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  5. Medicine and Therapeutics
  6. MT5003: Drug Metabolism & Toxicology

MT5003: DRUG METABOLISM & TOXICOLOGY (2018-2019)

Last modified: 22 May 2019 17:07


Course Overview

This course provides advanced level learning in drug metabolism, discovery and development. It includes the importance of drug transporters in the drug discovery process, regulatory issues and molecular toxicology and pharmacology at an advanced level. Mechanisms of drug-induced and oxidative stress and immunopharmacology are described. External experts are invited to provide their unique expertise on a range of topics which can include toxicopathology, immunotoxicology, risk assessment and an industrial perspective on the drug discovery process.

Course Details

Study Type Postgraduate Level 5
Term First Term Credit Points 15 credits (7.5 ECTS credits)
Campus None. Sustained Study No
Co-ordinators
  • Professor Heather Wallace

What courses & programmes must have been taken before this course?

  • One of MRes Drug Discovery or MSc Clinical Pharmacology or MSc Drug Discovery and Development or Master Of Science In Molecular Medicine or MSc Bio-Business and Medical Sciences or Master Of Research In Medical Sciences or Master Of Science In Reproductive And Developmental Biology

What other courses must be taken with this course?

None.

What courses cannot be taken with this course?

None.

Are there a limited number of places available?

No

Course Description

Topics include absorption, distribution, metabolism, excretion and transport of drugs.

Human drug metabolism - cytochrome P450.

Induction/inhibition of cytochrome P450.

Identification of cytochrome P450 and transporters at an early stage in drug discovery.

Mechanisms of drug induced toxicity: reactive metabolites; cytoprotective mechanisms; agents conferring protection against drug toxicity - clinical applications; mechanisms of cell death; apoptosis and necrosis.

Immunotoxicology and risk assessment.

Pathology of drug toxicity.

Haematological indices of drug toxicity.


Contact Teaching Time

Information on contact teaching time is available from the course guide.

Teaching Breakdown

More Information about Week Numbers


Details, including assessments, may be subject to change until 30 August 2024 for 1st term courses and 20 December 2024 for 2nd term courses.

Summative Assessments

Individual lab report (20%); Editorial (15%); Debate (15%); Examination (50%).

Formative Assessment

There are no assessments for this course.

Feedback

None.

Course Learning Outcomes

None.
 

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