BSc (Hons), MLitt, PhD
Senior Trial Manager
- About
-
- Email Address
- s.c.cotton@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438178
- Office Address
Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I joined HSRU in 2007 as a trial manager. I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007. Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.
I am the Senior Trial Manager within CHaRT supporting the portfolio of trials. I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.
Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENO, EMPOWER and ELECTRIC (all now completed). I also worked as trial manager on a number of CHaRT trials, including TWICS, CLASS, NIAMI, FOCCUS, REFLUX and the Cysteamine in CF study.
I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.
Qualifications
- BSc Health Sciences1993 - University of Aberdeen
- MLitt by research1994 - University of Aberdeen
- PhD Public Health2008 - University of Aberdeen
- Research
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Research Overview
Trial methodology & trial management
Research Areas
Applied Health Sciences
Nutrition and Health
Current Research
I am the Senior Trial Manager within CHaRT supporting the portfolio of trials. I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.
I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.
Past Research
Since joining the Unit I have worked on a number of trials that have now been completed.
TWICS - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.
CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;
NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;
FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery
REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.
The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.
I also supported RAACENO, EMPOWER and ELECTRIC (all now completed) as senior trial manager.
- Teaching
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Teaching Responsibilities
I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.
Non-course Teaching Responsibilities
Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).
- Publications
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Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
RCOG World Congress 2024Contributions to Conferences: PostersPatient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
The International Continence SocietyContributions to Conferences: PostersRCT comparing the clinical and cost effectiveness of various catheter washout policies
RCOG World Congress 2024Contributions to Conferences: PostersRCT comparing the clinical and cost effectiveness of various catheter washout policies
The International Continence SocietyContributions to Conferences: PostersText Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial
JAMA, vol. 332, no. 1, pp. 31-40Contributions to Journals: ArticlesLaparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT
Health Technology Assessment, vol. 28, no. 26, pp. 1-151Contributions to Journals: ArticlesDirect and indirect costs of paediatric asthma in the UK: a cost analysis
Archives of Disease in ChildhoodContributions to Journals: ArticlesBisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial
JAMA, vol. 332, no. 6, pp. 462-470Contributions to Journals: ArticlesExploring Opinions and Concerns about the Human Papillomavirus Vaccine on a United Kingdom Online Discussion Forum
Journal of Colposcopy and Lower Genital Tract Pathology, vol. 1, no. 3, pp. 117-123Contributions to Journals: ArticlesThe Bisoprolol in COPD Study (BICS): A UK Randomized Controlled Trial of Bisoprolol in People With COPD at Risk of Exacerbation
American Journal of Respiratory and Critical Care Medicine, vol. 2024, no. 209Contributions to Journals: AbstractsEffectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial
BMJ, vol. 383, e075383Contributions to Journals: ArticlesEmergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients with Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial
JAMA, vol. 330, no. 19, pp. 1862-1871Contributions to Journals: ArticlesA qualitative process evaluation within a clinical trial that used healthcare technologies for children with asthma: insights and implications
PloS ONE, vol. 18, no. 1, 0280086Contributions to Journals: ArticlesAn interview study within a clinical trial that used healthcare technologies for children with asthma – insights and implications
ICTMC 2022, pp. 370Contributions to Conferences: AbstractsTrial Forge Guidance 3: Randomised trials and how to recruit and retain individuals from ethnic minority groups– practical guidance to support better practice
Trials, vol. 23, no. 1, 672Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-022-06669-z
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/19111/1/Dawson_etal_T_Trial_forge_guidance_VOR.pdf
- [ONLINE] Correction
Randomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study
Trials, vol. 23, no. 1, 630Contributions to Journals: ArticlesEffectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial
Trials, vol. 23, no. 1, 582Contributions to Journals: ArticlesReducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial
The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592Contributions to Journals: ArticlesTreatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT
Efficacy and Mechanism Evaluation, vol. 9, no. 4Contributions to Journals: ArticlesTreatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT
Efficacy and Mechanism Evaluation, vol. 9, no. 4, pp. 1-153Contributions to Journals: ArticlesScotCap - A large observational cohort study
Colorectal Disease, vol. 24, no. 4, pp. 411-421Contributions to Journals: ArticlesUse of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)
Trials, vol. 23, no. 1, 307Contributions to Journals: ArticlesThe relative importance of information items and preferred mode of delivery when disseminating results from trials to participants: a mixed methods study
Health Expectations, vol. 25, no. 1, pp. 419-429Contributions to Journals: ArticlesThe ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery
Trials, vol. 23, no. 1, 84Contributions to Journals: ArticlesHas the human papillomavirus (HPV) immunization programme improved obstetric outcomes in spontaneous delivery?: An ecological study
European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 262, pp. 221-227Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejogrb.2021.05.037
Tibial nerve stimulation compared with sham to reduce incontinence in care home residents: ELECTRIC RCT
Health technology assessment (Winchester, England), vol. 25, no. 41, pp. 1-109Contributions to Journals: ArticlesProviding trial results to participants in Phase III pragmatic effectiveness RCTs: a scoping review
Trials, vol. 22, 361Contributions to Journals: ArticlesDeveloping the INCLUDE Ethnicity Framework: a tool to help trialists design trials that better reflect the communities they serve
Trials, vol. 22, 337Contributions to Journals: ArticlesIt is unprecedented: trial management during the COVID-19 pandemic and beyond
Trials, vol. 21, pp. 784Contributions to Journals: ArticlesHow to Deal with a Temporary Suspension and Restarting Your Trial: Our Experiences and lessons Learnt
Trials, vol. 21, no. 1, pp. 765Contributions to Journals: ArticlesUsing systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project
Trials, vol. 21, no. 1, pp. 535Contributions to Journals: ArticlesVerifying participant-reported clinical outcomes: challenges and implications
Trials, vol. 21, no. 1, pp. 241Contributions to Journals: ArticlesTrial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed
Trials, vol. 21, 33Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-019-3980-5
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13499/1/Treweek_Trials_Trial_forge_VOR.pdf
- [ONLINE] View publication in Scopus
Women’s Preferences for Communication with the Cervical Screening Programme: A Qualitative Study
Cytopathology, vol. 31, no. 1, pp. 47-52Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/cyt.12783
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15573/1/Ravindran_et_al_2019_Cytopathology_AAM.pdf
- [ONLINE] View publication in Scopus
ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes: protocol for the ELECTRIC randomised trial
Trials, vol. 20, 723Contributions to Journals: ArticlesFive-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins
The New England Journal of Medicine, vol. 381, no. 10, pp. 912-922Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1056/NEJMoa1805186
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13810/1/NEJMFive_year_outcomes_Brittenden_at_al_VoR.pdf
- [ONLINE] Publisher permissions
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31483962
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
Low-dose oral theophylline combined with inhaled corticosteroids for people with chronic obstructive pulmonary disease and high risk of exacerbations: a RCT
Health technology assessment (Winchester, England), vol. 23, no. 37, pp. 1-146Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta23370
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12765/1/HTA_23_37_23370_VOR.pdf
- [ONLINE] View publication in Scopus
Estimating Site Performance (ESP): can trial managers predict recruitment success at trial sites? An exploratory study
Trials, vol. 20, 192Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-019-3287-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12141/1/Estimating_Site_Performance.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy: a randomised trial (RAACENO)
Trials, vol. 20, 573Contributions to Journals: ArticlesInformation needs of young women vaccinated against HPV attending colposcopy: a qualitative study
BMC Women's Health, vol. 18, no. 1, 200Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12905-018-0691-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11662/1/s12905_018_0691_0.pdf
Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial
JAMA, vol. 320, no. 15, pp. 1548-1559Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1001/jama.2018.14432
- [ONLINE] Deposit in PMC
Relative importance of informational items in Participant Information Leaflets for trials: a Q-Methodology approach
BMJ Open, vol. 8, no. 9, e023303Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2018-023303
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11064/1/e023303.full.pdf
Patient reported measures of informed consent for clinical trials: A systematic review
PloS ONE, vol. 13, no. 6, e0199775Contributions to Journals: ArticlesUse of 'Low-Dose' Theophylline to Reduce Exacerbations of COPD: A Pragmatic Multicentre Randomised Placebo Controlled Trial
American Thoracic Society 2018 International Conference, A7709Contributions to Journals: AbstractsTrial Forge Guidance 1: What is a Study Within A Trial (SWAT)
Trials, vol. 19, 139Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1186/s13063-018-2535-5
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10095/1/s13063_018_2535_5.pdf
The influence of early research experience in medical school on the decision to intercalate and future career in clinical academia: A questionnaire study
BMC Medical Education, vol. 17, 245Contributions to Journals: ArticlesReduction in colposcopy workload and associated clinical activity following HPV catch-up vaccination programme in Scotland: an ecological study
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 124, no. 9, pp. 1386-1393Contributions to Journals: ArticlesThe impact of HPV type on colposcopy performance in women offered HPV immunisation in a catch-up vaccine programme: a two centre observational study
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 124, no. 9, pp. 1394-1401Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.14563
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10154/2/COHGSpaperBJOG_R2.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10154/5/Figure_1_supp.doc
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10154/4/Figure_2.doc
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10154/1/Table123_Secondrevision_1.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10154/3/Table_4.doc
Psychosocial morbidity in women with abnormal cervical cytology managed by cytological surveillance or initial colposcopy: longitudinal analysis from the TOMBOLA randomised trial
Psycho-Oncology, vol. 26, no. 4, pp. 476–483Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/pon.4163
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8478/9/SFielding_longitudinalPOSM_REVISION3_clean.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8478/8/Supplemtal_Tables.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8478/7/Figure_S1_CONSORT.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8478/3/Figure1.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8478/4/Figure_S2B.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8478/5/Figure_S2A.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8478/1/Fielding_et_al_2017_Psycho_Oncology.pdf
An Open-Label Investigation of the Pharmacokinetics and Tolerability of Oral Cysteamine in Adults with Cystic Fibrosis
Clinical Drug Investigation, vol. 36, no. 8, pp. 605-612Contributions to Journals: Articles