Lecturer
- Email Address
- tara.sutherland@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated with a BSc with Honours degree from the University of Melbourne in Australia before embarking on PhD in Pharmacology studying oestrogen metabolites in cancer using breast tumour models. After a stint studying ligand-receptor modelling at Monash University, I moved to Edinburgh to begin learning all about immunology and how the lung responds to infections, allergens and injury.
I obtained an Asthma UK and Medical Research Fellowship and moved to the University of Manchester to develop and utilise models of allergic airway pathology to study immune responses and extracellular matrix remodelling in the lung. In 2022, I joined the University of Aberdeen, have a fantastic and growing research group who work on a central lab theme of uncovering key immuno-matrix networks that contribute to keeping our lungs healthy or drive development of disease.
Join our lab as a funded Post-Doc to study immune-ECM crosstalk in the lung
We have an open position to join the lab in Aberdeen as a PDRA studying IL-13 regulation of hyaluronan matrices in the lung during health, infection, injury/repair and fibrosis. Working closely with a very collaborative team (University of Manchester and University of Virginia), work on cutting edge technologies and work toward developing spatial transcriptomic and proteomic datasets of immune-ECM networks in the lung. See the advert and reach out to discuss more.
Latest Publications
Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 Embryos
Parkinson, J. E., Baldwin, G. E., Papotto, P. H., Humphreys, N. E., Adamson, A. D., Allen, J. E., Sutherland, T. E.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.1101/2025.03.10.642405
An optimised faecal microRNA sequencing pipeline reveals fibrosis in Trichuris muris infection
Layton, E., Goldsworthy, S., Yang, E., Ong, W. Y., Sutherland, T. E., Bancroft, A. J., Thompson, S., Au, V. B., Griffiths-Jones, S., Grencis, R. K., Fairhurst, A., Roberts, I. S.Nature Communications, vol. 16, 1589Contributions to Journals: ArticlesInjury From Nematode Lung Migration Induces an IL-13-Dependent Hyaluronan Matrix
Dodd, R., Moffatt, D., Vachiteva, M., Parkinson, J. E., Chan, B., Day, A. J., Allen, J. E., Sutherland, T.Proteoglycan Research, vol. 2, no. 4, e70012Contributions to Journals: ArticlesExtracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation
Parkinson, J. E., Ghafoor, M., Dodd, R. J., Tompkins, H. E., Fergie, M., Rattray, M., Allen, J. E., Sutherland, T. E.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.1101/2024.11.15.623782
IL-13 MODULATES THE HYALURONAN MATRIX FOLLOWING INJURY BY THE LUNG MIGRATING NEMATODE NIPPOSTRONGYLUS BRASILIENSIS
Sutherland, T.Proteoglycan ResearchContributions to Journals: Articles
Research Overview
The extracellular matrix (ECM) is the non-cellular part in all tissues and organs and is made up of molecules like glycosaminoglycans & proteoglycans (e.g. hyaluronan, chondroitin sulphate, heparin sulphate), fibrous proteins (e.g. collagen, elastin) and mucins. More than just physical architectural scaffold within our tissues, the matrix is biologically active with many functions including the ability to direct cell migration and influence cell function. In turn, tissues and immune cells provide critical cues that work together to maintain a healthy tissue matrix. However, if communication and interactions between the matrix and cells is compromised in light of infections, injury, inflammation or insults, tissue pathology ensues.
The Sutherland lab studies specifically focus on the lung, working at the interface between immunology and extracellular matrix biology. Our vision is to improve respiratory health by identifying the interactions between the physical tissue environment (e.g. ECM) and our immune system and why these interactions go wrong during disease.
The lab has diverse experience, inclusive and supportive environment that allows for imaginative research. I’m a big believer in providing a variety of career development opportunities and helping people succeed in their own goals.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Allergy
- Biological Sciences
- Biomedical Sciences
- Immunology
- Pathology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
Our team includes senior post-doc Matthew Burgess, PhD students Morgan Bryant and Andrew Love, and is held together with excellent technical help from Megan Robertson. Projects are supported by generous funding from Medical Research Scotland, University of Aberdeen Development Trust, Medical Research Council and Wellcome Trust. We use a range of cutting-edge technologies, bioinformatic analysis and immunological, biochemical assays that enable us to explore the lung tissue environment in various projects outlined below.
IL-13-hyaluronan axis during lung infection, injury, repair and fibrosis
The type 2 arm of the immune response is associated with both helminth infections and allergic inflammation but also critical in orchestrating tissue repair and fibrosis. However, we recently found that type 2 cytokine IL-13 as a driver of severe COVID-19 pathology through regulation of ECM component hyaluronan. Now we have funding from long-term funding Wellcome to mechanistically understand the IL-13-hyaluronan axis in the lungs, and why this pathway is important in pulmonary diseases. We are looking for a post-doc to join the team and work closely with collaborators at University of Manchester (Judi Allen, Tony Day and Tracy Hussell) and University of Virginia (William Petri). Lots of exciting potential to use spatial transcriptomics, high-dimensional imaging, and 3D cultures. Get in touch to discuss more - tara.sutherland@abdn.ac.uk.
Immunostaining for hyaluronan (green) in the lungs from patients with or without
COVID-19. Donlan et al (2021) JCI Insights.Pathological matrix remodelling asthma: role for chitinase-like proteins, macrophages and fibroblasts.
Chitinase-like proteins (CLPs) are highly expressed during inflammation, tissue injury/repair and fibrosis. During helminth parasite infection, CLPs regulate immune responses and drive tissue repair. However, in more chronic settings like allergic airway pathology akin to asthma in people, CLPs are responsible for ECM remodelling in the lung, independent of effects on the adaptive immune response. Using animal models, human lung tissue resection, 3D lung slice cultures and a range of sophisticated techniques (e.g. microscopy, flow cytometry, scRNAseq, qPCR) we are exploring how CLPs influence the matrix, with a focus on macrophage-fibroblast cross-regulation. See our preprint that describes the ability of CLPs to influence ECM remodelling
Increased expression of murine CLPs Ym1 and Ym2
following chronic administration of a cocktail of allergens
(DRA). Parkinson et al (2021) Immune Cell Biol.Characterising fibroblast dynamics during immune responses and lung pathology.
Fibroblasts are the most abundant cells within the tissue stroma, probably best known for their roles in synthesising and regulating the ECM. However, fibroblasts can also influence immune responses directly or indirectly. Conversely immune cells influence fibroblast function. We are using 3D lung slice cultures, advanced imaging and more traditional methods to investigate the different types of fibroblast populations found in the lung and whether the communication between fibroblasts and macrophages are influence by specific ECM environments.
Role of vascular remodelling in immune responses during allergic airway pathology
The airway vasculature serves many vital functions in maintaining lung health. However, during disease remodelling of the cells and matrix within and surrounding the vasculature will likely contribute inappropriate immune responses, and remodelling and hyper-reactivity of the airway during broncho-constriction. We are interested in understanding how pathogenic vascular remodelling changes the ability of the host to mount an appropriate immune response when faced with numerous challenges.
New analysis approaches to study ECM-cell interactions spatially in the tissue
New preprint shows cellular and ECM organisation in the lung during allergic pathology using imaging mass cytometry. We used methods to integrate analysis of cell segmentation and spatial ECM composition to ask questions about the lung environment during health versus pathology and how cell-cell and cell-ECM organisation changes.
Supervision
My current supervision areas are: Biomedical Sciences.
Current PhD students in the lab
James Parkinson - University of Manchester (part-time started in 2022)
Morgan Bryant - University of Aberdeen (started in 2023)
Andrew Love - University of Aberdeen (started in 2024)
Constantin Doerner - University of Aberdeen with Karolin Hijazi's lab (started in 2024)Recently graduated
Dr Hannah Tompkins - Wellcome Trust Immuno-matrix in complex disease; University of Manchester
Hannah recently passed her viva without corrections and was the first graduate of the Sutherland Lab!Funding and Grants
Medical Research Scotland (Jan 2024- July 2025) - Using human and mouse 3D lung tissue cultures to study immune cells and extracellular matrix organisation
Medical Research Council (April 2024 - April 2027) - Cell-matrix cross-talk in lung pathology and the role of chitinase-like proteins
Wellcome Discovery Award (Feb 2025 - Feb 2031) - Immune regulation of the hyaluronan matrix during lung infection, injury and repairPage 1 of 1 Results 1 to 44 of 44
Generation of a Ym1 Deficient Mouse utilising CRISPR-Cas9 in CB6 Embryos
Parkinson, J. E., Baldwin, G. E., Papotto, P. H., Humphreys, N. E., Adamson, A. D., Allen, J. E., Sutherland, T. E.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.1101/2025.03.10.642405
An optimised faecal microRNA sequencing pipeline reveals fibrosis in Trichuris muris infection
Layton, E., Goldsworthy, S., Yang, E., Ong, W. Y., Sutherland, T. E., Bancroft, A. J., Thompson, S., Au, V. B., Griffiths-Jones, S., Grencis, R. K., Fairhurst, A., Roberts, I. S.Nature Communications, vol. 16, 1589Contributions to Journals: ArticlesInjury From Nematode Lung Migration Induces an IL-13-Dependent Hyaluronan Matrix
Dodd, R., Moffatt, D., Vachiteva, M., Parkinson, J. E., Chan, B., Day, A. J., Allen, J. E., Sutherland, T.Proteoglycan Research, vol. 2, no. 4, e70012Contributions to Journals: ArticlesExtracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation
Parkinson, J. E., Ghafoor, M., Dodd, R. J., Tompkins, H. E., Fergie, M., Rattray, M., Allen, J. E., Sutherland, T. E.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.1101/2024.11.15.623782
IL-13 MODULATES THE HYALURONAN MATRIX FOLLOWING INJURY BY THE LUNG MIGRATING NEMATODE NIPPOSTRONGYLUS BRASILIENSIS
Sutherland, T.Proteoglycan ResearchContributions to Journals: ArticlesThe IL-17A-neutrophil axis promotes epithelial cell IL-33 production during nematode lung migration
Ajendra, J., Papotto, P. H., Parkinson, J. E., Dodd, R. J., Bombeiro, A. L., Pearson, S., Chan, B. H., Ribot, J. C., McSorley, H. J., Sutherland, T. E., Allen, J. E.Mucosal Immunology, vol. 16, no. 6, pp. 767-775Contributions to Journals: ArticlesAllergen-induced airway matrix remodelling in mice can be prevented or reversed by targeting chitinase-like proteins
Parkinson, J. E., Adamson, A., MacDonald, A. S., Allen, J. E., Sutherland, T. E.Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.08.18.553857
The extracellular matrix and the immune system: A mutually dependent relationship
Sutherland, T. E., Dyer, D. P., Allen, J. E.Science, vol. 379, no. 6633, eabp8964Contributions to Journals: Review articlesTaming the neutrophil: Balance between anti‐parasite defence and pathogenesis
Sutherland, T. E., Steen, P. E. V. d.Parasite Immunology, e12923Contributions to Journals: ArticlesA Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease
Ebner, F., Lindner, K., Janek, K., Niewienda, A., Malecki, P., Weiss, M., Sutherland, T., Heuser, A., Kühl, A., Zentek, J., Hofmann, A., Hartmann, S.Journal of Immunology Research, vol. 2021, 234836,Contributions to Journals: ArticlesIL-13 is a driver of COVID-19 severity
Donlan, A. N., Sutherland, T. E., Marie, C., Preissner, S., Bradley, B. T., Carpenter, R. M., Sturek, J. M., Ma, J. Z., Moreau, G. B., Donowitz, J. R., Buck, G. A., Serrano, M. G., Burgess, S. L., Abhyankar, M. M., Mura, C., Bourne, P. E., Preissner, R., Young, M. K., Lyons, G. R., Loomba, J. J., Ratcliffe, S. J., Poulter, M. D., Mathers, A. J., Day, A. J., Mann, B. J., Allen, J. E., Jr, W. A. P.JCI Insight, vol. 6, no. 15, 150107Contributions to Journals: ArticlesOngoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity
Sutherland, T. E., Shaw, T. N., Lennon, R., Herrick, S. E., Rückerl, D.Frontiers in Immunology, vol. 12, 715209Contributions to Journals: ArticlesThe magnitude of airway remodeling is not altered by distinct allergic inflammatory responses in BALB/c versus C57BL/6 mice but matrix composition differs
Parkinson, J. E., Pearson, S., Rückerl, D., Allen, J. E., Sutherland, T. E.Immunology and Cell Biology, vol. 99, no. 6, pp. 640-655Contributions to Journals: ArticlesIL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection
Chenery, A., Rosini, S., Parkinson, J. E., Ajendra, J., Herrera, J., Lawless, C., Chan, B. H. K., Loke, P., MacDonald, A. S., Kadler, K. E., Sutherland, T. E., Allen, J. E.Life Science Alliance, vol. 4, no. 8, e202001000Contributions to Journals: ArticlesThe magnitude of airway remodelling is not altered by distinct allergic inflammatory responses in BALB/c vs C57BL/6 mice but matrix composition differs
Parkinson, J. E., Pearson, S., Rückerl, D., Allen, J. E., Sutherland, T. E.Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2020.10.20.347096
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection
Chenery, A., Rosini, S., Parkinson, J., Herrera, J., Lawless, C., Chan, B., Loke, P., MacDonald, A., Kadler, K., Sutherland, T., Allen, J.Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2020.10.14.337949
IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type 2 immune response to nematode infection
Ajendra, J., Chenery, A., Parkinson, J., Chan, B., Pearson, S., Colombo, S., Boon, L., Grencis, R., Sutherland, T., Allen, J.Mucosal Immunology, vol. 13, pp. 958–968Contributions to Journals: ArticlesInflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung
Chenery, A. L., Alhallaf, R., Agha, Z., Ajendra, J., Parkinson, J. E., Cooper, M. M., Chan, B. H. K., Eichenberger, R. M., Dent, L. A., Robertson, A. A. B., Kupz, A., Brough, D., Loukas, A., Sutherland, T. E., Allen, J. E., Giacomin, P. R.Journal of Immunology, vol. 203, no. 10, pp. 2724-2734Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.4049/jimmunol.1900640
Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung
Chenery, A. L., Alhallaf, R., Agha, Z., Ajendra, J., Parkinson, J., Cooper, M., Chan, B., Eichenberger, R., Dent, L., Robertson, A., Kupz, A., Brough, D., Loukas, A., Sutherland, T., Allen, J., Giacomin, P.Working Papers: Preprint Papers- [ONLINE] http://biorxiv.org/content/early/2019/06/07/606392.abstract
- [ONLINE] DOI: https://doi.org/10.1101/606392
Crystal-clear treatment for allergic disease: Protein crystals could be targeted therapeutically to treat allergic pathology
Allen, J. E., Sutherland, T. E.Science, vol. 364, no. 6442, pp. 738-739Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1126/science.aax6175
A helminth chitinase structurally similar to mammalian chitinase displays immunomodulatory properties
Ebner, F., Balster, K., Janek, K., Niewienda, A., Malecki, P. H., Weiss, M. S., Sutherland, T. E., Heuser, A., Kühl, A. A., Zentek, J., Hofmann, A., Hartmann, S.Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/641837
The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation
Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H., Madsen, J., Evans, C. M., Sutherland, T. E., Ivens, A. C., Thornton, D. J., Grencis, R. K., Hussell, T., Cunoosamy, D. M., Cook, P. C., MacDonald, A. S.Nature Immunology, vol. 20, no. 5, pp. 571-580Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41590-019-0352-y
Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection
Sutherland, T. E., Rückerl, D., Logan, N., Duncan, S., Wynn, T. A., Allen, J. E.PLoS Pathogens, vol. 14, no. 11, : e1007423Contributions to Journals: ArticlesChitinase-like proteins as regulators of innate immunity and tissue repair: helpful lessons for asthma?
Sutherland, T.Biochemical Society Transactions, vol. 46, no. 1, pp. 145-151Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/BST20170108
Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver
Minutti, C. M., Jackson-Jones, L. H., Garcia-Fojeda, B., Knipper, J. A., Sutherland, T., Logan, N., Rinqvist, E., Guillamat-Prats, R., Ferenbach, D. A., Artigas, A., Stamme, C., Chroneos, Z. C., Zaiss, D. M., Casals, C., Allen, J.Science, vol. 356, no. 6342, pp. 1076-1080Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1126/science.aaj2067
Macrophage Origin Limits Functional Plasticity in Helminth-Bacterial Co-infection
Ruckerl, D., Campbell, S. M., Duncan, S., Sutherland, T., Jenkins, S. J., Hewitson, J. P., Barr, T. A., Jackson-Jones, L. H., Maizels, R. M., Allen, J.PLoS Pathogens, vol. 13, no. 3Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.ppat.1006233
IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha
Jackson-Jones, L. H., Rückerl, D., Svedberg, F., Duncan, S., Maizels, R. M., Sutherland, T. E., Jenkins, S. J., McSorley, H. J., Bénézech, C., MacDonald, A. S., Allen, J. E.European Journal of Immunology, vol. 46, no. 10, pp. 2311–2321Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/eji.201646442
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair.
Knipper, J. A., Willenborg, S., Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T., Munitz, A., Rothenberg, M. E., Niehoff, A., Richardson, R., Hammerschmidt, M., Allen, J. E., Eming, S. A.Immunity, vol. 43, no. 4, pp. 803-816Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.immuni.2015.09.005
IL-17 and neutrophils: unexpected players in the type 2 immune response.
Allen, J. E., Sutherland, T., Ruckerl, D.Current Opinion in Immunology, vol. 34, pp. 99-106Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.coi.2015.03.001
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Cook, P., Owen, H., Deaton, A. M., Borger, J. G., Brown, S., Clouaire, T., Jones, G., Jones, L. H., Lundie, R. J., Marley, A. K., Morrison, V. L., Phythian-Adams, A., Wachter, E., Webb, L., Sutherland, T., Thomas, G. D., Grainger, J. R., Selfridge, J., McKenzie, A. N. J., Allen, J., Fagerholm, S. C., Maizels, R. M., Ivens, A. C., Bird, A., MacDonald, A. S.Nature Communications, vol. 6, 6920Contributions to Journals: ArticlesA dominant role for the methyl-CpG-binding protein Mbd2 in controlling dendritic cell induction of type-2 inflammation
Cook, P. C., Owen, H., Deaton, A. M., Borger, J. G., Brown, S., Clouaire, T., Jones, G., Jones, L. H., Lundie, R. J., Marley, A., Morrison, V. L., Phythian-Adams, A., Wachter, E., Webb, L., Sutherland, T. E., Thomas, G. D., Grainger, J., Selfridge, J., McKenzie, A. N. J., Allen, J. E., Fagerholm, S. C., Maizels, R. M., Ivens, A. C., Bird, A., Macdonald, A.Immunology, vol. 143, pp. 41-42Contributions to Journals: AbstractsUncoupling of inflammatory responses in hookworm induced emphysema
Ringqvist, E., Sutherland, T., Duncan, S., Logan, N., Harcus, Y., Maizels, R., Allen, J.Immunology, vol. 143, pp. 164-165Contributions to Journals: AbstractsChitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.
Sutherland, T., Logan, N., Ruckerl, D., Humbles, A. A., Allan, S., Papayannopoulos, V., Stockinger, B., Maizels, R. M., Allen, J.Nature Immunology, vol. 15, no. 12, pp. 1116-1125Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ni.3023
Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin.
Allen, J., Sutherland, T.Seminars in Immunology, vol. 26, no. 4, pp. 329-340Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.smim.2014.06.003
Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
Osborne, L. C., Monticelli, L. A., Nice, T. J., Sutherland, T., Siracusa, M. C., Hepworth, M. R., Tomov, V. T., Kobuley, D., Tran, S. V., Bittinger, K., Bailey, A. G., Laughlin, A. L., Boucher, J., Wherry, E. J., Bushman, F. D., Allen, J., Virgin, H. W., Artis, D.Science, vol. 345, no. 6196, pp. 578-582Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1126/science.1256942
- [ONLINE] View publication in Scopus
Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo.
Ruckerl, D., Jenkins, S. J., Laqtom, N. N., Gallagher, I. J., Sutherland, T., Duncan, S., Buck, A. H., Allen, J.Blood, vol. 120, no. 11, pp. 2307-2316Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2012-02-408252
Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus: Immunomodulation
McSorley, H. J., O'Gorman, M. T., Blair, N., Sutherland, T. E., Filbey, K. J., Maizels, R. M.European Journal of Immunology, vol. 42, no. 10, pp. 2667-2682Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/eji.201142161
- [ONLINE] View publication in Scopus
Analyzing airway inflammation with chemical biology
Sutherland, T., Andersen, O. A., Betou, M., Eggleston, I. M., Maizels, R. M., van Aalten, D., Allen, J.Chemistry & Biology, vol. 18, no. 5, pp. 569-579Contributions to Journals: ArticlesAnimal models of airway inflammation and airway smooth muscle remodelling in asthma
Allen, J. E., Bischof, R. J., Sucie Chang, H., Hirota, J. A., Hirst, S. J., Inman, M. D., Mitzner, W., Sutherland, T.Pharmacology & Therapeutics, vol. 22, no. 5, pp. 455-465Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pupt.2009.04.001
Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies
Maizels, R. M., Sutherland, T., Allen, J. E.Clinical & experimental allergy, vol. 39, no. 7, pp. 943-955Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2222.2009.03243.x
Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice
Langenbach, S. Y., Wheaton, B. J., Fernandes, D. J., Jones, C., Sutherland, T. E., Wraith, B. C., Harris, T., Schuliga, M. J., McLean, C., Stewart, A. G.Canadian Journal of Physiology and Pharmacology, vol. 85, no. 7, pp. 727-738Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1139/Y07-065
2-Methoxyestradiol - a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents
Sutherland, T. E., Anderson, R. L., Hughes, R. A., Altmann, E., Schuliga, M., Ziogas, J., Stewart, A. G.Drug Discovery Today, vol. 12, no. 13-14, pp. 577-584Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.drudis.2007.05.005
2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer
Sutherland, T. E., Schuliga, M., Harris, T., Eckhardt, B. L., Anderson, R. L., Quan, L., Stewart, A. G.Clinical Cancer Research, vol. 11, no. 5, pp. 1722-1732Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-04-1789
The potential and suitability of 2-methoxyestradiol in cancer therapy: multiple letters
Sidor, C., D'Amato, R., Miller, K., Stewart, A., Sutherland, T., Schuliga, M., Harris, T., Quan, L., McAllister, D., Pool, B., Eckhardt, B., Anderson, R.Clinical Cancer Research, vol. 11, no. 16, pp. 6094-6096Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-05-0724
- [ONLINE] View publication in Scopus
