Last modified: 31 May 2022 13:05
This course introduces a core discipline within drug discovery, namely drug metabolism and pharmacokinetics (DMPK). DMPK is primarily concerned with safety evaluation, drug absorption and how a drug is metabolised. The course will combine an introduction to basic pathways of enzymatic xenobiotic metabolism, the measurement and modelling of drug and metabolite concentrations and the regulatory framework overseeing this stage of drug development.
Study Type | Postgraduate | Level | 5 |
---|---|---|---|
Term | First Term | Credit Points | 15 credits (7.5 ECTS credits) |
Campus | Aberdeen | Sustained Study | No |
Co-ordinators |
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This course provides an introduction to drug metabolism and pharmacokinetics (DMPK). DMPK is primarily concerned with safety evaluation in drug development. In recent times DMPK has become a core discipline within drug discovery, development and post-marketing.
Basic pathways of enzymatic xenobiotic metabolism will be explained. The course will go on to explain standard methodologies for measuring drug and metabolite concentrations in biological fluids (bioanalysis) and to promote an understanding of how this data is modelled using pharmacokinetics. The course will conclude by covering the regulatory requirements and guidance set out by the main government and international agencies that are relevant to conducting this work during pharmaceutical development.
Information on contact teaching time is available from the course guide.
Assessment Type | Summative | Weighting | 25 | |
---|---|---|---|---|
Assessment Weeks | 16 | Feedback Weeks | 18 | |
Feedback |
Written |
Word Count | 1000 |
Knowledge Level | Thinking Skill | Outcome |
---|---|---|
Conceptual | Understand | Understand the key metabolic pathways in vivo. |
Conceptual | Understand | Understand the origins and development of DMPK. |
Procedural | Apply | Understand the key analytical methodology to obtain relevant data for DMPK |
Procedural | Apply | Understand the application of DMPK to drug development. |
Procedural | Evaluate | Basic understanding of DMPK statistical analysis including evaluation of data. |
Assessment Type | Summative | Weighting | 75 | |
---|---|---|---|---|
Assessment Weeks | 19,20 | Feedback Weeks | ||
Feedback |
Written |
Knowledge Level | Thinking Skill | Outcome |
---|---|---|
Conceptual | Understand | Understand the key metabolic pathways in vivo. |
Conceptual | Understand | Understand the origins and development of DMPK. |
Procedural | Apply | Understand the application of DMPK to drug development. |
Procedural | Apply | Understand the key analytical methodology to obtain relevant data for DMPK |
Procedural | Evaluate | Basic understanding of DMPK statistical analysis including evaluation of data. |
There are no assessments for this course.
Assessment Type | Summative | Weighting | 25 | |
---|---|---|---|---|
Assessment Weeks | Feedback Weeks | |||
Feedback |
Written |
Word Count | 1000 |
Knowledge Level | Thinking Skill | Outcome |
---|---|---|
Conceptual | Understand | Understand the key metabolic pathways in vivo. |
Conceptual | Understand | Understand the origins and development of DMPK. |
Procedural | Apply | Understand the key analytical methodology to obtain relevant data for DMPK |
Procedural | Apply | Understand the application of DMPK to drug development. |
Procedural | Evaluate | Basic understanding of DMPK statistical analysis including evaluation of data. |
Assessment Type | Summative | Weighting | 75 | |
---|---|---|---|---|
Assessment Weeks | Feedback Weeks | |||
Feedback |
Written. |
Knowledge Level | Thinking Skill | Outcome |
---|---|---|
Conceptual | Understand | Understand the key metabolic pathways in vivo. |
Conceptual | Understand | Understand the origins and development of DMPK. |
Procedural | Apply | Understand the application of DMPK to drug development. |
Procedural | Apply | Understand the key analytical methodology to obtain relevant data for DMPK |
Procedural | Evaluate | Basic understanding of DMPK statistical analysis including evaluation of data. |
Knowledge Level | Thinking Skill | Outcome |
---|---|---|
Procedural | Apply | Understand the key analytical methodology to obtain relevant data for DMPK |
Conceptual | Understand | Understand the origins and development of DMPK. |
Procedural | Evaluate | Basic understanding of DMPK statistical analysis including evaluation of data. |
Conceptual | Understand | Understand the key metabolic pathways in vivo. |
Procedural | Apply | Understand the application of DMPK to drug development. |
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