FRSE
Regius Chair of Physiology
- About
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- Office Address
University of Aberdeen
School of Medicine, Medical Sciences and Nutrition
Institute of Medical Sciences (IMS)
Aberdeen, AB25 2ZD, UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
EDUCATION
2022: Massachusetts Institute of Technology (MIT) Sloan Executive Education; Entrepreneurship Development Program, Cambridge, MA, USA
2003-2007: American Heart Association Postdoctoral Fellowship, Harvard Medical School, Boston, USA
1999- 2003: University of Dundee: PhD in Biochemistry, MRC Protein Phosphorylation Unit, Dundee, UK. Supervisor Professor Dame Patricia T.W. Cohen
1995–1999: University of Edinburgh Medical School: BSc Honours in Pharmacology, Edinburgh, UK.
RESEARCH AND PROFESSIONAL EXPERIENCE
2024-: Regius Chair of Physiology
2019-2023: Dean for Industrial Engagement in Research and Knowledge Exchange
2018-: Director, Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen
2018-2022: Systems Physiology Programme Lead, Institute of Medical Sciences
2015-: Professor in Diabetes Physiology and Signalling, University of Aberdeen
2014-2015: Reader; University of Aberdeen, School of Medical Sciences
2012-2014: Senior Research Fellow, University of Aberdeen, School of medical sciences
2010-2012: Lecturer, University of Aberdeen, School of Biological Sciences
2007-2012: Research Councils UK (RCUK) 5-year tenure-track Fellowship, University of Aberdeen, School of Biological Sciences.
2003–2007: Harvard Medical School, Division of Medicine, Department of Hematology & Oncology. American Heart Association (AHA) Postdoctoral Fellowship. Mentor: Prof. Benjamin Neel.
Short Bio
Prof. Mirela Delibegovic is an academic and entrepreneurial research leader in biomedical sciences, initiating and developing constructive collaborations leading to successful outcomes, including key publications, significant sustainable funding, and impactful translational discovery research. Experienced line manager, leader and mentor, she pioneers strategic professional development of academic and research staff, and is also elected chair of key University and grant-funding committees.
Qualifications
- PhD Biochemistry2003 - University of Dundee
- BSc Hons Pharmacology1999 - University of Edinburgh
External Memberships
2023-2027: Medical Research Council, Population and Systems Medicine Board
2022-2024: Chair, British Heart Foundation Project Grants Committee
2023-: Danish Diabetes and Endocrine Academy Grant Review Committee
2023-: Medical Research Council, Centres of Research Excellence (CoRE) Panel
2022-: Agence Nationale de la Recherche (ANR), France 2030 Investment Plan, Bioclusters, Panel Member
2022-: Fellow of the Royal Society of Edinburgh (FRSE)
2022-: Barts Charity, Grants Committee (Large Project Grants and Transformational Funding)
2022: Acting Chair, British Heart Foundation Project Grants Committee
2022-: Mentor, Deutsches Centrum Fur Herz-Kreislauf-Forschung (DZHK) Mentoring Programme
2022, 2024: Chair, RD Lawrence Fellowship Committee, Diabetes UK
2021-2022: Vice-Chair: British Heart Foundation Project Grants Committee
2021-: Diabetes Research & Wellness Foundation, Research Advisory Board
2019-2024: British Heart Foundation Project Grants Committee Member
2015-2021: Diabetes UK Main Research Grants Committee
2018–: University of Aberdeen Theme Lead, Scottish Universities Life Sciences Alliance (SULSA)
2015-: Carnegie Trust Assessor
2011 (Inaugural elected member): The Royal Society of Edinburgh (RSE) Young Academy of Scotland
Prizes and Awards
Scotland's Life Sciences Awards 2023 (Finalist), Innovation Collaboration category (with Vertebrate Antibodies Ltd and NHS Grampian)
Royal Society of Edinburgh Fellow (FRSE) (Elected 2022)
International Academy of Sciences and Arts Bosnia and Herzegovina (Internacionalna Akademija Nauka i Umjetnosti u Bosni i Hercegovini) (Elected 2022)
Excellence Awards 2022, Winner, Public Engagement with Research (2022)
Excellence Awards 2022, Shortlisted, Best PGR Supervisor (2022)
Champion 2022 (Finalist) of the Scottish Knowledge Exchange Award (Interface, 2022)
Royal Society of Edinburgh (RSE) Young Academy of Scotland Fellow (Inaugural Elected Fellow) (2011)
Winner of the 2018 Wellcome Prize for Outstanding Achievement in Public Engagement in the Biomedical Sciences, University of Aberdeen
Joint winner: Public prize, Principal’s Prize for Public Engagement with Research 2018, University of Aberdeen
“Super Zena” (“Super Woman”) 2018 award at the First International Women’s conference, Bosnia and Hercegovina
- Research
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Research Overview
Translational research activities
- Lead for development of Covid-19 diagnostic tests using Artificial Intelligence (AI), funded by Scottish Government (2020-2022) through the Rapid Research in Covid-19 (RARC) programme. Delivered highly sensitive, accurate and affordable diagnostic tests suitable for mass rollout:https://www.abdn.ac.uk/news/14759/; https://abdn.ac.uk/ims/news/15626
- Our work was highlighted by the United Nations Academic Impact publication as the example of a successful collaboration between academia and industry https://www.un.org/en/academic-impact/helping-fight-covid-19-pandemic-artificial-intelligence
- Technology/platform developed during the RARC programme has led significant new investment from Innova Medical Group (IMG) as well as Innovate UK Knowledge Transfer Partnership project with Vertebrate Antibodies Ltd (2024 -), towards the development of novel antibody tests (single test) for type 1 diabetes subtypes.
- Consultant and Project Lead for start up Cohen Pharmaceuticals Ltd (2018-2023). Leading drug discovery project with a team of medicinal chemists, in vitro and in vivo biologists and modellers towards Phase 1 clinical trials.
- Development of novel drug treatments for diabetic retinopathy (most common complication: sight loss): https://abdn.ac.uk/ims/news/15345
- Treatment of atherosclerosis using PTP1B inhibitors: https://www.abdn.ac.uk/news/11280/
Current Research
We currently have several translational projects in the lab focused on metabolic diseases with emphasis on type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease (NALFD/NASH models) and cognitive dysfunction (with focus on Alzheimer's disease). Our projects range from drug discovery approaches using bioinformatic and medicinal chemistry approaches, artificial intelligence (AI) machine learning approaches for novel diagnostics, to in vitro and in vivo testing and most recently focused on patient-derived organoid cultures and patient populations. We do this in collaboration with our colleagues within Aberdeen Cardiovascular and Diabetes Centre, nationally and internationally.
Our lab is and has always been "open to all and dedicated to the pursuit of truth in the service of others" as stated in our Aberdeen 2040 Foundational Purpose. Our research culture is a positive and fun one! Pictures speak louder than words (Pre-holiday party; December 2022 lab photo).
Current research staff and graduate students in the lab
Research Fellows
Ruta Dekeryte (since 2014-) started in the lab as the final year undergraduate Honours project student, after which she was awarded the competitive IMS PhD studentship to work on the project investigating dietary and pharmacological approaches in combating cognitive dysfunction in models of Alzheimer's disease (2014 - 2018). Ruta is now working as Research Fellow in the lab on a commercial drug discovery project (since 2018 -). Meghan Hamer (since 2021-) is a medicinal chemist and research fellow in the lab working on a commercial drug discovery project. Meghan is a peptide chemist working alongside Dr Sergio Dall'Angelo. Meghan did her PhD at the University of Strathclyde.Dr Ayaz Ali (2022- 2025) is a research fellow working on the British Heart Foundation
funded project on novel treatments for diabetic retinopathy.
Joseph Smith (since 2021 -) is a biologist and research fellow working on assay development and high throughput screening. Joe did his PhD studies at the University College London (UCL). Dr Marina Souza Matos started in the lab as the PhD student (since 2019-) funded by two separate PhD studentships (Elphinstone Scholarship and the IMS studentship), co-supervised by Prof Bettina Platt, and working on the role of essential amino acid signalling in cognitive function (graduating in July 2023). She obtained her undergraduate in Pharmacy from the Federal University of Rio de Janeiro in 2016. She did her undergraduate internship at Beth Israel Deaconess Medical Centre, Harvard medical school, in the laboratory of Prof Hollenberg in 2015. In 2019, she obtained her Masters in Physiology from the Federal University of Rio de Janeiro. Marina is now a postdoctoral fellow in our lab and Prof John Forrester, working on the role of PTP1B in dendritic cells and autoimmune uveitis. Ms Sarah Kamli-Salino did her final year Honours project in our laboratory and obtained her BSc Hons in Physiology at the University of Aberdeen in 2018. She then did her 1-year MRes project (2018-2019) in our laboratory, testing novel drugs for treatment of cardiovascular disease, funded by the Development Trust. She was then funded by Medical Research Scotland/ Astra Zeneca (2019-2024) for her PhD studies on synthetic cannabinoids in diabetic nephropathy, which she successfully defended in June 2024. Sarah is now a Research Associate in our laboratory working on independent projects.
Current PhD students
Dr Fiona Clegg is a SCREDS Clinical Lecturer in Gastroenterology, working towards her PhD in my lab (since 2018-). Fiona's research interests are in Gastroenterology and Hepatology, and particularly in liver fibrosis, hepatocarcinogenesis and non-alcoholic fatty liver disease (NAFLD). Fiona works on patient-derived human organoid cultures and novel therapeutic approaches for treatment of NAFLD/NASH/HCC. Fiona is currently writing up her PhD thesis and back to her clinical duties. Ms Abrar Othman is a PhD student (2019-2024) funded by the Saudi Arabian Cultural Bureau working on the role of PTP1B in macrophage signalling and inflammation. She obtained her Bachelor of Applied Medical Sciences at King Abdul-Aziz University (Jeddah, Saudi Arabia) and her Masters (Honours) of Clinical Biochemistry from the University of Manchester in 2016. Abrar submitted recently defended her PhD thesis successfully and has returned to Saudi Arabia as a lecturer at King Abdul-Aziz University. Ms Morgan Boyne is the BHF- funded PhD student in the lab (2022-2025) working on novel treatments for diabetic retinopathy. This is a collaboration with our clinical colleagues Prof John Forrester and Dr Lucia Kuffova (NHS Grampian). Morgan obtained her MSc in Precision Medicine and Pharmacological Innovation with Distinction (Uni of Aberdeen, Glasgow and Strathclyde partnership; 2021). She was awarded 1st Class Honours in BSc (Hons) Bioscience with Biomedical Sciences from Robert Gordon University (2020).Lab technician
Ms Michela Donarumma joined our laboratory as the core lab technician in December 2020; prior to her joining the University of Aberdeen in 2010, Michela worked as a research assistant at Brigham and Women's Hospital in Boston, USA.Past Research
The aim of our laboratory is to understand how ageing and poor nutrition lead to development of diseases such as diabetes, cardiovascular disease, cancer and other age-associated comorbidities.
One of our publications in which we compared two nutritional interventions, achievable in humans, on metabolic health was selected as the Editor's Choice: highlight in Ageing research by Scientific Reports.
Lab News
Congratulations to Sarah Kamli Salino for successfully defending her PhD thesis, investigating novel synthetic cannabinoids in treatment of diabetic nephropathy (secondary supervisors: Prof Heather Wilson, AstraZeneca industrial supervisors: Lihuan Liang, Timo Haschler). Special thanks to her examiners Prof Gavin Welsh (University of Bristol) and Dr Fiona Murray (Institute of Medical Sciences).
June 2024 (L to R: Heather Wilson, Sarah Kamli Salino, Fiona Murray, Mirela Delibegovic)
Congratulations to Abrar Othman for successfully defending her PhD thesis, delineating the role of myeloid PTP1B in wound healing in diabetes (secondary supervisors: Prof Heather Wilson, Dr Nimesh Mody). Special thanks to her examiners Dr Li Kang (University of Dundee) and Dr Ann Rajnicek (Institute of Medical Sciences).
April 2024 (L to R: Nimesh Mody, Li Kang, Abrar Othman, Ann Rajnicek, Heather Wilson, Mirela Delibegovic)
Congratulations to Marina Souza Matos for successfully defending her PhD thesis, studying the role of essential amino acids and methionine restriction in models of cognitive dysfunction (second supervisor: Prof Bettina Platt). Special thanks to her examiners Prof Colin Selman (University of Glasgow) and Dr Derek Garden (Institute of Medical Sciences).
April 2023 (L to R: Colin Selman, Mirela Delibegovic, Marina Matos, Bettina Platt, Derek Garden)
Thanks to everyone who supported my run at the Royal Parks Half Marathon in London (Oct 2022) raising funds for life saving research supported by the British Heart Foundation!
It was a wonderful day on 30th May 2022 at the Royal Society of Edinburgh! I was inducted to the Scottish national academy as the elected fellow (FRSE) alongside some amazing scientists, artists, activists and thinkers!
In March '22, we were delighted to welcome the British Heart Foundation and invited politicians consisting of MPs and MSPs and show them around our labs and tell them more about our science but also answer some really important questions they had about the impact of our work!
Celebrations of the Centenary of Insulin Discovery have been going on since Oct '21 and continuing well into late '22!!! We organised webinars, podcasts, school visits, exhibits at Aberdeen Science Centre as well as the Parliament, RSE, seminars and so much more... This involved our undergraduate medical students as well as our PhD students, postdocs and academic staff (current and emeritus).
City Hall Reception JDRF Civic Reception Aberdeen Science Centre weekend Congratulations to Ms Besa Veseli Emini for successfully defending her dual degree MoGlyNet Program Marie-Curie PhD thesis in Aberdeen and in Antwerp (Dec 2021); 2 viva voce on the same day (Aberdeen morning, Antwerp afternoon)! Online celebrations still managed to be fun and I managed to join virtually the in person celebrations in Antwerp!
Congratulations to Mr Oliver Helk for successfully defending his PhD thesis on "Investigating the role of PTP1B in human health: a translational approach" in Dec 2020. Oliver is now the clinical associate professor at the Medical University of Vienna, Austria. Special thanks to his examiners Prof Faisal Kahn (University of Dundee) and Dr Antonio Gonzalez Sanchez (Rowett Institute).
Congratulations to Ms Fabiana Baganha Carreiras for successfully defending her dual degree MoGlyNet Program Marie-Curie PhD thesis in Leiden and in Aberdeen (May 2020); 2 viva voce, 1 week apart. Online celebrations still managed to be fun!
Congratulations to Ms Sarah Kamli-Salino for successfully defending her Masters by Research (MRes) thesis (Feb 2020) and being awarded the Distinction! Hard work pays off; Sarah is now doing her PhD in the lab funded by MRS/AstraZeneca PhD studentship. Thanks to Sarah's examiners: Dr Paul Meakin (University of Leeds) and Dr Justin Rochford (Rowett Institute).
I run the Royal Parks Half Marathon (Oct 2019) raising funds for Diabetes UK; I managed to raise an amazing £1,521 for this great charity and the funds will go towards funding of new research into causes, treatment and care of diabetes! Thanks to all the supporters!!!! In Oct 2022, I'm doing the Royal Parks half again, this time raising funds for the BHF and their life saving research into metabolic diseases.
Knowledge Exchange
Public Engagement in Research Awards
Excellence Awards 2022, Winner, Public Engagement with Research (2022)
Champion 2022 (Finalist) of the Scottish Knowledge Exchange Award (Interface, 2022)
To listen to our podcast on the panel dicussion organised for International Women's Day 2021 "Different Day Same Problem: Covid-19, Leadership and Inequality" follow this link: https://share.transistor.fm/s/05c80a76 For the BHF Alumni organised panel discussion in which I took part on "The Future of the Lab after Covid-19" register here: https://alumni.bhf.org.uk/events/45004•
Winner of the 2018 Wellcome Prize for Outstanding Achievement in Public Engagement in the Biomedical Sciences•
Joint winner: Public prize, Principal’s Prize for Public Engagement with Research 2018•
“Super Zena” (“Super Woman”) 2018 award at the First International Women’s conference, Bosnia and Hercegovina•
Vitae (global leader in supporting the professional development of researchers) “Talking heads: PIs on mentoring research staff” project; invited speaker to help new PIs achieve most from their research staff; series of short online videos• National Coordinating Centre for Public Outreach – recognized as 1 out of 20 top UK scientists in 2010 for their outreach activities.
- Teaching
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Teaching Responsibilities
- Programme and Course coordinator for the PGT course: MSc in Cardiovascular Science and Diabetes
- Teaching on a range of courses within the School of Medicine, Medical Sciences and Nutrition, from 2nd year undergraduate to Masters level.
Non-course Teaching Responsibilities
Delivering CPD courses and staff development courses; examples include:
- State of Qatar Ministry of Public Health and Qatar University, Continuous Professional Development lecture on “Acute and chronic complications associated with diabetes”
- Physiological Society: “Creating impact for your research - Building relationships and creating opportunities”
- International Women’s Day 2021: “Different Day, Same Problem: Covid-19, Leadership and Inequality”
- British Heart Foundation: “Future of the lab after COVID-19”
- Publications
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Neuronal human BACE1 knock-in induces systemic diabetes in mice
Diabetologia, vol. 59, no. 7, pp. 1513-1523Contributions to Journals: ArticlesPhotoperiod- and Triiodothyronine-Dependent Regulation of Reproductive Neuropeptides, Proinflammatory Cytokines, and Peripheral Physiology in Siberian Hamsters (Phodopus sungorus).
Journal of Biological Rhythms, vol. 31, no. 3, pp. 299-307Contributions to Journals: ArticlesExecutive functions predict conceptual learning of science
British Journal of Developmental Psychology, vol. 34, no. 2, pp. 261-275Contributions to Journals: ArticlesElevated fibroblast growth factor 21 (FGF21) levels in obese, insulin resistant states are normalised by fenretinide treatment via retinoic acid signalling
Diabetic Medicine, vol. 33, pp. 48Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/dme.5_13048
Investigation of a Type 2 diabetes-like phenotype in a mouse model of Alzheimer's disease
Diabetic Medicine, vol. 33, no. Suppl. 1, pp. 82Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/dme.21_13048
Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
Biochemical Pharmacology, vol. 100, pp. 86-97Contributions to Journals: ArticlesA key role for PTP1B in dendritic cell maturation, migration and T cell activation
Journal of Molecular Cell Biology, vol. 7, no. 6, pp. 517-528Contributions to Journals: ArticlesFenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen-signaling
Obesity, vol. 23, no. 8, pp. 1655-1662Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/oby.21164
Deletion of myeloid-PTP1B decreases MHC Class I expression and peptide presentation through an IL-10 dependent mechanism in response to LPS challenge
Journal of Inflammation, vol. 12, no. Suppl. 1, P1Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1476-9255-12-S1-P1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4619/1/1476_9255_12_S1_P1.pdf
Comparison between beneficial effects of leucine and methionine restriction on regulation of body mass, adiposity, glucose and lipid homeostasis
Diabetic Medicine, vol. 32, no. S1, pp. 47-47Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/dme.12668
Mechanisms of improved glucose homeostasis by the synthetic retinoid fenretinide: altered genes, metabolites and lipids
Diabetic Medicine, vol. 32, no. S1, pp. 47-48Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/dme.12668
Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice
Metabolism, vol. 64, no. 2, pp. 305-314Contributions to Journals: ArticlesRegulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B
Diabetes & Metabolism, vol. 41, no. 1, pp. 95-101Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.diabet.2014.02.008
Protein Tyrosine Phosphatase 1B (PTP1B) in the immune system
Inflammation & Cell Signaling, vol. 2, no. 2, e965Contributions to Journals: ArticlesHepatic protein tyrosine phosphatase 1B (PTP1B) deficiency protects against obesity-induced endothelial dysfunction
Biochemical Pharmacology, vol. 92, no. 4, pp. 607-617Contributions to Journals: ArticlesMethionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21
Aging Cell, vol. 13, no. 5, pp. 817-827Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/acel.12238
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3721/1/acel12238.pdf
Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism
Diabetes, vol. 63, no. 2, pp. 456-470Contributions to Journals: ArticlesEvidence for a role of executive functions in learning biology
Infant and Child Development, vol. 23, no. 1, pp. 67-83Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/icd.1823
Inducible Liver-Specific Knockdown of Protein Tyrosine Phosphatase 1B Improves Glucose and Lipid Homeostasis in Adult Mice
Diabetologia, vol. 56, no. 10, pp. 2286-2296Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00125-013-2992-z
High fat diet-induced deterioration of cognitive deficits in hBACE1 knock-in mouse model of Alzheimer’s disease, reversal by anti-obesity, anti-diabetes compound MN101
British Neuroscience Association FestivalContributions to Conferences: PostersBACE1: The missing link between Alzheimer’s disease, diabetes and obesity?
Alzheimer Research UKContributions to Conferences: PostersFenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver and Hypothalamus
Diabetes, vol. 62, no. 3, pp. 825-836Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2337/db12-0458
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5375/1/Diabetes_2013_Mcilroy_825_36.pdf
PTP1B in the periphery: regulating insulin sensitivity and ER stress
Protein tyrosine phosphatase control of metabolism. Bence, K. K. (ed.). Springer, pp. 91-105, 15 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-1-4614-7855-3_5
Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes
International Journal of General Medicine, vol. 5, pp. 403-411Contributions to Journals: ArticlesAdipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
PloS ONE, vol. 7, no. 2, e32700Contributions to Journals: ArticlesMicroparticles from patients with metabolic syndrome induce vascular hypo-reactivity via Fas/Fas-ligand pathway in mice
PloS ONE, vol. 6, no. 11, e27809Contributions to Journals: ArticlesLiver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress
Biochemical Journal, vol. 438, no. 2, pp. 369-378Contributions to Journals: ArticlesSusceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein
Diabetologia, vol. 54, no. 8, pp. 2143-2151Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00125-011-2160-2
Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2
The Journal of Biological Chemistry, vol. 285, no. 51, pp. 39750-39758Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M110.153734
In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues
Biochemical and Biophysical Research Communications, vol. 401, no. 1, pp. 104-111Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbrc.2010.09.018
Addendum: Neuronal PTP1B regulates body weight, adiposity and leptin action
Nature Medicine, vol. 16, no. 237Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1038/nm0210-237b
Protein Tyrosine Phosphatase 1B (PTP1B) in obesity and type 2 diabetes
Acta Medica Saliniana, vol. 38, no. 1, pp. 2-7Contributions to Journals: ArticlesNeuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues
Molecular and Cellular Biology, vol. 29, no. 16, pp. 4563-4573Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/MCB.01914-08
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
Diabetes, vol. 58, no. 3, pp. 590-9Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2337/db08-0913
Improved glucose Homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
Molecular and Cellular Biology, vol. 27, no. 21, pp. 7727-7734Contributions to Journals: ArticlesNeuronal PTP1B regulates body weight, adiposity and leptin action
Nature Medicine, vol. 12, no. 8, pp. 917-924Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/NM1435
Generating a novel 3D primary human hepatic organoid model for study of metabolic diseases
Chapters in Books, Reports and Conference Proceedings: Conference Proceedings- [ONLINE] DOI: https://doi.org/10.1136/heartjnl-SCF-2023.17
Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance
Diabetes, vol. 52, no. 3, pp. 596-604Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2337/diabetes.52.3.596
Assay of protein phosphatase 1 complexes
Methods in Enzymology, vol. 366, pp. 135-44Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0076-6879(03)66012-X
The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats
Biochemical Journal, vol. 360, no. 2, pp. 449-459Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/0264-6021:3600449