Postgraduate Medicine and Therapeutics 2015-2016

This course provides advanced level drug metabolism and includes the importance of drug transporters in the drug discovery process, dealing with molecular toxicology and pharmacology at an advanced level. Mechanisms of drug and oxidative stress and immunopharmacology are described. External experts are invited to provide their unique expertise on a range of topics which can include toxicopathology, immunotoxicology, risk assessment and an industrial perspective on the drug discovery process.

This course is designed to provide or revise the basic skills you will require for your MSc. The course will revise basic laboratory skills and techniques and advance these to a level required to undertake graduate practical classes and projects by developing hands-on experience, competence and confidence in key laboratory skills. An expert for the library will explain the use and facilities of the library and the basics of database searching to enhance research skills and project validation.

This course is designed for Academic Foundation Program (AFP) doctors, although it is also open to any doctor aspiring to clinical academia. You will apply the generic research skills that you learned within MT5026 to a clinical context to further develop your skills towards a career in academic medicine. This course will facilitate your understanding of the important strategies and approaches that will underpin your future research career.

This course covers the principles of drug discovery and describes how drugs are designed to target specific diseases. This includes drugs in cancer, cardiovascular disease, musculo-skeletal disease and immune disease.  An introduction to drug regulation is included.

This course will cover a wide range of topics and will include revision of receptor theory and intra- and inter- cellular communication.  Cancer will be used a s model disease and the molecular basis of cancer, how it is treated, clinical issues, drug resistance and chemotherapy and prevention

This course is designed for Academic Foundation Program (AFP) doctors, although it is also open to any doctor aspiring to clinical academia. You will be provided with training in generic research skills within a clinical context to allow you to develop your skills towards a career in academic medicine. The teaching combines interactive and practical approaches which will facilitate your understanding of the important strategies and approaches that will underpin your future research career.

This course will describe and review the use of medicinal compounds in man together with methods to assess and describe efficacy and toxicity. A number of exemplar disease areas and at risk populations will be selected and the drugs used to treat these conditions and populations discussed and explained. The importance of understand drug mechanisms of action and associated risk as well as benefit will be emphasised in a clinical setting. The course will consider both drugs in current use and those in development.

The will comprise lectures, tutorials and seminars. The curriculum will provide an in-depth look at pharmacovigilance using examples from both first and third world countries and will include detection of adverse drug reactions; causality assessment; prevention of adverse drug reactions including correct prescribing, prevention of drug errors and promotion of rational drug use; and communication of risk-benefit information to the general public.

This course will provide you with an introduction to evidence-based medicine. It will also include a description of the elements of pharmaceutical research as well as of the drug development process.

Pharmacokinetics (PK) is what the body does to the drug and is critical to understanding the use of drugs in man. Toxicokinetics (TK) is the extension of PK to toxic molecules and processes.  The basic parameters of PK and TK are described and explained together with the mathematical equations and modelling.

This course reviews a range of methodologies that are currently used in basic research.  Experts in the various techniques describe the methodology and showcase the equipment.

Pharmacokinetics describe “what the body does to a drug” and thus is a central feature of applied pharmacology. The course will develop an understanding of the role that pharmacokinetics play in all aspects of drug administration, distribution, metabolism and excretion and how these effects can be modelled and predicted graphically and mathematically. Such modelling is a fundament of therapeutic regimen design, drug development, clinical pharmacology and drug safety and will be considered within all of these contexts providing a broad and relevant appreciation of the importance of pharmacokinetics to the pharmacologist

This course offers the student the opportunity to study in depth a topic of interest within the broad area of medical science. Usually the topic and the scope of the essay will be chosen and agreed in collaboration with the course co-ordinator.