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The Institute of Medical Sciences

Dr Ian Fleming

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Dr Ian Fleming
Dr Ian Fleming
Dr Ian Fleming

Senior Lecturer

About
Email Address
i.n.fleming@abdn.ac.uk
Telephone Number
+44 (0)1224 438357
Office Address

Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK

School/Department
School of Medicine, Medical Sciences and Nutrition
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Research

Research Overview

Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.

Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.

Current Research

Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis. 

Collaborations

Prof Fiona Gilbert, University of Cambridge

Prof Paula Ghaneh, University of Liverpool

Prof David O'Hagan, University of St Andrews

Kemotech, Italy

 

  

Funding and Grants

Current Grants:

Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)

18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)

Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)

Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)   

Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)

Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)  

Teaching

Teaching Responsibilities

Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills

Programme coordinator BT5007: Industrial Placement/MSci course

Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease

Course coordinator & lecturer BP5003: Biomedical and other Professional Topics

Lecturer SM2501: Research skills for Medical Sciences

Coordinator of Hotstart programme   

Publications

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  • 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

    Wang, S., Meades, C., Wood, G., Osnowski, A., Anderson, S., Yuill, R., Thomas, M., Mezna, M., Jackson, W., Midgley, C., Griffiths, G., Fleming, I. N., Green, S. R., McNae, I., Wu, S., McInnes, C., Zheleva, D., Walkinshaw, M. D., Fischer, P. M.
    Journal of Medicinal Chemistry, vol. 47, no. 7, pp. 1662-1675
    Contributions to Journals: Articles

  • Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

    Watt, S. A., Kimber, W. A., Fleming, I. N., Leslie, N. R., Downes, C. P., Lucocq, J. M.
    Biochemical Journal, vol. 377, no. 3, pp. 653-663
    Contributions to Journals: Articles

  • Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1

    Watt, S. A., Kular, G., Fleming, I. N., Downes, C. P., Lucocq, J. M.
    Biochemical Journal, vol. 363, no. Pt 3, pp. 657-66
    Contributions to Journals: Articles

  • Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

    Fleming, I. N., Gray, A., Downes, C. P.
    Biochemical Journal, vol. 351, no. Pt 1, pp. 173-82
    Contributions to Journals: Articles

  • Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

    Fleming, I. N., Elliott, C. M., Buchanan, F. G., Downes, C. P., Exton, J. H.
    The Journal of Biological Chemistry, vol. 274, no. 18, pp. 12753-8
    Contributions to Journals: Articles

  • Determination of interaction sites on the small G protein RhoA for phospholipase D

    Bae, C. D., Min, D. S., Fleming, I. N., Exton, J. H.
    The Journal of Biological Chemistry, vol. 273, no. 19, pp. 11596-604
    Contributions to Journals: Articles

  • Phospholipase C-gamma, protein kinase C and Ca2+/calmodulin-dependent protein kinase II are involved in platelet-derived growth factor-induced phosphorylation of Tiam1

    Fleming, I. N., Elliott, C. M., Exton, J. H.
    FEBS Letters, vol. 429, no. 3, pp. 229-33
    Contributions to Journals: Articles

  • Lysophosphatidic acid induces threonine phosphorylation of Tiam1 in Swiss 3T3 fibroblasts via activation of protein kinase C

    Fleming, I. N., Elliott, C. M., Collard, J. G., Exton, J. H.
    The Journal of Biological Chemistry, vol. 272, no. 52, pp. 33105-10
    Contributions to Journals: Articles

  • Differential translocation of rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor

    Fleming, I. N., Elliott, C. M., Exton, J. H.
    The Journal of Biological Chemistry, vol. 271, no. 51, pp. 33067-73
    Contributions to Journals: Articles

  • Purification and characterization of N-ethylmaleimide-insensitive phosphatidic acid phosphohydrolase (PAP2) from rat liver

    Fleming, I. N., Yeaman, S. J.
    Biochemical Journal, vol. 308 ( Pt 3), pp. 983-9
    Contributions to Journals: Articles
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