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The Institute of Medical Sciences

Dr Ian Fleming

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Dr Ian Fleming
Dr Ian Fleming
Dr Ian Fleming

Senior Lecturer

About
Email Address
i.n.fleming@abdn.ac.uk
Telephone Number
+44 (0)1224 438357
Office Address

Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK

School/Department
School of Medicine, Medical Sciences and Nutrition
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Research

Research Overview

Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.

Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.

Current Research

Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis. 

Collaborations

Prof Fiona Gilbert, University of Cambridge

Prof Paula Ghaneh, University of Liverpool

Prof David O'Hagan, University of St Andrews

Kemotech, Italy

 

  

Funding and Grants

Current Grants:

Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)

18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)

Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)

Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)   

Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)

Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)  

Teaching

Teaching Responsibilities

Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills

Programme coordinator BT5007: Industrial Placement/MSci course

Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease

Course coordinator & lecturer BP5003: Biomedical and other Professional Topics

Lecturer SM2501: Research skills for Medical Sciences

Coordinator of Hotstart programme   

Publications

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  • Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of αvβ3 integrin receptor

    Dall'angelo, S., Zhang, Q., Fleming, I. N., Piras, M., Schweiger, L. F., O'Hagan, D., Zanda, M.
    Organic & Biomolecular Chemistry, vol. 27, no. 11, pp. 4551-4558
    Contributions to Journals: Articles

  • Response to trastuzumab by HER2 expressing breast tumour xenografts is accompanied by decreased Hexokinase II, glut1 and [18F]-FDG incorporation and changes in 31P-NMR detectable phosphomonesters

    Smith, T. A. D., Appleyard, M. V. C. L., Sharp, S., Fleming, I. N., Murray, K., Thompson, A. M.
    Cancer Chemotherapy and Pharmacology, vol. 71, no. 2, pp. 473-480
    Contributions to Journals: Articles

  • Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers

    Fleming, I. N., Whelan, M., Baxendale, R., Gilbert, F. J., Matthews, P. P., Aigbirhio, F. I.
    Nuclear Medicine Communications, vol. 33, no. 9, pp. 899-906
    Contributions to Journals: Articles

  • Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

    Aboagye, E. O., Gilbert, F. J., Fleming, I. N., Beer, A. J., Cunningham, V. J., Marsden, P. K., Visvikis, D., Gee, A. D., Groves, A. M., Kenny, L. M., Cook, G. J., Kinahan, P. E., Myers, M., Clarke, L., Experimental Cancer Medicine Centre 13 Imaging Network Group
    European Radiology, vol. 22, no. 7, pp. 1465-1478
    Contributions to Journals: Articles

  • Positron emission tomography oncology research in the UK: a comparison with USA and Europe

    Fleming, I. N., Regel, S. J., Pike, L. C., Marsden, P. K., Gilbert, F. J.
    Nuclear Medicine Communications, vol. 33, no. 4, pp. 341-348
    Contributions to Journals: Articles

  • Hypoxia imaging with PET: which tracers and why?

    Chia, K., Fleming, I. N., Blower, P. J.
    Nuclear Medicine Communications, vol. 33, no. 3, pp. 217-222
    Contributions to Journals: Editorials

  • Building PET research collaborations

    Fleming, I. N., Gilbert, F. J., Blower, P. J.
    Nuclear Medicine Communications, vol. 33, no. 1, pp. 1-3
    Contributions to Journals: Articles

  • Linear Trifluoroethylamine RGD Peptidomimetics: Stereoselective Synthesis and Integrin alphavbeta3 affinity

    Piras, M., Fleming, I. N., Harrison, W. T. A., Zanda, M.
    Synlett, vol. 23, no. 20, pp. 2899-2902
    Contributions to Journals: Articles

  • Beyond 18F-fluorodeoxyglucose: making the next generation of PET radiotracers available for oncology research in the UK

    Gilbert, F. J., Fleming, I. N., Marsden, P. K.
    Nuclear Medicine Communications, vol. 32, no. 1, pp. 1-3
    Contributions to Journals: Editorials

  • Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types

    Green, S. R., Choudhary, A. K., Fleming, I. N.
    British Journal of Cancer, vol. 103, no. 9, pp. 1391-1399
    Contributions to Journals: Articles

  • Opportunities for PET to deliver clinical benefit in cancer: breast cancer as a paradigm

    Fleming, I. N., Gilbert, F. J., Miles, K. A., Cameron, D.
    Cancer Imaging, vol. 10, no. 1, pp. 144-152
    Contributions to Journals: Articles

  • Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents

    Fleming, I. N., Hogben, M., Frame, S., McClue, S. J., Green, S. R.
    Clinical Cancer Research, vol. 14, no. 13, pp. 4326-4335
    Contributions to Journals: Articles

  • The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups

    Downes, C. P., Gray, A., Fairservice, A., Safrany, S. T., Batty, I. H., Fleming, I. N.
    Biochemical Society Transactions, vol. 33, no. Pt 6, pp. 1303-1307
    Contributions to Journals: Articles

  • Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

    Fleming, I. N., Batty, I. H., Prescott, A. R., Gray, A., Kular, G. S., Stewart, H., Downes, C. P.
    Biochemical Journal, vol. 382, no. 3, pp. 857-865
    Contributions to Journals: Articles

  • Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells

    Batty, I. H., Fleming, I. N., Downes, C. P.
    Biochemical Journal, vol. 379, no. 3, pp. 641-651
    Contributions to Journals: Articles

  • 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

    Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., Fleming, I. N., Green, S. R., McNae, I., Wu, S., McInnes, C., Zheleva, D., Walkinshaw, M. D., Fischer, P. M.
    Journal of Medicinal Chemistry, vol. 47, no. 7, pp. 1662-1675
    Contributions to Journals: Articles

  • Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

    Watt, S. A., Kimber, W. A., Fleming, I. N., Leslie, N. R., Downes, C. P., Lucocq, J. M.
    Biochemical Journal, vol. 377, no. 3, pp. 653-663
    Contributions to Journals: Articles

  • Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1

    Watt, S. A., Kular, G., Fleming, I. N., Downes, C. P., Lucocq, J. M.
    Biochemical Journal, vol. 363, no. Pt 3, pp. 657-66
    Contributions to Journals: Articles

  • Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

    Fleming, I. N., Gray, A., Downes, C. P.
    Biochemical Journal, vol. 351, no. Pt 1, pp. 173-82
    Contributions to Journals: Articles

  • Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

    Fleming, I. N., Elliott, C. M., Buchanan, F. G., Downes, C. P., Exton, J. H.
    The Journal of Biological Chemistry, vol. 274, no. 18, pp. 12753-8
    Contributions to Journals: Articles

  • Determination of interaction sites on the small G protein RhoA for phospholipase D

    Bae, C. D., Min, D. S., Fleming, I. N., Exton, J. H.
    The Journal of Biological Chemistry, vol. 273, no. 19, pp. 11596-604
    Contributions to Journals: Articles

  • Phospholipase C-gamma, protein kinase C and Ca2+/calmodulin-dependent protein kinase II are involved in platelet-derived growth factor-induced phosphorylation of Tiam1

    Fleming, I. N., Elliott, C. M., Exton, J. H.
    FEBS Letters, vol. 429, no. 3, pp. 229-33
    Contributions to Journals: Articles

  • Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C

    Fleming, I. N., Elliott, C. M., Collard, J. G., Exton, J. H.
    The Journal of Biological Chemistry, vol. 272, no. 52, pp. 33105-10
    Contributions to Journals: Articles

  • Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor

    Fleming, I. N., Elliott, C. M., Exton, J. H.
    The Journal of Biological Chemistry, vol. 271, no. 51, pp. 33067-73
    Contributions to Journals: Articles

  • Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver

    Fleming, I. N., Yeaman, S. J.
    Biochemical Journal, vol. 308 ( Pt 3), pp. 983-9
    Contributions to Journals: Articles
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