Advanced Research Fellow
- About
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- Email Address
- fiona.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438617
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am a principal investigator based at the Rowett Institute and coordinator of the PGT Human Nutrition MSc programme. My research focuses on advanced glycation end-products (AGEs) in the diet. During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body during digestion. To investigate how dietary AGEs, contribute to diet induced conditions such as type 2 diabetes and dementia we are using human intervention studies to test the effects of highly processed foods high in AGEs on sensitive measures of metabolic health and cognition. I am also researching the role of processing methods in improving food quality and the potential for phytochemicals incorporated into processed foods to ameliorate negative health outcomes.
External Memberships
Registered Nutritionist with the AfN (RNutr)
Member of the Nutrition Society,
Member of Biochemical Society,
Member of British Society for Proteome Resarch (BSPR).
Latest Publications
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
Journal of Nutrition and Metabolism, vol. 2022, 4715965Contributions to Journals: ArticlesThe Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Molecular Nutrition & Food Research, vol. 65, no. 1, 1900934Contributions to Journals: Review articlesAnthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin
Journal of Functional Foods, vol. 64, 103597Contributions to Journals: ArticlesCinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion
Plant Foods for Human Nutrition, vol. 74, no. 4, pp. 544-552Contributions to Journals: ArticlesEarly and reversible changes to the hippocampal proteome in mice on a high-fat diet
Nutrition and Metabolism, vol. 16, no. 1, 57Contributions to Journals: Articles- [ONLINE] https://rdcu.be/bPqy4
- [ONLINE] DOI: https://doi.org/10.1186/s12986-019-0387-y
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12782/1/McLean2019_Article_EarlyAndReversibleChangesToThe_VoR.pdf
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31462902 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6708244
- [ONLINE] View publication in Mendeley
- Research
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Research Overview
A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.
Current Research
Current research in my laboratory is focused on investigating damaged proteins/advanced glycation end-products (AGEs) in the diet.
During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body in the course of digestion. AGEs are associated with the metabolic syndrome and dementia. We aim to identify foods high in AGEs and test the effects of these foods on sensitive measures of metabolic health and cognition in human intervention studies.
In addition we are investigating the role of processing methods in improving food quality e.g. avoiding prolonged heat treatment of dairy products known to increase AGE formation. We are also determining the potential of phytochemicals incorporated into processed foods to ameliorate these negative metabolic outcomes.
This research could lead to the development of new functional foods and improvements to existing food products. It will also provide health professionals and the public with better information on how changes in diet can be beneficial.
This research is part of Scottish Government Strategic Research Programme funded through the Rural and Environment Science and Analytical Services (RESAS) division to advance the evidence base in the development of rural affairs, food and environment policies.
- Teaching
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Teaching Responsibilities
Programme coordinator for MSc Human Nutrition
Course Coordinator for RN5001 Fundamentals of human nutrition and metabolism and RN5003 Foundations of Nutrition.
- Publications
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Identification and partial characterization of Fatty-Acid-Binding Sites in Sheep Placental Membranes
Biochemical Society Transactions, vol. 22, no. 2, pp. S117Contributions to Journals: ArticlesIdentification of a low molecular mass (14.2 kDa) a-tocopherol-binding protein in the cytosol of rat liver and heart
Biochemical and Biophysical Research Communications, vol. 196, no. 3, pp. 1108-1112Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1006/bbrc.1993.2365
A low molecular weight (12-15kDa) protein fraction in rat liver binds alpha-tocopherol
Biochemical Society Transactions, vol. 21, no. 4, pp. 408SContributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1042/bst021408s
Alpha-Tocopherol-Binding Protein in Bovine Heart Cytosol
The FASEB Journal, vol. 7, no. 3Contributions to Journals: Abstracts