TOPKAT was a multicentre randomised controlled trial, funded by the NIHR HTA Programme. TOPKAT aimed to compare the effectiveness and cost-effectiveness of total versus uni-compartmental knee replacement for the management of knee osteoarthritis. TOPKAT recruited 529 participants from 27 different UK orthopaedic units over a two year period. The study incorporated a standard randomised design for surgeons willing to randomise between the two interventions and an expertise-based design for surgeons who have an approach of choice.
The primary outcome is the Oxford Knee Score at five years post randomisation.
TOPKAT was led by Professor David Beard based at the University of Oxford.
For more information please see the TOPKAT Study Website
Contacts
- Diana Johnson; diana.johnson@abdn.ac.uk
Status
CompletedPublications
TOPKAT protocol was published and is available here -
https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-14-292
Beard DJ, Davies LJ, Cook JA, et al. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial. Lancet. 2019 Aug 31;394(10200):746-756. doi: 10.1016/S0140-6736(19)31281-4.
Beard DJ, Davies LJ, Cook JA, et al. Total versus partial knee replacement in patients with medial compartment knee osteoarthritis: the TOPKAT RCT. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial. Health Technology Assessment. 2020; 24(20). https://doi.org/10.3310/hta24200
Harrison CJ, Plessen CY, Leigl G, et al. Item response theory may account for unequal item weighting and individual-level measurement error in trials that use PROMs: a psychometric sensitivity analysis of the TOPKAT trial. J Clin Epidemiol. 2023; 158:62-69. https://doi.org/10.1016/j.jclinepi.2023.03.013
Beard DJ, Price AJ, Campbell MK. Further reflections on TOPKAT and Partial vs. Total Knee Replacement – responses to authors. Ann Transl Med. 2020; 8(11):730. doi: 10.21037/atm-2020-59