Professor Marion Campbell | Aberdeen Centre for Evaluation

Professor Marion Campbell

BSc (Hons), MSc, PhD, CStat, FSS, FFPH, FSCT, FRSE, FMedSci

Chair in HSRU

About

Email Address: m.k.campbell@abdn.ac.uk
Telephone Number: +44 (0)1224 273161
Office Address: HSRU Health Sciences Building
Foresterhill Campus
Foresterhill
AB25 2ZD
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School/Department: School of Medicine, Medical Sciences and Nutrition

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Biography

Professor Marion Campbell is Professor of Health Services Research at the University of Aberdeen. She is also co-Director of the RCSEng Aberdeen Surgical Trials Centre. Marion is a medical statistician by training, a clinical trialist and methodologist. Her main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has published widely on clinical trials methodology including on cluster randomised trials, design of trials of surgical interventions, pragmatic trials and trials reporting. She has served on many national and international funding agencies and committees and is an elected Fellow of the Academy of Medical Sciences, the Royal Society of Edinburgh, the Faculty of Public Health, and the International Society for Clinical Trials and is a previous NIHR senior investigator.

Previously Marion was Vice-Principal (Research) for the University of Aberdeen. In this role, she had primary responsibility for promoting the University's research ambitions, ensuring effective delivery of the University's strategic objectives for research. and for enabling a research context for academic colleagues to deliver world-leading, impactful research. She also led on the establishment of interdisciplinary research across the institution. Prior to this, Marion was Dean of Research for Life Sciences and Medicine following ten years as Director of the Scottish government core-funded Health Services Research Unit.

Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health. Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the University of Aberdeen in 1993.

External Memberships

Chair. MRC Better Methods Better Research Panel

Member of REF2021 UoA2 sub-panel

Research

Research Overview

Marion’s main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has also published widely on clinical trials methodology including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting.

Some examples of current and recent research include:

REINFORCE: The NIHR-funded REINFORCE study aims to evaluation the introduction and scale up of robot-assisted surgery across the NHS. Further information is available at: https://www.abdn.ac.uk/hsru/what-we-do/research/projects/reinforce-291

UK-REBOA: The NIHR-funded UK-REBOA trial aims to establish the clinical and cost-effectiveness of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), in addition to standard major trauma centre treatment, for the treatment of patients with life-threatening torso haemorrhage. The trial is currently live across major trauma centres in England. Further information is available on the trial website: https://w3.abdn.ac.uk/hsru/REBOA/Public/Public/index.cshtml

TOPKAT: The NIHR-funded TOPKAT trial is investigating the clinical and cost effectiveness of partial (PKR) vs total (THR) knee replacements. The trial recruited 528 patients from across the UK. Five year results have been published in the Lancet (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31281-4/fulltext) and showed that PKR has similar, if not a slightly better clinical outcome than TKR. More importantly, the economic benefit of using PKR is substantial. Patients are now being followed up to 10 years.

CLASS: The NIHR-funded CLASS trial is assessing the clinical and cost-effectiveness of three treatment modalities for the treatment of varicose veins: a) foam; b) EVLA with subsequent foam to varicosities when required; and c) surgery. A total of 798 adult patients were recruited into the trial and randomised to one of the treatment options. Six weeks results have been published in the NEJM (http://www.nejm.org/doi/full/10.1056/NEJMoa1400781). Five year follow-up is now complete.

KAT: The NIHR-funded KAT trial, explores different knee replacement surgery options (the effects of patellar resurfacing, mobile bearings and metal backing were investigated). A total of 116 surgeons in 34 UK centres participated and 2352 participants were randomised. Ten year outcomes were previously published (https://www.journalslibrary.nihr.ac.uk/hta/hta18190/#/abstract); long term follow up to 20 years is underway.

Research Areas

Applied Health Sciences

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Research Specialisms

Healthcare Science
Medical Statistics

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Publications

Update

Biography

External Memberships

Research Overview

Research Areas

Applied Health Sciences

Research Specialisms

Recombinant human erythropoietin for chronic renal failure anaemia in pre-dialysis patients

A centralised public information resource for randomised trials: a scoping study to explore desirability and feasibility

Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial

Determinants of the intracluster correlation coefficient in cluster randomized trials: the case of implementation research

Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women

Issues in data monitoring and interim analysis of trials

A proposed charter for clinical trial data monitoring committees: helping them to do their job well.

An integrated approach to consumer representation and involvement in a multicentre randomised controlled trial

An integrated approach to consumer representation and involvement in a multicentre randomized controlled trial

An investigation into People's perceptions of 'Quality of Life' when completing health-related quality of life questionnaires

Cluster randomised trials of professional and organisational behaviour change interventions in health care settings.

Data monitoring in randomised controlled trials: surveys of recent practice and policies

Experimental evaluations of change and improvements strategies

Improving the referral process for familial breast cancer genetic counselling: findings of three randomised controlled trials of two interventions - Introduction

The CONSORT statement for cluster randomised trials

Low Back Pain: Influence of Early MR Imaging or CT on Treatment and Outcome—Multicenter Randomized Trial

Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement

Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported

Cervical screening in women over the age of fifty: results of a population based multicentre study

Lower estimates of net endogenous noncarbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women

Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids

Aminobisphosphonate versus other active treatment for Paget's disease of the bone in adults

CONSORT statement: extension to cluster randomised trials

Continuous ambulatory peritoneal dialysis (CAPD) versus hospital or home haemodialysis for end-stage renal disease in adults

Delivering clinical trial supplies by post to elderly trial participants: a feasibility study

Does early magnetic resonance imaging influence management or improve outcome in patients referred to secondary care with low back pain? A pragmatic randomised controlled trial

Influence of weight and weight change on bone loss in perimenopausal and early postmenopausal Scottish women

Quality of life data: What to do when it is missing?

Recruitment to multicentre trials

Reported use of data monitoring committees in the main published reports of randomized controlled trials: a cross-sectional study

Sample size calculator for cluster randomized trials

Small group processes relevant to data monitoring committees in controlled clinical trials: an overview of reviews

Systematic qualitative review of the literature on data monitoring committees for randomized controlled trials

The effects of an open design on trial participant recruitment, compliance and retention - a randomised controlled trial comparison with a blinded, placebo-controlled design

What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials

What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions

Determinants of the intracluster correlation coefficient in cluster randomised trials

Continuous ambulatory peritoneal dialysis (CAPD) versus hospital or home haemodialysis for end-stage renal disease in adults

Experiences of consumer organisation involvement in a UK multicentre randomised controlled trial

Longitudinal changes in weight in perimenopausal and early postmenopausal women: effects of dietary energy intake, energy expenditure, dietary calcium intake and hormone replacement therapy

Research designs for studies evaluating the effectiveness of change and improvement strategies

Research designs for studies evaluating the effectiveness of change and improvement strategies

The PRISM Trial: A DNA repository sub-study

The PRISM Trial: A randomised trial of intensive vs. symptomatic management for Paget’s disease of the bone

Changes in public awareness of, attitudes to, and use of complementary therapy in North East Scotland: Surveys in 1993 and 1999

Frequency of administration of recombinant human erythropoietin for anaemia of end-stage renal disease in dialysis patients

Age-restricted cervical screening: HPV testing at age 50 identifies a high risk group for cervical disease

The method of minimization for allocation to clinical trials: a review

Epidemiological methods

Double bag or Y-set versus standard transfer systems for continuous ambulatory peritoneal dialysis in end-stage renal disease

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