PhD (Dr rer. nat.), Dipl. Biol., FRSB
Chair in Translational Neuroscience
- About
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- Email Address
- b.platt@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437402
- Office Address
Room 6.28; School of Medicine, Medical Sciences & Nutrition University of Aberdeen Institute of Medical Sciences Foresterhill ABERDEEN AB25 2ZD Scotland, UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Bettina Platt graduated with distinction from the University of Mainz, Germany and received her PhD from the University of Düsseldorf, Germany. After completing a prestigious personal European Fellowship at the University of Leeds, Prof Platt joined the University of Aberdeen in 1997, initially within the Department of Biomedical Sciences. Since 2009, Prof Platt holds the Chair in Translational Neuroscience within the School of Medical Sciences. She heads a multi-disciplinary research team that investigates aspects of brain function and malfunction from the single molecule to the systems level. Prof Platt has acted as Research Director for a number of large research initiatives, some of which were co-funded by the pharmaceutical industry and the Scottish government. Her national and international collaborations have brought together novel research strategies, technologies and disciplines such as imaging, drug discovery, electronics, and computer science. Prof Platt is a Fellow of the Society of Biology and a founding member of the Scottish Dementia Research Consortium (SDRC). Additionally, Prof Platt was a member of the SDRC executive board until 2016 and previously sat on the Alzheimer’s Society funding board. She currently is a member of the Scottish Alzheimer Research UK (ARUK) network board, and the ARUK Scientific Advisory Board.
External Memberships
Executive Board member, Scottish Dementia Research Consortium
North-East of Scotland Alzheimer Research UK (ARUK) network coordinator (preclinical)
Member of the ARUK Scientific Advisory Board
Alzheimer’s Society Grant Advisory Board.
Editorial Advisory Board, Recent Patents on CNS Drug Discovery
Latest Publications
Advanced qEEG analyses discriminate between dementia subtypes
Journal of Neuroscience Methods, vol. 409, 110195Contributions to Journals: ArticlesMouse Exploratory Behaviour in the Open Field with and without NAT-1 EEG Device: Effects of MK801 and Scopolamine
Biomolecules, vol. 14, no. 8, 1008Contributions to Journals: ArticlesComparison of automated video tracking systems in the open field test: ANY-Maze versus EthoVision XT
Journal of Neuroscience Methods, vol. 397, 109940Contributions to Journals: ArticlesHow stra(i)nge are your controls?: A comparative analysis of metabolic phenotypes in commonly used C57BL/6 substrains
PloS ONE, vol. 18, no. 8, e0289472Contributions to Journals: ArticlesBACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice
Neurobiology of Disease, vol. 182, 106142Contributions to Journals: Articles
- Research
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Research Overview
Research interests: Alzheimer's disease and other dementias, mechanisms of neuronal plasticity, neurodegeneration and neuroprotection.
The amazing ability of the nervous system to learn and adapt to changing conditions forms the basis of our cognitive and intellectual abilities as humans, and how crucially we depend on this is demonstrated in patients suffering from neurodegenerative diseases such as Alzheimer's disease (AD).
We are currently combining various procedures, from standard histology and immunocytochemistry, to cell death essays and more functional techniques based on electrophysiological and imaging techniques, as well as behavioural studies. Latest developments include the use of EEG recordings, and PET/CT applications. Together, we cover aspects from the systems to the single cell level, and even to single receptors / channels, for disease target identification, drug development and testing within the sector of CNS diseases.
The main projects currently under investigation can be summarised as follows:
1) Alzheimer’s disease and neurodegeneration: causes, biomarkers and treatments.
2) Mechanisms of neuronal plasticity.
3) Therapeutics in CNS disorders.
4) Translational technologies.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biomedical Sciences
- Neuroscience
- Animal Physiology
- Dementia Studies
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
Alzheimer's disease, FTD, dementia, cognition, neurodegeneration, neurotoxicity, neuroprotection, neuronal plasticity, EEG, imaging, Ca signalling, plasticity.
Techniques and Skills:
- Models of dementia: transgenic, pharmacological & viral models in vivo and in vitro (beta amyloid, tau, PS1, BACE; single / double & triple combinations; siRNA).
- Drug discovery
- Translational Technologies
- In vitro electrophysiological recording techniques in brain slices, neuronal cultures, and isolated neurones (patch-clamping and field recordings).
- In vivo electrophysiological recordings (evoked potentials and EEG recordings (wireless).
- In vivo imaging (PET/CT & MRI)
- Behavioural assessments (Cognition & Phenotyper).
- Immunocytochemical and histological techniques, ELISAs, Western Blots.
- Confocal / fluorescent microscopy.
- Time-lapse imaging
- Cell culture, brain slice, cell lines
- Assays for cell death / neuroprotection / viability
Collaborations
1) Within Aberdeen University:
Prof Gernot Riedel (animal models / behaviour); Prof Roger Pertwee (cannabinoids); Prof Matteo Zanda (novel PET ligands); Dr Rod Scott & Prof Marcel Jaspars (natural toxins and cell transfection); Dr Derryck Shewan (neurite outgrowth / time lapse); Prof Andy Welch (PET/CT); Dr Hugh Seton (MRI); Dr Thiel, Dr Schelter & Prof Grebogi (Computer Science & Modelling); Dr Delibegovic & Dr Mody (phosphatases; diabetes and AD)
2) External Collaborators:
Prof Peer Wulff (viral strategies); Prof Jim Austin (University of York): EEG and image analyses, data sharing; Prof. Thanos Salifoglou (University of Crete, Greece): Aluminium speciation and toxicity; Prof. J. Micheau (Univ. Bordeaux II): CREB and hippocampal function, cell transfection, siRNA; Dr. Grazina Niewadomska (Univ. Warsaw, Poland): Tau pathology; Dr K. Bruce (U Penn., USA) and Dr Neel (U Ontario): Phosphatase knock-out mice.
3) Industry-based collaborators
Dr Karsten Wicke (Abbott / AbbVie), B Cruts (BrainMarker, The Netherlands), Dr Hong Wan (Pfizer), J McAvoy (Cybula) and Prof Hugh Marston (Lilly).
- Teaching
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Teaching Responsibilities
Course co-ordinator for AN4002/AN4003 (Brain function & malfunction)
- Publications
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Of mice and motion: Behavioural-EEG phenotyping of Alzheimer’s disease mouse models
Journal of Neuroscience Methods, vol. 319, pp. 89-98Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jneumeth.2018.06.028
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12465/1/1_s2.0_S0165027018302061_main.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease
Brain Research, vol. 1699, pp. 121-134Contributions to Journals: ArticlesHistological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse
Journal of Alzheimer's Disease, vol. 65, no. 1, pp. 165-180Contributions to Journals: ArticlesDetection of time-, frequency- and direction-resolved communication within brain networks
Scientific Reports, vol. 8, 1825Contributions to Journals: ArticlesAlzheimer's disease pathology and the unfolded protein response: Prospective pathways and therapeutic targets
Behavioural Pharmacology, vol. 28, no. 2 and 3 - Special Issue, pp. 161-178Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1097/FBP.0000000000000299
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10126/1/BP_17_20_R1_1_.pdf
- [ONLINE] View publication in Scopus
Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline
Acta Neuropathologica, vol. 132, no. 6, pp. 875–895Contributions to Journals: ArticlesMutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology
Neurobiology of Disease, vol. 91, pp. 105-123Contributions to Journals: ArticlesNeuronal human BACE1 knock-in induces systemic diabetes in mice
Diabetologia, vol. 59, no. 7, pp. 1513-1523Contributions to Journals: ArticlesTime-variant estimation of connectivity and Kalman's filter
Methods in Brain Connectivity Inference through Multivariate Time Series Analysis. Sameshima, K., Baccala, L. A. (eds.). CRC Press, pp. 161-177, 17 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] View publication in Scopus
Investigation of a Type 2 diabetes-like phenotype in a mouse model of Alzheimer's disease
Diabetic Medicine, vol. 33, no. Suppl. 1, pp. 82Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/dme.21_13048
Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits
Cellular and Molecular Life Sciences, vol. 72, no. 23, pp. 4613-4632Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00018-015-1949-4
Progressive age-related changes in sleep and EEG profiles in the PLB1(Triple) mouse model of Alzheimer's disease
Neurobiology of Aging, vol. 36, no. 10, pp. 2768-2784Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.neurobiolaging.2015.07.001
On the identification of sleep stages in mouse electroencephalography time-series
Journal of Neuroscience Methods, vol. 246, pp. 52-64Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jneumeth.2015.03.007
Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459
Behavioural Pharmacology, vol. 26, no. 3, pp. 289-303Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/FBP.0000000000000108
Assessing the strength of directed influences among neural signals: An approach to noisy data
Journal of Neuroscience Methods, vol. 239, pp. 47-64Contributions to Journals: ArticlesKnock-in of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like PhenoTypes
Journal of Neuroscience, vol. 34, no. 32, pp. 10710-10728Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1523/JNEUROSCI.0433-14.2014
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4223/1/10710.full.pdf
The contribution of APP, tau and presenilin to cognitive phenotypes in PLB mouse lines
Alzheimer's Association International ConferenceContributions to Conferences: PostersThe contribution of APP, tau and presenilin to cognitive phenotypes in PLB mouse lines
Alzheimer's Association International ConferenceContributions to Conferences: PostersThe transgenic PLB lines: Behavioural and histopathological alterations induced by knock-in of APP, tau and PS1
Alzheimer Research UK (2014)Contributions to Conferences: PostersThe transgenic PLB lines: Behavioural and histopathological alterations induced by knock-in of APP, tau and PS1
Alzheimer Research UK (2014)Contributions to Conferences: PostersOverarching framework for data-based modelling
Europhysics Letters, vol. 105, no. 3, 30004Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1209/0295-5075/105/30004
- [ONLINE] View publication in Scopus
Time-Variant Estimation of Connectivity and Kalman Filter
Methods in Brain Connectivity Inference through Multivariate Time Series Analysis. Baccalá, L. A. (ed.). CRC Press, pp. 161–177, 17 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1201/b16550-12
Mapping Changes in Mouse Brain Metabolism with PET/CT
Journal of Nuclear Medicine, vol. 54, no. 11, pp. 1946-1953Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2967/jnumed.113.121509
Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1(Triple) Alzheimer mouse
Cellular and Molecular Life Sciences, vol. 70, no. 14, pp. 2585-2601Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00018-013-1273-9
Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent
Cellular and Molecular Life Sciences, vol. 70, no. 14, pp. 2603-2619Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00018-013-1314-4