Dr Elaina Collie-Duguid

Dr Elaina Collie-Duguid
Dr Elaina Collie-Duguid
Dr Elaina Collie-Duguid

BSc (Hons) (First Class, Brisbane, Australia, 1990), PhD (Aberdeen, 1997)

Manager, Centre for Genome Enabled Biology & Medicine

About
Email Address
e.collie-duguid@abdn.ac.uk
Telephone Number
+44 (0)1224 437958
Office Address

School of Medicine, Medical Sciences and Nutrition. Room 4.015. Polwarth Bulding. Foresterhill. Aberdeen. AB25 2ZD

and

Centre for Genome Enabled Biology and Medicine. Room G17. 23 St Machar Drive. Old Aberdeen. Aberdeen. AB24 3RY.

 

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Elaina Collie-Duguid was awarded a first class BSc (Hons) degree in molecular biology from the University of Queensland, Brisbane, Australia in 1990. Her time as a research assistant at the Centre for Molecular Biology and Biotechnology (currently The Institute of Molecular Bioscience), University of Queensland, was followed by a period of international travel, culminating in a move to Aberdeen in 1993 to begin a PhD in molecular and cellular biology at the Rowett Research Institute. In 1996, Dr Collie-Duguid took up post as a post-doctoral scientist in the Department of Medicine and Therapeutics at the University of Aberdeen and she now heads a Cancer Medicine research group with a particular focus on breast cancer within the Cancer Biomedicine programme.

Dr Collie-Duguid manages the Centre for Genome Enabled Biology and Medicine (CGEBM) at the University of Aberdeen. CGEBM provides strategic direction and coordinated management of the University of Aberdeen’s genomics facilities and facilitates genomics enabled interdisciplinary research by provision of specialised expertise, infrastructure, training, a focal point for collaboration and information exchange and genomics services to the research community. CGEBM provides specialist services in next generation sequencing (NGS), microarrays, bioinformatics and biostatistics. CGEBM helps to drive genome focused research forward by developing and exploiting modern genomic technologies to accelerate discovery of novel approaches to improve human health, the environment and agriculture within the diverse programmes of applied translational, clinical, biomedical and biological research at the University of Aberdeen.

 

 

External Memberships

Scientific Member of the Experimental and Translational Medicine Research Committee of the Chief Scientist Office, 2009-2014

Scientific Member of the Biomedical and Therapeutics Research Committee of the Chief Scientist Office, 2005-2009.

Research

Research Overview

Dr Collie-Duguid's research interest is to understand the molecular and cellular mechanisms controlling tumorigenesis, survival of cancer patients and chemoresistance in solid tumours, with a particular focus on breast cancers.  Biomarker discovery for prediction of clinical outcomes, including response to therapy; and novel drug target identification for drug development are key elements of her translational research programme. Dr Collie-Duguid has an interest in using genomic tools to understand human disease and important biological processes.

Teaching

Teaching Responsibilities

Dr Collie-Duguid teaches on level 5 courses MB5021 Bioinformatics, MT5003 Drug Metabolism and Toxicology, and MT5515 Research Methods, level 4 PA4302 Molecular Toxicology, level 3 PA3802 Mechanisms of Disease and Principles of Chemotherapy and Intercalated BSc MB ChB teaching in Genetic variation and Bioinformatics, and provides research project supervision to level 5 MSc students in the field of genomics.  

Publications

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  • Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines

    Wang, W., Collie-Duguid, E. S. R., Cassidy, J.
    FEBS Letters, vol. 531, no. 3, pp. 415-420
    Contributions to Journals: Articles
  • Pyrimidine Metabolism and G1/S transition in colon tumours.

    Collie-Duguid, E. S. R., McKay, J. A., Ladner, R. D., Lynch, F. J., Ross, V. G., Mcintosh, R. A., Murray, G. I., Cassidy, J.
    British Journal of Cancer, vol. 86, no. S1
    Contributions to Journals: Articles
  • Thymidine phosphorylase and dihydropyrimidine dehydrogenase protein expression in colorectal cancer

    Collie-Duguid, E. S. R., Johnston, S. J., Boyce, L., Smith, N., Cowieson, A., Cassidy, J., Murray, G. I., McLeod, H. L.
    International Journal of Cancer, vol. 94, no. 2, pp. 297-301
    Contributions to Journals: Articles
  • A clinician's guide to the polmerase chain reaction

    Collie-Duguid, E. S. R., McLeod, H.
    UroOncology, vol. 1, pp. 103-112
    Contributions to Journals: Literature Reviews
  • Cloning and initial characterization of the human DPYD gene promoter

    Collie-Duguid, E. S. R., Johnston, S. J., Powrie, R. H., Milano, G., Etienne, M. C., Rochat, B., Watson, G. C., McLeod, H. L.
    Biochemical and Biophysical Research Communications, vol. 271, pp. 28-35
    Contributions to Journals: Articles
  • Estimation of dihydropyrimidine dehydrogenase activity: Does it have a role in cancer therapy?

    Collie-Duguid, E. S. R., McLeod, H. L., Cassidy, J.
    Annals of Oncology, vol. 11, pp. 255-257
    Contributions to Journals: Editorials
  • Known variant DPYD alleles do not explain DPD deficiency in cancer patients

    Collie-Duguid, E. S. R., Etienne, M. C., Milano, G., McLeod, H. L.
    Pharmacogenetics, vol. 10, pp. 217-223
    Contributions to Journals: Articles
  • Therapeutic opportunities from tumour biology in metastatic colon cancer

    McLeod, H. L., McKay, J. A., Collie-Duguid, E. S. R., Cassidy, J.
    European Journal of Cancer, vol. 36, pp. 1706-1712
    Contributions to Journals: Articles
  • Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations

    Marsh, S., Collie-Duguid, E. S. R., Li, T., Liu, X. H., McLeod, H. L.
    Genomics, vol. 58, no. 3, pp. 310-312
    Contributions to Journals: Articles
  • Ethnic differences in thiopurine methyltransferase pharmacogenetics: evidence for allele specificity in Caucasian and Kenyan individuals

    McLeod, H. L., Pritchard, S. C., Githang'a, J., Indalo, A., Ameyaw, M. M., Powrie, R. H., Booth, L., Collie-Duguid, E. S. R.
    Pharmacogenetics, vol. 9, pp. 773-776
    Contributions to Journals: Articles
  • The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations

    Collie-Duguid, E. S. R., Pritchard, S. C., Powrie, R. H., Sludden, J., Collier, D. A., Li, T., McLeod, H. L.
    Pharmacogenetics, vol. 9, pp. 37-42
    Contributions to Journals: Articles
  • Thiopurine methyltransferase alleles in British and Ghanaian populations

    Ameyaw, M. M., Collie-Duguid, E. S. R., Powrie, R. H., Ofori-Adjei, D., McLeod, H. L.
    Human Molecular Genetics, vol. 8, pp. 367-370
    Contributions to Journals: Articles
  • Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from Azathioprine

    Black, A., McLeod, H., Capell, H., Powrie, R., Matowe, L., Pritchard, S. C., Collie-Duguid, E. S. R., Reid, D. M.
    Annals of Internal Medicine, vol. 129, no. 9, pp. 716-718
    Contributions to Journals: Articles
  • Nomenclature for human DPYD alleles

    McLeod, H. L., Collie-Duguid, E. S. R., Vreken, P., Johnson, M. R., Wei, X., Sapone, A., Diasio, R. B., Fernandez-Salguero, P., van Kuilenberg, A. B. P., van Gennip, A. H., Gonzalez, F. J.
    Pharmacogenetics, vol. 8, pp. 455-459
    Contributions to Journals: Articles
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