![Professor Heather Wilson Professor Heather Wilson](/img/200x200/staffpages/uploads/mmd212/profile_pic_heather2.jpg)
BSc (Biochemistry) PhD
Chair in Immunology
- About
-
- Email Address
- h.m.wilson@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437350
- Office Address
Immunity and Infection Programme Lead
University of Aberdeen, School of Medicine, Medical Sciences and Nutrition
Institute of Medical Sciences (IMS), Office 3.24, Lab 4.49/4.51/1.16
College of Life Sciences and Medicine
Foresterhill Health Campus
AberdeenAB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated with a first class honours degree in Biochemistry and was awarded a Carnegie prize scholarship to fund my PhD investigating lipid mediators driving coronary heart disease (awarded 1990). My early postdoctoral years focussed on factors mediating the pathophysiology of atherosclerosis and progression of glomerulonephritis to end stage renal disease. I was awarded MRC, Kidney Research UK and British Heart Foundation funding to continue my research on the effects of macrophage inflammatory mediators on controlling glomerular extracellular matrix turnover and how increased deposition and/or decreased protease degradation resulted in renal scarring. A further MRC funded project directed my research interests to the earlier inflammatory stage of nephritis and the cellular and molecular mechanisms controlling inflammation, focussing on the role of macrophages in experimental models. I was appointed to Lecturer in 2008, promoted to Senior Lecturer in 2013 then awarded a personal chair in 2019. My current research is primarily directed towards understanding the signalling pathways that control macrophage activation and function, especially in inflammmatory diseases including nephritis, atherosclerosis and wound healing. I also have interests in macrophage signalling pathways relating to infection control focussing on Candida albicans.
I teach on and coordinate BSc, MSc and MBChB courses with a primary focus on inflammation and human disease. I am Chair of Foresterhill Biological Safety Committee and programme Co-lead for the Immunity and Infection research programme. I am a reviewer for NHS Grampian Biorepositiry tissue bank.
I am an active member of the Renal Association, British Society of Immunology and Biochemical Society. I have external examining roles at University of Bristol and have examined many external MSc and PhD thesis. I mentor for the Carnegie Trust Future Leaders programme and an ambassador for promoting career development of ECRs.
Qualifications
- BSc Biochemistry1987 - University of Aberdeen
- PhD Biochemistry1990 - University of Aberdeen
Memberships and Affiliations
- Internal Memberships
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Foresterhill Biological Safety committee chair
Academic line manager
Programme co-lead Immunity and infection
- External Memberships
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External
Committees: Elected member of Renal Association, renal scientists working party (elected 2005 for 5 years) and education and training committee (2010)
Mentor for Carnegie scholars
Editorial Boards: Frontiers in Immunology, World Journal of Immunology
Ad hoc reviewer -Kidney International, Experimental Cell Research, Nephron-Experimental Nephrology, Journal of Leukocyte Biology, British Journal of Pharmacology, Journal of Immunology, European Journal of Neurology, Journal of Cellular and Molecular Medicine, Journal of Vascular Research, Journal of American Society of Nephrology.
Grant reviewer: Wellcome Trust, Medical Research Council (MRC), Heart Research UK, Medical Research Scotland
Committe member for Grampian NHS Biorepository ethics Committee
- Research
-
Research Overview
My research interests are directed towards a better understanding of the role of macrophages and other immune cells in controlling the pathogenesis of inflammatory and immune-mediated diseases. I have focussed primarily on the factors that polarise macrophage functions to pro- or anti-inflammatory subsets and the ways in which differentially activated macrophage subsets regulate tissue injury or tissue repair, especially in rodent models of nephritis and human atherosclerosis, wound healing and cancer. The aim is to be able to control immune and inflammatory mediated diseases by manipulating macrophage function. For this I am dissecting the role of the intracellular signalling pathways that direct macrophage activation, and how these pathways can be switched to exploit macrophage reparative attributes and restore regulation to the inflammatory response. I have developed a multitude of techniques to efficiently isolate tissue infiltrating macrophages and analyse their intracellular signalling pathways and using these have, for example, demonstrated that inhibiting the SOCS3 and PTP1B induces macrophages to become profoundly anti-inflammatory when exposed an inflamed environment. I also have projects studing how changing macrophage function in infection e.g. by clinical drugs can alter the outcome and the implications of this.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biological and Environmental Sciences, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Medical Sciences
- Pathology
- Biological Sciences
- Cell Biology
- Immunology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
My research is currently focussed on manipulating macrophage function using physiological inhibitors. I am also exploring potential biomarkers of macrophage activity in macrophage mediated diseases (glomerulonephritis, atherosclerosis, wound healing and cancer) to establish the phenotype, function and balance of macrophage functional subsets throughout the pathogenesis of these diseases to provide pointers as to the most effective therapeutic strategies to manipulate macrophage activity and restore tissue homeostasis.
When tissues are wounded, direct current extracellular electric fields are established. Moreover synthetically applied electric fields can speed up healing and reduce inflammation in chronic wounds. The group is also determining how small electric fields, influence the polarisation and antibacterial/wound reparative properties of macrophages and activation and proliferation of T cell subsets. Another physical stimulus we are showing to influence macrophage function is shockwave therapy that can alter the functions of macrophages to accelerate the healing properties in chronic wounds.
A third area of research is determining how manipulating immune cell function, for example using clinical drugs, can change the susceptibility to infection and the pathways essential for this. For example, we are currently researching and have shown that inhibition of PTP1B is important in regulating infection susceptibility to Candida albicans.
PhD projects on offer
Masters by research projects on offer
Funding and Grants
Vickers M, Wilson HM, Campbell J. Reprogramming the innate immune system to treat malignancy: targeting ovarian cancer. Medical Research Scotland 2020-2024.
McEwan IJ, Wilson HM, Dundas S. Impact of the immune landscape on androgen ablation therapy and progression to therapy-resistant disease. Eastbio studentship 2020-2024.
Vickers M, Wilson HM Vickers M, Wilson HM. High mannose exposure on blood cells and development of new therapeutic modalities for sickle cell disease and cancer. (Clinical Fellowship for Dr Charlotte Robertson). Friends of Anchor. 2020-2022. £160,811
Thompson D, Delibegovic M, Wilson HM. The FPR2 ligand W-peptide: A new therapeutic approach to treat atherosclerosis. British Heart Foundation 2020-2023 £252,229 PG/19/30/34327
Galley HM, Wilson HM. Interactions between melatonin and endogenous opioid peptide release from macrophages. British Journal of Anaesthesia/Royal College of anaesthesia.2019-2022 £89,426
Delibegovic M, Wilson HM, Baker D. Potential new strategies for the treatment of kidney disease due to diabetes. Medical Research Scotland, 2019-2023 £115133
Gibson I, Wilson HM Can regenerative medicine scaffolds efficiently modulate the immune response to improve the outcome of bone tissue repair? Eastbio studentship 2019-2023
Mclean M, Wilson HM. Interleukin-27 as a new therapy for acute severe inflammatory bowel disease. Cunningham Trust 2019-2022, £85429
Wilson HM, Vickers M. Cao, H. Development of potential new diagnostics and therapies for sickle cell anaemia. Friends of Anchor 2018-2020, £15000
Wilson HM, Forrester JV, Kuffova L. Using potential antigen-specific regulatory T cells as a novel therapeutic strategy to ameliorate autoimmune uveitis. Fight for Sight 2018-2020 £199508
Wilson HM Camera upgrade for the UltraVIEW Spinning Disk confocal live cell microscope. Friends of Anchor. £20,410
Wilson HM, Cooper B Clinical benefits and mechanism of action of shock wave therapy for healing chronic venous ulcers. NHS Grampian Endowment Funds. £11,302
Murray F, Dawson D & Wilson HM Stress-induced heart disease G17.10 Tenovus 2017-2018 £11,750
Delibegovic M, Wilson HM, Rajnicek A Inhibition of macrophage protein tyrosine phosphatase 1B (PTP1B) as a novel therapy for improved wound healing in diabetes. Diabetes UK 2017-2019 £ 165735
Mclean M, Wilson HM & Murray G. The role of HMBG1 in the pathogenesis of colorectal cancer. Friends of Anchor. 2017-2018 £9757
Wilson HM, Delibegovic M, Brown GD, Arthur S. The role of innate cell PTP1B in susceptibility to infection. EastBio DTP studentship. 2017-2021
Nixon G, Wilson HM. Inhibiting angiogenesis in human aortic valves: a new therapeutic target. British Heart Foundation studentship 2017-2020. £107465
Wilson HM, Delibegovic M, Brown GD. Unravelling the role of innate cell PTP1B in controlling susceptibility to fungal infection. Wellcome Trust Institutional Strategic Support Fund Seedcorn Award. £18,184
Nixon G, Wilson HM. Inhibiting angiogenesis in human aortic valves: a new therapeutic target. British Heart Foundation studentship 2017-2020. £107465
Mclean M, Wilson HM, Murray G. Interleukin 27 (IL-27) as a new therapy for inflammatory bowel disease-defining IL-27 evoked responses in the gastrointestinal epithelial barrier. NHS Grampian Endowment Funds. 2017-2018, £11850
Wilson HM, Delibegovic. New treatments for diabetic nephropathy. NHS Grampian Endowment Funds. 2017-2018, £11911
Hislop J, Wilson HM, Thompson D. Formyl Peptide Receptors: A potential target in the design of anti-inflammatory therapeutics for the treatment of Sepsis. NHS Grampian Endowment Funds. 2017-2018, £9139
McLean M & Wilson HM Interleukin-27 responses in inflammatory bowel disease - a potential new therapeutic? CIRCA PhD studentship; 2016-2020; £116,786
Dawson D, Wilson HM, Newby D, Ahearn T, Dweck M, Semple S, Kerr K, Brown PAJ “A study into the inflammatory mechanisms and protracted recovery of tako-tsubo cardiomyopathy” BHF Project Grant; 2016-2019; £348,855
Delibegovic M, Wilson HM, Mody N, Dawson D, Whitfield P, Brown PAJ. Effects of protein tyrosine phosphatase 1B (PTP1B) inhibition on inflammation and atherosclerosis development. British Heart Foundation 2015-2017 £236,108
Wilson HM Smith & Nephew award 2015-2016 £4000
Crane I & Wilson HM Monocyte subset markers as biomarkers in asthma . NHS Grampian Endowment Funds. 2015-2016 £5525
Wilson HM & Rajnicek A Electrical stimulation to enhance macrophage function and accelerate wound healing NHS Grampian Endowment Funds. 2015-2016 £11,985
Thompson D, Brittenden J, Delibegovic M, Wilson HM PTP1B Inhibition: A potential new target in the treatment of atherosclerosis. NHS Grampian Endowment Funds. 2015-2016 £11,163
Wilson HM & Morley T. Novel small molecule modulators of the antioxidant response pathway: potential for therapy in cancer/inflammatory disease. Medical Research Scotland. 2012-16. £110,803
Wilson HM & Erwig LP The role of macrophage SOCS3 in the pathogenesis of renal disease. Kidney Research UK. 2013-15. £119,513
Wilson HM, Barker RN, McCaig. Electric Fields – A novel regulators of macrophage activity. Institute of Medical Sciences Studentship. 2011-15. £72760
Wilson HM Targeting macrophage SOCS3 for therapy in human renal disease NHS Grampian Endowments Fund. 2012-2013. £7365
Houslay M MacNee W, Wilson HM, Arthur S, Novel drugs for treatment of Chronic obstructive pulmonary disease (COPD). SULSA 2013-14 £59,073
Nixon G & Wilson HM. The role of sphingolipids in monocyte binding: a potential therapeutic target in restenosis. British Heart Foundation 2013-2016 £104,438
Delibegovic M, Wilson HM, Brown PAJ. Effects of Dietary Methionine Restriction on Kidney Pathology and Insulin NHS Grampian Endowment Funds. 2014-2015 £12000
Dawson D, Wilson HM, Kerr K, Liversidge J. Targeting the inflammation mechanism in stress-induced acute cardiomyopathy. NHS Grampian Endowment Funds. 2014-2015
2006-2010. Medical Research Council - Deviating macrophage activation in glomerulonephritis by SOCS proteins.
- Teaching
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Courses
Teaching Responsibilities
IM3501 Fundamentals of Immunology -course co-ordinator
IM3502 Applied Immunology - Human Health -course co-ordinator
Honours Immunology IM4007- Immunity and infection - course coordinator
Honours Immunology IM4005-Current Topics in Immunology-course coordinator
IM4006 current research in immunology - course coordinator
IM4307 option 2 immunology
Teach on
BM5502 MSc Immunology in Health and Disease
MB5028 MSc Cardiovascular Science and Diabetes
MB5518 MSc Research tutorials
MB5903 MSc Research projects
BA3004 Biochemical Pharmacology and Toxicology
Year1 MBChB (medicine) Science for Medicine
Year 1 MBChB (medicine) Student selected component (Immunology & Infection) co-ordinator
BM4009 Staying alive, adaptations in physiological systems
BT5007 Industrial projects
BI25M7 Energy for Life
External roles
External Examiner for the BSc Clinical Science unit/programme(s) in the Bristol Medical School
- Publications
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Page 1 of 2 Results 1 to 50 of 83
Recent Developments in the Role of Protein Tyrosine Phosphatase 1B (PTP1B) as a Regulator of Immune Cell Signalling in Health and Disease
International Journal of Molecular Sciences, vol. 25, no. 13, 7207Contributions to Journals: ArticlesMyeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism
Journal of translational medicine, vol. 21, 715Contributions to Journals: ArticlesModulation of macrophages by biophysical cues in health and beyond
Discovery Immunology, vol. 2, no. 1, kyad013Contributions to Journals: ArticlesInduction of experimental diabetes and diabetic nephropathy using anomer-equilibrated streptozotocin in male C57Bl/6J mice
Biochemical and Biophysical Research Communications, vol. 650, pp. 109-116Contributions to Journals: ArticlesColitis in a transgenic mouse model of autoimmune uveitis may be induced by neoantigen presentation in the bowel
Scientific Reports, vol. 13, 1256Contributions to Journals: ArticlesAn endogenous inhibitor of angiogenesis downregulated by hypoxia in human aortic valve stenosis promotes disease pathogenesis
Journal of Molecular and Cellular Cardiology, vol. 174, pp. 25-37Contributions to Journals: ArticlesThe intracellular signalling pathways governing macrophage activation and function in human atherosclerosis
Biochemical Society Transactions, vol. 50, no. 6, pp. 1673–1682Contributions to Journals: ArticlesInterleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model
Biology, vol. 11, no. 3, 427Contributions to Journals: ArticlesLow intensity shockwave treatment modulates macrophage functions beneficial to healing chronic wounds
International Journal of Molecular Sciences, vol. 22, no. 15, 7844Contributions to Journals: ArticlesMonocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation
International Journal of Molecular Sciences, vol. 22, no. 12, 6591Contributions to Journals: ArticlesA Role for Folate in Microbiome-Linked Control of Autoimmunity
Journal of Immunology Research, vol. 2021, 9998200Contributions to Journals: Review articlesRed blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
Nature Communications, vol. 12, no. 1, 1792Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41467-021-21814-z
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16159/1/Cao_etal_NC_Red_blood_Cell_VoR.pdf
- [ONLINE] View publication in Scopus
Effects of 6-hydroxymelatonin in human macrophage model of inflammasome activation in conditions mimicking sepsis
Anaesthesia Research Conference, pp. E79-E80Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.bja.2020.11.011
Immune Privilege: the Microbiome and Uveitis
Frontiers in Immunology, vol. 11, 608337Contributions to Journals: ArticlesThe Rab32/BLOC-3–dependent pathway mediates host defense against different pathogens in human macrophages
Science Advances, vol. 7, no. 3, eabb1795Contributions to Journals: ArticlesThe early dynamic of ECG in takotsubo syndrome presenting with ST-elevation: A comparison with age and gender-matched ST-elevation myocardial infarction
International Journal of Cardiology, vol. 323, pp. 125-125Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/j.ijcard.2020.09.023
- [ONLINE] View publication in Scopus
High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria
bioRxivContributions to Journals: ArticlesTreatment with FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis
Frontiers in Immunology, vol. 11, pp. 1-17Contributions to Journals: ArticlesCFTR modulators dampen Aspergillus-induced reactive oxygen species production by cystic fibrosis phagocytes
Frontiers in cellular and infection microbiology, vol. 10, pp. 372Contributions to Journals: ArticlesFast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept
Journal of Magnetic Resonance, vol. 313, 106722Contributions to Journals: ArticlesThe burden of metabolic syndrome on osteoarthritic joints
Arthritis Research & Therapy, vol. 21, 289Contributions to Journals: Review articlesPhysiological strength electric fields modulate human T cell activation and polarisation
Scientific Reports, vol. 9, 17604Contributions to Journals: ArticlesDifferential expression of CCR2 and CX3CR1 on CD16+ monocyte subsets is associated with asthma severity
Allergy, Asthma, and Clinical Immunology, vol. 15, 64Contributions to Journals: ArticlesMyocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy
Circulation, vol. 139, no. 13, pp. 1581-1592Contributions to Journals: Articles- [ONLINE] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438459/
- [ONLINE] DOI: https://doi.org/10.1161/CIRCULATIONAHA.118.037975
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
- [ONLINE] http://europepmc.org/abstract/med/30586731
Gene expression data analysis identifies multiple deregulated pathways in patients with asthma
Bioscience Reports, vol. 38, no. 6, BSR20180548Contributions to Journals: ArticlesThe effects of maternal smoking and BMI on the first and second trimester human fetal kidney
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 125, pp. 53-53Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.15493
Similarities and differences in surface receptor expression by THP-1 monocytes and differentiated macrophages polarized using seven different conditioning regimens
Cellular Immunology, vol. 332, pp. 58-76Contributions to Journals: ArticlesThe effect of maternal BMI on the development of human fetal kidney
34th Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), pp. 349-349Contributions to Conferences: AbstractsResponse to comment by Moxon et al
Clinical Science, vol. 132, no. 1, pp. 39-41Contributions to Journals: LettersDeficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia
Cancer Research, vol. 78, no. 1, pp. 75-87Contributions to Journals: ArticlesExteriorisation of Mannoses on Human Erythrocyte Membrane Skeleton Provides 'Eat Me' Signals for Oxidatively Damaged Cells to be Cleared By Macrophages: A Pathway Mediating Hemolysis in Sickle Cell Disease
Blood, vol. 130, no. 1, pp. 919Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.V130.Suppl_1.919.919
- [ONLINE] View publication in Scopus
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis
Clinical Science, vol. 131, no. 20, pp. 2489-2501Contributions to Journals: ArticlesMyeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Molecular Metabolism, vol. 6, no. 8, pp. 845-853Contributions to Journals: ArticlesSOCS3 is a modulator of human macrophage phagocytosis
Journal of Leukocyte Biology, vol. 100, no. 4, pp. 771-780Contributions to Journals: ArticlesSphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells
Biochemical Pharmacology, vol. 115, pp. 43-50Contributions to Journals: ArticlesMethionine restriction improves renal insulin signalling in aged kidneys
Mechanisms of Ageing and Development, vol. 157, pp. 35-43Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.mad.2016.07.003
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/7/Kidney_MR_paper_RESUBMISSION_FINAL_UNDERLINED_CHANGES.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/3/Figure_1.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/2/Figure_2.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/5/Figure_3.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/4/Figure_4.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/6/Figure_5.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/1/Figure_6.pdf
Electric fields are novel determinants of human macrophage functions
Journal of Leukocyte Biology, vol. 99, no. 6, pp. 1141-1151Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1189/jlb.3A0815-390R
Critical Role for Inflammatory Macrophages in Driving Antigen-dependent Th17 Cell Responses?
Journal of Cytokine Biology, vol. 1, no. 1, pp. 1-3Contributions to Journals: ArticlesThe activation status of human macrophages presenting antigen determines the efficiency of Th17 responses
Immunobiology, vol. 220, no. 1, pp. 10-19Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.imbio.2014.09.022
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4130/1/immunobiology.pdf
Electric fields: a novel non-chemical regulator of human macrophage function
Immunology, vol. 143, no. Suppl 2, pp. 96-96Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/imm.12406
SOCS3: a novel regulator of phagocytosis in m1 macrophages
British Society for Immunology Annual Congress 2014, pp. 101-101Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/imm.12406
SOCS Proteins in Macrophage Polarization and Function
Frontiers in Immunology, vol. 5, 357Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fimmu.2014.00357
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4129/1/fimmu_05_00357.pdf
Comparison of fluorodeoxyglucose uptake in symptomatic carotid artery and stable femoral artery plaques
British Journal of Surgery, vol. 101, no. 3, pp. 363-370Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bjs.9403
Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism
Diabetes, vol. 63, no. 2, pp. 456-470Contributions to Journals: ArticlesA critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo
Immunology, vol. 141, no. 1, pp. 96-110Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/imm.12173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5484/1/Arnold_et_al_2014_Immunology.pdf
Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions
Clinical and Experimental Immunology, vol. 173, no. 1, pp. 38-46Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/cei.12086
Cytokines
els. John Wiley & SonsChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1002/9780470015902.a0000929.pub3
Macrophage subtypes in symptomatic carotid artery and femoral artery plaques
European Journal of Vascular and Endovascular Surgery, vol. 44, no. 5, pp. 491-497Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejvs.2012.08.005
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2798/1/EJVESfinal.docx
Lycopene inhibits lymphocyte proliferation through mechanisms dependent on early cell activation
Molecular Nutrition & Food Research, vol. 56, no. 7, pp. 1034-1042Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mnfr.201200047
Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide
The Journal of Biological Chemistry, vol. 287, no. 14, pp. 10791-10798Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M111.311316