Last modified: 31 May 2022 13:30
This course will cover the principles of toxicology including molecular toxicology and target organ toxicity, mechanisms of cell death, molecular carcinogenesis and safety evaluation of carcinogens, adverse outcome pathways (AOPs) and new alternative methods (NAMs). These elements will be taught around the processes involved in drug discovery and development and will include advanced learning on drug metabolism and drug transporters. The course will also provide the principles and practice of risk assessment and regulatory toxicology. External experts are invited to provide their unique expertise on a range of topics, which include regulatory aspects as well as an industrial perspective on the drug discovery process.
| Study Type | Postgraduate | Level | 5 |
|---|---|---|---|
| Term | First Term | Credit Points | 15 credits (7.5 ECTS credits) |
| Campus | Aberdeen | Sustained Study | No |
| Co-ordinators |
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Topics - Principles of toxicology; target organ toxicity and oxidative stress; molecular toxicology; mechanisms of cell death; molecular and chemical carcinogenesis; use of biomarkers; safety evaluation of carcinogens; drug metabolism and transporters; Risk Assessment; regulatory toxicology.
Information on contact teaching time is available from the course guide.
| Assessment Type | Summative | Weighting | 10 | |
|---|---|---|---|---|
| Assessment Weeks | Feedback Weeks | |||
| Feedback | ||||
| Knowledge Level | Thinking Skill | Outcome |
|---|---|---|
| Conceptual | Evaluate | Describe various types of biomarkers particularly in relation to cancer and cancer therapies |
| Procedural | Evaluate | Discuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies |
| Procedural | Understand | Understand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity |
| Reflection | Create | improved scientific communication |
| Reflection | Evaluate | Evaluating industrial drug research and development and risk assessment |
| Assessment Type | Summative | Weighting | 35 | |
|---|---|---|---|---|
| Assessment Weeks | Feedback Weeks | |||
| Feedback | Word Count | |||
| Knowledge Level | Thinking Skill | Outcome |
|---|---|---|
| Conceptual | Evaluate | Describe various types of biomarkers particularly in relation to cancer and cancer therapies |
| Procedural | Evaluate | Discuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies |
| Procedural | Understand | Understand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity |
| Assessment Type | Summative | Weighting | 40 | |
|---|---|---|---|---|
| Assessment Weeks | 15,17 | Feedback Weeks | 17,19 | |
| Feedback |
Toxicology scenarios There are 2 scenarios and one write up on the methods used in the scenarios. The scenarios have 5 questions for short answers. The write up will select 2 methods used in the scenarios and provide a review of the advantages and disadvantages of these 2 methods. |
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| Knowledge Level | Thinking Skill | Outcome |
|---|---|---|
| Conceptual | Evaluate | Describe various types of biomarkers particularly in relation to cancer and cancer therapies |
| Procedural | Evaluate | Discuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies |
| Procedural | Understand | Understand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity |
| Reflection | Create | improved scientific communication |
| Reflection | Evaluate | Evaluating industrial drug research and development and risk assessment |
| Assessment Type | Summative | Weighting | 15 | |
|---|---|---|---|---|
| Assessment Weeks | Feedback Weeks | |||
| Feedback | ||||
| Knowledge Level | Thinking Skill | Outcome |
|---|---|---|
| Procedural | Evaluate | Discuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies |
| Procedural | Understand | Understand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity |
There are no assessments for this course.
| Knowledge Level | Thinking Skill | Outcome |
|---|---|---|
| Conceptual | Evaluate | Describe various types of biomarkers particularly in relation to cancer and cancer therapies |
| Reflection | Create | improved scientific communication |
| Procedural | Evaluate | Discuss advanced aspects of molecular pharmacology, drug metabolism and stem cell therapies |
| Procedural | Understand | Understand advanced concepts in toxicology, including AOPs, oxidative stress and organ specific toxicity |
| Reflection | Evaluate | Evaluating industrial drug research and development and risk assessment |
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