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Aberdeen Cardiovascular & Diabetes Centre

Dr Fiona Murray

Dr Fiona Murray
Dr Fiona Murray
Dr Fiona Murray

PhD Pharmacology

Senior Lecturer

Accepting PhDs

About
Email Address
fmurray@abdn.ac.uk
Telephone Number
+44 (0)1224 437594
Telephone Number
+44 (0)1224 437391
Office Address

Room 6.20, Institute of Medical Sciences

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I moved to the University of Aberdeen from the University of California, San Diego, where I initially did my postdoctoral training with Professor Paul Insel in the Department of Pharmacology before joining the Department of Medicine as junior faculty.

The overall goal of my research is to examine the role of cyclic adenosine 3',5'-monophosphate (cAMP) signalling in disease, in particular the progression of pulmonary arterial hypertension (PAH) and B- and T-cell lymphomas, to uncover novel therapeutic targets. Model systems studied include cultured human lymphoma, pulmonary artery smooth muscle and pulmonary artery endothelial cells and models of disease. Current research focuses on the role of G protein-coupled receptors, in particular GPR75, which we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension. In addition, we have an interest in re-purposing PDE1 inhibitors for pulmonary arterial hypertension.Current research focuses on the role of G protein-coupled receptors, in particular GPR75, which we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension.

Qualifications

  • BSc Pharmacology 
    1998 - University of Aberdeen 
  • PhD Pharmacology 
    2003 - University of Glasgow 

Memberships and Affiliations

Internal Memberships

Active mentor in the University mentoring scheme

IMS Radiation Protection Supervisor

Athena SWAN committee member

Duly elected to serve as Senate members from the IMS

External Memberships

British Pharmacological Society Member

American Society for Pharmacology and Experimental Therapeutics Member

British Physiology Society Member

Committee member of the Scottish Cardiovascular forum

2009-2020 Editorial Board member of the British Journal of Pharmacology

2021-present Editor of Cellular Signalling 

 

 

Prizes and Awards

AHA CPCC Cournand & Comroe Young Investigator Award Finalist,

TiP’s Young Pharmacologist of the Year Finalist,

ASPET/Molecular Pharmacology Division Postdoctoral Winner,

APS respiratory section Hermann Rahn Award

Diagnosis and treatment of chronic lymphocytic leukaemia (CLL): United States Patent 7846664

G-protein coupled receptor-associated diagnosis and drug targets: United States Patent 10107816

Research

Research Overview

The overall goal of my research is to examine the role of cyclic adenosine 3',5'-monophosphate (cAMP) signalling in disease, in particular the progression of pulmonary arterial hypertension (PAH) and  B- and T-cell lymphomas, to uncover novel therapeutic targets.  Model systems studied include cultured human lymphoma, pulmonary artery smooth muscle and pulmonary artery endothelial cells and models of disease.

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Biomedical Sciences

Supervising
Accepting PhDs
View Research Area

Research Specialisms

  • Pharmacology
  • Physiology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

My current research focuses on the role of G protein-coupled receptors, in particular GPR75, that we believe could be a novel target and possible circulating biomarker for pulmonary arterial hypertension.  In addition I have an interest in re-purposing PDE1 inhibitors for pulmonary arterial hypertension. 

Knowledge Exchange

SHMU radio and science demonstrations at summer community fairs, local preschools (Scott et al., Primary School Children can Take the Lead in Teaching Anatomy and Physiology to their Peers, HAPS, 2020) and Physiology Friday, Doors open day (University of Aberdeen). University of Aberdeen YouTube channel. LUNGEVITY: research driven activity for schools, community groups and open days to increase understanding of the role of the lung and highlight the effects of disease and smoking.

Collaborations

Elasmogen to develop antibodies for the treatment of age-related-macular-degeneration.

European Lead Factory (GPR75-screen).

Consultant for Enthorin 

Funding and Grants

A NOVEL G PROTEIN-COUPLED RECEPTOR TARGET FOR METABOLIC SYNDROME. 02/02/21-01/02/22, TENOVUS SCOTLAND

REPURPOSING OF A SELECTIVE PHOSPHODIESTERASE 1 INHIBITOR FOR LEUKAEMIA AND LYMPHOMA. 1/5/21 – 30/4/22, FRIENDS OF ANCHOR

GPR75: A NOVEL DRUG TARGET AND BIOMARKER FOR AGE RELATED MACULAR DEGENERATION Crane, I. J., Collinson, J. M. & Murray, F. 3/09/19 → 2/09/20, TENOVUS SCOTLAND

EXPLOITING THE BODY'S ENDOCANNABINOID SYSTEM IN CHRONIC LYMPHOCYTIC LEUKAEMIA Vickers, M. A., Murray, F. & Pertwee, R. 1/10/18 → 30/09/19 £14,648, FRIENDS OF ANCHOR

REPURPOSING OF A SELECTIVE PHOSPHODIESTERASE 1 INHIBITOR FOR PULMONARY ARTERIAL HYPERTENSION Murray, F. 1/04/18 → 31/03/19, NHS GRAMPIAN

UNCOVERING THE PHARMACOLOGY OF GPR75: ROLE IN PULMONARY ARTERIAL HYPERTENSION. Murray, F. 1/03/17 → 1/07/19,  WELLCOME TRUST

Teaching

Courses

Teaching Responsibilities

Course-coordinator - BM3501(Cardiovascular Physiology and Pharmacology)

Course-coordinator - MT5024/MT5524 (Molecular Pharmacology)

Lecturer - PA4005 (Molecular Pharmacology)

Lecturer - SM3002 (Frontiers of Biomedical Sciences)

Lecturer - BM5003 (Cardiovascular Health and Disease)

Non-course Teaching Responsibilities

Lab supervisor for undergraduates and postgraduates 

Publications

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  • Quantitative Functional Cardiac Magnetic Resonance Imaging in Mice with Pulmonary Arterial Hypertension

    Breen, E., Scadeng, M., Murray, F., Bigby, T.
    The FASEB Journal, vol. 29, no. 1 supplement 662.8
    Contributions to Journals: Abstracts

  • Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

    Lee, J., Kim, T. H., Murray, F., Li, X., Choi, S. S., Broide, D. H., Corr, M., Lee, J., Webster, N. J. G., Insel, P. A., Raz, E.
    PNAS, vol. 112, no. 5, pp. 1529-1534
    Contributions to Journals: Articles

  • Interleukin 33 And Its Receptor, St2, Participate In The Development Of Pulmonary Arterial Hypertension In A Mouse Model

    Lerner, A. D., Lai, N. C., Tsui, C., Breen, E., Murray, F., Bigby, T. D.
    International Conference of the American-Thoracic-Society (ATS), A5284
    Contributions to Journals: Abstracts

  • Renal phosphate wasting in the absence of adenylyl cyclase 6

    Fenton, R. A., Murray, F., Dominguez Rieg, J. A., Tang, T., Levi, M., Rieg, T.
    Journal of the American Society of Nephrology, vol. 25, no. 12, pp. 2822-2834
    Contributions to Journals: Articles

  • GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis

    Lopez-Sanchez, I., Dunkel, Y., Roh, Y., Mittal, Y., De Minicis, S., Muranyi, A., Singh, S., Shanmugam, K., Aroonsakool, N., Murray, F., Ho, S. B., Seki, E., Brenner, D. A., Ghosh, P.
    Nature Communications, vol. 5, 4451
    Contributions to Journals: Articles

  • G protein-coupled receptor expression and function in pulmonary artery smooth muscle cells: new targets in pulmonary arterial hypertension

    McDonald, D., Aroonsakool, N., Kwon, O., Insel, P., Murray, F.
    The FASEB Journal, vol. 28, no. Suppl 1, 1090.3
    Contributions to Journals: Abstracts

  • Interleukin-33 in pulmonary arterial hypertension: a role in disease pathogenesis?

    Aroonsakool, N., Titone, D., Li, J., Dumouchel, J., Lombardi, S., Kim, N., Poch, D., Bigby, T., Murray, F.
    The FASEB Journal, vol. 28, no. 1, 1090.4
    Contributions to Journals: Abstracts

  • Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome

    Guibinga, G., Murray, F., Barron, N., Pandori, W., Hrustanovic, G.
    Human Molecular Genetics, vol. 22, no. 22, pp. 4502-15
    Contributions to Journals: Articles

  • Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma

    Murray, F., Insel, P. A.
    Expert Opinion on Therapeutic Targets, vol. 17, no. 8, pp. 937-49
    Contributions to Journals: Articles

  • HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?

    Guibinga, G., Murray, F., Barron, N.
    PloS ONE, vol. 8, no. 5, pp. 1-11
    Contributions to Journals: Articles

  • Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets

    Li, X., Murray, F., Koide, N., Goldstone, J., Dann, S. M., Chen, J., Bertin, S., Fu, G., Weinstein, L. S., Chen, M., Corr, M., Eckmann, L., Insel, P. A., Raz, E.
    The Journal of Clinical Investigation, vol. 122, no. 3, pp. 963-973
    Contributions to Journals: Articles

  • Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia (vol 471, pg 499, 2011)

    Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., Iakoucheva, L. M., Krastoshevsky, O., Krause, V., Larach-Walters, V., Welsh, D. K., Craig, D., Kelsoe, J. R., Gershon, E. S., Leal, S. M., Aquila, M. D., Morris, D. W., Gill, M., Corvin, A., Insel, P. A., McClellan, J., King, M., Karayiorgou, M., Levy, D. L., DeLisi, L. E., Sebat, J.
    Nature, vol. 474, no. 7349, pp. 114-114
    Contributions to Journals: Letters

  • Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling

    Horikawa, Y. T., Panneerselvam, M., Kawaraguchi, Y., Tsutsumi, Y. M., Ali, S. S., Balijepalli, R. C., Murray, F., Head, B. P., Niesman, I. R., Rieg, T., Vallon, V., Insel, P. A., Patel, H. H., Roth, D. M.
    Journal of the American College of Cardiology, vol. 57, no. 22, pp. 2273-2283
    Contributions to Journals: Articles

  • Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

    Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H., Peoples, A., Makarov, V., Yoon, S., Bhandari, A., Corominas, R., Iakoucheva, L. M., Krastoshevsky, O., Krause, V., Larach-Walters, V., Welsh, D. K., Craig, D., Kelsoe, J. R., Gershon, E. S., Leal, S. M., Aquila, M. D., Morris, D. W., Gill, M., Corvin, A., Insel, P. A., McClellan, J., King, M., Karayiorgou, M., Levy, D. L., DeLisi, L. E., Sebat, J.
    Nature, vol. 471, no. 7339, pp. 499-503
    Contributions to Journals: Letters

  • Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

    Zhang, L., Murray, F., Zahno, A., Kanter, J. R., Chou, D., Suda, R., Fenlon, M., Rassenti, L., Cottam, H., Kipps, T. J., Insel, P. A.
    PNAS, vol. 105, no. 49, pp. 19532-19537
    Contributions to Journals: Articles
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