Ph.D. in Industrial Chemistry (Universita' Statale di Milano)
Advanced Research Fellow
- About
-
- Email Address
- s.dallangelo@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437563
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.
In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University. In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen.
Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.
Memberships and Affiliations
- Internal Memberships
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Member of the Concordat Steering Group
Member of the IMS Health, Safety & Wellbeing Committee
Member of Nvision Committee
IMS First Aider
- External Memberships
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Member of the Royal Society of Chemistry (RSC) https://www.rsc.org/
Member of European Society for Molecular Imaging (ESMI) https://e-smi.eu/
Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) http://www.sinapse.ac.uk/
Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics
Latest Publications
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
Patents: PatentsProtein tyrosine phosphatase 1B in metabolic diseases and drug development
Nature Reviews Endocrinology , vol. 20, no. 6, pp. 366-378Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1038/s41574-024-00965-1
- [ONLINE] View publication in Scopus
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Experimental Physiology, vol. 109, no. 1, pp. 81-99Contributions to Journals: ArticlesChemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides
Angewandte Chemie International Edition, vol. 62, no. 16, e202215979Contributions to Journals: ArticlesMetal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications
Electrochemical Science Advances, vol. 2, no. 6, e2100164Contributions to Journals: Articles
- Research
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Research Overview
Research interest in:
- PET Chemistry
- Peptide synthesis
- Synthetic Organic Chemistry
- Medicinal Chemistry
My research current research is focused on:
- the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
- the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
- the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)
I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Chemistry, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Diagnostic Imaging
- Medicinal Chemistry
- Applied Chemistry
- Organic Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
- Development of prostate cancer PET tracers
- [18F]FAZA and [18F]FMISO hypoxia PET imaging
- Fluorinase mediate Fluorine-18 tracers synthesis
- Peptide synthesis
- Teaching
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Courses
Course coordinator
Coordinator
Supervisor
- Masters Research Project (LABORATORY) - MB5904
Course Co-Coordinator
Supervisor
Practical on Drug Discovery
Practical on Drug Discovery
Radiochemistry
- Student Selected Component 2 (ME3013)
Coordinator
Supervisor
Practical on Protein purification
Lecturer on Peptide Therapeutics
Supervisor
- Introduction to Chemistry for Biologists - EastBio masterclass
http://www.eastscotbiodtp.ac.uk/foundation-masterclasses
- Masters Research Project (LABORATORY) - MB5904 MB5021
Course co-coordinator
Supervisor
- Publications
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Page 4 of 5 Results 31 to 40 of 41
Arginine Analogues Incorporating Carboxylate Bioisosteric Functions are Micromolar Inhibitors of Human Recombinant DDAH-1
Organic & Biomolecular Chemistry, vol. 46, no. 13, pp. 11315-11330Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/C5OB01843A
An Efficient Route to N-Monosubstituted Guanidino-Lactams
Synthesis, vol. 47, no. 19, pp. 3067-3078Contributions to Journals: ArticlesPyrazole-type Cannabinoid Ligands conjugated with Fluoro-deoxy-carbohydrates as Potential PET-Imaging Agents: Synthesis and CB1/CB2 receptor affinity evaluation
Journal of Fluorine Chemistry, vol. 152, pp. 166-172Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jfluchem.2013.03.006
Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of αvβ3 integrin receptor
Organic & Biomolecular Chemistry, vol. 27, no. 11, pp. 4551-4558Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/c3ob40550h
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4027/1/RGD_OBC_Template_for_AURA.docx
Molecular insights into bacteroid development during Rhizobium-legume symbiosis
FEMS Microbiology Reviews, vol. 37, no. 3, pp. 364-383Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/1574-6976.12003
Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18F]fluoro-5-deoxyribose as a novel tracer
Nuclear Medicine and Biology, vol. 40, no. 4, pp. 464-470Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.nucmedbio.2013.02.006
[18F]-Barbiturates as PET-tracers for Alzheimer's disease
245th National Spring Meeting of the American-Chemical-Society (ACS)Contributions to Journals: Abstracts18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease
Chemical Communications, vol. 49, no. 8, pp. 792-794Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/c2cc38443d
[18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging
Chemical Communications, vol. 48, no. 43, pp. 5247-5249Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/C2CC31262J
Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide
The Journal of Biological Chemistry, vol. 287, no. 14, pp. 10791-10798Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M111.311316
