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Aberdeen Cardiovascular & Diabetes Centre

Professor Mary MacLeod

Professor Mary MacLeod
Professor Mary MacLeod
Professor Mary MacLeod

BSc MBChB PhD FRCP

Personal Chair (Clinical)

About
Email Address
m.j.macleod@abdn.ac.uk
Telephone Number
+44 (0)1224 437842
School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Dr Macleod is a Clinical Pharmacologist with a personal chair (Teaching and Research) at the University of Aberdeen and honorary Consultant Physician within NHS Grampian.  Her clinical work is largely in the area of acute stroke management, hypertension clinics and primary and secondary cardiovascular prevention.  Current research interests include:

Novel imaging markers in stroke and small vessel disease using fast field cycling MRI

Using linked datasets to explore management of stroke including service organisation and secondary prevention

Interactions between stroke and other diseases (e.g. cancer)

Memberships and Affiliations

Internal Memberships

Chair, Clinical Studies Oversight Group

External Memberships

Chair of Scotland A and B Research Ethics Committees

Honorary Deputy Secretary, British and Irish Association of Stroke Physicians

Trustee SHARP (Scottish Heart and Arterial Disease Prevention)

Latest Publications

View My Publications

Teaching

Teaching Responsibilities

Year 5 MBChB OSCE coordinator

Situational Judgement Test lead

Year 1, 3 and 4 Clinical Pharmacology teaching

MSc Clinical Pharmacology: Pharmacovigilance, Medicines Management

Delivers teaching to MSc Cardiovascular and Diabetes, BSc Neurosciences, BSc Genetics

MRCP PACES examiner

Publications

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  • Scottish stroke care audit: can we use routine data to investigate optimal care of stroke patients?

    Macleod, M., Turner, M. E., Barber, M. H., Langhorne, P., Dodds, H., Dennis, M. S.
    International Journal of Stroke, vol. 7, no. 2 supplement, pp. 64
    Contributions to Journals: Abstracts

  • Service redesign: Address the barriers and deliver acute stroke care.

    Jacobson, E. U., Bayer, S., MacLeod, M. J.
    Health Service Journal, vol. 122, no. 6323, pp. 28-29
    Contributions to Journals: Articles

  • Emotion processing and social participation following stroke: study protocol

    Scott, C. L., Phillips, L. H., Johnston, M., Whyte, M. M., MacLeod, M. J.
    BMC Neurology, vol. 12, 56
    Contributions to Journals: Articles

  • Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

    Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., Jackson, C. A., Traylor, M., Strange, A., Su, Z., Band, G., Syme, P. D., Malik, R., Pera, J., Norrving, B., Lemmens, R., Freeman, C., Schanz, R., James, T., Poole, D., Murphy, L., Segal, H., Cortellini, L., Cheng, Y., Woo, D., Nalls, M. A., Müller-Myhsok, B., Meisinger, C., Seedorf, U., Ross-Adams, H., Boonen, S., Wloch-Kopec, D., Valant, V., Slark, J., Furie, K., Delavaran, H., Langford, C., Deloukas, P., Edkins, S., Hunt, S., Gray, E., Dronov, S., Peltonen, L., Gretarsdottir, S., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K., Boncoraglio, G. B., Parati, E. A., Macleod, M. J., The International Stroke Genetics Consortium (ISGC), The Wellcome Trust Case Control Consortium 2 (WTCCC2)
    Nature Genetics, vol. 44, no. 3, pp. 328-333
    Contributions to Journals: Letters

  • Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds

    Dani, K. A., Thomas, R. G. R., Chappell, F. M., Shuler, K., MacLeod, M. J., Muir, K. W., Wardlaw, J. M., Translational Medicine Research Collaboration Multicentre Acute Stroke Imaging Study
    Annals of Neurology, vol. 70, no. 3, pp. 384-401
    Contributions to Journals: Articles

  • Procedures to evaluate the importance of dietary polyamines

    Acheampong, P., Macleod, M. J., Wallace, H. M.
    Methods in Molecular Medicine, vol. 720, no. 6, pp. 349-364
    Contributions to Journals: Articles

  • Risk of stroke and cardiovascular events after ischemic stroke or transient ischemic attack in patients with type 2 diabetes or metabolic syndrome: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial

    Callahan, A., Amarenco, P., Goldstein, L. B., Sillesen, H., Messig, M., Samsa, G. P., Altafullah, I., Ledbetter, L. Y., MacLeod, M. J., Scott, R., Hennerici, M., Zivin, J. A., Welch, K. M. A., SPARCL Investigators
    Archives of Neurology, vol. 68, no. 10, pp. 1245-1251
    Contributions to Journals: Articles

  • Improved detection following neuro-eye therapy in patients with post-geniculate brain damage

    Sahraie, A., Macleod, M. J., Trevethan, C. T., Robson, S. E., Olson, J. A., Callaghan, P., Yip, B.
    Experimental Brain Research, vol. 206, no. 1, pp. 25-34
    Contributions to Journals: Articles

  • Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial

    Goldstein, L. B., Amarenco, P., Zivin, J., Messig, M., Altafullah, I., Callahan, A., Hennerici, M., MacLeod, M. J., Sillesen, H., Zweiffler, R., Michael, K., Welch, A., SPARCL Investigators
    Stroke, vol. 40, no. 11, pp. 3526-3531
    Contributions to Journals: Articles

  • Perceptual Learning in the Blind Field of Hemianopic Patients

    Saharie, A., MacLeod, M. J.
    49th Annual Meeting of the Society-for-Psychophysiological-Research
    Contributions to Conferences: Abstracts

  • Evaluation of spermine as a biomarker for clinical research in stroke

    Acheampong, P., Wallace, H. M., MacLeod, M. J.
    Contributions to Conferences: Abstracts

  • Pharmacokinetics of blood polyamines after an oral bolus of polyamines

    Acheampong, P., MacLeod, M. J., Wallace, H. M.
    European Association of Clinical Pharmacology and Therapeutics, pp. 122-123
    Contributions to Conferences: Abstracts

  • Retrospective audit of pre-admission warfarin use in acute stroke patients with pre-existing atrial fibrillation

    Elofuke, P., Pickering, G., Shields, L., MacLeod, M. J., Reid, J. M.
    European Journal of Clinical Pharmacology, vol. 105, pp. 35-35
    Contributions to Journals: Abstracts

  • What is the scale of prescribing errors committed by junior doctors?: A systematic review

    Ross, S., Bond, C., Rothnie, H., Thomas, S., MacLeod, M. J.
    British Journal of Clinical Pharmacology, vol. 67, no. 6, pp. 629-640
    Contributions to Journals: Articles

  • Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke

    Gschwendtner, A., Bevan, S., Cole, J. W., Plourde, A., Matarin, M., Ross-Adams, H., Meitinger, T., Wichmann, E., Mitchell, B. D., Furie, K., Slowik, A., Rich, S. S., Syme, P. D., MacLeod, M. J., Meschia, J. F., Rosand, J., Kittner, S. J., Markus, H. S., Mueller-Myhsok, B., Dichgans, M., Int Stroke Genetics Consortium
    Annals of Neurology, vol. 65, no. 5, pp. 531-539
    Contributions to Journals: Articles

  • Neutrophil-Lymphocyte Ratio as a Predictor of Stroke Subtype and Outcome

    Acheampong, P., Eduful, B. J., MacLeod, M. J.
    American-Association-International-Stroke Conference 2009
    Contributions to Conferences: Abstracts

  • Validation of MAP2K6 as a Novel Stroke Candidate Gene

    Ross-Adams, H., Pasdar, A., Mayer, C., MacLeod, M. J.
    International Stroke Conference 2009, pp. E179
    Contributions to Journals: Abstracts

  • Emotion perception and activity limitations following stroke: A pilot study

    Scott, C. L., Phillips, L. H., Johnston, M., MacLeod, M. J., Whyte, M.
    Psychology & Health, vol. 23, no. Suppl. 1, pp. 231
    Contributions to Journals: Abstracts

  • Temporal properties of spatial channel of processing in hemianopia

    Sahraie, A., Trevethan, C. T., MacLeod, M.
    Neuropsychologia, vol. 46, no. 3, pp. 879-885
    Contributions to Journals: Articles

  • Validation of stroke candidate genes identified with DNA pools and SNP chips

    Ross-Adams, H., Pasdar, A., Mayer, C., MacLeod, M. J.
    Stroke, vol. 39, no. 2, pp. 630-631
    Contributions to Journals: Abstracts

  • Saccadic distractor effect and S-cone processing in normal observers and two cases of hemianopia

    Ridgway, N., MacLeod, M. J., Milders, M., Sahraie, A.
    31st European Conference on Visual Perception, pp. 63
    Contributions to Journals: Abstracts

  • Blindsight and visual rehabilitation in the cortically blind

    Sahraie, A., Trevethan, C. T., MacLeod, M. J., Olson, J., Weiskrantz, L.
    Perception, vol. 35, pp. 232-232
    Contributions to Journals: Articles

  • Increased sensitivity after repeated stimulation of residual spatial channels in blindsight

    Sahraie, A., Trevethan, C. T., MacLeod, M. J., Murray, A. D., Olson, J. A., Weiskrantz, L.
    PNAS, vol. 103, no. 40, pp. 14971-14976
    Contributions to Journals: Articles

  • Stress, debt and undergraduate medical student performance

    Ross, S., Cleland, J. A., MacLeod, M. J.
    Medical Education, vol. 40, no. 6, pp. 584-589
    Contributions to Journals: Articles

  • Study of CETP gene polymophisms and ischaemic stroke in a Scottish population, using pooled DNA samples

    Pasdar, A., Ross-Adams, H. E., St Clair, D. M., MacLeod, M. J.
    Contributions to Conferences: Other Contributions

  • Poster Presentation - Design and validation of DNA pools in an ischaemic stroke population

    Ross-Adams, H. E., Pasdar, A., St Clair, D. M., MacLeod, M. J.
    Contributions to Conferences: Other Contributions

  • Paraoxonase gene polymorphisms and haplotype analysis in a stroke population

    Pasdar, A., Ross-Adams, H., Cumming, A., Cheung, J., Whalley, L., St Clair, D., MacLeod, M. J.
    BMC Medical Genetics, vol. 7, 28
    Contributions to Journals: Articles

  • Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population

    Helgadottir, A., Gretasdottir, S., St Clair, D. M., Maolescu, A., Cheung, J. K. S., Thorleifsson, G., Pasdar, A., Grant, S. F., Whalley, L. J., Hakonarson, H., Thorsteinsdottir, U., Kong, A., Gulcher, J. R., Stefansson, K., MacLeod, M. J.
    American Journal of Human Genetics, vol. 76, no. 3, pp. 505-509
    Contributions to Journals: Articles

  • ABCA1 gene polymoprhism and lipid profile in a Scottish population

    Pasdar, A., Cumming, A. M., St Clair, D. M., MacLeod, M. J.
    Contributions to Conferences: Abstracts

  • Antihypertensive drug prescribing in Grampian

    Ross, S., MacLeod, M. J.
    British Journal of Clinical Pharmacology, vol. 60, no. 3, pp. 300-305
    Contributions to Journals: Articles

  • Timing of aspirin use in acute stroke and use of secondary prevention: stroke unit vs medical unit

    Reid, J., MacLeod, M. J., Williams, D.
    Scottish Medical Journal, vol. 50, pp. 69-72
    Contributions to Journals: Articles

  • Patient compliance in hypertension: role of illness perceptions and treatment beliefs

    Ross, S., Walker, A. E., MacLeod, M. J.
    Journal of Human Hypertension, vol. 18, no. 9, pp. 607-613
    Contributions to Journals: Articles

  • Genotype and haplotype analysis of ABCA1 gene in ischaemic stroke

    Pasdar, A., St Clair, D. M., MacLeod, M. J.
    Stroke, vol. 35, pp. 253-340
    Contributions to Journals: Articles

  • Poster Presentation - Using the TOAST Criteria for Retrospective Classification of Ischemic Stroke Patients

    Pasdar, A., St Clair, D. M., MacLeod, M. J.
    Contributions to Conferences: Other Contributions

  • Spatial channels of visual processing in cortical blindness

    Sahraie, A., Trevethan, C. T., Weiskrantz, L., Olson, J., MacLeod, M. J., Murray, A. D., Dijkhuizen, R. S., Counsell, C. E., Coleman, R.
    European Journal of Neuroscience, vol. 18, no. 5, pp. 1189-1196
    Contributions to Journals: Articles

  • Hypertension in Diabetes: A Perspective from Clinical Pharmacology

    Ross, S., MacLeod, M. J.
    British Journal of Diabetes and Vascular Disease, vol. 3, no. 4, pp. 252-256
    Contributions to Journals: Review articles

  • Paraoxonase genes (PON1, 2 and 3) polymorphisms and ischaemic stroke in a Scottish population

    Pasdar, A., St Clair, D. M., MacLeod, M. J.
    Contributions to Conferences: Abstracts

  • Paraxonase 3 gene (PON3) polymorphism, ischaemic stroke and lipid profile in a Scottish population

    Pasdar, A., St Clair, D. M., MacLeod, M. J.
    Contributions to Conferences: Other Contributions

  • Paraxonase genes (PON1, PON2 and PON3) polymorphisms and lipid profile in a Scottish population

    Pasdar, A., MacLeod, M. J., St Clair, D. M., Cumming, A. M.
    Contributions to Conferences: Abstracts

  • Effects of mailed dissemination of the Royal College of Radiologists' guidelines on general practitioner referrals for radiography: a time series analysis

    Matowe, L., Ramsay, C. R., Gilbert, F. J., MacLeod, M. J., Needham, G.
    Clinical Radiology, vol. 57, no. 7, pp. 575-578
    Contributions to Journals: Articles

  • Genotype and Haplotype Analysis of Paraoxanase Genes (PON 1&2 ) and Ishcaemic Stroke in a Northern Scottish Population

    Pasdar, A., MacLeod, M. J., St Clair, D. M.
    Contributions to Conferences: Abstracts

  • Lack of association between apolipoprotein E genotype and ischaemic stroke in a Scottish population

    MacLeod, M. J., De Lange, R. P., Breen, G. D., Meiklejohn, D., Lemmon, H., St Clair, D. M.
    European Journal of Clinical Investigation, vol. 31, no. 7, pp. 570-573
    Contributions to Journals: Articles

  • Predicted impact of intravenous thrombolysis

    Berwaerts, J., Macleod, M., Johnston, A., Hoffman, J., Jørgensen, H.
    BMJ, vol. 320, 1006
    Contributions to Journals: Letters

  • Pharmacokinetic factors in the modern drug treatment of tuberculosis

    Douglas, J. G., Macleod, M.
    Clinical Pharmacokinetics, vol. 37, no. 2, pp. 127-146
    Contributions to Journals: Review articles

  • No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

    MacLeod, M. J., Dahiyat, M. T., Cumming, A., Meiklejohn, D., Shaw, D., St Clair, D.
    Neurology, vol. 53, pp. 418-420
    Contributions to Journals: Articles

  • Drug Treatment of Hypertension Complicating Diabetes Mellitus

    MacLeod, M. J., McLay, J.
    Drugs, vol. 56, no. 2, pp. 189-202
    Contributions to Journals: Articles

  • Identification of a common low density lipoprotein receptor mutation (C163Y) in the west of Scotland

    Lee, W., Haddad, L., Macleod, M., Dorrance, A., Wilson, D., Gaffney, D., Dominiczak, M., Packard, C., Day, I., Humphries, S., Dominiczak, A.
    Journal of Medical Genetics, vol. 35, no. 7
    Contributions to Journals: Articles

  • Renal artery stent placement in renal artery stenosis: Technical and early clinical results

    Taylor, A., Sheppard, D., Macleod, M., Harden, P., Baxter, G., Edwards, R., Moss, J.
    Brain and Language, vol. 52, no. 6, pp. 451-457
    Contributions to Journals: Articles

  • Effect of renal-artery stenting on progression of renovascular renal failure

    Harden, P., MacLeod, M., Rodger, R., Baxter, G., Connell, J., Dominiczak, A., Junor, B., Briggs, J., Moss, J.
    Lancet, vol. 349, no. 9059, pp. 1133-1136
    Contributions to Journals: Articles

  • Sodium-lithium countertransport, sodium-hydrogen exchange and membrane microviscosity in patients with hyperlipidaemia

    Macleod, M., Lee, W., Devlin, A., Caslake, M., Anderson, N., Packard, C., Dominiczak, M., Reid, J., Dominiczak, A.
    Clinical Science, vol. 92, no. 3, pp. 237-246
    Contributions to Journals: Articles

  • Renal artery stenosis managed by Palmaz stent insertion: Technical and clinical outcome

    MacLeod, M., Taylor, A., Baxter, G., Harden, P., Briggs, D., Moss, J., Semple, P., Connell, J., Dominiczak, A.
    Journal of Hypertension, vol. 13, no. 12, pp. 1791-1795
    Contributions to Journals: Articles

  • Hypertension: targets for treatment

    MacLeod, M., Reid, J.
    Practitioner, vol. 239, no. 1556, pp. 670-673
    Contributions to Journals: Articles

  • Transluminal vascular stents for ostial atherosclerotic renal artery stenosis

    Plouin, P., Raynaud, A., Azizi, M., Chatellier, G., MacLeod, M., Connell, J., Harden, P., Douglas Briggs, J., Moss, J., Dominiczak, A.
    The Lancet, vol. 346, no. 8982, pp. 1109-110
    Contributions to Journals: Articles
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