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Aberdeen Centre for Arthritis and Musculoskeletal Health

Dr Fraser Collins

Dr Fraser Collins
Dr Fraser Collins
Dr Fraser Collins

Ph.D

Research Fellow

About
Email Address
fraser.collins@abdn.ac.uk
Office Address

Institute of Medical Sciences

Rm 2.26 / 2.08 / 2.09 / 2.11 / 2.13

School of Medicine, Medical Sciences and Nutrition

Foresterhill

Aberdeen

AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Fraser graduated from the University of Swansea in 2004 with a degree in Genetics and Zoology.  He then spent 5 years working as a Quality Control Scientist for British Biocell before going back to study at Cardiff University in 2009 for his Ph.D entitled: Death Receptor 3: A Regulator of Bone Turnover and New target for Therapy for Osteoporosis?  Following successful completion of his Ph.D Fraser moved to Michigan State University to take up a post-doctoral position where his research focussed on the gut-bone axis and how probiotic bacteria can be utilised to treat adverse bone pathology.  Specifically, how probioitics can modulate the intestinal environment, immune system and have long-ranging effects on the bone marrow and bone health.  In 2017, Fraser took up a Research Fellow position in the Arthrtitis and Regenerative Medicine laboratory at the University of Aberdeen where his research focusses on understanding how Gdf5-lineage synovial cells can be exploited for the development of novel therapies for osteoarthritis.

Research

Research Overview

Osteoarthritis; Cartilage regeneration; Mesenchymal stem cell biology; Osteoporosis; Single-cell RNA-sequencing

Current Research

My current research focuses on understanding the relationship between the mesenchymal stromal cells within the synovial joint, in both naive and injured states.  Using single cell RNA-sequencing and specific lineage-tracing models I aim to identify the synovial mesenchymal stem cell for the development of novel osteoarthritis therapies.

Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.

Publications

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  • Immunology of Gut-Bone Signaling

    Collins, F. L., Schepper, J. D., Rios-Arce, N. D., Steury, M. D., Kang, H. J., Mallin, H., Schoenherr, D., Camfield, G., Chishti, S., McCabe, L. R., Parameswaran, N.
    Understanding the Gut-Bone Signaling Axis: Mechanisms and Therapeutic Implications. McCabe, L. R., Parameswaran, N. (eds.). Springer, pp. 59-94, 36 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Intestinal Microbiota and Bone Health: The Role of Prebiotics, Probiotics, and Diet

    Collins, F. L., Kim, S. M., McCabe, L. R., Weaver, C. M.
    Bone Toxicology. Springer, pp. 417-443, 27 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting

    Collins, F. L., Irwin, R., Bierhalter, H., Schepper, J., Britton, R. A., Parameswaran, N., McCabe, L. R.
    PloS ONE, vol. 11, no. 4, e0153180
    Contributions to Journals: Articles

  • Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice

    Bloom, A. C., Collins, F. L., van't Hof, R. J., Ryan, E. S., Jones, E., Hughes, T. R., Morgan, B. P., Erlandsson, M., Bokarewa, M., Aeschlimann, D., Evans, B. A., Williams, A. S.
    Bone, vol. 84, pp. 253-261
    Contributions to Journals: Articles

  • Death receptor 3 (TNFRSF25) increases mineral apposition by osteoblasts and region specific new bone formation in the axial skeleton of male DBA/1 mice

    Collins, F. L., Williams, J. O., Bloom, A. C., Stone, M. D., Choy, E., Wang, E. C., Williams, A. S.
    Journal of Immunology Research, vol. 2015, 901679
    Contributions to Journals: Articles

  • Regulation of Early Cartilage Destruction in Inflammatory Arthritis by Death Receptor 3

    Wang, E. C., Newton, Z., Hayward, O. A., Clark, S. R., Collins, F., Perks, W. V., Singh, R. K., Twohig, J. P., Williams, A. S.
    Arthritis & Rheumatology, vol. 66, no. 10, pp. 2762-2772
    Contributions to Journals: Articles

  • Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

    Greenhill, C. J., Jones, G. W., Nowell, M. A., Newton, Z., Harvey, A. K., Moideen, A. N., Collins, F. L., Bloom, A. C., Coll, R. C., Robertson, A. A., Cooper, M. A., Rosas, M., Taylor, P. R., O'Neill, L. A., Humphreys, I. R., Williams, A. S., Jones, S. A.
    Arthritis Research & Therapy, vol. 16, no. 4, 419
    Contributions to Journals: Articles
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