Dr Sharon Mitchell
PhD (Aberdeen University 2002)
Advanced Research Fellow
- Email Address
- s.e.mitchell@abdn.ac.uk
- Office Address
319, Zoology Building, Tillydrone Avenue, Aberdeen, AB24 2TZ
- School/Department
- School of Biological Sciences
Biography
2015-date Research Fellow, Lab Manager Energetics Research Group
Research Overview
PhD Students
2016-date Megan Simpson
2016-2020 Jazmin Mendoza “Impacts of the thermic effect of food on feeding behaviour in mice: a test of the heat dissipation limits theory”
2015-2020 Emem Udoh PhD “Impacts of Calorie Restriction on Behaviour and Post-restriction Hyperphagia”
2015-2017 Heba Althubaiti “Fruit and Vegetable Intake and its Relationship with Health Parameters in Primary School Children”
Masters
2021-2022 Master of Science by Research Daniel Phillips “Bioinformatic Characterisation of Alternative Splicing in Three Different Tissues of Male C57BL/6 Mice Following Short-Term Graded Calorie Restriction"
2019-2020 MSci Daniel Phillips “Remodelling of three different tissues in the male C57BL/6 mouse during short-term graded caloric restriction is caused by tissue-specific variations in cell size and number”
2018-2019 MRes Stephanie Summers "The Impact of Short-Term Graded Calorie Restriction on Melanocortin-3 receptor (MC3R) Knockout Mice"
2013-2015 MSci Megan Simpson “The effect of maternal age on offspring susceptibility to high fat diet induced obesity and offspring expression of hypothalamic obesity related genes”.
2011-2013 MRes Dawn Graham, “The Role of Neuropeptides and their Receptors in Response to Increased Hunger, Reduced Food Intake and Reduced Body Fat Content”.
2011-2013 MRes Nicole Culbert, “Does Hunger Neuropeptide and Energy Balance Manipulation Affect Metabolic Rate and Antioxidant Activity in C57BL/6 Mice under Caloric Restriction?”
Supervisor of a number of Erasmus Funded Internships from AgroSup, Djon, France.
Teaching Responsibilities
Lab Skills in Biosciences (BI3812), co-coordinator with Cath Jones
Parasitology Field trip (BI25F3), co-coordinator with Jerry Sternberg
Supervisor for laboratory-based research projects for Honours students
Lecturer on following courses:
Environmental Physiology (ZO3513)
Principles of Animal Physiology (BI2510)
Diversity of Life 2 (BI1512)
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Limits to sustained energy intake XXIV: impact of suckling behaviour on the body temperatures of lactating female mice
Gamo, Y., Bernard, A., Troup, C., Munro, F., Derrer, K., Jeannesson, N., Campbell, A., Gray, H., Miller, J., Dixon, J., Mitchell, S. E., Hambly, C., Vaanholt, L. M., Speakman, J. R.Scientific Reports, vol. 6, pp. 1-12Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/srep25665
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6011/1/srep25665.pdf
The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks
Derous, D., Mitchell, S. E., Green, C. L., Wang, Y., Chen, L., Promislow, D. E. L., Lusseau, D., Speakman, J. R., Douglas, A.Aging, vol. 8, no. 4, pp. 917-931Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.18632/aging.100944
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10744/1/aging_08_0917.pdf
- [ONLINE] View publication in Scopus
CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction
Lipina, C., Vaanholt, L. M., Davidova, A., Mitchell, S. E., Storey-Gordon, E., Hambly, C., Irving, A. J., Speakman, J. R., Hundal, H. S.Aging Cell, vol. 15, no. 2, pp. 325-335Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/acel.12438
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5920/1/Lipina_et_al_2016_Aging_Cell.pdf
The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways
Derous, D., Mitchell, S. E., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D. E. L., Lusseau, D., Speakman, J. R., Douglas, A.Aging, vol. 8, no. 4, pp. 642-661Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.18632/aging.100895
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5562/2/aging_08_642.pdf
The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse
Mitchell, S. E., Delville, C., Konstantopedos, P., Derous, D., Green, C. L., Wang, Y., Han, J. J., Promislow, D. E. L., Douglas, A., Chen, L., Lusseau, D., Speakman, J. R.Oncotarget, vol. 7, no. 15, pp. 19147-19170Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.8158
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7370/1/8158_124048_8_PB.pdf
Oxidative costs of reproduction: Oxidative stress in mice fed standard and low antioxidant diets
Vaanholt, L. M., Milne, A., Zheng, Y., Hambly, C., Mitchell, S. E., Valencak, T. G., Allison, D. B., Speakman, J. R.Physiology and Behavior, vol. 154, pp. 1-7Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.physbeh.2015.11.009
The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction
Lusseau, D., Mitchell, S. E., Barros, C., Derous, D., Green, C., Chen, L., Han, J. J., Wang, Y., Promislow, D. E. L., Douglas, A., Speakman, J. R.Scientific Reports, vol. 5, 13198Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/srep13198
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4968/1/srep13198.pdf
The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse
Mitchell, S. E., Delville, C., Konstantopedos, P., Derous, D., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D. E., Douglas, A., Lusseau, D., Speakman, J. R.Oncotarget, vol. 6, no. 21, pp. 18314-18337Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.4506
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4988/1/4506_69963_1_PB_1_.pdf
Mice that are resistant to diet-induced weight loss have greater food anticipatory activity and altered melanocortin-3 receptor (MC3R) and Dopamine receptor 2 (D2) gene expression
Vaanholt, L. M., Mitchell, S. E., Sinclair, R. E., Speakman, J. R.Hormones and Behavior, vol. 73, pp. 83-93Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.yhbeh.2015.06.006
The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse
Mitchell, S. E., Tang, Z., Kerbois, C., Delville, C., Konstantopedos, P., Bruel, A., Derous, D., Green, C., Aspden, R. M., Goodyear, S. R., Chen, L., Han, J. J. D., Wang, Y., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.Oncotarget, vol. 6, no. 18, pp. 15902-15930Contributions to Journals: ArticlesThe effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice
Mitchell, S. E., Delville, C., Konstantopedos, P., Hurst, J., Derous, D., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.Oncotarget, vol. 6, no. 27, pp. 23213-23237Contributions to Journals: ArticlesFactors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice
Vaanholt, L. M., Sinclair, R. E., Mitchell, S. E., Speakman, J. R.Physiology and Behavior, vol. 144, pp. 146-155Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.physbeh.2015.03.029
Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet-induced obese mice
Zhang, L., Sinclair, R., Selman, C., Mitchell, S., Morgan, D., Clapham, J. C., Speakman, J. R.Obesity, vol. 22, no. 3, pp. 681-690Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/oby.20418
Limits to sustained energy intake. XXI. Effect of exposing the mother, but not her pups, to a cold environment during lactation in mice
Valencak, T. G., Wright, P., Weir, A., Mitchell, S. E., Vaanholt, L. M., Hambly, C., Król, E., Speakman, J. R.Journal of Experimental Biology, vol. 216, no. 23, pp. 4326-4333Contributions to Journals: ArticlesLimits to sustained energy intake. XX. Body temperatures and physical activity of female mice during lactation
Gamo, Y., Troup, C., Mitchell, S. E., Hambly, C., Vaanholt, L. M., Speakman, J. R.Journal of Experimental Biology, vol. 216, no. 19, pp. 3751-3761Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jeb.090308
Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy
Gamo, Y., Bernard, A., Mitchell, S. E., Hambly, C., Al Jothery, A., Vaanholt, L. M., Król, E., Speakman, J. R.Journal of Experimental Biology, vol. 216, no. 12, pp. 2328-2338Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jeb.078410
Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced Obese C57BL/6 Mice
Zhang, L., Gamo, Y., Sinclair, R., Mitchell, S. E., Morgan, D. G., Clapham, J. C., Speakman, J. R.Obesity, vol. 20, no. 5, pp. 954-962Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/oby.2011.357
Physiological and behavioral responses to intermittent starvation in C57BL/6J mice
Zhang, L., Mitchell, S. E., Hambly, C., Morgan, D. G., Clapham, J. C., Speakman, J. R.Physiology and Behavior, vol. 105, no. 2, pp. 376-387Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.physbeh.2011.08.035
Traversing the ovine cervix: a challenge for cryopreserved semen and creative science
Robinson, J. J., McKelvey, W. A. C., King, M. E., Mitchell, S. E., Mylne, M. J. A., McEvoy, T. G., Dingwall, W. S., Williams, L.Animal , vol. 5, no. 11, pp. 1791-1804Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S1751731111000978
Caloric Restriction
Speakman, J. R., Mitchell, S. E.Molecular Aspects of Medicine, vol. 32, no. 3, pp. 159-221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.mam.2011.07.001
The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice
Hempenstall, S., Picchio, L., Mitchell, S. E., Speakman, J. R., Selman, C.Mechanisms of Ageing and Development, vol. 131, no. 2, pp. 111-118Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.mad.2009.12.008
Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats
Sneddon, A. A., Rayner, D. V., Mitchell, S. E., Bashir, S., Ha, J., Wahle, K. W., Morris, A. C., Williams, L. M.Nutrients, vol. 1, no. 2, pp. 178-196Contributions to Journals: ArticlesLeptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status
Mitchell, S. E., Nogueiras, R., Morris, A., Tovar, S., Grant, C., Cruickshank, M., Rayner, D. V., Dieguez, C., Williams, L. M.The Journal of Physiology, vol. 587, no. 14, pp. 3573-3585Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1113/jphysiol.2009.173328
- [ONLINE] View publication in Scopus
The contribution of animal models to the study of obesity
Speakman, J. R., Hambly, C., Mitchell, S. E., Król, E.Laboratory Animals, vol. 42, no. 4, pp. 413-432Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1258/la.2007.006067
The Lou/C rat is proportionally smaller than the Wistar and not anorexic or hyperactive as previously reported
Hambly, C., Mitchell, S. E., Speakman, J. R., Williams, L.International Journal of Obesity, vol. 31, no. S1, pp. S84-S84Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1038/sj.ijo.0803597
