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The Institute of Medical Sciences

Dr Samantha Miller

Dr Samantha Miller
Dr Samantha Miller
Dr Samantha Miller

Senior Lecturer

Accepting PhDs

About
Email Address
sam.miller@abdn.ac.uk
Telephone Number
+44 (0)1224 437484
Office Address

Office 5.25, SMMSN, IMS building, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Internal Memberships

Academic Lead Postgraduate Research (IMS)

Deputy Lead IMS Health and Safety Co-ordinator

Research

Research Overview

I am currently a senior lecturer in the Institute of Medical Sciences. I am a biochemist and molecular biologist working with bacteria in the Microbiology Programme of SMMSN. My research focusses on bacterial ion channels and transporters. These specialised membrane proteins help bacteria survive their environment. I investigate the molecular mechanisms of these proteins and how to use this knowledge to inhibit bacterial cell growth. 

 

 

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Supervising
Accepting PhDs
View Research Area

Research Specialisms

  • Biotechnology
  • Biochemistry
  • Microbiology
  • Bacteriology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Collaborations

Prof. I. R. Booth (Aberdeen), Dr T.Rasmussen (Aberdeen), Dr A. Moura (Aberdeen), Prof. J. Naismith (St. Andrews), Prof. S. Conway (Oxford), Prof. B. Poolman (Groningen), Prof. Z. Ignatova (Pottsdam),  Prof. C. Grebogi (Aberdeen), Prof. J. Banga (CSIC), Dr J. Yates (AstraZeneca), Dr. A.  Valleriani (MPIKG), Prof. R. Bovenberg (DSM)

Funding and Grants

Marie Curie Initial Training Networks (ITN) Call: FP7-PEOPLE-2011-ITN (awarded 2011) ‘NICHE’ Network for Integrated Cellular Homeostasis. This grant brings together 8 partners from 6 academic institutions across Europe and 3 industrial partners to create a training network that will fund 11 PhD students and 2 Postdoctoral workers.  My position on this proposal is Assistant Coordinator, also with responsibility for the training programme.   

Medical Research Scotland Vacation Scholarship (awarded 03/2011)  for Mr Vojtech Prazak (1st year undergraduate University of Aberdeen), funding for 8 weeks summer project 2011. Structure-Function studies of critical gating residues in mechanosensitive channels   

Wellcome Trust Programme Grant Renewal (awarded 07/2010).  Principal Applicant Prof. Ian Booth.  Coapplicant (1) Prof. J.H. Naismith, (St. Andrews), Coapplicant (2) Dr S. Conway (Oxford), Coapplicant (3) Dr S. Miller, Coapplicant (4) Dr T. Rasmussen, Coapplicant (5) Dr M.D. Edwards.Molecular mechanisms of gating ion channels and transporters in bacterial homeostasis. 01.01.11-31.12.16  

BBSRC Research Grant (awarded 06/10) Principal Investigator 01.07.10-30.06.15 Conformational states of membrane proteins: Technology development for bioscience  

SFC (SULSA pool) Summer Studentship (with Morgiane Richard and A. Moura) for Aljosa Sarcevic from 31/05/10 for a 10 week project ‘Model of a Toxic metabolic Switch:  Production of Methylglyoxal by Gram-Negative Bacteria’

BBSRC (SysMo Initiative). Awarded March 2007.  Principal Investigator Professor I.R. Booth, Co-Investigators; Dr S.Miller, Professor C. Grebogi and Dr A. Moura (University of Aberdeen):   01.06.07-01.06.10 Ion and Solute Homeostasis in Enteric Bacteria (Kosmobac) 

Wellcome Trust Programme Grant Renewal (awarded 2005).  Principal Applicant Professor I.R. Booth, Coapplicant (1) Dr S. Miller, Coapplicant (2) Dr M.D. Edwards January 2006-December 2011.  Gating of bacterial transporters and ion channels in cellular homeostasis

Royal society Conference Award 2005 

MRC New Investigator Award (awarded 2004) July 2005-2008  Biogenesis and Structure-Function analysis of the MscS Mechanosensitive Channel in Escherichia coli.

Teaching

Teaching Responsibilities

Course Co-ordinator MC3504 Molecular Microbiology

Publications

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  • Mechanosensitive channels in bacteria: signs of closure?

    Booth, I. R., Edwards, M. D., Black, S. S., Schumann, U., Miller, S.
    Nature Reviews Microbiology, vol. 5, no. 6, pp. 431-440
    Contributions to Journals: Literature Reviews

  • The C-terminus of α2-antiplasmin interacts with endothelial cells

    Thomas, L., Moore, N. R., Miller, S., Booth, N. A.
    British Journal of Haematology, vol. 136, no. 3, pp. 472-479
    Contributions to Journals: Articles

  • Physiological analysis of bacterial mechanosensitive channels

    Booth, I. R., Edwards, M. D., Black, S. S., Schumann, U., Bartlett, W., Rasmussen, T., Rasmussen, A., Miller, S.
    Methods in Enzymology: Osmosensing and Osmosignaling. Häussinger, D., Sies, H. (eds.). Academic Press, pp. 47-61, 15 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel

    Edwards, M. D., Li, Y., Kim, S., Miller, S., Bartlett, W., Black, S., Dennison, S., Iscla, I., Blount, P., Bowie, J. U., Booth, I. R.
    Nature Structural & Molecular Biology, vol. 12, no. 2, pp. 113-119
    Contributions to Journals: Articles

  • Gating the bacterial mechanosensitive channels: MscS a new paradigm?

    Edwards, M. D., Booth, I. R., Miller, S.
    Current Opinion in Microbiology, vol. 7, no. 2, pp. 163-167
    Contributions to Journals: Articles

  • A role for mechanosensitive channels in survival of stationary phase: regulation of channel expression by RpoS

    Stokes, N. R., Murray, H. D., Subramaniam, C., Gourse, R. L., Louis, P., Bartlett, W., Miller, S., Booth, I. R.
    PNAS, vol. 100, no. 26, pp. 15959-15964
    Contributions to Journals: Articles

  • The closed structure of the MscS mechanosensitive channel. Cross-linking of single cysteine mutants

    Miller, S., Edwards, M. D., Ozdemir, C., Booth, I. R.
    The Journal of Biological Chemistry, vol. 278, no. 34, pp. 32246-32250
    Contributions to Journals: Articles

  • Domain organization of the MscS mechanosensitive channel of Escherichia coli

    Miller, S., Bartlett, W., Chandrasekaran, S., Simpson, S., Edwards, M. D., Booth, I. R.
    EMBO Journal, vol. 22, no. 1, pp. 36-46
    Contributions to Journals: Articles

  • Bacterial ion channels

    Booth, I. R., Edwards, M. D., Miller, S.
    Biochemistry, vol. 42, no. 34, pp. 10045-10053
    Contributions to Journals: Articles

  • Two families of mechanosensitive channel proteins

    Pivetti, C. D., Yen, M. R., Miller, S., Busch, W., Tseng, Y. H., Booth, I. R., Saier, M. H.
    Microbiology and Molecular Biology Reviews : MMBR, vol. 67, no. 1, pp. 66-85, table of contents
    Contributions to Journals: Editorials

  • A mechanism of regulating transmembrane potassium flux through a ligand-mediated conformational switch

    Roosild, T. P., Miller, S., Booth, I. R., Choe, S.
    Cell, vol. 109, no. 6, pp. 781-791
    Contributions to Journals: Articles

  • Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli

    Miller, S., Ness, L. S., Wood, C. M., Fox, B. C., Booth, I. R.
    Journal of Bacteriology, vol. 182, pp. 6536-6540
    Contributions to Journals: Articles

  • Mutations in the glutathione-gated KefC K+ efflux system of Escherichia coli that cause constitutive activation

    Miller, S., Douglas, R. M., Carter, P., Booth, I. R.
    Journal of Biological Chemistry, vol. 272, no. 40, pp. 24942-24947
    Contributions to Journals: Articles

  • Bacterial ion channels

    Booth, I. R., Jones, M. A., McLaggan, D., Nikolaev, Y., Ness, L. S., Wood, C. M., Miller, S., Tötemeyer, S., Ferguson, G. P.
    Transport Processes in Eukaryotic and Prokaryotic Organisms, pp. 693-729, 37 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
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