![Dr Sergiy Sylantyev Dr Sergiy Sylantyev](/img/200x200/staffpages/assets/images/default-profile-picture.jpg)
Lecturer
- About
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- Email Address
- s.sylantyev@abdn.ac.uk
- Office Address
Rowett Institute, University of Aberdeen,
Ashgrove Rd. West, Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated with an MSc in animal and human physiology from the Odesa National University (Odesa, Ukraine) in 1998. After that I began my PhD research project on pharmacological profiles of the ligands of type A receptor of γ-aminobutyric acid (GABAAR) under supervision of Prof. Zinkovsky. This initiated my interest to ionotropic receptors' biophysics, molecular pharmacology and connected modulatory signalling. After gaining a PhD degree in Neuropharmacology in 2002 I worked as a postdoc in several institutions on various projects connected to cellular and molecular neuroscience, focusing on different types of ionotropic receptors. First, under supervision of Dr. Shyu Bai-Chuang (Institute of Biomedical Sciences, Taipei, Taiwan) I studied GABAAR signalling and its modulation in anterior cingulate cortex. Next, in the laboratory of Dr. John Clements (The John Curtin School of Medical Research, Australian National University, Canberra, Australia) I studied the effects of various mutations on signalling properties of the glycine receptor. After that I moved to the UK, where I obtained a Senior Postdoctoral Fellow position in the Queen Square Institute of Neurology (University College London). At this position working in a team led by Prof. Dmitri Rusakov, I was involved in a number of projects connected to fundamental neuroscience, which resulted in several high-profile publications. My first independent Chancellor's Fellow position was in the University of Edinburgh, where from 2014 to 2019 I studied molecular pharmacology and the functional role of spontaneously opening GABAARs in the brain. I joined the University of Aberdeen in 2020, aiming to investigate the role of GABAARs in modulation of appetite and feeding behaviour.
Qualifications
- PhD Pharmacology2002 - Odesa Medical University, Ukraine
- MSc Animal and Human Physiology1998 - Odesa National University, Ukraine
Prizes and Awards
Burgen Scholar Award of Academia Europaea, 2008
- Research
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Research Overview
My current research interests are focused on the impact of GABAAR ligands on feeding behaviour and appetite, with a specific attention to underlying molecular mechanisms. One research direction is a role of GABAAR-mediated signalling in neurons of a specific type (AgRP cells), localized in hypothalamus, in regulation of feeding behaviour. Hypothalamic pool of AgRP cells seems to play a pivotal role in modulation of appetite, with GABAAR-mediated outgoing signalling as the main mechanism of fine tuning of feeding activity. This helps to understand neural mechanisms controlling development of obesity and related disorders (such as a Prader-Willi syndrome). Another focus is on the regulation of GABAAR function by pH fluctuations in the fish brain, and connected changes in feeding of fish species of industrial importance (rainbow trout, Atlantic salmon). The latter research direction, apart from clarification of understudied fundamental mechanisms of pH-mediated neural inhibitory signalling, in a long-term perspective should lead to optimization of fish feeding in aquaculture.
Research Areas
Biological and Environmental Sciences
Biomedical Sciences
Research Specialisms
- Neuroscience
- Zoology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Funding and Grants
Research grants in the University of Aberdeen
The Wellcome Trust ISSF Award, 2020: £20,000. GABAARs control over taste perception
BBSRC Research Grant, 2021 (co-investigator): £457,906. Regulation of feeding by brainstem GABA neurons.
Pump-Prime Interdisciplinary Research Grant, 2021: £10,000. The role of GABAARs in regulation of fish appetite.
- Teaching
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Non-course Teaching Responsibilities
Invited lecturer: University of Edinburgh, course Pharmacology 3.
- Publications
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Biphasic Modulation of NMDA Receptor Function by Metabotropic Glutamate Receptors
Journal of Neuroscience, vol. 38, no. 46, pp. 9840-9855Contributions to Journals: ArticlesFeature Article: Selective modulation of tonically active GABAA receptor functional subgroups by G-proteins and protein kinase C
Experimental Biology and Medicine, vol. 243, no. 13, pp. 1046-1055Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/1535370218800980
Spontaneously opening GABAA receptors play a significant role in neuronal signal filtering and integration
Cell Death & Disease, vol. 9, 813Contributions to Journals: ArticlesGABA A receptors activate fish feeding behaviour via two distinct functional pathways
Journal of Experimental Biology, vol. 221, no. 3, jeb170514Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jeb.170514
Successful worldwide invasion of the veined rapa whelk, Rapana venosa, despite a dramatic genetic bottleneck
Biological Invasions, vol. 20, pp. 3297-3314Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10530-018-1774-4
- [ONLINE] View publication in Scopus
Hemichannel-mediated release of lactate
Journal of Cerebral Blood Flow and Metabolism, vol. 36, no. 7, pp. 1202-1211Contributions to Journals: ArticlesRapa whelk controls demersal community structure off Zmiinyi island, Black sea
Aquatic Invasions, vol. 8, no. 3, pp. 289-297Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3391/ai.2013.8.3.05
- [ONLINE] View publication in Scopus
Sub-millisecond ligand probing of cell receptors with multiple solution exchange
Nature Protocols, vol. 8, no. 7, pp. 1299–1306Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/nprot.2013.075
- [ONLINE] View publication in Scopus
Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses
PNAS, vol. 110, no. 13, pp. 5193-5198Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1211204110
- [ONLINE] View publication in Scopus
GABA-Independent GABAA Receptor Openings Maintain Tonic Currents
Journal of Neuroscience, vol. 33, no. 9, pp. 3905-3914Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1523/JNEUROSCI.4193-12.2013
- [ONLINE] View publication in Scopus