Dr Thomas Baddeley
Senior Research Fellow
- About
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- Telephone Number
- +44 (0)1224 274238
- School/Department
- School of Natural and Computing Sciences
- Research
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Research Overview
The development and use of new analytical methods in the study of small organic molecules undergoing clinical evaluation.
The synthesis and study of novel organic compounds for use as potential drug candiates and excipients.
The study of the physical properties of novel oligosaccharides
- Publications
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Page 1 of 1 Results 1 to 33 of 33
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesConcentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519Contributions to Journals: ArticlesConcentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946Contributions to Journals: ArticlesCrystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton-structural comparisons with reported tetrahydrobenz[e]indene derivatives
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 74, no. 9, pp. 649-663Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1515/znb-2019-0094
- [ONLINE] View publication in Scopus
N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry
Acta Crystallographica Section E: Crystallographic Communications, vol. 75, no. 4, pp. 516-523Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S2056989019003980/hb7809Isup3.cml
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12442/1/hb7809.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives
Journal of Molecular Structure, vol. 1178, pp. 655-668Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.molstruc.2018.10.030
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements
Steroids, vol. 140, pp. 92-103Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.steroids.2018.09.010
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131Contributions to Journals: ArticlesA Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
Frontiers in Molecular Neuroscience, vol. 10, 447Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
Structural studies of (E)-2-(benzylidene)-1- tetralone derivatives: Crystal structures and Hirshfeld surface analysis
Zeitschrift fur Kristallographie - Crystalline Materials, vol. 232, no. 10, pp. 697-718Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1515/zkri-2017-2048
- [ONLINE] View publication in Scopus
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development
Frontiers in Immunology, vol. 8, 1361Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fimmu.2017.01361
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9601/1/fimmu_08_01361.pdf
Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives
Journal of Molecular Structure, vol. 1128, pp. 579-589Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.molstruc.2016.09.021
Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease
Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1124/jpet.114.219352
Tautomers and polymorphs of pyrazolinone derivatives, generated from reactions of arylhydrazines, ArNHNH2, with 1,3-dicarbonyl compounds
Zeitschrift fur Kristallographie, vol. 228, no. 2, pp. 77-91Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1524/zkri.2013.1575
- [ONLINE] View publication in Scopus
New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes
Patents: PatentsVariation in supramolecular arrangements of hydrazones, o-H2NC6H4CMe=NNHC6H4X (X = H, o-, m- and p-NO2), derived from o-aminoacetophenone and phenylhydrazines
Journal of Molecular Structure, vol. 1020, pp. 16-22Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.molstruc.2012.04.023
1,3-Diphenyl-4,5-dihydro-1H-pyrazol-5-one
Acta Crystallographica Section E: Structure Reports Online, vol. E68, pp. o1016-o1017Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S1600536812009567
3,7-diamino-10H-phenothiazine salts and their use: WO2007110627
Patents: Patents(Pyrazinecarbonyl)hydrazone halobenzaldehydes: Supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions
Zeitschrift fur Kristallographie, vol. 224, no. 10, pp. 506-514Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1524/zkri.2009.1182
- [ONLINE] View publication in Scopus
2-Hydroxyacetophenone arylhydrazones. Supramolecular arrangements based on C–H · · · O(H), CH · · · O(NO), N–H · · · O(H), N–H · · · O(NO), C–H · · · π or π · · · π interactions
Zeitschrift für Kristallographie, vol. 224, no. 4, pp. 213-224Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1524/zkri.2009.1121
Synthesis of Per- and Poly Substituted Trehalose Derivatives: Studies of Properties Relevant to Their Use as Excipients for Controlled Drug Release
Journal of Carbohydrate Chemistry, vol. 28, no. 4, pp. 198-221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/07328300902887672
Methods of synthesis and/or purification of diaminophenothiazinium compounds
Patents: PatentsStudies of distannylated-1,2-dithiolato compounds: Synthesis of 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-thiones, (R3SnCH2)(2)(dmit), and 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-ones, (R3SnCH2)(2)(dmio) - Crystal structures of (Ph3SnCH2)(2)(dmit) and (Ph3SnCH2)(2)(dmio)
Journal of Organometallic Chemistry, vol. 692, no. 25, pp. 5583-5588Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jorganchem.2007.09.008
Co-crystallised alpha- and beta-Anomers of 2,3,4,6-Tetra-acetyl-D-glucopyranose, in which the alpha- and beta-Anomers are Randomly Distributed in the Hydrogen-bonded Chains of Molecules
Journal of Chemical Crystallography, vol. 37, no. 12, pp. 853-858Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10870-007-9259-9
A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry
Tetrahedron, vol. 62, pp. 8770-8778Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.tet.2006.06.102
1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranuronic acid monohydrate at 120 K and anhydrous 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose at 292 K
Acta Crystallographica Section C, Crystal Structure Communications, vol. 61, no. 12, pp. o711-o714Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S0108270105034979
Supramolecular structures of substituted a,a'-trehalose derivatives
Acta Crystallographica Section B, Structural Science, vol. B60, no. 4, pp. 461-471Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S0108768104010912
Disordered 2,2 ',3,3 ',4,6,6 '-hepta-O-pivaloyl-alpha,alpha '-trehalose
Acta Crystallographica Section E: Structure Reports Online, vol. 59, pp. 753-755Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S1600536803009474
Disordered 4,4 '-di-O-isobutyroyl-2,2 ',-3,3 ',6,6 '-hex-O-acetyl-alpha,alpha '-trehalose
Acta Crystallographica Section E: Structure Reports Online, vol. 59, pp. o848-o850Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S1600536803010729
Ethyl 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranuronate
Journal of Chemical Crystallography, vol. 33, pp. 33-38Contributions to Journals: ArticlesDitrityl alpha,alpha-trehalose hexaacetate
Acta Crystallographica Section E: Structure Reports Online, vol. 58, no. 5, pp. o476-o477Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S1600536802005408
1,2,3,4-Tetra-O-acetyl-alpha-D-glucopyranuronamide
Acta Crystallographica Section E: Structure Reports Online, vol. 58, no. 4, pp. o447-o449Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S1600536802003562
alpha,alpha-trehalose octaacetate ethyl acetate solvate
Acta Crystallographica Section E: Structure Reports Online, vol. 57Contributions to Journals: Articles