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  4. 2014-2015
  5. Medicine and Therapeutics
  6. MT5003: Drug Metabolism & Toxicology

MT5003: DRUG METABOLISM & TOXICOLOGY (2014-2015)

Last modified: 28 Jun 2018 10:27


Course Overview

This course provides advanced level drug metabolism and includes the importance of drug transporters in the drug discovery process. Mechanisms of drug and oxidative stress and immunopharmacology are described. External experts provide detailed teaching on a range of topics which can include toxicopathology, immunotoxicology, reproductive toxicology, risk assessment and an industrial perspective on the drug discovery process.

Course Details

Study Type Postgraduate Level 5
Term First Term Credit Points 15 credits (7.5 ECTS credits)
Campus None. Sustained Study No
Co-ordinators
  • Professor Heather Wallace

What courses & programmes must have been taken before this course?

None.

What other courses must be taken with this course?

None.

What courses cannot be taken with this course?

None.

Are there a limited number of places available?

No

Course Description

Lectures, tutorials and practical classes. Topics - absorption, distribution, metabolism and excretion of drugs. Human drug metabolism - cytochrome P450. Induction/inhibition of cytochrome P450. Identification of cytochrome P450 at an early stage in drug discovery. Pharmacogenetics of human drug metabolism - implication for drug safety in clinical practice. Mechanisms of drug induced toxicity: reactive metabolites; glutathoine conjugate-mediated toxicity; cytoprotective mechanisms; agents conferring protection against drug toxicity - clinical applications; mechanisms of cell death; apoptosis and necrosis. Target organ toxicity. Toxicology of specified organ systems. Clinical biochemistry of drug toxicity. Pathology of drug toxicity. Haematological indices of drug toxicity.

Contact Teaching Time

Information on contact teaching time is available from the course guide.

Teaching Breakdown

More Information about Week Numbers


Details, including assessments, may be subject to change until 30 August 2024 for 1st term courses and 20 December 2024 for 2nd term courses.

Summative Assessments

Continues assessment 50% (essay (15%), practical 1 (10%), practical 2 (15%), presentation (10%); written examination 50%.

Formative Assessment

There are no assessments for this course.

Feedback

None.

Course Learning Outcomes

None.
 

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