Professor Claude Wischik | The School of Medicine, Medical Sciences and Nutrition

Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks
2021 - Published
Schwab, K., Melis, V., Harrington, C. R., Wischik, C. M., Magbagbeolu, M., Theuring, F., Riedel, G.
Cells, vol. 10, no. 8, 2162
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells10082162
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17282/1/Schwab_cells_Proteomic_analysis_of_vor.pdf
- [ONLINE] View publication in Scopus
Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
2021 - Published
Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Cells, vol. 10, no. 3, 703
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/cells10030703
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16165/1/Maina_etal_CELLS_Oxidative_Stress_Conditions_VoR.pdf
Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia
2020 - Published
Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.
Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523
Contributions to Journals: Articles
- [ONLINE] http://www.jbc.org/content/early/2020/10/30/jbc.RA120.014890.abstract
- [ONLINE] DOI: https://doi.org/10.1074/jbc.RA120.014890
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15308/2/Lemke_etal_Differential_compartmental_VOR.pdf
- [ONLINE] View publication in Scopus
Adaptive neurological testing method
2020 - Published
Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.
Patents: Patents
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
2020 - Published
Arastoo, M., Lofthouse, R., Penny, L., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.
International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/ijms21228673
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15385/1/Arastoo_et_al_IJMS_CurrentProgressAndFuture_VoR.pdf
- [ONLINE] View publication in Scopus
Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
2020 - Published
Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Frontiers in Neurology, vol. 11, 590754
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fneur.2020.590754
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15357/1/Oakley_et_al_Fneur_TauFilamentSelf_Assembly_VoR.pdf
- [ONLINE] View publication in Scopus
Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells
2020 - Published
Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2020.05.027
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14862/1/Pollack_etal_Paired_helical_VOR.pdf
- [ONLINE] View publication in Scopus
Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease
2020 - Published
Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. ?., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.
Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-200146
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
2020 - Published
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-191173
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14427/2/Shiells_et_al_JAD_ConcentrationDependentActivity_VoR.pdf
- [ONLINE] View publication in Scopus
Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
2020 - Published
Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.
Current Alzheimer Research, vol. 17, no. 3, pp. 285-296
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.2174/1567205017666200224120926
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15752/1/Riedel_et_al_CAR_MechanismsOfAnticholinesterase_AAM.pdf
- [ONLINE] View publication in Scopus
Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration
2020 - Published
Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G., Niewiadomska, G.
Brain Communications, vol. 2, no. 1, fcaa033
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/braincomms/fcaa033
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14871/1/Cranston_etal_BC_Cholinergenic_VOR.pdf
Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
2020 - Published
Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W., Wischik, C. M., Serpell, L. C.
FEBS LETTERS, vol. 594, no. 5, pp. 944-950
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/1873-3468.13675
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13414/2/AlHilaly_etal_FEBS_VOR.pdf
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
2019 - Published
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190772
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13339/1/Schelter_et_al_JoAD_ConcentrationDependentActivity_VoR.pdf
Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study
2019 - Published
Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J., Luna-Muñoz, J.
Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 631-645
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-190155
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12795/1/JAD_Flores_Accepted_Manuscript.pdf
- [ONLINE] https://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-190155
- [ONLINE] View publication in Mendeley
Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia
2019 - Published
Vuksanovic, V., Staff, R. T., Ahearn, T., Murray, A. D., Wischik, C. M.
International Journal of Neural Systems, vol. 29, no. 6, 1850055
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1142/S0129065718500557
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11981/3/Cortical_Thickness_and_Surface_Area_Networks_in_Healthy_Aging_Alzheimer_s_Disease_and_Behavioral_Variant_Fronto_Temporal_Dementia.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)
2019 - Published
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G., Klein, J.
ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1021/acschemneuro.8b00274
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12993/1/ACSChemNsci_Konig.pdf
- [ONLINE] View publication in Mendeley
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
2018 - Published
Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2018.08.010
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11249/1/1_s2.0_S0022283618305606_main.pdf
Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development
2018 - Published
Wischik, C. M., Schelter, B. O., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
Journal of Alzheimer's Disease, vol. 62, no. 3, pp. 1287-1303
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170727
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10181/1/Modeling_Prion_Like_Processing_of_Tau_Protein_in_Alzheimer_s_Disease_for_Pharmaceutical_Development.pdf
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease
2018 - Published
Frahm, S., Melis, V., Horsley, D., Rickard, J., Riedel, G., Fadda, P., Scherma, M., Harrington, C., Wischik, C., Theuring, F., Schwab, K.
Behavioural Brain Research, vol. 339, pp. 153-168
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.bbr.2017.11.025
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9815/1/Alpha_Synuclein_transgenic_mice_h_SynL62_display_Syn_aggregation_and_a_dopaminergic_phenotype_reminiscent_of_Parkinson_s_disease.pdf
A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
2018 - Published
Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.
Frontiers in Molecular Neuroscience, vol. 10, 447
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
2017 - Published
Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457
Contributions to Journals: Articles
- [ONLINE] https://www.j-alz.com/vol61-1
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170560
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9693/1/Potential_of_Low_Dose.pdf
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking
2017 - Published
Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 429, no. 23, pp. 3650-3665
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2017.09.007
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9614/1/Alzheimer_s_Disease_like_Paired_Helical_Filament_Assembly_from_Truncated_Tau_Protein_Is_Independent_of_Disulfide_Crosslinking.pdf
The effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks
2017 - Published
Shiells, H. C., Thiel, M., Wischik, C., Schelter, B.
Medical Research Archives , vol. 5, no. 9, 1298
Contributions to Journals: Articles
- [ONLINE] http://www.journals.ke-i.org/index.php/mra/article/view/1298
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9406/1/document.pdf
Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes
2017 - Published
Vuksanovic, V., Staff, R., Ahearn, T., Bentham, P., Murray, A. D., Wischik, C. M.
6th Cambridge Neuroscience Symposium
Contributions to Conferences: Abstracts
Method and system for determining network connections
2017 - Published
Sommerlade, L., Schelter, B., Wischik, C.
Patents: Patents

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Research Overview

Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia

Adaptive neurological testing method

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

The effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks

Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes

Method and system for determining network connections

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Chapters in Books, Reports and Conference Proceedings

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