New publication investigating transcription factors involved in heart muscle differentiation.
This study, published in Developmental Biology, at the end of 2017 shows the results of collaboration of former CGEBM bioinformatician Dr. Eduardo de Paiva Alves with Prof. Stefan Hoppler of the University of Aberdeen. Here genome wide transcriptomic analysis was used to identify genes regulated by the gata4 transcription factor, associated with heart muscle differentiation. SoxF family members, sox7 and sox18 were both found to be directly regulated by gata4 and this finding was confirmed with experimental analysis in mouse embryonic stem cells. This analysis has furthered the understanding of the regulatory axis involved in cardiomyogenesis.
For more information on Prof. Stefan Hoppler's research - https://www.abdn.ac.uk/ims/profiles/s.p.hoppler.
For more details on this study, see the publication.