fertility.The FREIA project has received €6.1 million funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 825100 (FREIA). FREIA focused on chemicals that can disturb the endocrine sysatem, these chemicals are called "Endocrine Disrupting Compounds" (EDCs).Hormones and the endocrine system are vital for pregnancy and fetal development, making this an especially vulnerable time.
![Professor Paul Fowler Professor Paul Fowler](/img/200x200/staffpages/uploads/ogy056/PAF_pic_website_b_Aug2012.jpg)
BSc Hons, PhD, FRSB
Chair in Translational Medical Sciences
- About
-
- Email Address
- p.a.fowler@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437528
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I received my BSc Hons and PhD in Zoology at the University of Aberdeen. I later moved to Obstetrics & Gynaecology, University of Aberdeen, to work on ovarian hormones and antiprogesterones. In 2000 I moved to the Institute of Medical Sciences, University of Aberdeen as a Professor of Translational Medical Sciences. I was the Director of the Institute of Medical Sciences in the School of Medicine, Medical Sciences & Nutrition at Aberdeen from 2015 to 2021.
I have spent much of my career working on elucidating mechanisms in the regulation of reproduction and have over 140 peer-reviewed publications, book chapters and editorials. At each stage I made contributions in the use of technologies to answer reproductive questions, including: remote telemetry of body-testis temperature differentials, MRI analysis of body composition and mammary gland, phage library and protein purification techniques to investigate reproductive proteins and proteomic and microarray techniques to study fetal development and endometriosis. Since the turn of the century, my research has focused on the effects of maternal factors, environmental exposures and endocrine disruption on fetal development and subsequent health in both human and animal models. My group is one of the few to work on the normal first and second trimester human fetus and uses maternal smoking, obesity and deprivation as a model to understand how adverse in-utero environment disturbs fetal development in our own species.
Air pollution nanoparticles get into fetal human organs in the 1st and 2nd trimester
Maternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies. Bongaerts E, Lecante LL, Bové H, Roeffaers MBJ, Ameloot M, Fowler PA, Nawrot TS. Lancet Planet Health. 2022 Oct;6(10):e804-e811. doi: 10.1016/S2542-5196(22)00200-5.
Qualifications
- BSc Hons Zoology1982 - University of Aberdeen
- PhD Reproductive Biology1986 - University of Aberdeen
Memberships and Affiliations
- Internal Memberships
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- Chair SMMSN Back-To-Work Group
- Co-Chair University/NHS Grampian COVID-19 group
- Chair SMSN Core Facilities Committee
- Deputy Chair, University Research Facilities Working Group
- regular Depute for Head of School meetings
- IMS Equality & Diversity Group (Athena Swan)
- REF2021 UoA1 Committee
- University Health & Safety Committee
- Division of Applied Medicine REF committee, 2012-2014
- Joint Research Committee, 2011-2015
- Division of Applied Medicine Executive Board, 2011-2015
- Programme lead for the Cell, Developmental & Cancer Biology research programme, 2011-2015
- European Advisory Committee, 2011-2014
- College of Life Sciences & Medicine Graduate School Management Team, 2005-2009
- IMS Safety Committee, 2004-2009
- Medical Faculty Postgraduate Teaching Group, 1998-2005
- Medical Faculty IT Group, 1996-2003
- Medical Faculty Research Profile Editorial Board, 1994-1995
- Medical Faculty Research Advisory Committee, 1992
- External Memberships
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- Member, Breast Cancer UK Independent Scientific Review Panel, 2022-
- Member, UKRI Future Leaders Interview Panel 16, 2022
- Named, invited, signatory of the Consensus Statement on paracetamol use during pregnancy – a call for precautionary action https://www.nature.com/articles/s41574-021-00553-7 2021
- Review Editor, Frontiers in Toxicology - Developmental and Reproductive Toxicology, 2020-
- Member, Editorial Board, Molecular Human Reproduction, 2019-
- Member, EFSA FAF (Food Additives and Flavourings) Panel, 2018-2024 https://www.efsa.europa.eu/en/panels/faf
- Member, EFSA Flavourings Working Group, 2018-2024 https://www.efsa.europa.eu/en/food-ingredients-and-packaging/working-groups
- Chair, EFSA Special Working Group on the evaluation of substances used to reduce microbial contamination from products of animal origin, 2018
- Member Editorial Board, Scientific Reports, 2017-18
- Member, Glasgow Children’s Hospital Charity Research Fund Steering Committee, 2017-20
- Member, Panel 14 (Pathophysiology) of the French National Research Agency, 2017-2019
- Member, Grampian Biorepository Steering Group, 2016-
- Member, promotions committee, Norwegian University of Life Sciences, 2015-2016
- Member Habilitation à Diriger des Recherches (HDR) Jury, University of Rennes, France, 2015
- Member Editorial Board, Molecular & Cellular Endocrinology, 2014-
- Member, EFSA CEF (Food Contact Materials, Enzymes, Flavourings and Processing Aids) Panel, 2014-2018 http://www.efsa.europa.eu/en/panels/fip.htm
- Member, EFSA Flavourings Working Group, 2014-2018 http://www.efsa.europa.eu/en/fip/fipwgs.htm
- Expert Evaluator, European Commission, 2014-
- Vice-chair, HCERES (was AERES) research & tertiary education evaluation committee, France, 2014
- Expert panel member, Endocrine Society & EU sponsored report & publications “Economic costs of endocrine disrupting compounds”. 2014-2016
- Rapporteur for COST action TN1201 “genderSTE”, 2014
- Member Editorial Board, Endocrinology, 2014-2017
- External Examiner, taught Masters in Medical Science: Assisted Reproduction Technology, University of Nottingham, 2013-2016
- Member, Society for Reproduction & Fertility Programme committee, 2013-2017
- Member, AERES (now HCERES) research & tertiary education evaluation committee, France, 2013
- Member, Promotions Panel, Technical University of Denmark, 2013
- Named, invited, signatory of the Berlaymont Declaration on Endocrine Disruptors, http://www.brunel.ac.uk/__data/assets/pdf_file/0005/300200/The_Berlaymont_Declaration_on_Endocrine_Disrupters.pdf
- Member, Expert Review Panel to assess applications submitted to 2012 CRACK IT Challenges
- Member, Expert Working Group on Bisphenol A (BPA) toxicology of the European Food Safety Authority (EFSA), 2012-14 http://www.efsa.europa.eu/en/efsajournal/pub/3978.htm
- Member, Gendered Innovations, FP7 case study panel, 2012
- Fellow of the Royal Society of Biology, UK (FRSB), 2010
- Member, Standing Evaluation Panel, Environmental Pollution at the Swedish Research Council Formas, 2010
- Member, Scientific Committee, 5th Copenhagen Workshop on Endocrine Disrupters, 2009
- Chair, Society for Reproduction & Fertility, 2009-2013
- External Examiner, year 3 Reproductive Biology, University of Edinburgh, 2008-2013
- External Examiner, Masters by Research (MRes), St George’s Hospital Medical School, London, 2008-2012
- Editorial Advisory Board for Current Medicinal Chemistry, 2005-2009
- Society for Reproduction and Fertility, Council Member, 2005-2013
- Editorial Board of the journal Reproductive Biology & Endocrinology, 2002-2008
- Chair, Local Organising Committee for Fertility 2003, joint meeting of BAS, BFS, SRF, 2000-2003. This conference was held in Aberdeen July 13-17 2003 and is considered to be one of the most successful Fertility conferences, with 685 delegates and £45,000 surplus
- Society for Reproduction & Fertility, Meetings Committee, 2000-2004
- Acted on various BFS/SRF sub-committees, including scientific referee for abstracts, poster/presentation judge and assessment of applications for the Serono/BFS Studentships etc
- British Fertility Society Committee, 1993-1996
Latest Publications
The profile of steroid hormones in human fetal and adult ovaries
Reproductive Biology and Endocrinology, vol. 22, 60Contributions to Journals: ArticlesIn utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study
The Lancet Planetary Health, vol. 8, no. 1, pp. e5-e17Contributions to Journals: ArticlesMaternal exposure to ambient black carbon particles and their presence in maternal and fetal circulation and organs: an analysis of two independent population-based observational studies
The lancet. Planetary health, vol. 6, no. 10, pp. e804-e811Contributions to Journals: ArticlesP06-20 Characterisation of the effects of Ketoconazole and Diethylstilbestrol on the human fetal adrenal
XVIth International Congress of Toxicology, pp. S120Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.toxlet.2022.07.338
Exposure to a Human Relevant Mixture of Persistent Organic Pollutants or to Perfluorooctane Sulfonic Acid Alone Dysregulates the Developing Cerebellum of Chicken Embryo
Environment International, vol. 166, 107379Contributions to Journals: Articles
Prizes and Awards
FRSB, 2010
- Research
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Research Overview
Since the breakthrough epidemiological studies of the 1980s it has been clear that adult human health is dependent upon fetal development and fetal programming (‘early life programming’). Fetal growth restriction, for example, can lead to hypertension, type 2 diabetes, obesity and cardiovascular disease in the adult. This fetal programming is also termed "Developmental Origins of Health and Disease" (DOHaD) or "Fetal Origins of Adult Disease. Dysfunctional changes in the fetus can arise through a range of mechanisms, such as:
- maternal cigarette smoking
- maternal obesity
- maternal deprivation
- maternal nutrition
- maternal environmental pollutant exposure (such as air pollution)
- maternal medication use
We are studying these factors primarily in the human itself, by studying fetuses aborted for non-medical reasons. This is supported by the SAFeR Study (Scottish Advanced Fetal Research study). The health trajectory of an individual offspring is likely to depend upon a range of maternal and lifestyle factors, including the chemical burden carried at birth. Fetal pollutant exposure has clear adverse effects on development but we have very little knowledge about levels of fetal exposure to “real-life” complex pollutant cocktails and developmental consequences. This fundamental lack of knowledge is a major impasse to developing strategies for reducing fetal pollutant burdens and predicting likely health outcomes. Available data is limited, and often indirect (i.e. animal models or surrogates of exposure), but all studies suggest that fetal pollutant exposure affects lifelong health outcomes and, thereby, impacts on the general economy.
As well as laboratory-based studies of the human fetus my group has also become involved in epidemiological studies in the same field. Our intention with this move is to improve linkage between the individual fetus/mother (laboratory) and population-wide (epidemiology) analyses of maternal environment/lifestyle effects on the fetus and its future health.
Our aim is to understand how maternal factors disturb human fetal development, leading to offspring with greater risk of adverse health outcomes.
Our objective is to identify mechanisms linking these maternal factors with sub-optimal fetal development and lifelong health burdens.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biological and Environmental Sciences, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Toxicology
- Developmental Biology
- Reproductive Biology
- Obstetrics and Gynaecology
- Endocrinology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
Current Team
- Dr Laetitia Lecants (post-doc)
- Dr Peng Liu (post-doc)
- Ms Ausra Lionikiene(Research technician)
- Mr Jimmy Marsden (PhD student)
- Cosupervised PhD students: Katharina Kusse (Prof Val Speirs 1°) & Francesca Moramarco (Prof Peter McCaffery 1°)
RECENT MEMBERS
- Dr Pan Filis (post-doc)
- Dr Natasha Walker (PhD in my lab funded Glasgow Children's Hospital Charity)
- Dr Chiara Talia (PhD in my lab funded by EU MSCA-ITN PROTECTED)
- Dr Aikaterini Zafeiri (EASTBIO PhD student)
- Dr Claire Walker (Research technician)
Recent Visiting Scientists
- Mr Ajay Yadav, 3 months secondment as part of PROTECTED MSCA-ITN, Norwegian University of Life Sciences, Oslo, Norway
- Ms Laetitia Lecante (3 months visit, Universite de Rennes 1, Rennes, France, PhD student)
- Mr Glen Gauderat (3 months on Royal Society grant: Ecole Nationale Veterinaire de Toulouse, France, PhD student)
- Ms Hanna Johansson (Technical University of Denmark, PhD student)
Current Project Highlight
Recent plenary and invited presentations
- Maternal exposure to air pollution nanoparticles and adverse birth outcomes. CHE (Collaborative on Health and the Environment) Webinar https://www.healthandenvironment.org/webinars/96654 19 January 2023.
- Laying the foundations for future life and reproduction. Distinguished Scientist (Anne McLaren) Award Lecture. Fertility 2023, Belfast, 10-13 January 2023.
- Toxicants and maternal lifestyle disturb human fetal developmental programming. Society for Reproductive Investigation Annual Conference, Fetal Physiology Satellite meeting, Boston, July 2021.
- Exposure to the complex mixture of environmental chemicals found in human biosolids. Virtual University of Michigan Symposium on Chemical Mixtures, 12 February 2021.
- Maternal lifestyle, endocrine disruption and the developing fetus. Vrije Universiteit Amsterdam, 19 February 2020, Amsterdam, Netherlands.
- Preparing for a healthy life – maternal lifestyle and fetal programming. Toxalim, 12 October 2018, Toulouse, France.
- Effect of prenatal exposure to environmental toxins on female reproduction. Fertility 2018, 4-6 January 2018, Liverpool, UK.
- Evidence for EDC involvement in reproductive dysfunction in women. Invited seminar at PhD Course in Reproductive Toxicology, Centre for Reproductive Biology in Uppsala (CRU) and Swedish Toxicological Sciences Research Centre (SWETOX), 12-16 June 2016, Uppsala, Sweden.
- Real-world chemical mixtures disturb fetal endocrine systems and gonad development humans and animal models. Symposium: “Mixtures, medicines and diet, where now for endocrine disrupting compounds?” ECE2016: European Congress of Endocrinology, 28-31 May 2016, Munich, Germany.
- Effects of in-utero exposure to toxicants on the fetal gonad and liver. Invited seminar, BIOSIT, combined University of Rennes, CNRS & INSERM unit, 9 November 2015, Rennes, France.
- Sex, drugs, oestrogens and the human fetus. Invited public talk, Aberdeen Medico-Chirurgical Society, 1 October 2015, Aberdeen, UK.
- New insights into human fetal development: endogenous oestrogens, maternal smoking and gene methylation. 8th Copenhagen Workshop of Endocrine Disrupters, 27-30 April 2015, Copenhagen, Denmark.
- Environmental factors in sex differences and metabolism. ESE basic Endocrinology Course in reproductive Endocrinology, 18-20 February 2015, Edinburgh, UK.
- The exposed proteome. Understanding biology and disease: the application of proteomics. University of Aberdeen Symposium, 9 December 2014, Aberdeen, UK. Regulation and dysregulation of primordial follicle formation and activation. 3rd World Congress of Reproductive Biology, 2-4 September 2014, Edinburgh, UK.
- Environmental chemicals and fetal development. 2ieme Journee des Jeunes Chercheurs de L’IRSET, February 4th 2014, University of Rennes, France.
- On women and sheep: making and breaking the fetal ovary. INRA, 13 December 2013, Jouy-en-Josas, France.
- The evidence for EDC involvement in reproductive dysfunction in women. International Workshop: Endocrine Disrupting Chemicals and Female Reproduction. 5-6 November 2013, Uppsala, Sweden.
- Environment and endocrine disruptors in fetal reproductive development. IfLS Conference: Reproductive Biology – from gametes to systems, and between generations. 17 September 2013, Southampton, UK.
- Human fetal reproductive development and endocrinology: effects of maternal smoking. 7th Copenhagen Workshop of Endocrine Disrupters, 28-31 May 2013, Copenhagen, Denmark.
- Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Fertility 2013, Liverpool, January 3-5 2013.
- Effects of exposure to environmental chemicals during pregnancy on the development of the male and female reproductive access“. 17th International Congress on Animal Reproduction (ICAR 29012) in Vancouver, British Columbia, Canada, July 29 – August 2, 2012.
Taking painkillers in pregnancy more likely to lead to complications
Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151 141 singleton pregnancies. Zafeiri A, Raja EA, Mitchell RT, Hay DC, Bhattacharya S, Fowler PA. BMJ Open. 2022 May 3;12(5):e048092. doi: 10.1136/bmjopen-2020-048092.
Knowledge Exchange
Public Engagement
- Maternal exposure to air pollution nanoparticles and adverse birth outcomes. CHE (Collaborative on Health and the Environment) Webinar https://www.healthandenvironment.org/webinars/96654 19 January 2023.
- “The Truth About Fetal Tissue Research”, Nature 528, 2015.
- “Mother’s Smoking During Pregnancy Affects Baby’s DNA”, Scientific American, April 2016.
- “Science Unwrapped: Fertility”, /BBC Radio programme http://www.bbc.co.uk/programmes/p04vvspr and Naked Scientists podcast “Is modern life affecting fertility?” https://www.thenakedscientists.com/podcasts/naked-scientists/modern-life-reducing-our-fertility 21st March 2017.
- “Move over testosterone, another hormone is also vital for making boys – and it doesn’t come from the testes” The Conversation 14/02/2019
- PODCAST: Hormones: The Inside Story. Series 1: Episode 6 https://podcasts.apple.com/gb/podcast/hormones-the-inside-story/id1538409023?i=1000501691883 . Also see https://www.yourhormones.info/podcast, Society for Endocrinology.
- Naked Scientists “Endocrine disruptors and fertility” BBC Radio interview & podcast, 26/02/2021 https://www.thenakedscientists.com/articles/interviews/endocrine-disruptors-and-fertility
Press Releases
- £6m study on impact of environment on immune system in unborn babies and young children
- Top award for Professor Fowler
- 'Painkiller advice for pregnant women should always be followed' as use linked to newborn problems
- What makes a man? Testosterone only half the story
- Aberdeen scientists to pioneer safety tests for household chemicals harming female fertility
- Smoking in pregnancy linked to “worrying” thyroid changes in unborn baby
- Premature babies' low blood pressure puzzle explained
- Girls inherit smoking miscarriage risk
- Scientists find that smoking harms livers of unborn babies
- Chemicals in household products linked to £1bn in European women's health care costs
- Agricultural fertiliser could pose risk to human fertility, sheep study finds
- Smoking while pregnant affects the livers of boys and girdl differenty
- Gender divide for health risk to babies of smoking mothers: Sunday Herald Scotland
- Smoke gets in your genes: Further dangers of smoking while pregnant revealed by new study
- Smoking damage to foetus detected from 12 weeks: Sunday Herald Scotland
- Scientists to investigate impact of smoking and drinking on the developing liver
- Science Careers: adding sex- and gender- dimensions to your research
- Chemicals in environment 'damaging male fertility'
- Pregnancy smoking fertility link
- Smoking Moms Risk Daughters’ Fertility
- Increase in breast cancer linked to pollution levels
- Human sewage harms sheep foetuses
- Findings: Sex change mongooses
Collaborations
- Prof Richard Anderson MRC Centre for Reproductive Health, University of Edinburgh, Scotland
- Dr Jean-Philippe Antignac SARAF, Nantes-Atantique National College of Veterinary Medicine, Food Science & Engineering (ONIRIS), Nantes, France
- Dr Michelle Bellingham Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Scotland
- Prof Siladitya Bhattacharya OBGYN, University of Aberdeen, Scotland
- Dr Lisa Connolly, School of Biological Sciences, Queen's University Belfast, UK
- Dr Corinne Cotinot INRA, Jouy en Josas, France
- Dr Amanda Drake Child Life and Health/MRC Centre for Reproductive Health, University of Edinburgh, Scotland
- Prof Colin Duncan MRC Centre for Reproductive Health, University of Edinburgh, Scotland
- Prof Neil Evans Institute of Comparative Medicine, University of Glasgow, Scotland
- Prof Bernd Fischer Department of Anatomy & Cell Biology, Martin Luther University faculty of Medicine, Halle, Germany
- Prof Veronique Gayrard TOXALIM, Ecole Nationale Veterinaire de Toulouse, France
- Dr Kais Al-Gubory INRA, Jouy en Josas, France
- Dr David Hay Centre for Regenerative Medicine, University of Edinburgh, Scotland
- Dr Sabine Hombach-Klonisch Human Anatomy & Cell Science, University of Manitoba, Canada
- Prof Ilpo Huhtaniemi Reproductive Biology, Imperial College London, UK
- Dr Marilyn Huestis National Institute on Drug Abuse, Baltimore, USA
- Prof John Iredale MRC Centre for Inflammation Research, University of Edinburgh, Scotland
- Prof Thomas Klonisch Human Anatomy & Cell Science, University of Manitoba, Canada
- Prof Bruno Le Bizec LABERCA, Nantes-Atantique National College of Veterinary Medicine, Food Science & Engineering (ONIRIS), Nantes, France
- Dr Richard Lea School of Veterinary Medicine & Science, University of Nottingham, Sutton Bonnington, UK
- Prof Philippa Saunders MRC Centre for Inflammation Research, University of Edinburgh, Scotland
- Prof Peter O'Shaughnessy Institute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Scotland
- Dr Paola Pocar Unit of Veterinary Anatomy &Histology, University of Milan, Italy
- Dr Mick Rae School of Applied Sciences, Edinburgh Napier University, Edinburgh, Scotland
- Prof Erik Ropstad Norwegian School of Veterinary Science, University of Oslo, Norway
- Prof Richard Sharpe MRC Centre for Reproductive Health, University of Edinburgh, Scotland
- Prof Kevin Sinclair School of Biosciences, University of Nottingham, Sutton Bonnington, UK
- Prof Anne Marie Vinggaard Division of Toxicology & Risk Assessment, Technical University of Denmark, Copenhagen, Denmark
- Grateful thanks to Dr Stewart Rhind (James Hutton Institute, Aberdeen, Scotland) for the years of friendship and collaboration before his untimely death.
Funding and Grants
Career total = £24 million
major grants:
2007-10 Wellcome Trust (080388) Effect of in-utero exposure to environmental chemicals via maternal pasture ingestion on fetal development. £426k [PI: collaboration with Macaulay, Edinburgh, Glasgow & INRA]
2008-12 European Commission FP7 (212855) Reproductive effects of environmental chemicals in females (REEF). £2,646k. (PI: collaboration with Macaulay, Edinburgh, INRA, Nottingham, Martin-Luther, Milan]
2009-11 Chief Scientist Office (CZB/4/742) Bioincubator system to model toxic effects on the human fetal testis. £62k [PI]
2014-17 MRC (L010011/1) The human fetal liver: development and response to maternal drug use. £589k [PI: collaboration with Glasgow, Edinburgh]
2014-18 MRC DTP (K501335/1) Development of the human fetal adrenal gland and effects of maternal smoking. £63k [CoI: Bellingham, Glasgow is PI]
2016-19 Glasgow Children’s Hospital Charity (YRSS/PHD/2016/05) Maternal smoking, drinking and deprivation: when and how of placental damage. £60k [PI: collaboration with Glasgow]
2017-21 European Commission H2020 MSCA-ITN (722634) PROTECTion against Endocrine Disruptors; detection, mixtures, health effects, risk assessment and communication (PROTECTED). £3,152k [CoI: Connolly Queen’s Belfast is PI]
2017-20 MRC (L011535/1) Sex-specific disease aetiology from developmental steroid insults: mechanistic understanding and biomarker development towards disease prevention. £637k [CoI: Rae, Edinburgh is PI]
2017-21 BBSRC EASTBIO DTP Mechanisms via which the human fetus is at risk from over-the-counter analgesics. £97k [PI: collaboration with Edinburgh]
2018-21 Arthritis Research UK (21800) Unlocking the joint morphogenetic code in mesenchymal stem cells from human synovium. £328k [CoI: De Bari is PI]
2019-24 European Commission H2020 (825100) Female Reproductive toxicity of Endocrine disrupting chemicals (EDCs): a human evidence-based screening and Identification Approach (FREIA). £5,217k [CoI: van Duursen, VU Amsterdam, is PI]
2022-25 Cunningham Trust (PhD-CT-21-18) Discovery of retinoic acid receptor control of stress granules as a treatment for neurodegenerative diseases. £97k [CoI: Mccaffery, Aberdeen, is PI]
2022-25 BCUK (2122029) Evaluating the effects of BPA on breast cancer development. £99k [CoI: Speirs, Aberdeen, is PI]
2022-25 MRC (MR/W015439/1) Towards a novel treatment targeting obesity in women with polycystic ovary syndrome. £380k [CoI: Duncan, Edinburgh, is PI]
2022-29 European Commission, Horizon Europe (10045444) Partnership for the assessment of risks from chemicals (PARC). €400 million cofund [CoI: ANSES+199 other institutions/agencies]
2023-27 European Commission, Horizon Europe (101094099) Inflammation in human early life: targeting impacts on life-course health (INITIALISE). £6,209k [CoI: Oresic, University of Turku is PI]
- Teaching
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Courses
Teaching Responsibilities
Honours and MSc students undertake research projects in my lab.
Non-course Teaching Responsibilities
I usually have 9 tutees at any one time.
- Publications
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Page 2 of 6 Results 51 to 100 of 292
Scientific Opinion on Flavouring Group Evaluation 61 Revision 2 (FGE.61Rev2): consideration of aliphatic acetals evaluated by JECFA (57th, 63rd and 68th meetings) structurally related to acetals evaluated by EFSA in FGE.03Rev2
EFSA Journal, vol. 18, pp. e05923Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, α,β-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3
EFSA Journal, vol. 18, pp. e05924Contributions to Specialist Publications: ArticlesFetal androgen exposure is a determinant of adult male metabolic health
Scientific Reports, vol. 9, 20195Contributions to Journals: ArticlesOpinion on the re-evaluation of acacia gum (E 414) as a food additive in foods for infants below 16 weeks of age and the follow-up of its re-evaluation as a food additive for uses in foods for all population groups
EFSA Journal, vol. 17, pp. e05922Contributions to Specialist Publications: ArticlesSafety of use of Monk fruit extract as a food additive in different food categories
EFSA Journal, vol. 17, pp. e05921Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 215 Revision 1 (FGE.215Rev1): seven α,β-unsaturated cinnamyl ketones from subgroup 3.2 of FGE.19
EFSA Journal, vol. 17, pp. e05875Contributions to Specialist Publications: ArticlesRe-evaluation of benzyl alcohol (E 1519) as food additive
EFSA Journal, vol. 17, pp. e05876Contributions to Specialist Publications: ArticlesRe-evaluation of sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, 514 (i), 514 (ii), 515 (i), 515 (ii), 516 and 517) as food additive
EFSA Journal, vol. 17, pp. e05868Contributions to Specialist Publications: ArticlesSafety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract
EFSA Journal, vol. 17, pp. e05867Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19
EFSA Journal, vol. 17, pp. e05750Contributions to Specialist Publications: ArticlesRe-evaluation of hydrochloric acid (E 507), potassium chloride (E 508), calcium chloride (E 509) and magnesium chloride (E 511) as food additives
EFSA Journal, vol. 17, pp. e05751Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 5, Revision 3 (FGE.05Rev3): Branched- and straight-chain unsaturated aldehydes, dienals, unsaturated and saturated carboxylic acids and related esters with saturated and unsaturated aliphatic alcohols and a phenylacetic acid related ester from chemical groups 1, 2, 3, 5 and 15
EFSA Journal, vol. 17, pp. e05761Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 70, Revision 1 (FGE.70Rev1): consideration of aliphatic, linear, α,β-unsaturated, di- and trienals and related alcohols, acids and esters evaluated by JECFA (61st-68th-69th meeting)
EFSA Journal, vol. 17, pp. e05749Contributions to Specialist Publications: ArticlesScientific opinion on the proposed amendment of the EU specifications for titanium dioxide (E 171) with respect to the inclusion of additional parameters related to its particle size distribution
EFSA Journal, vol. 17, no. 7, pp. e05760Contributions to Journals: ArticlesRe-evaluation of phosphoric acid–phosphates – di-, tri- and polyphosphates (E 338–341, E 343, E 450–452) as food additives and the safety of proposed extension of use
EFSA Journal, vol. 17, pp. e05674Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 210 Revision 3 (FGE.210Rev3): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19
EFSA Journal, vol. 17, pp. e05676Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 501 (FGE.501): Grill flavour concentrate (vegetable)
EFSA Journal, vol. 17, pp. e05675Contributions to Specialist Publications: ArticlesLong-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males
Environment International, vol. 124, pp. 98-108Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.envint.2019.01.003
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11766/1/Long_term_exposure_to_chemicals_in_sewage_sludge_fertilizer_alters_liver_lipid_content_in_females_and_cancer_marker_expression_in_males.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Maternal Smoking during Pregnancy and Changes in Prostaglandin Enzymes in the Human Fetus.
66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), pp. 244A-244AContributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1177/1933719119834079
Polyomic Analyses of Human Fetal Endocrine Organs Predict Persistent Fetal Inflammation and Reduced Fetal Vitamin D Signalling in Pregnancies of Mothers with High BMI.
66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), pp. 333A-333AContributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1177/1933719119834079
Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking
Placenta, vol. 78, pp. 10-17Contributions to Journals: ArticlesOpinion on the follow-up of the re-evaluation of sorbic acid (E200) and potassium sorbate (E202) as food additives
EFSA Journal, vol. 17, pp. e05625Contributions to Specialist Publications: ArticlesRe-evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use
EFSA Journal, vol. 17, pp. e05622Contributions to Specialist Publications: ArticlesSafety of annatto E and the exposure to the annatto colouring principles bixin and norbixin (E 160b) when used as a food additive
EFSA Journal, vol. 17, pp. e05626Contributions to Specialist Publications: ArticlesSafety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use
EFSA Journal, vol. 17, pp. e05621Contributions to Specialist Publications: ArticlesSerotonin Delivery and Metabolism are Affected by High Maternal BMI in the Human Fetus.
66th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), pp. 250A-250AContributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1177/1933719119834079
Alternative (backdoor) androgen production and masculinization in the human fetus
PLoS Biology, vol. 17, no. 2, e3000002Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pbio.3000002.s009
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11944/1/journal.pbio.3000002.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Move over testosterone, another hormone is also vital for making boys – and it doesn't come from the testes
The ConversationContributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): consideration of genotoxicity data on alicyclic aldehydes with α,β-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE.19
EFSA Journal, vol. 17, pp. e05569Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 217 Revision 2 (FGE.217Rev2), consideration of genotoxic potential for α,β-unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones
EFSA Journal, vol. 17, pp. e05568Contributions to Specialist Publications: ArticlesRe-evaluation of propane-1,2-diol esters of fatty acids (E 477) as a food additive
EFSA Journal, vol. 16, pp. e05497Contributions to Specialist Publications: ArticlesThe effects of maternal smoking and BMI on the first and second trimester human fetal kidney
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 125, pp. 53-53Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.15493
Maternal smoking and high BMI disrupt thyroid gland development
BMC medicine , vol. 16, 194Contributions to Journals: ArticlesScientific Opinion of Flavouring Group Evaluation 411 (FGE.411): 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide from chemical group 30 (miscellaneous substances)
EFSA Journal, vol. 16Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19
EFSA Journal, vol. 16Contributions to Specialist Publications: ArticlesIn utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus
54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, pp. S63-S64Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.toxlet.2018.06.064
Re-evaluation of oxidised soya bean oil interacted with mono- and diglycerides of fatty acids (E 479b) as a food additive
EFSA Journal, vol. 16, pp. e05420Contributions to Specialist Publications: ArticlesScientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19
EFSA Journal, vol. 16Contributions to Specialist Publications: ArticlesSex-specific Disturbance of Early-Mid Pregnancy Placental Transporter Protein Expression Associated with Maternal Overweight/Obesity
Meeting of the International-Federation-of-Placenta-Associations (IFPA) 2018, pp. E44-E45Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.placenta.2018.06.004
Safety assessment of the process 'Linpac', based on Linpac super clean technology, used to recycle post-consumer PET into food contact materials
EFSA Journal, vol. 16, pp. e05323Contributions to Specialist Publications: ArticlesSUPERSEDED: Safety assessment of the substance poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) for use in food contact materials
EFSA Journal, vol. 16, pp. e05326Contributions to Specialist Publications: ArticlesSafety evaluation of the food enzyme α-amylase from a genetically modified Aspergillus niger (strain NZYM-SB)
EFSA Journal, vol. 16, pp. e05320Contributions to Specialist Publications: ArticlesSafety assessment of the process 'Gneuss 1', based on Gneuss technology, used to recycle post-consumer PET into food contact materials
EFSA Journal, vol. 16, pp. 13Contributions to Specialist Publications: ArticlesSafety assessment of the process 'Gneuss 2', based on Gneuss technology, used to recycle post-consumer PET into food contact materials
EFSA Journal, vol. 16Contributions to Specialist Publications: ArticlesSafety evaluation of the food enzyme α-amylase from a genetically modified Bacillus licheniformis (strain NZYM-AV)
EFSA Journal, vol. 16Contributions to Specialist Publications: ArticlesThe effect of maternal BMI on the development of human fetal kidney
34th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), pp. 349-349Contributions to Conferences: AbstractsSafety evaluation of food enzyme glucan 1,4-α-maltohydrolase produced with a genetically modified Bacillus subtilis (strain MAM)
EFSA Journal, vol. 16Contributions to Specialist Publications: ArticlesThe human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester
BMC medicine , vol. 16, 23Contributions to Journals: ArticlesQuantification of ethyl glucuronide, ethyl sulfate, nicotine, and its metabolites in human fetal liver and placenta
Forensic Toxicology, vol. 36, no. 1, pp. 102-112Contributions to Journals: ArticlesSafety assessment of the active substance selenium nanoparticles, for use in active food contact materials
EFSA Journal, vol. 16, pp. e05115Contributions to Specialist Publications: Articles