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Health Economics Research Unit (HERU)

Professor Graeme MacLennan

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Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • Applying psychological theories to evidence-based clinical practice: identifying factors predictive of lumbar spine x-ray for low back pain in UK primary care practice

    Grimshaw, J. M., Eccles, M. P., Steen, N., Johnston, M., Pitts, N. B., Glidewell, E., Maclennan, G., Thomas, R. E., Bonetti, D. L., Walker, A. E.
    Implementation Science, vol. 6, pp. 55
    Contributions to Journals: Articles

  • Developing and evaluating interventions to reduce inappropriate prescribing by general practitioners of antibiotics for upper respiratory tract infections: a randomised controlled trial to compare paper-based and web-based modelling experiments

    Treweek, S. P., Ricketts, I. W., Francis, J., Eccles, M., Bonetti, D., Pitts, N. B., Maclennan, G., Sullivan, F., Jones, C., Weal, M., Barnett, K.
    Implementation Science, vol. 6, no. 1, pp. 16
    Contributions to Journals: Articles

  • Systematic review of the clinical effectiveness of surgical management for localised renal cell carcinoma

    Imamura, M., MacLennan, S., Lapitan, M. C. M., Omar, M. I., Lam, T., Hilvano-Cabungcal, A. M., Royle, P. L., Stewart, F., MacLennan, G., MacLennan, S., Canfield, S. E., McClinton, S., Griffiths, T. R. L., Ljungberg, B., N'Dow, J., UCAN Systematic Review Reference Group, EAU Guideline Group for renal cell carcinoma
    Commissioned by European Association of Urology. University of Aberdeen: Academic Urology Unit
    Books and Reports: Commissioned Reports

  • Calcium and heart attacks: Authors' reply

    Bolland, M. J., Avenell, A., Baron, J. A., Grey, A., Reid, I. R., MacLennan, G. S., Gamble, G. D.
    BMJ (Online), vol. 341, no. 7773, pp. 569
    Contributions to Journals: Letters

  • Clinicians' caseload management behaviours as explanatory factors in patients' length of time on caseloads: a predictive multilevel study in paediatric community occupational therapy

    Kolehmainen, N., MacLennan, G., Francis, J. J., Duncan, E. A. S.
    BMC Health Services Research, vol. 10, no. 249, 249
    Contributions to Journals: Articles

  • Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis

    Bolland, M. J., Avenell, A., Baron, J. A., Grey, A., MacLennan, G. S., Gamble, G. D., Reid, I. R.
    British Medical Journal, vol. 341, no. -, c3691
    Contributions to Journals: Articles

  • Study of progesterone for the prevention of preterm birth in twins (STOPPIT): findings from a trial-based cost-effectiveness analysis

    Eddama, O., Petrou, S., Regier, D., Norrie, J., MacLennan, G., MacKenzie, F., Norman, J. E.
    International Journal of Technology Assessment in Health Care, vol. 26, no. 2, pp. 141-148
    Contributions to Journals: Articles

  • Applying psychological theories to evidence-based clinical practice: identifying factors predictive of placing preventive fissure sealants

    Bonetti, D., Johnston, M., Clarkson, J. E., Grimshaw, J., Pitts, N. B., Eccles, M., Steen, N., Thomas, R., Maclennan, G., Glidewell, E., Walker, A. E.
    Implementation Science, vol. 5, pp. 25
    Contributions to Journals: Articles

  • The clinical effectiveness of transurethral incision of the prostate: a systematic review of randomised controlled trials

    Lourenco, T., Shaw, M., Fraser, C. M., MacLennan, G. S., N'Dow, J. M. O., Pickard, R.
    World Journal of Urology, vol. 28, no. 1, pp. 23-32
    Contributions to Journals: Articles

  • Quality of life in the five years after intensive care: a cohort study

    Cuthbertson, B., Roughton, S., Jenkinson, D. J., MacLennan, G. S., Vale, L. D.
    Critical Care, vol. 14, no. 1, R6
    Contributions to Journals: Articles

  • Factors Influencing the Participation of Older People in Clinical Trials: Data Analysis from the MAVIS Trial

    Fearn, P., Avenell, A., McCann, S. K., Milne, A. C., MacLennan, G. S., MAVIS Trial Group
    Journal of Nutrition, Health & Aging, vol. 14, no. 1, pp. 51-56
    Contributions to Journals: Articles

  • Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone

    Langston, A. L., Campbell, M. K., Fraser, W. D., MacLennan, G. S., Selby, P. L., Ralston, S. H., PRISM Trial Group
    Journal of Bone and Mineral Research, vol. 25, no. 1, pp. 20-31
    Contributions to Journals: Articles

  • Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery

    Cuthbertson, B., Campbell, M. K., Stott, S., Vale, L. D., Norrie, J. D. T., Kinsella, J., Cook, J. A., Brittenden, J., Grant, A. M., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, G. C., McDonald, A. M., Cotton, S. C., Elders, A. S., MacLennan, G. S., Boyers, D., Hernández, R. A.
    Edinburgh, United Kingdom: Chief Scientist Office. 7 pages
    Books and Reports: Commissioned Reports

  • Surveillance following breast cancer: is it cost-effective?

    Ternent, L., MacLennan, G., Heys, S. D., Gilbert, F., Vale, L., Mammographic Surveillance HTA Group
    Breast Cancer Research, vol. 12, no. Suppl. 3, pp. 5-6
    Contributions to Journals: Articles

  • Development and exploratory cluster-randomised opportunistic trial of a theory-based intervention to enhance physical activity among adolescents

    Araujo-Soares, V., McIntyre, T., MacLennan, G. S., Sniehotta, F.
    Psychology & Health, vol. 24, no. 7, pp. 805-822
    Contributions to Journals: Articles

  • Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)

    Avenell, A., Cook, J. A., MacLennan, G. S., McPherson, G. C., RECORD Trial Group
    Age and Ageing, vol. 38, no. 5, pp. 606-609
    Contributions to Journals: Articles

  • Uric acid levels and outcome from coronary artery bypass grafting

    Hillis, G. S., Cuthbertson, B. H., Gibson, P. H., McNeilly, J. D., Maclennan, G. S., Jeffrey, R. R., Buchan, K. G., El-Shafei, H., Gibson, G., Croal, B. L.
    Journal of Thoracic and Cardiovascular Surgery, vol. 138, no. 1, pp. 200-205
    Contributions to Journals: Articles

  • Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis

    Norman, J. E., Mackenzie, F., Owen, P., Mactier, H., Hanretty, K., Cooper, S., Calder, A., Mires, G., Danielian, P., Sturgiss, S., MacLennan, G., Tydeman, G., Thornton, S., Martin, B., Thornton, J. G., Neilson, J. P., Norrie, J.
    The Lancet, vol. 373, no. 9680, pp. 2034-2040
    Contributions to Journals: Articles

  • Meaning behind measurement: self-comparisons affect responses to health-related quality of life questionnaires

    Robertson, C., Langston, A. L., Stapley, S., McColl, E., Campbell, M. K., Fraser, W. D., MacLennan, G., Selby, P. L., Ralston, S. H., Fayers, P. M., PRISM Trial Group
    Quality of Life Research, vol. 18, no. 2, pp. 221-230
    Contributions to Journals: Articles

  • The Knee Arthroplasty Trial (KAT): design features, baseline characteristics, and two-year functional outcomes after alternative approaches to knee replacement

    Campbell, M., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Morris, R., Murray, D., Rowley, D., Johnston, L., MacLennan, G., McCormack, K., Ramsay, C., Walker, A., KAT Trial Group
    The Journal of Bone & Joint Surgery. American Volume, vol. 91, no. 1, pp. 134-141
    Contributions to Journals: Articles

  • Systematic review and economic modelling of effectiveness and cost utility of surgical treatments for men with benign prostatic enlargement

    Lourenco, T., Armstrong, N., N'Dow, J., Nabi, G., Deverill, M., Pickard, R., Vale, L., MacLennan, G., Fraser, C., McClinton, S., Wong, S., Coutts, A., Mowatt, G., Grant, A.
    Health Technology Assessment, vol. 12, no. 35, pp. 1-168
    Contributions to Journals: Literature Reviews

  • Minimally invasive treatments for benign prostatic enlargement: systematic review of randomised controlled trials

    Lourenco, T., Pickard, R., Vale, L., Grant, A., Fraser, C., MacLennan, G., N'Dow, J., The Benign Prostatic Enlargement Team
    British Medical Journal, vol. 337, a1662
    Contributions to Journals: Articles

  • A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes

    Fielding, S., MacLennan, G. S., Cook, J. A., Ramsay, C. R.
    Trials, vol. 9, 51
    Contributions to Journals: Articles

  • Alternative approaches to endoscopic ablation for benign enlargement of the prostate: systematic review of randomised controlled trials

    Lourenco, T., Pickard, R., Vale, L., Grant, A., Fraser, C., MacLennan, G., N'Dow, J., Benign Prostatic Enlargement Team
    British Medical Journal, vol. 337
    Contributions to Journals: Articles

  • Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of bone): a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventive treatment if they were available

    Langston, A. L., Johnston, M., Francis, J., Robertson, C., Campbell, M. K., Entwistle, V. A., Marteau, T., Maclennan, G., Weinman, J., McCallum, M., Miedzybrodska, Z., Charnock, K., Ralston, S. H., Miedzybrodzka, Z.
    BMC Health Services Research, vol. 8, no. 116, pp. 116
    Contributions to Journals: Articles
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