![Dr Fiona Saunders Dr Fiona Saunders](/img/200x200/staffpages/uploads/mmd928/avatar/KvX1lMpwFHt1ql1CN2OkCCp8urgLeDhnM0wsYoMM.jpeg)
PhD
Research Assistant
- About
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- Email Address
- f.r.saunders@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I studied Biomedical Sciences, specialising in Pharmacology at the University of Aberdeen. I graduated in 2004 with upper second class honours. My honours project was a literature review assessing the role of non-steroidal anti-inflammatory drugs (NSAIDs) as a potential class of chemopreventative agents for colorectal cancer, supervised by Prof. Heather Wallace. This lead toa PhD studying the role of polyamines in the chemoprevantative actions of NSAIDs in a colorectal cell line models, again supervised by Prof. Heather Wallace, awarded in 2009.
I then move to the Orthopaedic Research group, led by Prof Richard Aspden to work with Dr Jenny Gregory on her MRC New Investigator award investigating bone shape in knee osteoarthritis, first as a Research Assistant and then as a Post-Doctoral Research Fellow. I also worked as a Technician and Resaerch Manager within the wider Bone & Musculoskeletal group. I then worked with Prof. Richard Aspden, Dr Jenny Gregory and Dr Rebecca Barr as one of two Post-Docs investigating the life course and bone shape in the hip and spine, funded by the MRC in collaboration with the MRC Unit of Lifelong Health and Ageing at UCL.
I then moved to laboratory of Dr Fiona Murray within the IMS to study the role of GPR75 in the pancreas funded by the Wellcome Trust ISSF fund for 6 months. I then returned to the Orthopaedic group for 6 months to complete the MRC funded work before returning to Dr Murray's lab to work on GRP75, funded by the Wellcome Trust for 18 months.
I moved back to the Orthopaedic group to take up the position of Post-Doc on a Wellcome Trust Collaborative Grant, led by Prof. Jon Tobias at the University of Bristol to derive bone phenotypes from 100,000 participant's DXA scans using statistical shape modelling (SSM) aquired as part of the UK BioBank.
I moved to Prof Val Speirs lab in 2023 working on several projects related to breast cancer and developing animal-free culture systems.
Qualifications
- PhD Medicine & Therapeutics2009 - University of Aberdeen
- BSc (hons) Biomedical Sciences (Pharmacology)2004 - University of Aberdeen
Latest Publications
Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: findings from a study of 37,843 people in UK Biobank.
Osteoarthritis and Cartilage Open, vol. 6, no. 2, 100468Contributions to Journals: ArticlesAssociations between life course longitudinal growth and hip shapes at ages 60 to 64 years: evidence from the MRC National Survey of Health and Development
RMD Open, vol. 10, no. 2Contributions to Journals: ArticlesFemoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures
Journal of Bone and Mineral Research, vol. 39, no. 3, pp. 241–251Contributions to Journals: ArticlesHip geometric parameters are associated with radiographic and clinical hip osteoarthritis: findings from a cross-sectional study in UK Biobank
Osteoarthritis and Cartilage, vol. 31, no. 12, pp. 1627-1635Contributions to Journals: ArticlesComparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis
Osteoarthritis and CartilageContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.joca.2023.10.006
- Research
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Research Areas
Biomedical Sciences
Current Research
I currently work in the lab of Prof Val Speirs. The lab's main interest is Breast Cancer and in particular understanding the differences between male and female breast cancers. We are also working on developing animal-free culture systems.
I have worked as a Post-Doc on a Wellcome Trust Collaborative Project led by Prof. Jon Tobias, University of Bristol. Partners in this grant are University of Bristol, University of Manchester, University of Aberdeen, University of Southampton, Cardiff University, University of Oxford and University of Queensland Diamatina Institute.
In this project we were deriving bone phenotypes from DXA scans acquired from 100,000 participants of the UK BioBank. This work was to develop and test statisical shape models of the hips and knees. We then looked at the associations between outcomes such as Osteoarthritis and shape models. GWAS and Mendalian Analysis were also perfomed to investigate genetic associations. We have also derived spine bone shape phenotypes as part of this large-scale project.
Past Research
National Survey of Health and Development - Associations between life course factors and statistical shape models of the hip and spine
Prof Rachel Cooper (Newcastle, fomerly UCL), Prof Rebecca Hardy (Loughborough, formerly UCL), Prof Diana Kuh (Emerita UCL), Dr Stella Muthuri (Fomerly UCL), Dr Rebecca Barr (Dundee, fomerly Aberdeen), Dr Jenny Gregory, Dr Kathryn Martin, Dr Anastasia Pavlova (RGU, formerly Aberdeen), Prof Richard Aspden
Collaborations
AUGMENT Statistical Shape modelling of the UK Biobank imaging cohort - Prof Jon Tobias (Bristol), Prof Tim Cootes (Manchester), Prof Nick Harvey (Southampton)
Dr Katherine Brooke-Wavell, Loughborough University - statistical shape modelling of DXA scans from exercise intervention studies and athletes.
Supervision
2nd Supervisor to Celia Rodriquez Rodriquez with Prof Val Speirs
- Teaching
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Courses
- MT5515 - Basic Research Methods
- Publications
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Page 2 of 5 Results 11 to 20 of 49
A novel semi-automated classifier of hip osteoarthritis on DXA images shows expected relationships with clinical outcomes in UK Biobank
Rheumatology, vol. 61, no. 9, pp. 3586–3595Contributions to Journals: ArticlesMachine-learning derived acetabular dysplasia and cam morphology are features of severe hip osteoarthritis: findings from UK Biobank
Journal of Bone and Mineral Research, vol. 37, no. 9, pp. 1720-1732Contributions to Journals: ArticlesCam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank
Osteoarthritis and Cartilage, vol. 29, no. 11, pp. 1521-1529Contributions to Journals: ArticlesPredictors of total hip replacement in community based older adults: a cohort study
Osteoarthritis and Cartilage, vol. 29, no. 8, pp. 1130-1137Contributions to Journals: ArticlesDeriving alpha angle from anterior-posterior dual-energy x-ray absorptiometry scans: an automated and validated approach
Wellcome open research, vol. 6, no. 60Contributions to Journals: ArticlesMotor development in infancy and spine shape in early old age: findings from a British birth cohort study
Journal of Orthopaedic Research, vol. 38, no. 12, pp. 2740-2748Contributions to Journals: ArticlesSubregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study
Osteoarthritis and Cartilage, vol. 28, no. 8, pp. 1071-1078Contributions to Journals: ArticlesAge at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age
Journal of Bone and Mineral Research, vol. 34, no. 3, pp. 455-463Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/jbmr.3627
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12031/3/Ireland_et_al_2019_Journal_of_Bone_and_Mineral_Research.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
- [ONLINE] https://abdn.pure.elsevier.com/en/en/researchoutput/age-at-onset-of-walking-in-infancy-is-associated-with-hip-shape-in-early-old-age(17e3f63c-be3f-4ec2-9e20-b834f51f7df6).html
Identification of Novel Loci Associated With Hip Shape: A Meta‐Analysis of Genomewide Association Studies
Journal of Bone and Mineral Research, vol. 34, no. 2, pp. 241-251Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/jbmr.3605
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11532/3/Identification_of_Novel_Loci_Associated_With_Hip_Shape_A_Meta_Analysis_of_Genomewide_Association_Studies.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Mendeley
Osteoarthritis as an organ disease: from the cradle to the grave
European Cells & Materials, vol. 37, pp. 74-87Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.22203/eCM.v037a06
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11845/1/v037a06.pdf
- [ONLINE] View publication in Scopus