Ph.D. in Industrial Chemistry (Universita' Statale di Milano)
Lecturer
- Email Address
- s.dallangelo@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437563
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.
In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University. In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen.
Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.
Memberships and Affiliations
Member of the Concordat Steering Group
Member of the IMS Health, Safety & Wellbeing Committee
Member of Nvision Committee
IMS First Aider
Member of the Royal Society of Chemistry (RSC) https://www.rsc.org/
Member of European Society for Molecular Imaging (ESMI) https://e-smi.eu/
Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) http://www.sinapse.ac.uk/
Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics
Latest Publications
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
Delibegovic, M., Dall'Angelo, S., Hamer, M. M., Dekeryte, R., McEwan, A. R., Greig, I.Patents: PatentsProtein tyrosine phosphatase 1B in metabolic diseases and drug development
Delibegovic, M., Dall'Angelo, S., Dekeryte, R.Nature Reviews Endocrinology , vol. 20, no. 6, pp. 366-378Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1038/s41574-024-00965-1
- [ONLINE] View publication in Scopus
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Thompson, K. J., Watson, S., Zanato, C., Dall'Angelo, S., De Nooij, J. C., Pace-Bonello, B., Shenton, F. C., Sanger, H. E., Heinz, B. A., Broad, L. M., Grosjean, N., McQuillian, J. R., Dubini, M., Pyner, S., Greig, I., Zanda, M., Bleakman, D., Banks, R. W., Bewick, G. S.Experimental Physiology, vol. 109, no. 1, pp. 81-99Contributions to Journals: ArticlesChemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides
Colombano, A., Dalponte, L., Dall'Angelo, S., Clemente, C., Idress, M. S., Ghazal, A., Houssen, W. E.Angewandte Chemie International Edition, vol. 62, no. 16, e202215979Contributions to Journals: ArticlesMetal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications
Magni, M., Dall'Angelo, S., Baldoli, C., Licandro, E., Falciola, L., Mussini, P.Electrochemical Science Advances, vol. 2, no. 6, e2100164Contributions to Journals: Articles
Research Overview
Research interest in:
- PET Chemistry
- Peptide synthesis
- Synthetic Organic Chemistry
- Medicinal Chemistry
My research current research is focused on:
- the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
- the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
- the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)
I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Chemistry, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Diagnostic Imaging
- Medicinal Chemistry
- Applied Chemistry
- Organic Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
- Development of prostate cancer PET tracers
- [18F]FAZA and [18F]FMISO hypoxia PET imaging
- Fluorinase mediate Fluorine-18 tracers synthesis
- Peptide synthesis
Courses
Course coordinator
Coordinator
Supervisor
- Masters Research Project (LABORATORY) - MB5904
Course Co-Coordinator
Supervisor
Practical on Drug Discovery
Practical on Drug Discovery
Radiochemistry
- Student Selected Component 2 (ME3013)
Coordinator
Supervisor
Practical on Protein purification
Lecturer on Peptide Therapeutics
Supervisor
- Introduction to Chemistry for Biologists - EastBio masterclass
http://www.eastscotbiodtp.ac.uk/foundation-masterclasses
- Masters Research Project (LABORATORY) - MB5904 MB5021
Course co-coordinator
Supervisor
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Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status
Andriu, A., Crockett, J., Dall'Angelo, S., Piras, M., Zanda, M., Fleming, I. N.Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36Contributions to Journals: ArticlesA New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic 18F Fluorination for PET Imaging
Lowe, P. T., Dall'Angello, S., Mulder-Krieger, T., Ijzerman, A. P., Zanda, M., O'Hagan, D.ChemBioChem, vol. 18, no. 21, pp. 2156-2164Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cbic.201700382
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11141/1/Manuscript_Edited_002_.docx
High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin
Piras, M., Testa, A., Fleming, I. N., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G. D., Forster, D., Williams, K. J., Zanda, M.ChemMedChem, vol. 12, no. 14, pp. 1142-1151Contributions to Journals: ArticlesSynthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy
Fernandez Diaz-Rullo, F., Zamberlan, F., Mewis, R. E., Fekete, M., Broche, L., Cheyne, L. A., Dall'Angelo, S., Duckett, S. B., Dawson, D., Zanda, M.Bioorganic & Medicinal Chemistry, vol. 25, no. 10, pp. 2730-2742Contributions to Journals: ArticlesSynthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline
Sani, M., Lazzari, P., Folini, M., Spiga, M., Zuco, V., De Cesare, M., Manca, I., Dall'Angelo, S., Frigerio, M., Usai, I., Testa, A., Zaffaroni, N., Zanda, M.Chemistry : a European Journal, vol. 23, no. 24, pp. 5842-5850Contributions to Journals: ArticlesDesign, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters
Testa, A., Dall'Angelo, S., Mingarelli, M., Augello, A., Schweiger, L., Welch, A. E., Elmore, C. S., Sharma, P., Zanda, M.Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976Contributions to Journals: ArticlesSynthesis and radio-synthesis of prospective 2-nitroimidazole hypoxia PET tracers via thiazolidine ligation with 5-fluorodeoxyribose (FDR)
Musolino, M., Dall'angelo, S., Zanda, M.SynOpen, vol. 1, no. 1, pp. 173-179Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1055/s-0036-1591863
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9795/1/s_0036_1591863.pdf
Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers
Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E., Zanda, M.Organic & Biomolecular Chemistry, vol. 15, no. 9, pp. 2086-2096Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/C6OB02796B
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10024/1/C6OB02796B.pdf
Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers
Zhang, Q., Dall'Angelo, S., Fleming, I. N., Schweiger, L. F., Zanda, M., O'Hagan, D.Chemistry : a European Journal, vol. 22, no. 31, pp. 10998-11004Contributions to Journals: ArticlesNGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting
Graziadio, A., Zanda, M., Frau, S., Fleming, I. N., Musolino, M., Dall'Angelo, S., Baldassarre, M., Piras, M.Bioconjugate Chemistry, vol. 27, no. 5, pp. 1332-1340Contributions to Journals: Articles
