MSc (Jagiellonian University, Poland); PhD (Jagiellonian University, Poland)
Lecturer
- About
-
- Email Address
- e.krol@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272883
- School/Department
- School of Biological Sciences
- Research
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Research Overview
My research interests focus on whole animal energetics and physiology. This framework provides the common theme that links my interests in the role of energy use during both reproduction and the development of obesity.
Current Research
My doctoral work on the energetics of hedgehogs (Jagiellonian University, Poland) and postdoctoral work on reproduction in laboratory mice (University of Aberdeen, Scotland) and deer mice (University of California, Riverside, USA) have resulted in a novel hypothesis that the limits to sustained energy intake at peak lactation are imposed by the capacity of the animal to dissipate body heat. This hypothesis is currently under further investigation.
My obesity related work focuses on the effects of photoperiod on body mass, food intake, body composition, energy balance and hypothalamic gene expression in the field vole, which provides a new animal model for the investigation of seasonal adiposity at both organism and molecular levels. The major finding of this project is that the photoperiod-induced increase in body mass is associated with the up-regulation of the suppressor of cytokine signalling (SOCS3). This appears to act as a desensitisation mechanism that allows animals to ignore elevated leptin levels generated by increased adiposity, leading to an accumulation of body fat without counter-regulatory mechanisms.
- Publications
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Page 4 of 6 Results 31 to 40 of 51
Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein
Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, vol. 182, no. 4, pp. 553-567Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00360-011-0637-4
Negative correlation between milk production and brown adipose tissue gene expression in lactating mice
Journal of Experimental Biology, vol. 214, no. 24, pp. 4160-4170Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jeb.061382
- [ONLINE] View publication in Scopus
Limits to sustained energy intake. XIII. Recent progress and future perspectives
Journal of Experimental Biology, vol. 214, no. 2, pp. 230-241Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jeb.048603
- [ONLINE] View publication in Scopus
The heat dissipation limit theory and evolution of life histories in endotherms-time to dispose of the disposable soma theory?
Integrative and Comparative Biology, vol. 50, no. 5, pp. 793-807Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/icb/icq049
- [ONLINE] View publication in Scopus
Shaved mice have improved performance during lactation
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, vol. 153, no. 2, pp. S149Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.cbpa.2009.04.289
The contribution of animal models to the study of obesity
Laboratory Animals, vol. 42, no. 4, pp. 413-432Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1258/la.2007.006067
Limits to sustained energy intake. X.: Effects of fur removal on reproductive performance in laboratory mice
Journal of Experimental Biology, vol. 210, pp. 4233-4243Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jeb.009779
Animal models of obesity
Obesity Reviews, vol. 8, no. Suppl 1, pp. 55-61Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1467-789X.2007.00319.x
Regulation of body mass and adiposity in the field vole, Microtus agrestis: a model of leptin resistance
Journal of Endocrinology, vol. 192, no. 2, pp. 271-278Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1677/JOE-06-0074
Limits to sustained energy intake IX: a review of hypotheses
Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, vol. 175, pp. 375-394Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1007/s00360-005-0013-3