BSc (Hons), MLitt, PhD
Senior Trial Manager
- About
-
- Email Address
- s.c.cotton@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438178
- Office Address
Health Services Research Unit Health Sciences Building (Third Floor) Foresterhill Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I joined HSRU in 2007 as a trial manager. I graduated from the University of Aberdeen with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007. Prior to joining the Unit, I worked in the Department of Public Health at the University of Aberdeen.
I am the Senior Trial Manager within CHaRT supporting the portfolio of trials. I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.
Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENO, EMPOWER and ELECTRIC (all now completed). I also worked as trial manager on a number of CHaRT trials, including TWICS, CLASS, NIAMI, FOCCUS, REFLUX and the Cysteamine in CF study.
I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.
Qualifications
- BSc Health Sciences1993 - University of Aberdeen
- MLitt by research1994 - University of Aberdeen
- PhD Public Health2008 - University of Aberdeen
- Research
-
Research Overview
Trial methodology & trial management
Research Areas
Applied Health Sciences
Nutrition and Health
Current Research
I am the Senior Trial Manager within CHaRT supporting the portfolio of trials. I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.
I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.
Past Research
Since joining the Unit I have worked on a number of trials that have now been completed.
TWICS - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.
CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;
NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;
FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery
REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.
The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.
I also supported RAACENO, EMPOWER and ELECTRIC (all now completed) as senior trial manager.
- Teaching
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Teaching Responsibilities
I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.
Non-course Teaching Responsibilities
Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC).
- Publications
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HPV immunisation and cervical screening - confirmation of changed performance of cytology as a screening test in immunised women: a retrospective population based cohort study
British Journal of Cancer, vol. 114, no. 5, pp. 582-589Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2015.474
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7421/3/bjc2015474a.pdf
Behavioural recovery after treatment for varicose veins
British Journal of Surgery, vol. 103, no. 4, pp. 374-381Contributions to Journals: ArticlesImpact of post-colposcopy management on women's long-term worries: results from the UK population-based TOMBOLA trial
Journal of Family Planning and Reproductive Health Care, vol. 42, no. 1, pp. 43-51Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jfprhc-2015-101170
Decision aids for people considering taking part in clinical trials
Cochrane Database of Systematic Reviews, no. 11, CD009736Contributions to Journals: ArticlesLong-term Worries after Colposcopy: Which Women Are at Increased Risk?
Women's Health Issues, vol. 25, no. 5, pp. 517-527Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.whi.2015.04.002
SMS text pre-notification and delivery of reminder e-mails to increase response rates to postal questionnaires in the SUSPEND trial: a factorial design, randomised controlled trial
Trials, vol. 16, 295Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-015-0808-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5080/1/s13063_015_0808_9.pdf
Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial
Trials, vol. 16, 267Contributions to Journals: ArticlesMaking randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform
Trials, vol. 16, 261Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-015-0776-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5136/1/s13063_015_0776_0.pdf
A normal colposcopy examination fails to provide psychological reassurance for women who have had low-grade abnormal cervical cytology
Cytopathology, vol. 26, no. 3, pp. 178-187Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/cyt.12173
- [ONLINE] View publication in Scopus
Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial
Health Technology Assessment, vol. 19, no. 27, pp. 1-342Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta19270
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4430/1/CLASS.pdf
Management of women with low grade cytology: how reassuring is a normal colposcopy examination?
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 122, no. 3, pp. 380-386Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.12932
Normative data for the Hospital Anxiety and Depression Scale
Quality of Life Research, vol. 24, no. 2, pp. 391-398Contributions to Journals: ArticlesMeasuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM)
Health and Quality of Life Outcomes, vol. 12, 154Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12955-014-0154-8
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4927/1/TOMBOLA_HQLO_FApaper.pdf
Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial
British Journal of Surgery, vol. 101, no. 12, pp. 1532-1540Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bjs.9595
A randomized trial comparing treatments for varicose veins
The New England Journal of Medicine, vol. 371, no. 13, pp. 1218-1227Contributions to Journals: ArticlesIntravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)
European Heart Journal, vol. 35, no. 19, pp. 1255-1262Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/eurheartj/ehu096
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4482/1/Siddiqi_2014.pdf
The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance
Journal of Lower Genital Tract Disease, vol. 18, no. 2, pp. 142-150Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/LGT.0b013e31829c97d8
Patient information leaflets (PILs) for UK randomised controlled trials: a feasibility study exploring whether they contain information to support decision making about trial participation
Trials, vol. 15, 62Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-15-62
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3317/1/Gillies_2014.pdf
Nitrites in Acute Myocardial Infarction
Circulation, vol. 128, no. 24, pp. 2705Contributions to Journals: AbstractsImpact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy
European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 169, no. 1, pp. 88-92Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejogrb.2013.02.006
Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)
Health Technology Assessment, vol. 17, no. 22, pp. 1-166Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta17220
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2867/1/Grant_2013.pdf
Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)
Journal of translational medicine, vol. 11, 116Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1479-5876-11-116
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3089/1/Siddiqi_2013.pdf
Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)
BMJ, vol. 346, f1908Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.f1908
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2865/1/Grant_2013.pdf
Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial
Cytopathology, vol. 23, no. 3, pp. 150-160Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2303.2011.00848.x
A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study
Critical Care, vol. 15, no. 6, R296Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/cc10592
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2650/1/Cuthbertson_2011.pdf