Claudiu Giuraniuc has a BSc in Physics from “Al.I. Cuza” University, Iasi, Romania and a MSc in Physics from Lille 1 University, France. He obtained a PhD in Physics in 2006 from Katholieke Universiteit Leuven, Belgium. He has experience in mathematical modeling, computer simulations, microfabrication, image analysis and cell tracking.
After his PhD he worked in the field of biological and medical research, acquiring also knowledge of molecular biology techniques, microfluidics and microscopy. He was a post-doc in the Interdisciplinary Research Institute, Lille, France and in Institute of Systems & Synthetic Biology, Evry, France.
Since 2010 he works at the University of Aberdeen on gene regulatory networks modelling and analysis, microfluidics, microbiology, medical image analysis and electrophysiology.
Microfluidics, also called lab-on-a-chip or organ-on-a-chip, is a state-of-the-art technology which offers tremendous experimental possibilities. Cells can be cultured in miniaturized culture chambers and their behaviour observed in real-time for extended periods using complex conditions in which chemical gradients, electrical stimulation and recording, mechanical stress and drug exposure are varied.
Mathematical modelling plays an increasingly important role in biology. It allows exploration of a wide range of parameters, sometimes even outside experimental possibilities. Conclusions drawn from modelling inform experimental choices, revealing unexpected properties while saving time and resources.
Funding and Grants
PI:
2021-2022: “Microfluidic tools for personalized medicine” - NHS Endowment grant -£11,964.48
2021: “Novel experimental possibilities trough active involvement with microfluidic culture chambers manufacturers” - Knowledge Exchange and Commercialisation Award - £5,900), together with ibidi® as industrial partner.
Co-I:
2021-2022: “Novel nanoparticle-embedded membranes for long-term bioactive SARS-CoV-2 prevention” - NHS Endowment grant, PI - Dr. Alfonso Martinez-Felipe - £11,602
2019: “Development of microfluidic devices for nerve-muscle co-cultures as a multimodal test platform for neuro-muscular function and disease studies” - “Investment in School PIs” internal IMS funding competition, PI - Dr. Guy Bewick - £4,800.
Positive feedback regulation of fzd7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate
Subregional statistical shape modelling identifies lesser trochanter size as a possible risk factor for radiographic hip osteoarthritis, a cross-sectional analysis from the Osteoporotic Fractures in Men Study
Faber, B., Bredbenner, T., Baird, D., Gregory, J., Saunders, F., Giuraniuc, C., Aspden, R., Lane, N., Orwoll, E., Tobias, J.
Osteoarthritis and Cartilage, vol. 28, no. 8, pp. 1071-1078
Identification of Novel Loci Associated With Hip Shape: A Meta‐Analysis of Genomewide Association Studies
Baird, D. A., Evans, D. S., Kamanu, F. K., Gregory, J. S., Saunders, F. R., Giuraniuc, C. V., Barr, R. J., Aspden, R. M., Jenkins, D., Kiel, D. P., Orwoll, E. S., Cummings, S. R., Lane, N. E., Mullin, B. H., Williams, F. M., Richards, J. B., Wilson, S. G., Spector, T. D., Faber, B. G., Lawlor, D. A., Grundberg, E., Ohlsson, C., Pettersson-Kymmer, U., Capellini, T. D., Richard, D., Beck, T. J., Evans, D. M., Paternoster, L., Karasik, D., Tobias, J. H.
Journal of Bone and Mineral Research, vol. 34, no. 2, pp. 241-251
Investigation of the Relationship Between Susceptibility Loci for Hip Osteoarthritis and Dual X‐Ray Absorptiometry–Derived Hip Shape in a Population‐Based Cohort of Perimenopausal Women
Baird, D. A., Paternoster, L., Gregory, J. S., Faber, B. G., Saunders, F. R., Giuraniuc, C. V., Barr, R. J., Lawlor, D. A., Aspden, R. M., Tobias, J. H.
Arthritis & Rheumatology, vol. 70, no. 12, pp. 1984-1993
The genetic architecture of hip statistical shape models suggests that endochondral bone formation makes an important contribution to hip shape
Baird, D., Evans, D. S., Gregory, J. S., Saunders, F. R., Giuraniuc, C. V., Barr, R. J., Aspden, R. M., Kamanu, F. K., Kiel, D. P., Orwoll, E. S., Cummings, S. R., Lane, N. E., Mullins, B. H., Williams, F. M., Richards, B., Wilson, S. G., Spector, T. D., Faber, B. G., Lawlor, D. A., Beck, T. J., Evans, D. M., Paternoster, L., Karasikl, D., Tobias, J. H.
OARSI World Congress on Osteoarthritis - Promoting Clinical and Basic Research in Osteoarthritis, pp. S157-S157
