Professor of Virology, Interim Head of School
- About
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- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
David’s PhD (1990) is in molecular genetics and he has worked on different aspects of virology and immunology including in the USA, where he worked at the University of California (UC) for nine years on HIV and Kaposi’s sarcoma herpesvirus (KSHV), including six years with Dr Jay A. Levy.
David’s research more recently has focused on viruses that are responsible for causing cancer. In particular, he concentrates on how such viruses hide from the immune system. By studying human viruses that have evolved with their host for at least 25 million years, David believes that unique insight into the workings of the immune system can be gained. This knowledge can then be put to good use to treat immune system disorders. Techniques include a combination of molecular virology and immunology.
He has either authored or co-authored over £8m in funded research grant awards and published over 75 manuscripts that have been cited over 5000 times (Google Scholar), with two papers cited over 600 times each and a further three papers cited over 200 times each.
David returned to the UK from the USA in 1999 to his first lectureship at the University of Glasgow. In 2005 he moved to the University of Birmingham and received his Chair there in 2010. He moved to the University of Surrey to be Head of the Department of Microbial Sciences in August 2013 and in December of that year was appointed Head of the School of Biosciences and Medicine, consisting of four departments, a clinical trials faciility and a clinical trials unit. He held that position for eight years.
David is proud to have been appointed Director of the Institute of Medical Sciences at the University of Aberdeen, commencing January 2022, and from July 2024 Interim Head of the School of Medicine, Medical Sciences and Nutrition.
ORCID ID: https://orcid.org/0000-0002-6703-4497
External Memberships
David is one of three Founding Directors of Ducentis Biotherapeutics (www.ducentisbio.com) established in 2015 to exploit his research findings to create next generation anti-inflammatory and autoimmune medicines. David serves as a non-executive board member for Ducentis, which has secured c£4m in start-up funding, including from LifeArc.
He is one of three Editors-in-Chief for FEMS Microbiology Reviews (https://academic.oup.com/femsre), which publishes invited comprehensive and authoritative reviews on all aspects of microbiology from leading authors. FEMS Microbiology Reviews ranked 6th of 134 Microbiology journals in the 2020 Journal Citation Reports.
Latest Publications
Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)
Critical Reviews in Clinical Laboratory Sciences, vol. 60, no. 3, pp. 189-211Contributions to Journals: Review articlesVitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort
Nutrients, vol. 13, no. 11, 4104Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/nu13114104
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17816/1/Vearing_etal_Vitamin_D_Status_VOR.pdf
- [ONLINE] View publication in Scopus
KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection
Cell Reports, vol. 35, no. 5, 109056Contributions to Journals: ArticlesVery high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: Analysis of the UK Biobank Cohort
British Journal of Nutrition, vol. 125, no. 4, pp. 448-459Contributions to Journals: ArticlesMembrane-associated and secreted forms of the rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on rhesus macaque CD200 receptor signaling and regulation of myeloid cell activation
Journal of Virology, vol. 95, no. 5, e01654-20Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.01654-20
- [ONLINE] View publication in Scopus
- Research
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Research Overview
David is Professor of Virology and took up the role of interim Head of the School of Medicine, Medical Sciences and Nutrition at the University of Aberdeen in July 2024.
David’s research interests have centred on understanding mechanisms of virus immune modulation and hence what these mechanisms can teach us about immune system regulation. After over eight years in the US working on HIV and related viruses, his independent academic career began in Glasgow in 1999 and continued at the University of Birmingham. In 2013 he was appointed Head of the School of Biosciences and Medicine, at the University of Surrey and in January 2022 he moved to the role of Director of the Institute of Medical Sciences at the University of Aberdeen.
David was one of three Founding Directors of Ducentis Biotherapeutics established in 2015 to exploit his research creating next generation anti-inflammatory and autoimmune medicines. After an exit to Arcutis Biotherapeutics in September 2022, he co-founded Dioka Therapeutics (www.diokatherapeutics.com) to create a new intervention for high blood pressure.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Biomedical Sciences
Accepting PhDs - Publications
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Page 1 of 2 Results 1 to 50 of 79
Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)
Critical Reviews in Clinical Laboratory Sciences, vol. 60, no. 3, pp. 189-211Contributions to Journals: Review articlesVitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort
Nutrients, vol. 13, no. 11, 4104Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/nu13114104
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17816/1/Vearing_etal_Vitamin_D_Status_VOR.pdf
- [ONLINE] View publication in Scopus
KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection
Cell Reports, vol. 35, no. 5, 109056Contributions to Journals: ArticlesVery high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: Analysis of the UK Biobank Cohort
British Journal of Nutrition, vol. 125, no. 4, pp. 448-459Contributions to Journals: ArticlesMembrane-associated and secreted forms of the rhesus macaque rhadinovirus-encoded CD200 homologue and cellular CD200 demonstrate differential effects on rhesus macaque CD200 receptor signaling and regulation of myeloid cell activation
Journal of Virology, vol. 95, no. 5, e01654-20Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.01654-20
- [ONLINE] View publication in Scopus
Vitamin D supplement use and associated demographic, dietary and lifestyle factors in 8024 South Asians aged 40-69 years: Analysis of the UK Biobank cohort
Public Health Nutrition, vol. 21, no. 14, pp. 2678-2688Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S1368980018001404
- [ONLINE] View publication in Scopus
Merkel cell polyomavirus small T antigen drives cell motility via Rho-GTPase-induced filopodium formation
Journal of Virology, vol. 92, no. 2, e00940-17Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.00940-17
- [ONLINE] View publication in Scopus
Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression
Cell Host and Microbe, vol. 22, no. 1, pp. 61-73.e7Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.chom.2017.06.009
- [ONLINE] View publication in Scopus
Aflatoxin B1 inhibits the type 1 interferon response pathway via STAT1 suggesting another mechanism of hepatocellular carcinoma
Infectious Agents and Cancer, vol. 12, no. 1, 17Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13027-017-0127-8
- [ONLINE] View publication in Scopus
Activation of DNA damage response pathways during lytic replication of KSHV
Viruses, vol. 7, no. 6, pp. 2908-2927Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/v7062752
- [ONLINE] View publication in Scopus
Structural properties of a viral orthologue of cellular CD200 protein: KSHV vOX2
Virology, vol. 474, pp. 94-104Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.virol.2014.10.020
- [ONLINE] View publication in Scopus
Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration
Journal of Virology, vol. 89, no. 1, pp. 35-47Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.02317-14
- [ONLINE] View publication in Scopus
Functional analysis of Kaposi's sarcoma-associated herpesvirus vFLIP expression reveals a new mode of IRES-mediated translation
RNA , vol. 20, no. 11, pp. 1803-1814Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1261/rna.045328.114
- [ONLINE] View publication in Scopus
Inflammatory cell distribution in primary Merkel cell carcinoma
Cancers, vol. 6, no. 2, pp. 1047-1064Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/cancers6021047
- [ONLINE] View publication in Scopus
Infection and transmission dynamics of rKSHV.219 in primary endothelial cells
Journal of Virological Methods, vol. 193, no. 1, pp. 251-259Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jviromet.2013.06.001
- [ONLINE] View publication in Scopus
An analysis of the function and expression of D6 on lymphatic endothelial cells
Blood, vol. 121, no. 18, pp. 3768-3777Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2012-04-425314
- [ONLINE] View publication in Scopus
Introducing viruses and cancer
Microbiology Today, vol. 40, no. 1, pp. 16-21Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Innate barriers to viral infection
Future Microbiology, vol. 7, no. 7, pp. 815-822Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2217/fmb.12.52
- [ONLINE] View publication in Scopus
Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3
Journal of Virology, vol. 86, no. 13, pp. 7158-7166Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.06908-11
- [ONLINE] View publication in Scopus
Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200
Journal of Virology, vol. 86, no. 11, pp. 6246-6257Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.07168-11
- [ONLINE] View publication in Scopus
Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1
Virology, vol. 421, no. 2, pp. 149-158Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.virol.2011.09.025
- [ONLINE] View publication in Scopus
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3
Journal of General Virology, vol. 92, no. 10, pp. 2394-2398Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1099/vir.0.034322-0
- [ONLINE] View publication in Scopus
An interaction between kshv orf57 and uif provides mrna-adaptor redundancy in herpesvirus intronless mrna export
PLoS Pathogens, vol. 7, no. 7, e1002138Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.ppat.1002138
- [ONLINE] View publication in Scopus
Kaposi's sarcoma-associated herpesvirus infection of endothelial cells inhibits neutrophil recruitment through an interleukin-6-dependent mechanism: A new paradigm for viral immune evasion
Journal of Virology, vol. 85, no. 14, pp. 7321-7332Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.00021-11
- [ONLINE] View publication in Scopus
Infectious agents in human cancers: Lessons in immunity and immunomodulation from gammaherpesviruses EBV and KSHV
Cancer Letters, vol. 305, no. 2, pp. 263-278Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.canlet.2010.08.019
- [ONLINE] View publication in Scopus
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II
Journal of Biological Chemistry, vol. 285, no. 48, pp. 37641-37649Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M110.132415
- [ONLINE] View publication in Scopus
Identification of caspase-mediated decay of interferon regulatory factor-3, exploited by a Kaposi sarcoma-associated herpesvirus immunoregulatory protein
Journal of Biological Chemistry, vol. 284, no. 35, pp. 23272-23285Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M109.033290
- [ONLINE] View publication in Scopus
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus
Trends in Microbiology, vol. 17, no. 3, pp. 119-129Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.tim.2008.12.001
- [ONLINE] View publication in Scopus
Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP)
Journal of Biological Chemistry, vol. 284, no. 1, pp. 505-514Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M806669200
- [ONLINE] View publication in Scopus
Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus
Journal of General Virology, vol. 90, no. 5, pp. 1190-1201Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1099/vir.0.007971-0
- [ONLINE] View publication in Scopus
Risk factors in the development of Kaposis sarcoma
AIDS, vol. 22, no. 13, pp. 1629-1632Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1097/QAD.0b013e3283031a9f
- [ONLINE] View publication in Scopus
Separation of decay-accelerating and cofactor functional activities of Kaposi's sarcoma-associated herpesvirus complement control protein using monoclonal antibodies
Immunology, vol. 123, no. 2, pp. 228-238Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2567.2007.02692.x
- [ONLINE] View publication in Scopus
Kaposi's sarcoma-associated herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1
Journal of Virology, vol. 81, no. 8, pp. 3980-3991Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.02089-06
- [ONLINE] View publication in Scopus
Molecular characterization of the Rhesus rhadinovirus (RRV) ORF4 gene and the RRV complement control protein it encodes
Journal of Virology, vol. 81, no. 8, pp. 4166-4176Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.02069-06
- [ONLINE] View publication in Scopus
Kaposi's sarcoma-associated herpesvirus immune modulation: An overview
Journal of General Virology, vol. 87, no. 7, pp. 1781-1804Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1099/vir.0.81919-0
- [ONLINE] View publication in Scopus
HIV Tat-mediated transcriptional regulation of proteasome protein cleavage specificity.
The Biochemical journal, vol. 396, no. 2, pp. e13-15Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1042/BJ20060497
- [ONLINE] View publication in Scopus
Dissecting the regions of virion-associated Kaposi's sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding
Journal of Virology, vol. 80, no. 8, pp. 4068-4078Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.80.8.4068-4078.2006
- [ONLINE] View publication in Scopus
Inhibition of interferon signaling by the Kaposi's sarcoma-associated herpesvirus full-length viral interferon regulatory factor 2 protein
Journal of Virology, vol. 80, no. 6, pp. 3092-3097Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.80.6.3092-3097.2006
- [ONLINE] View publication in Scopus
Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein
AIDS, vol. 19, no. 16, pp. 1907-1910Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/01.aids.0000189849.75699.46
- [ONLINE] View publication in Scopus
The Kaposi's sarcoma-associated herpesvirus complement control protein mimics human molecular mechanisms for inhibition of the complement system
Journal of Biological Chemistry, vol. 279, no. 43, pp. 45093-45101Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M407558200
- [ONLINE] View publication in Scopus
Functional co-operation between the Kaposi's sarcoma-associated herpesvirus ORF57 and ORF50 regulatory proteins
Journal of General Virology, vol. 85, no. 8, pp. 2155-2166Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1099/vir.0.79784-0
- [ONLINE] View publication in Scopus
The evolutionarily conserved Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with REF protein and acts as an RNA export factor
Journal of Biological Chemistry, vol. 279, no. 31, pp. 33001-33011Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M313008200
- [ONLINE] View publication in Scopus
Anti-HHV-8/KSHV antibodies in infected individuals inhibit infection in vitro
AIDS, vol. 18, no. 9, pp. 1263-1270Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/00002030-200406180-00004
- [ONLINE] View publication in Scopus
Inflammatory Cytokines Inhibit Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Transcription in In Vitro-Infected Endothelial Cells
Journal of Virology, vol. 78, no. 5, pp. 2591-2596Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.78.5.2591-2596.2004
- [ONLINE] View publication in Scopus
The relevance of complement to virus biology
Contributions to Journals: Short Survey- [ONLINE] DOI: https://doi.org/10.1016/j.virol.2003.11.029
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Transcription mapping of human herpesvirus 8 genes encoding viral interferon regulatory factors
Journal of General Virology, vol. 84, no. 6, pp. 1471-1483Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1099/vir.0.19015-0
- [ONLINE] View publication in Scopus
Functional activity of the complement regulator encoded by Kaposi's sarcoma-associated herpesvirus
Journal of Biological Chemistry, vol. 278, no. 11, pp. 9283-9289Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M211579200
- [ONLINE] View publication in Scopus
Complement regulation by Kaposi's sarcoma-associated herpesvirus ORF4 protein
Journal of Virology, vol. 77, no. 1, pp. 592-599Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/JVI.77.1.592-599.2003
- [ONLINE] View publication in Scopus
Immune responses in baboons vaccinated with HIV-2 genetic expression libraries
Journal of Medical Primatology, vol. 31, no. 6, pp. 323-329Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1034/j.1600-0684.2002.01035.x
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Induction of human herpesvirus-8 gene expression by recombinant interferon gamma
AIDS, vol. 14, no. 1, pp. 98-99Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1097/00002030-200001070-00017
- [ONLINE] View publication in Scopus