![Professor Marion Campbell Professor Marion Campbell](/img/200x200/staffpages/uploads/sme098/avatar/ZLjE8vL4N76auwU15zJUYuOVjpMZZqvIXx1cI3SL.jpeg)
BSc (Hons), MSc, PhD, CStat, FSS, FFPH, FSCT, FRSE, FMedSci
Chair in HSRU
- About
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- Email Address
- m.k.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 273161
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Marion Campbell is Professor of Health Services Research at the University of Aberdeen. She is also co-Director of the RCSEng Aberdeen Surgical Trials Centre. Marion is a medical statistician by training, a clinical trialist and methodologist. Her main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has published widely on clinical trials methodology including on cluster randomised trials, design of trials of surgical interventions, pragmatic trials and trials reporting. She has served on many national and international funding agencies and committees and is an elected Fellow of the Academy of Medical Sciences, the Royal Society of Edinburgh, the Faculty of Public Health, and the International Society for Clinical Trials and is a previous NIHR senior investigator.
Previously Marion was Vice-Principal (Research) for the University of Aberdeen. In this role, she had primary responsibility for promoting the University's research ambitions, ensuring effective delivery of the University's strategic objectives for research. and for enabling a research context for academic colleagues to deliver world-leading, impactful research. She also led on the establishment of interdisciplinary research across the institution. Prior to this, Marion was Dean of Research for Life Sciences and Medicine following ten years as Director of the Scottish government core-funded Health Services Research Unit.
Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health. Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the University of Aberdeen in 1993.
External Memberships
Chair. MRC Better Methods Better Research Panel
Member of REF2021 UoA2 sub-panel
- Research
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Research Overview
Marion’s main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has also published widely on clinical trials methodology including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting.
Some examples of current and recent research include:
REINFORCE: The NIHR-funded REINFORCE study aims to evaluation the introduction and scale up of robot-assisted surgery across the NHS. Further information is available at: https://www.abdn.ac.uk/hsru/what-we-do/research/projects/reinforce-291
UK-REBOA: The NIHR-funded UK-REBOA trial aims to establish the clinical and cost-effectiveness of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), in addition to standard major trauma centre treatment, for the treatment of patients with life-threatening torso haemorrhage. The trial is currently live across major trauma centres in England. Further information is available on the trial website: https://w3.abdn.ac.uk/hsru/REBOA/Public/Public/index.cshtml
TOPKAT: The NIHR-funded TOPKAT trial is investigating the clinical and cost effectiveness of partial (PKR) vs total (THR) knee replacements. The trial recruited 528 patients from across the UK. Five year results have been published in the Lancet (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31281-4/fulltext) and showed that PKR has similar, if not a slightly better clinical outcome than TKR. More importantly, the economic benefit of using PKR is substantial. Patients are now being followed up to 10 years.
CLASS: The NIHR-funded CLASS trial is assessing the clinical and cost-effectiveness of three treatment modalities for the treatment of varicose veins: a) foam; b) EVLA with subsequent foam to varicosities when required; and c) surgery. A total of 798 adult patients were recruited into the trial and randomised to one of the treatment options. Six weeks results have been published in the NEJM (http://www.nejm.org/doi/full/10.1056/NEJMoa1400781). Five year follow-up is now complete.
KAT: The NIHR-funded KAT trial, explores different knee replacement surgery options (the effects of patellar resurfacing, mobile bearings and metal backing were investigated). A total of 116 surgeons in 34 UK centres participated and 2352 participants were randomised. Ten year outcomes were previously published (https://www.journalslibrary.nihr.ac.uk/hta/hta18190/#/abstract); long term follow up to 20 years is underway.
Research Areas
Applied Health Sciences
Research Specialisms
- Healthcare Science
- Medical Statistics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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The importance of decision intent within descriptions of pragmatic trials
Journal of Clinical Epidemiology, vol. 125, pp. 30-37Contributions to Journals: ArticlesConsiderations and methods for placebo controls in surgical trials (ASPIRE guidelines)
The Lancet, vol. 395, no. 10226, pp. 828-838Contributions to Journals: ArticlesReporting of key methodological issues in placebo-controlled trials of surgery needs improvement: a systematic review
Journal of Clinical Epidemiology, vol. 119, pp. 109-116Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.jclinepi.2019.11.016
- [ONLINE] View publication in Scopus
Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed
Trials, vol. 21, 33Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13063-019-3980-5
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13499/1/Treweek_Trials_Trial_forge_VOR.pdf
- [ONLINE] View publication in Scopus
What methods are used to involve patients and the public in numerical aspects of research?: A scoping review
5th International Clinical Trials Methodology Conference, pp. 28-28Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1186/s13063-019-3688-6
Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins
The New England Journal of Medicine, vol. 381, no. 10, pp. 912-922Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1056/NEJMoa1805186
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13810/1/NEJMFive_year_outcomes_Brittenden_at_al_VoR.pdf
- [ONLINE] Publisher permissions
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31483962
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial
The Lancet, vol. 394, no. 10200, pp. 746-756Contributions to Journals: ArticlesDevelopment and evaluation of decision aids for people considering taking part in a clinical trial: a conceptual framework
Trials, vol. 20, 401Contributions to Journals: ArticlesNo Surgical Innovation Without Evaluation: Evolution and Further Development of the IDEAL Framework and Recommendations
Annals of Surgery, vol. 269, no. 2, pp. 211-220Contributions to Journals: ArticlesInS:PIRE - Evaluation of the scaling up of a quality improvement initiative: abridged report
University of Aberdeen. 52 pagesBooks and Reports: Other Reports