MD PhD FRCP, Hon Consultant Rheumatologist
Clinical Chair in Experimental Medicine and Rheumatology
- About
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- Email Address
- c.debari@abdn.ac.uk
- Office Address
School of Medicine, Medical Sciences and Nutrition
University of Aberdeen
Aberdeen Centre for Arthritis and Musculoskeletal Health
Arthritis and Regenerative Medicine Laboratory
Institute of Medical Sciences
Foresterhill, Aberdeen AB25 2ZD
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.
Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.
Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.
External Memberships
Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.
Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.
- Research
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Research Overview
The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.
The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.
The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.
- Publications
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Page 3 of 4 Results 51 to 75 of 91
Mesenchymal stem cells from development to postnatal joint homeostasis, aging, and disease
Birth Defects Research. Part C, Embryo Today: Reviews, vol. 90, no. 4, pp. 257-271Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bdrc.20189
The regulation of differentiation in mesenchymal stem cells
Human Gene Therapy, vol. 21, no. 10, pp. 1226-1238Contributions to Journals: ArticlesMesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches
European Cells & Materials, vol. 20, pp. 121-133Contributions to Journals: ArticlesHuman single-chain variable fragment that specifically targets arthritic cartilage
Arthritis & Rheumatism, vol. 62, no. 4, pp. 1007-1016Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.27346
Yap is a novel regulator of C2C12 myogenesis
Biochemical and Biophysical Research Communications, vol. 393, no. 4, pp. 619-624Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbrc.2010.02.034
Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table
Stem Cells and Development, vol. 19, no. 2, pp. 143-154Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1089/scd.2009.0404
Distinct mesenchymal progenitor cell subsets in the adult human synovium
Rheumatology, vol. 48, no. 9, pp. 1057-1064Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/kep192
Mesenchymal stem cells find their niches in skeletal regenerative medicine
European Cells and Materials, vol. 18, no. SUPPL. 1Contributions to Journals: Articles- [ONLINE] View publication in Scopus
A novel in vivo murine model of cartilage regeneration: Age and strain-dependent outcome after joint surface injury
Osteoarthritis and Cartilage, vol. 17, no. 6, pp. 695-704Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.joca.2008.11.003
Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources
Differentiation: Research in Biological Diversity, vol. 76, no. 9, pp. 946-957Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1432-0436.2008.00279.x
A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination
Developmental Biology, vol. 320, no. 1, pp. 39-48Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ydbio.2008.12.001
The large functional spectrum of the heparin-binding cytokines MK and HB-GAM in continuously growing organs: The rodent incisor as a model
Developmental Biology, vol. 320, no. 1, pp. 256-266Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ydbio.2008.05.530
Stem cells for tooth engineering
European Cells & Materials, vol. 16, no. 1, pp. 1-9Contributions to Journals: ArticlesIdentification of the molecular response of articular cartilage to injury, by microarray screening
Arthritis & Rheumatism, vol. 58, no. 5, pp. 1410-1421Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.23444
Apoptosis in developmental and repair-related human tooth remodeling: a view from the inside
Experimental Cell Research, vol. 314, no. 4, pp. 869-877Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.yexcr.2007.11.001
Cell therapy: a challenge in modern medicine
3rd International Meeting on Medical Engineering and Therapy, pp. 11-17Contributions to Journals: Special IssuesA biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells
Arthritis & Rheumatism, vol. 58, no. 1, pp. 240-250Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.23143
Mesenchymal stem cells in rheumatology: A regenerative approach to joint repair
Clinical Science, vol. 113, no. 8, pp. 339-348Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/CS20070126
Stem cell niches in mammals
Experimental Cell Research, vol. 313, no. 16, pp. 3377-3385Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.yexcr.2007.07.027
Lessons from musculoskeletal stem cell research: The key to successful regenerative medicine development
Arthritis & Rheumatism, vol. 56, no. 3, pp. 714-721Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.22440
Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis
Arthritis & Rheumatism, vol. 56, no. 2, pp. 489-497Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.22372
Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
Arthritis Research & Therapy, vol. 9, no. 1, pp. 301Contributions to Journals: ArticlesEfficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells
Stem Cells, vol. 24, no. 4, pp. 896-907Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1634/stemcells.2003-0106
Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis
Arthritis & Rheumatism, vol. 54, no. 4, pp. 1209-1221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ART.21753
Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
Arthritis Research & Therapy, vol. 8, no. 5, pp. R139Contributions to Journals: Articles