FRSE
Regius Chair of Physiology
- About
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- Office Address
University of Aberdeen
School of Medicine, Medical Sciences and Nutrition
Institute of Medical Sciences (IMS)
Aberdeen, AB25 2ZD, UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
EDUCATION
2022: Massachusetts Institute of Technology (MIT) Sloan Executive Education; Entrepreneurship Development Program, Cambridge, MA, USA
2003-2007: American Heart Association Postdoctoral Fellowship, Harvard Medical School, Boston, USA
1999- 2003: University of Dundee: PhD in Biochemistry, MRC Protein Phosphorylation Unit, Dundee, UK. Supervisor Professor Dame Patricia T.W. Cohen
1995–1999: University of Edinburgh Medical School: BSc Honours in Pharmacology, Edinburgh, UK.
RESEARCH AND PROFESSIONAL EXPERIENCE
2024-: Regius Chair of Physiology
2019-2023: Dean for Industrial Engagement in Research and Knowledge Exchange
2018-: Director, Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen
2018-2022: Systems Physiology Programme Lead, Institute of Medical Sciences
2015-: Professor in Diabetes Physiology and Signalling, University of Aberdeen
2014-2015: Reader; University of Aberdeen, School of Medical Sciences
2012-2014: Senior Research Fellow, University of Aberdeen, School of medical sciences
2010-2012: Lecturer, University of Aberdeen, School of Biological Sciences
2007-2012: Research Councils UK (RCUK) 5-year tenure-track Fellowship, University of Aberdeen, School of Biological Sciences.
2003–2007: Harvard Medical School, Division of Medicine, Department of Hematology & Oncology. American Heart Association (AHA) Postdoctoral Fellowship. Mentor: Prof. Benjamin Neel.
Short Bio
Prof. Mirela Delibegovic is an academic and entrepreneurial research leader in biomedical sciences, initiating and developing constructive collaborations leading to successful outcomes, including key publications, significant sustainable funding, and impactful translational discovery research. Experienced line manager, leader and mentor, she pioneers strategic professional development of academic and research staff, and is also elected chair of key University and grant-funding committees.
Qualifications
- PhD Biochemistry2003 - University of Dundee
- BSc Hons Pharmacology1999 - University of Edinburgh
External Memberships
2023-2027: Medical Research Council, Population and Systems Medicine Board
2022-2024: Chair, British Heart Foundation Project Grants Committee
2023-: Danish Diabetes and Endocrine Academy Grant Review Committee
2023-: Medical Research Council, Centres of Research Excellence (CoRE) Panel
2022-: Agence Nationale de la Recherche (ANR), France 2030 Investment Plan, Bioclusters, Panel Member
2022-: Fellow of the Royal Society of Edinburgh (FRSE)
2022-: Barts Charity, Grants Committee (Large Project Grants and Transformational Funding)
2022: Acting Chair, British Heart Foundation Project Grants Committee
2022-: Mentor, Deutsches Centrum Fur Herz-Kreislauf-Forschung (DZHK) Mentoring Programme
2022, 2024: Chair, RD Lawrence Fellowship Committee, Diabetes UK
2021-2022: Vice-Chair: British Heart Foundation Project Grants Committee
2021-: Diabetes Research & Wellness Foundation, Research Advisory Board
2019-2024: British Heart Foundation Project Grants Committee Member
2015-2021: Diabetes UK Main Research Grants Committee
2018–: University of Aberdeen Theme Lead, Scottish Universities Life Sciences Alliance (SULSA)
2015-: Carnegie Trust Assessor
2011 (Inaugural elected member): The Royal Society of Edinburgh (RSE) Young Academy of Scotland
Prizes and Awards
Scotland's Life Sciences Awards 2023 (Finalist), Innovation Collaboration category (with Vertebrate Antibodies Ltd and NHS Grampian)
Royal Society of Edinburgh Fellow (FRSE) (Elected 2022)
International Academy of Sciences and Arts Bosnia and Herzegovina (Internacionalna Akademija Nauka i Umjetnosti u Bosni i Hercegovini) (Elected 2022)
Excellence Awards 2022, Winner, Public Engagement with Research (2022)
Excellence Awards 2022, Shortlisted, Best PGR Supervisor (2022)
Champion 2022 (Finalist) of the Scottish Knowledge Exchange Award (Interface, 2022)
Royal Society of Edinburgh (RSE) Young Academy of Scotland Fellow (Inaugural Elected Fellow) (2011)
Winner of the 2018 Wellcome Prize for Outstanding Achievement in Public Engagement in the Biomedical Sciences, University of Aberdeen
Joint winner: Public prize, Principal’s Prize for Public Engagement with Research 2018, University of Aberdeen
“Super Zena” (“Super Woman”) 2018 award at the First International Women’s conference, Bosnia and Hercegovina
- Research
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Research Overview
Translational research activities
- Lead for development of Covid-19 diagnostic tests using Artificial Intelligence (AI), funded by Scottish Government (2020-2022) through the Rapid Research in Covid-19 (RARC) programme. Delivered highly sensitive, accurate and affordable diagnostic tests suitable for mass rollout:https://www.abdn.ac.uk/news/14759/; https://abdn.ac.uk/ims/news/15626
- Our work was highlighted by the United Nations Academic Impact publication as the example of a successful collaboration between academia and industry https://www.un.org/en/academic-impact/helping-fight-covid-19-pandemic-artificial-intelligence
- Technology/platform developed during the RARC programme has led significant new investment from Innova Medical Group (IMG) as well as Innovate UK Knowledge Transfer Partnership project with Vertebrate Antibodies Ltd (2024 -), towards the development of novel antibody tests (single test) for type 1 diabetes subtypes.
- Consultant and Project Lead for start up Cohen Pharmaceuticals Ltd (2018-2023). Leading drug discovery project with a team of medicinal chemists, in vitro and in vivo biologists and modellers towards Phase 1 clinical trials.
- Development of novel drug treatments for diabetic retinopathy (most common complication: sight loss): https://abdn.ac.uk/ims/news/15345
- Treatment of atherosclerosis using PTP1B inhibitors: https://www.abdn.ac.uk/news/11280/
Current Research
We currently have several translational projects in the lab focused on metabolic diseases with emphasis on type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease (NALFD/NASH models) and cognitive dysfunction (with focus on Alzheimer's disease). Our projects range from drug discovery approaches using bioinformatic and medicinal chemistry approaches, artificial intelligence (AI) machine learning approaches for novel diagnostics, to in vitro and in vivo testing and most recently focused on patient-derived organoid cultures and patient populations. We do this in collaboration with our colleagues within Aberdeen Cardiovascular and Diabetes Centre, nationally and internationally.
Our lab is and has always been "open to all and dedicated to the pursuit of truth in the service of others" as stated in our Aberdeen 2040 Foundational Purpose. Our research culture is a positive and fun one! Pictures speak louder than words (Pre-holiday party; December 2022 lab photo).
Current research staff and graduate students in the lab
Research Fellows
Ruta Dekeryte (since 2014-) started in the lab as the final year undergraduate Honours project student, after which she was awarded the competitive IMS PhD studentship to work on the project investigating dietary and pharmacological approaches in combating cognitive dysfunction in models of Alzheimer's disease (2014 - 2018). Ruta is now working as Research Fellow in the lab on a commercial drug discovery project (since 2018 -). Meghan Hamer (since 2021-) is a medicinal chemist and research fellow in the lab working on a commercial drug discovery project. Meghan is a peptide chemist working alongside Dr Sergio Dall'Angelo. Meghan did her PhD at the University of Strathclyde.Dr Ayaz Ali (2022- 2025) is a research fellow working on the British Heart Foundation
funded project on novel treatments for diabetic retinopathy.
Joseph Smith (since 2021 -) is a biologist and research fellow working on assay development and high throughput screening. Joe did his PhD studies at the University College London (UCL). Dr Marina Souza Matos started in the lab as the PhD student (since 2019-) funded by two separate PhD studentships (Elphinstone Scholarship and the IMS studentship), co-supervised by Prof Bettina Platt, and working on the role of essential amino acid signalling in cognitive function (graduating in July 2023). She obtained her undergraduate in Pharmacy from the Federal University of Rio de Janeiro in 2016. She did her undergraduate internship at Beth Israel Deaconess Medical Centre, Harvard medical school, in the laboratory of Prof Hollenberg in 2015. In 2019, she obtained her Masters in Physiology from the Federal University of Rio de Janeiro. Marina is now a postdoctoral fellow in our lab and Prof John Forrester, working on the role of PTP1B in dendritic cells and autoimmune uveitis. Ms Sarah Kamli-Salino did her final year Honours project in our laboratory and obtained her BSc Hons in Physiology at the University of Aberdeen in 2018. She then did her 1-year MRes project (2018-2019) in our laboratory, testing novel drugs for treatment of cardiovascular disease, funded by the Development Trust. She was then funded by Medical Research Scotland/ Astra Zeneca (2019-2024) for her PhD studies on synthetic cannabinoids in diabetic nephropathy, which she successfully defended in June 2024. Sarah is now a Research Associate in our laboratory working on independent projects.
Current PhD students
Dr Fiona Clegg is a SCREDS Clinical Lecturer in Gastroenterology, working towards her PhD in my lab (since 2018-). Fiona's research interests are in Gastroenterology and Hepatology, and particularly in liver fibrosis, hepatocarcinogenesis and non-alcoholic fatty liver disease (NAFLD). Fiona works on patient-derived human organoid cultures and novel therapeutic approaches for treatment of NAFLD/NASH/HCC. Fiona is currently writing up her PhD thesis and back to her clinical duties. Ms Abrar Othman is a PhD student (2019-2024) funded by the Saudi Arabian Cultural Bureau working on the role of PTP1B in macrophage signalling and inflammation. She obtained her Bachelor of Applied Medical Sciences at King Abdul-Aziz University (Jeddah, Saudi Arabia) and her Masters (Honours) of Clinical Biochemistry from the University of Manchester in 2016. Abrar submitted recently defended her PhD thesis successfully and has returned to Saudi Arabia as a lecturer at King Abdul-Aziz University. Ms Morgan Boyne is the BHF- funded PhD student in the lab (2022-2025) working on novel treatments for diabetic retinopathy. This is a collaboration with our clinical colleagues Prof John Forrester and Dr Lucia Kuffova (NHS Grampian). Morgan obtained her MSc in Precision Medicine and Pharmacological Innovation with Distinction (Uni of Aberdeen, Glasgow and Strathclyde partnership; 2021). She was awarded 1st Class Honours in BSc (Hons) Bioscience with Biomedical Sciences from Robert Gordon University (2020).Lab technician
Ms Michela Donarumma joined our laboratory as the core lab technician in December 2020; prior to her joining the University of Aberdeen in 2010, Michela worked as a research assistant at Brigham and Women's Hospital in Boston, USA.Past Research
The aim of our laboratory is to understand how ageing and poor nutrition lead to development of diseases such as diabetes, cardiovascular disease, cancer and other age-associated comorbidities.
One of our publications in which we compared two nutritional interventions, achievable in humans, on metabolic health was selected as the Editor's Choice: highlight in Ageing research by Scientific Reports.
Lab News
Congratulations to Sarah Kamli Salino for successfully defending her PhD thesis, investigating novel synthetic cannabinoids in treatment of diabetic nephropathy (secondary supervisors: Prof Heather Wilson, AstraZeneca industrial supervisors: Lihuan Liang, Timo Haschler). Special thanks to her examiners Prof Gavin Welsh (University of Bristol) and Dr Fiona Murray (Institute of Medical Sciences).
June 2024 (L to R: Heather Wilson, Sarah Kamli Salino, Fiona Murray, Mirela Delibegovic)
Congratulations to Abrar Othman for successfully defending her PhD thesis, delineating the role of myeloid PTP1B in wound healing in diabetes (secondary supervisors: Prof Heather Wilson, Dr Nimesh Mody). Special thanks to her examiners Dr Li Kang (University of Dundee) and Dr Ann Rajnicek (Institute of Medical Sciences).
April 2024 (L to R: Nimesh Mody, Li Kang, Abrar Othman, Ann Rajnicek, Heather Wilson, Mirela Delibegovic)
Congratulations to Marina Souza Matos for successfully defending her PhD thesis, studying the role of essential amino acids and methionine restriction in models of cognitive dysfunction (second supervisor: Prof Bettina Platt). Special thanks to her examiners Prof Colin Selman (University of Glasgow) and Dr Derek Garden (Institute of Medical Sciences).
April 2023 (L to R: Colin Selman, Mirela Delibegovic, Marina Matos, Bettina Platt, Derek Garden)
Thanks to everyone who supported my run at the Royal Parks Half Marathon in London (Oct 2022) raising funds for life saving research supported by the British Heart Foundation!
It was a wonderful day on 30th May 2022 at the Royal Society of Edinburgh! I was inducted to the Scottish national academy as the elected fellow (FRSE) alongside some amazing scientists, artists, activists and thinkers!
In March '22, we were delighted to welcome the British Heart Foundation and invited politicians consisting of MPs and MSPs and show them around our labs and tell them more about our science but also answer some really important questions they had about the impact of our work!
Celebrations of the Centenary of Insulin Discovery have been going on since Oct '21 and continuing well into late '22!!! We organised webinars, podcasts, school visits, exhibits at Aberdeen Science Centre as well as the Parliament, RSE, seminars and so much more... This involved our undergraduate medical students as well as our PhD students, postdocs and academic staff (current and emeritus).
City Hall Reception JDRF Civic Reception Aberdeen Science Centre weekend Congratulations to Ms Besa Veseli Emini for successfully defending her dual degree MoGlyNet Program Marie-Curie PhD thesis in Aberdeen and in Antwerp (Dec 2021); 2 viva voce on the same day (Aberdeen morning, Antwerp afternoon)! Online celebrations still managed to be fun and I managed to join virtually the in person celebrations in Antwerp!
Congratulations to Mr Oliver Helk for successfully defending his PhD thesis on "Investigating the role of PTP1B in human health: a translational approach" in Dec 2020. Oliver is now the clinical associate professor at the Medical University of Vienna, Austria. Special thanks to his examiners Prof Faisal Kahn (University of Dundee) and Dr Antonio Gonzalez Sanchez (Rowett Institute).
Congratulations to Ms Fabiana Baganha Carreiras for successfully defending her dual degree MoGlyNet Program Marie-Curie PhD thesis in Leiden and in Aberdeen (May 2020); 2 viva voce, 1 week apart. Online celebrations still managed to be fun!
Congratulations to Ms Sarah Kamli-Salino for successfully defending her Masters by Research (MRes) thesis (Feb 2020) and being awarded the Distinction! Hard work pays off; Sarah is now doing her PhD in the lab funded by MRS/AstraZeneca PhD studentship. Thanks to Sarah's examiners: Dr Paul Meakin (University of Leeds) and Dr Justin Rochford (Rowett Institute).
I run the Royal Parks Half Marathon (Oct 2019) raising funds for Diabetes UK; I managed to raise an amazing £1,521 for this great charity and the funds will go towards funding of new research into causes, treatment and care of diabetes! Thanks to all the supporters!!!! In Oct 2022, I'm doing the Royal Parks half again, this time raising funds for the BHF and their life saving research into metabolic diseases.
Knowledge Exchange
Public Engagement in Research Awards
Excellence Awards 2022, Winner, Public Engagement with Research (2022)
Champion 2022 (Finalist) of the Scottish Knowledge Exchange Award (Interface, 2022)
To listen to our podcast on the panel dicussion organised for International Women's Day 2021 "Different Day Same Problem: Covid-19, Leadership and Inequality" follow this link: https://share.transistor.fm/s/05c80a76 For the BHF Alumni organised panel discussion in which I took part on "The Future of the Lab after Covid-19" register here: https://alumni.bhf.org.uk/events/45004•
Winner of the 2018 Wellcome Prize for Outstanding Achievement in Public Engagement in the Biomedical Sciences•
Joint winner: Public prize, Principal’s Prize for Public Engagement with Research 2018•
“Super Zena” (“Super Woman”) 2018 award at the First International Women’s conference, Bosnia and Hercegovina•
Vitae (global leader in supporting the professional development of researchers) “Talking heads: PIs on mentoring research staff” project; invited speaker to help new PIs achieve most from their research staff; series of short online videos• National Coordinating Centre for Public Outreach – recognized as 1 out of 20 top UK scientists in 2010 for their outreach activities.
- Teaching
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Teaching Responsibilities
- Programme and Course coordinator for the PGT course: MSc in Cardiovascular Science and Diabetes
- Teaching on a range of courses within the School of Medicine, Medical Sciences and Nutrition, from 2nd year undergraduate to Masters level.
Non-course Teaching Responsibilities
Delivering CPD courses and staff development courses; examples include:
- State of Qatar Ministry of Public Health and Qatar University, Continuous Professional Development lecture on “Acute and chronic complications associated with diabetes”
- Physiological Society: “Creating impact for your research - Building relationships and creating opportunities”
- International Women’s Day 2021: “Different Day, Same Problem: Covid-19, Leadership and Inequality”
- British Heart Foundation: “Future of the lab after COVID-19”
- Publications
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Page 1 of 2 Results 1 to 50 of 90
Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy
Gene TherapyContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41434-024-00471-z
- [ONLINE] View publication in Nature
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Nature Reviews Endocrinology , vol. 20, no. 6, pp. 366-378Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1038/s41574-024-00965-1
- [ONLINE] View publication in Scopus
Comparison of intramyocellular lipid metabolism in patients with diabetes and male athletes
Nature Communications, vol. 15, no. 1, pp. 3690Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.6084/m9.figshare.24219934
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23599/1/Mezincescu_etal_Comparison_intramyocellular_lipid_VOR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] https://abdn.elsevierpure.com/en/publications/32def9dd-91e5-4a39-8c0d-7bbdc7cc4c91
Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial
The Journal of PhysiologyContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1113/JP285722
An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans
Molecular Psychiatry, vol. 29, no. 3, pp. 660-670Contributions to Journals: ArticlesVolatile organic compounds for the detection of hepatocellular carcinoma: A scoping review
iLIVER, vol. 3, no. 1, 100070Contributions to Journals: Review articlesP125: Development and Evaluation of a Novel Antibody to Human FGF21
Chapters in Books, Reports and Conference Proceedings: Conference ProceedingsMyeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism
Journal of translational medicine, vol. 21, 715Contributions to Journals: ArticlesMorning exercise and pre-breakfast metformin interact to reduce glycaemia in people with Type 2 Diabetes: a randomized crossover trial
Working Papers: Preprint PapersHow stra(i)nge are your controls?: A comparative analysis of metabolic phenotypes in commonly used C57BL/6 substrains
PloS ONE, vol. 18, no. 8, e0289472Contributions to Journals: ArticlesWhen a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
Cell Metabolism, vol. 35, no. 7, pp. 1114-1131Contributions to Journals: Review articlesBACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice
Neurobiology of Disease, vol. 182, 106142Contributions to Journals: ArticlesInduction of experimental diabetes and diabetic nephropathy using anomer-equilibrated streptozotocin in male C57Bl/6J mice
Biochemical and Biophysical Research Communications, vol. 650, pp. 109-116Contributions to Journals: ArticlesFenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice
Scientific Reports, vol. 13, 3937Contributions to Journals: ArticlesIncreased Body Mass Index is Associated with Sarcopenia and Related Outcomes
European Journal of Clinical Investigation, vol. 53, no. 2, e13874Contributions to Journals: LettersA refined method of adult tissue resident stem cell derived primary human hepatic organoid cultures
Chapters in Books, Reports and Conference Proceedings: Conference Proceedings- [ONLINE] DOI: https://doi.org/10.1136/gutjnl-2023-BSG.101
FGF21 sensitivity in hepatocellular carcinoma could be impaired through reduction in FGFR1 and KLB expression
Chapters in Books, Reports and Conference Proceedings: Conference Proceedings- [ONLINE] DOI: https://doi.org/10.1136/gutjnl-2023-BSG.24
Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy
Molecular Therapy - Methods & Clinical Development, vol. 27, pp. 206-216Contributions to Journals: ArticlesPhosphorylcholine Monoclonal Antibody Therapy Decreases Intraplaque Angiogenesis and Intraplaque Hemorrhage in Murine Vein Grafts
International Journal of Molecular Sciences, vol. 23, no. 21, 13662Contributions to Journals: ArticlesDiabetes: Once a death sentence, Scottish scientist's work on insulin turned it into a treatable condition
The ScotsmanContributions to Specialist Publications: Articles- [ONLINE] Column contribution to the Scotsman
Impact of Diabetes on COVID-19 mortality and hospital outcomes, a global perspective: An umbrella systematic review and meta-analysis
Endocrinology, Diabetes & Metabolism, vol. 5, no. 3, e00338Contributions to Journals: Review articlesMetabolic alterations in a rat model of Takotsubo syndrome
Cardiovascular Research, vol. 118, no. 8, pp. 1932–1946Contributions to Journals: ArticlesHigh-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide
Nutritional Neuroscience, vol. 25, no. 4, pp. 719-736Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/1028415X.2020.1806190
- [ONLINE] View publication in Scopus
Apolipoprotein E Loss of Function: Influence on Murine Brain Markers of Physiology and Pathology Aging Brain
Aging Brain, vol. 2, 100055Contributions to Journals: ArticlesProtein tyrosine phosphatase 1B inhibition promotes diabetic wound healing via activation of the antioxidant enzyme heme oxygenase 1
Diabetologia, vol. 64, no. SUPPL 1, pp. 102-103Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1007/s00125-021-05519-y
Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization
Angiogenesis, vol. 24, pp. 567-581Contributions to Journals: ArticlesThe BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice
Biochimica et Biophysica Acta. Molecular Basis of Disease : BBA , vol. 1867, no. 7, 166149Contributions to Journals: ArticlesThe PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition
International Journal of Molecular Sciences, vol. 22, no. 11, e5970Contributions to Journals: ArticlesPositive and negative inflammatory markers for falls and sarcopaenia in the Malaysian Elders Longitudinal Research study - A five-year prospective study
Australasian journal on ageing, vol. 40, no. S1, pp. 1-2Contributions to Journals: AbstractsEffects of dietary restriction on metabolic and cognitive health
Nutrition Society Live 2020, pp. 126–138Contributions to Journals: Review articlesPhosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
Scientific Reports, vol. 11, 6949Contributions to Journals: ArticlesThe anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet
Cellular and Molecular Life Sciences, vol. 78, no. 6, pp. 3045-3055Contributions to Journals: ArticlesCRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake
Molecular Psychiatry, vol. 26, pp. 2263–2276Contributions to Journals: ArticlesNLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia
Neuropharmacology, vol. 180, 108305Contributions to Journals: ArticlesThe Role of Inflammation in Diabetic Retinopathy
Frontiers in Immunology, vol. 11, no. 20, pp. 10319-10329Contributions to Journals: ArticlesAblation of Bscl2/Seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy
Disease Models & Mechanisms, vol. 13, no. 1, dmm042655Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/dmm.042655
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13584/1/Mcilroy_etal_dmm042655_ablation_VOR.pdf
- [ONLINE] View publication in Scopus
Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia
Molecular Neurobiology, vol. 57, pp. 539-550Contributions to Journals: ArticlesCRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake
bioRxivContributions to Journals: ArticlesEffects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice
Biochemical Pharmacology, vol. 166, pp. 222-230Contributions to Journals: ArticlesFemale adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet
Scientific Reports, vol. 8, 17863Contributions to Journals: ArticlesAdipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease
Molecular Metabolism, vol. 10, pp. 55-65Contributions to Journals: ArticlesResponse to comment by Moxon et al
Clinical Science, vol. 132, no. 1, pp. 39-41Contributions to Journals: LettersDeficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia
Cancer Research, vol. 78, no. 1, pp. 75-87Contributions to Journals: ArticlesMyeloid-specific deletion of PTP1B leads to reduced serum cholesterol levels through lowered hepatic expression of SREBP1c and HMG-CoA-R
Wiener Klinische Wochenschrift, vol. 130, no. Suppl. 6, pp. 374Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1007/s00508-018-1393-1
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis
Clinical Science, vol. 131, no. 20, pp. 2489-2501Contributions to Journals: ArticlesMyeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Molecular Metabolism, vol. 6, no. 8, pp. 845-853Contributions to Journals: ArticlesNovel G protein-coupled receptors in Pancreatic Beta cells
Experimental Biology, 1052.1Contributions to Journals: AbstractsElevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
Scientific Reports, vol. 7, 43782Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/srep43782
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8293/1/srep43782.pdf
Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice
Scientific Reports, vol. 7, pp. 1-10Contributions to Journals: ArticlesMethionine restriction improves renal insulin signalling in aged kidneys
Mechanisms of Ageing and Development, vol. 157, pp. 35-43Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.mad.2016.07.003
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/7/Kidney_MR_paper_RESUBMISSION_FINAL_UNDERLINED_CHANGES.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/3/Figure_1.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/2/Figure_2.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/5/Figure_3.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/4/Figure_4.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/6/Figure_5.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8979/1/Figure_6.pdf