This is a past event
Dr Maike de la Roche's talk titled Immune Hedgehog signalling: novel biology and treatment opportunities
Immune Hedgehog signalling: novel biology and treatment opportunities.
Hedgehog is an ancient cell-cell signal transduction pathway known to control embryonic development and adult tissue maintenance. We found that Hedgehog signalling is initiated at the immune synapse of many immune cells and have identified the Hedgehog pathway as a key regulator of various immune responses.
During my talk I will touch upon a novel role for cell-autonomous Hedgehog signalling in Th17 polarisation and pathogenicity and discuss potential treatment opportunities for inflammatory bowel disease.
Furthermore, I will introduce a novel portfolio of immunotherapies, including CAR T cells, that we have generated against the cancer stem cell marker Leucine-rich repeat-containing G-protein receptor 5 (LGR5) for treatment of colorectal cancer.
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Maike completed her veterinary degree in Germany before pursuing her interest in immunology at the NIH, USA. In 2004 Maike moved to Cambridge, UK, to carry out her Doctoral work in the laboratory of Prof. D. T. Fearon at the MRC Laboratory of Molecular Biology and her Postdoctoral work with Prof. G.M. Griffiths at the Cambridge Institute for Medical Research. Maike is a recipient of a Sir Henry Dale Fellowship and started her own lab in 2016.
- Speaker
- Dr Maike de la Roche
- Hosted by
- Prof Lora Heisler
- Venue
- The Rowett Institute
- Contact
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Staff and students only