Dr Sharon Mitchell | People | The University of Aberdeen

Dr Sharon Mitchell

PhD (Aberdeen University 2002)

Advanced Research Fellow

About

Email Address: s.e.mitchell@abdn.ac.uk
Office Address: 319, Zoology Building, Tillydrone Avenue, Aberdeen, AB24 2TZ
School/Department: School of Biological Sciences

Biography

2015-date Research Fellow, Lab Manager Energetics Research Group

Research

Research Overview

PhD Students

2016-date Megan Simpson

2016-2020 Jazmin Mendoza “Impacts of the thermic effect of food on feeding behaviour in mice: a test of the heat dissipation limits theory”

2015-2020 Emem Udoh PhD “Impacts of Calorie Restriction on Behaviour and Post-restriction Hyperphagia”

2015-2017 Heba Althubaiti “Fruit and Vegetable Intake and its Relationship with Health Parameters in Primary School Children”

Masters

2021-2022 Master of Science by Research Daniel Phillips “Bioinformatic Characterisation of Alternative Splicing in Three Different Tissues of Male C57BL/6 Mice Following Short-Term Graded Calorie Restriction"

2019-2020 MSci Daniel Phillips “Remodelling of three different tissues in the male C57BL/6 mouse during short-term graded caloric restriction is caused by tissue-specific variations in cell size and number”

2018-2019 MRes Stephanie Summers "The Impact of Short-Term Graded Calorie Restriction on Melanocortin-3 receptor (MC3R) Knockout Mice"

2013-2015 MSci Megan Simpson “The effect of maternal age on offspring susceptibility to high fat diet induced obesity and offspring expression of hypothalamic obesity related genes”.

2011-2013 MRes Dawn Graham, “The Role of Neuropeptides and their Receptors in Response to Increased Hunger, Reduced Food Intake and Reduced Body Fat Content”.

2011-2013 MRes Nicole Culbert, “Does Hunger Neuropeptide and Energy Balance Manipulation Affect Metabolic Rate and Antioxidant Activity in C57BL/6 Mice under Caloric Restriction?”

Supervisor of a number of Erasmus Funded Internships from AgroSup, Djon, France.

Teaching

Teaching Responsibilities

Lab Skills in Biosciences (BI3812), co-coordinator with Cath Jones

Parasitology Field trip (BI25F3), co-coordinator with Jerry Sternberg

Supervisor for laboratory-based research projects for Honours students

Lecturer on following courses:

Environmental Physiology (ZO3513)

Principles of Animal Physiology (BI2510)

Diversity of Life 2 (BI1512)

Publications

Page 1 of 1 Results 1 to 64 of 64

Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory
2024 - Published
Mitchell, S. E., Simpson, M., Coulet, L., Gouedard, S., Hambly, C., Morimoto, J., Allison, D. B., Speakman, J. R.
Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 42, e2408682121
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1073/pnas.2408682121
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/24570/1/Mitchell_etal_PNAS_Reproduction_has_Immediate_VOR.pdf
- [ONLINE] View publication in Scopus
Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake
2024 - Published
Smith, D. L., Mitchell, S. E., Johnson, M. S., Gibbs, V. K., Dickinson, S., Henschel, B., Li, R., Kaiser, K. A., Chusyd, D. E., Brown, A. W., Allison, D. B., Speakman, J. R., Nagy, T. R.
GeroScience, vol. 46, pp. 4809–4826
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s11357-024-01166-4
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/24383/1/Smith_etal_GS_Benefits_Of_Calorie_VoR.pdf
Carbon, nitrogen, and sulfur elemental and isotopic variations in mouse hair and bone collagen during short-term graded calorie restriction
2024 - Published
Gutierrez, E., Mitchell, S., Hambly, C., Sayle, K. l., Von kriegsheim, A., Speakman, J. r., Britton, K.
iScience, vol. 27, no. 6, 110059
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.isci.2024.110059
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23793/1/Guitierrez_etal_i_Carbon_nitrogen_sulfur_VOR.pdf
Not feeling the heat?: Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature.
2024 - E-pub ahead of print
Osorio Mendoza, J., Mitchell, S., Hambly, C., Allison, D. B., Speakman, J.
Appetite
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.appet.2024.107421
Turmeric shortens lifespan in houseflies
2024 - Published
Laurie, S., Ainslie, L., Mitchell, S., Morimoto, J.
Frontiers in Insect Science, vol. 4, 1376011
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/finsc.2024.1376011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23888/1/Laurie_etal_FiIS_Turmeric_Shortens_Lifespan_VOR.pdf
- [ONLINE] View publication in Scopus
The effects of graded levels of calorie restriction: XX. impact of long term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice
2023 - Published
Mitchell, S. E., Togo, J., Green, C. L., Derous, D., Hambly, C., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 78, no. 11, pp. 1953-1963
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glad152
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22231/1/Mitchell_etal_TJOG_The_Effects_Of_VoR.pdf
A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation
2023 - Published
Semerciöz-Oduncuoğlu, A. S., Mitchell, S. E., Özilgen, M., Yilmaz, B., Speakman, J. R.
Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 37, e2300624120
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1073/pnas.2300624120
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22003/1/Selcen_etal_PNAS_A_Step_Toward_VoR.pdf
- [ONLINE] View publication in Scopus
Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice
2023 - Published
Krol, E., Turner, F., Derous, D., Mitchell, S. E., Martin, S., Douglas, A., Speakman, J.
Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, pp. 171-192
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s00360-023-01474-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/19855/1/Krol_etal_JCPB_Fur_Removal_Promotes_VoR.pdf
The effects of graded levels of calorie restriction XVIII: tissue specific changes in cell size and number in response to calorie restriction
2022 - Published
Phillips, D., Mathers, H., Mitchell, S. E., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 77, no. 10, pp. 1994-2001
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glac110
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/21227/1/Phillips_etal_JGSA_The_Effects_of_VOR.pdf
Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes
2021 - Published
Nychyk, O., Barton, W., Rudolf, A. M., Boscaini, S., Walsh, A., Bastiaanssen, T. F., Giblin, L., Cormican, P., Chen, L., Piotrowicz, Y., Derous, D., Fanning, ?., Yin, X., Grant, J., Melgar, S., Brennan, L., Mitchell, S. E., Cryan, J. F., Wang, J., Cotter, P. D., Speakman, J. R., Nilaweera, K. N.
Cell Reports, vol. 35, no. 6, 109093
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.celrep.2021.109093
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16444/1/Nychyk_etal_CR_Protein_Quality_And_VoR.pdf
Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
2021 - Published
Wu, Y., Li, B., Li, L., Mitchell, S. E., Green, C. L., D'Agostino, G., Wang, G., Wang, L., Li, M., Li, J., Niu, C., Jin, Z., Wang, A., Zheng, Y., Douglas, A., Speakman, J. R.
Cell Metabolism, vol. 33, no. 5, pp. P888-904.E6
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.cmet.2021.01.017
The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes
2020 - Published
Sun, D., Liu, F., Mitchell, S. E., Ma, H., Derous, D., Wang, Y., Han, J. J., Daniel E.L., P., Lusseau, D., Douglas, A., Speakman, J. R., Chen, L.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 5, pp. 858-866
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glaa055
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15966/1/Sun_etal_Effects_AAM.pdf
- [ONLINE] View publication in Scopus
The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice
2020 - Published
Green, C. L., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 2, pp. 218-229
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glz023
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13574/1/Green_etal_JGer_Effects_graded_XIV_VOR.pdf
- [ONLINE] https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glz023/5435643
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues
2019 - Published
Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L., Hundal, H. S.
The FASEB Journal, vol. 33, no. 1, pp. 1299-1312
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1096/fj.201800171R
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11743/1/FASEB_Article.pdf
- [ONLINE] View publication in Scopus
The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice
2019 - Published
Green, C. L., Soltow, Q. A., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Jones, D. P., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 74, no. 1, pp. 16-26
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/gly058
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11691/1/The_Effects_of_Graded_Levels_of_Calorie_Restriction.pdf
- [ONLINE] View publication in Scopus
Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet
2018 - Published
McIlroy, G., Mitchell, S. E., Han, W., Delibegovic, M., Rochford, J. J.
Scientific Reports, vol. 8, 17863
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41598-018-36078-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11669/1/Female_adipose_tissue_specific_Bscl2_knockout_mice_develop_only_moderate_metabolic_dysfunction_when_housed_at_thermoneutrality_and_fed_a_high_fat_diet.pdf
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon
2018 - Published
Fontana, L., Mitchell, S. E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D. S., Maissan, P., Speakman, J. R., Demaria, M.
Aging Cell, vol. 17, no. 3, e12746
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/acel.12746
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10451/1/Fontana_et_al_2018_Aging_Cell.pdf
Limits to sustained energy intake XXVII: trade-offs between first and second litters in lactating mice support the ecological context hypothesis
2018 - Published
Vaanholt, L. M., Osei, D. A., Balduci, S., Mitchell, S. E., Hambly, C., Speakman, J. R.
Journal of Experimental Biology, vol. 221, no. 5, jeb170902
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/jeb.170902
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12041/1/jeb170902.full.pdf
The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue
2018 - Published
Derous, D., Mitchell, S. E., Green, C. L., Wang, Y., Han, J. D. J., Chen, L., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 73, no. 3, pp. 279-288
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glx101
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10142/1/The_Effects_of_Graded_Levels_of_Calorie_Restriction.pdf
Limits to sustained energy intake XXVIII: Beneficial effects of high dietary fat on lactation performance in mice
2018 - Published
Kagya-Agyemang, J. K., Vaanholt, L. M., Hambly, C., Król, E., Mitchell, S. E., Speakman, J. R.
Journal of Experimental Biology, vol. 221, jeb180828
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/jeb.180828
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12758/1/Limits_to_sustained_energy_intake._XXVIII._Beneficial_effects_of_high.pdf
Energy balance and the sphingosine-1-phosphate/ceramide axis
2017 - Published
Green, C., Mitchell, S., Speakman, J.
Aging, vol. 9, no. 12, pp. 2463-2464
Contributions to Journals: Editorials
- [ONLINE] DOI: https://doi.org/10.18632/aging.101347
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9890/1/zzEbzToKopC5bGMkZ.pdf
- [ONLINE] View publication in Scopus
The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome
2017 - Published
Derous, D., Mitchell, S. E., Wang, L., Green, C. L., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
Aging, vol. 9, no. 7, pp. 1770-1824
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/aging.101269
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9096/1/The_effects_of_graded_levels_of_calorie_restriction_XI._Evaluation_of_the_main_hypotheses_underpinning_the_life_extension_effects_of_CR_using_the_hepatic_transcriptome.pdf
The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice
2017 - Published
Green, C. L., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
Aging Cell, vol. 16, no. 3, pp. 529-540
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/acel.12570
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8135/3/Green_et_al_2017_Aging_Cell_1_.pdf
The effects of graded levels of calorie restriction: VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse
2017 - Published
Mitchell, S. E., Tang, Z. H., Kerbois, C., Delville, C., Derous, D., Green, C. L., Wang, Y., Han, J. J. D., Chen, L., Douglas, A., Lusseau, D., Promislow, D. E. L., Speakman, J. R.
Oncotarget, vol. 8, no. 11, pp. 17453-17474
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.15294
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8366/1/The_effects_of_graded_levels_of_calorie_restriction.pdf
Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone
2016 - Published
Speakman, J. R., Mitchell, S. E., Mazidi, M.
Experimental Gerontology, vol. 86, pp. 28-38
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.exger.2016.03.011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8354/1/Protein_restriction_after_review.docx
- [ONLINE] View publication in Scopus
Limits to sustained energy intake XXIV: impact of suckling behaviour on the body temperatures of lactating female mice
2016 - Published
Gamo, Y., Bernard, A., Troup, C., Munro, F., Derrer, K., Jeannesson, N., Campbell, A., Gray, H., Miller, J., Dixon, J., Mitchell, S. E., Hambly, C., Vaanholt, L. M., Speakman, J. R.
Scientific Reports, vol. 6, pp. 1-12
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/srep25665
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6011/1/srep25665.pdf
The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks
2016 - Published
Derous, D., Mitchell, S. E., Green, C. L., Wang, Y., Chen, L., Promislow, D. E. L., Lusseau, D., Speakman, J. R., Douglas, A.
Aging, vol. 8, no. 4, pp. 917-931
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/aging.100944
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10744/1/aging_08_0917.pdf
- [ONLINE] View publication in Scopus
CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction
2016 - Published
Lipina, C., Vaanholt, L. M., Davidova, A., Mitchell, S. E., Storey-Gordon, E., Hambly, C., Irving, A. J., Speakman, J. R., Hundal, H. S.
Aging Cell, vol. 15, no. 2, pp. 325-335
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/acel.12438
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5920/1/Lipina_et_al_2016_Aging_Cell.pdf
The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways
2016 - Published
Derous, D., Mitchell, S. E., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D. E. L., Lusseau, D., Speakman, J. R., Douglas, A.
Aging, vol. 8, no. 4, pp. 642-661
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/aging.100895
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5562/2/aging_08_642.pdf
The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse
2016 - Published
Mitchell, S. E., Delville, C., Konstantopedos, P., Derous, D., Green, C. L., Wang, Y., Han, J. J., Promislow, D. E. L., Douglas, A., Chen, L., Lusseau, D., Speakman, J. R.
Oncotarget, vol. 7, no. 15, pp. 19147-19170
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.8158
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7370/1/8158_124048_8_PB.pdf
Oxidative costs of reproduction: Oxidative stress in mice fed standard and low antioxidant diets
2016 - Published
Vaanholt, L. M., Milne, A., Zheng, Y., Hambly, C., Mitchell, S. E., Valencak, T. G., Allison, D. B., Speakman, J. R.
Physiology and Behavior, vol. 154, pp. 1-7
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.physbeh.2015.11.009
The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction
2015 - Published
Lusseau, D., Mitchell, S. E., Barros, C., Derous, D., Green, C., Chen, L., Han, J. J., Wang, Y., Promislow, D. E. L., Douglas, A., Speakman, J. R.
Scientific Reports, vol. 5, 13198
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/srep13198
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4968/1/srep13198.pdf
The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse
2015 - Published
Mitchell, S. E., Delville, C., Konstantopedos, P., Derous, D., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D. E., Douglas, A., Lusseau, D., Speakman, J. R.
Oncotarget, vol. 6, no. 21, pp. 18314-18337
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.4506
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4988/1/4506_69963_1_PB_1_.pdf
Mice that are resistant to diet-induced weight loss have greater food anticipatory activity and altered melanocortin-3 receptor (MC3R) and Dopamine receptor 2 (D2) gene expression
2015 - Published
Vaanholt, L. M., Mitchell, S. E., Sinclair, R. E., Speakman, J. R.
Hormones and Behavior, vol. 73, pp. 83-93
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.yhbeh.2015.06.006
The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse
2015 - Published
Mitchell, S. E., Tang, Z., Kerbois, C., Delville, C., Konstantopedos, P., Bruel, A., Derous, D., Green, C., Aspden, R. M., Goodyear, S. R., Chen, L., Han, J. J. D., Wang, Y., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
Oncotarget, vol. 6, no. 18, pp. 15902-15930
Contributions to Journals: Articles
- [ONLINE] http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=4142
- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.4142
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4721/1/The_effects_of_graded_levels_of_calorie_restriction.pdf
The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice
2015 - Published
Mitchell, S. E., Delville, C., Konstantopedos, P., Hurst, J., Derous, D., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
Oncotarget, vol. 6, no. 27, pp. 23213-23237
Contributions to Journals: Articles
- [ONLINE] http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=4003&path%5B%5D=9790
- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.4003
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5092/1/4003_63044_2_PB.pdf
Factors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice
2015 - Published
Vaanholt, L. M., Sinclair, R. E., Mitchell, S. E., Speakman, J. R.
Physiology and Behavior, vol. 144, pp. 146-155
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.physbeh.2015.03.029
Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet-induced obese mice
2014 - Published
Zhang, L., Sinclair, R., Selman, C., Mitchell, S., Morgan, D., Clapham, J. C., Speakman, J. R.
Obesity, vol. 22, no. 3, pp. 681-690
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/oby.20418
Limits to sustained energy intake. XXI. Effect of exposing the mother, but not her pups, to a cold environment during lactation in mice
2013 - Published
Valencak, T. G., Wright, P., Weir, A., Mitchell, S. E., Vaanholt, L. M., Hambly, C., Król, E., Speakman, J. R.
Journal of Experimental Biology, vol. 216, no. 23, pp. 4326-4333
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/jeb.092023
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3420/1/Limits_to_sustained_energy_intake.pdf
Limits to sustained energy intake. XX. Body temperatures and physical activity of female mice during lactation
2013 - Published
Gamo, Y., Troup, C., Mitchell, S. E., Hambly, C., Vaanholt, L. M., Speakman, J. R.
Journal of Experimental Biology, vol. 216, no. 19, pp. 3751-3761
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/jeb.090308
Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy
2013 - Published
Gamo, Y., Bernard, A., Mitchell, S. E., Hambly, C., Al Jothery, A., Vaanholt, L. M., Król, E., Speakman, J. R.
Journal of Experimental Biology, vol. 216, no. 12, pp. 2328-2338
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/jeb.078410
Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced Obese C57BL/6 Mice
2012 - Published
Zhang, L., Gamo, Y., Sinclair, R., Mitchell, S. E., Morgan, D. G., Clapham, J. C., Speakman, J. R.
Obesity, vol. 20, no. 5, pp. 954-962
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/oby.2011.357
Physiological and behavioral responses to intermittent starvation in C57BL/6J mice
2012 - Published
Zhang, L., Mitchell, S. E., Hambly, C., Morgan, D. G., Clapham, J. C., Speakman, J. R.
Physiology and Behavior, vol. 105, no. 2, pp. 376-387
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.physbeh.2011.08.035
Traversing the ovine cervix: a challenge for cryopreserved semen and creative science
2011 - Published
Robinson, J. J., McKelvey, W. A. C., King, M. E., Mitchell, S. E., Mylne, M. J. A., McEvoy, T. G., Dingwall, W. S., Williams, L.
Animal , vol. 5, no. 11, pp. 1791-1804
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1017/S1751731111000978
Caloric Restriction
2011 - Published
Speakman, J. R., Mitchell, S. E.
Molecular Aspects of Medicine, vol. 32, no. 3, pp. 159-221
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.mam.2011.07.001
The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice
2010 - Published
Hempenstall, S., Picchio, L., Mitchell, S. E., Speakman, J. R., Selman, C.
Mechanisms of Ageing and Development, vol. 131, no. 2, pp. 111-118
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.mad.2009.12.008
Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats
2009 - Published
Sneddon, A. A., Rayner, D. V., Mitchell, S. E., Bashir, S., Ha, J., Wahle, K. W., Morris, A. C., Williams, L. M.
Nutrients, vol. 1, no. 2, pp. 178-196
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3390/nu1020178
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3077/1/Published_paper_nutrients_01_00178_1_.pdf
Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status
2009 - Published
Mitchell, S. E., Nogueiras, R., Morris, A., Tovar, S., Grant, C., Cruickshank, M., Rayner, D. V., Dieguez, C., Williams, L. M.
The Journal of Physiology, vol. 587, no. 14, pp. 3573-3585
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1113/jphysiol.2009.173328
- [ONLINE] View publication in Scopus
The contribution of animal models to the study of obesity
2008 - Published
Speakman, J. R., Hambly, C., Mitchell, S. E., Król, E.
Laboratory Animals, vol. 42, no. 4, pp. 413-432
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1258/la.2007.006067
The Lou/C rat is proportionally smaller than the Wistar and not anorexic or hyperactive as previously reported
2007 - Published
Hambly, C., Mitchell, S. E., Speakman, J. R., Williams, L.
International Journal of Obesity, vol. 31, no. S1, pp. S84-S84
Contributions to Journals: Abstracts
- [ONLINE] DOI: https://doi.org/10.1038/sj.ijo.0803597
Animal models of obesity
2007 - Published
Speakman, J., Hambly, C., Mitchell, S., Król, E.
Obesity Reviews, vol. 8, no. Suppl 1, pp. 55-61
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/j.1467-789X.2007.00319.x
Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents
2007 - Published
Nogueiras, R., Pfluger, P., Tovar, S., Arnold, M., Mitchell, S. E., Morris, A., Perez-Tilve, D., Vázquez, M. J., Wiedmer, P., Castañeda, T. R., DiMarchi, R., Tschöp, M., Schurmann, A., Joost, H. G., Williams, L. M., Langhans, W., Diéguez, C.
Endocrinology, vol. 148, no. 1, pp. 21-26
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1210/en.2006-0915
- [ONLINE] View publication in Scopus
Circulating hormones and hypothalamic energy balance: Regulatory gene expression in the Lou/C and Wistar rats
2006 - Published
Mitchell, S. E., Nogueiras, R., Rance, K., Rayner, D. V., Wood, S., Dieguez, C., Williams, L. M.
Journal of Endocrinology, vol. 190, no. 3, pp. 571-579
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1677/joe.1.06576
- [ONLINE] View publication in Scopus
Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis
2006 - Published
Nogueiras, R., Tovar, S., Mitchell, S. E., Barrett, P., Rayner, D. V., Dieguez, C., Williams, L.
Journal of Endocrinology, vol. 190, no. 2, pp. 545-553
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1677/joe.1.06577
Proteinase-activated receptors in ovine cervical function
2005 - Published
Mitchell, S. E., Robinson, J. J., King, M. E., Williams, L. M.
Reproduction, Fertility and Development, vol. 17, no. 7, pp. 693-699
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1071/RD05032
- [ONLINE] View publication in Scopus
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
2005 - Published
Kola, B., Hubina, E., Tucci, S. A., Kirkham, T. C., Garcia, E. A., Mitchell, S. E., Williams, L., Hawley, S. A., Hardie, D. G., Grossman, A. B., Korbonits, M.
The Journal of Biological Chemistry, vol. 280, no. 26, pp. 25196-25201
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1074/jbc.C500175200
Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin
2004 - Published
Nogueiras, R., Tovar, S., Mitchell, S. E., Rayner, D. V., Archer, Z. A., Dieguez, C., Williams, L.
Diabetes, vol. 53, no. 10, pp. 2552-2558
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.2337/diabetes.53.10.2552
Interleukin 8 in the cervix of non-pregnant ewes
2002 - Published
Mitchell, S. E., Robinson, J. J., King, M. E., McKelvey, W. A. C., Williams, L.
Reproduction, vol. 124, no. 3, pp. 409-416
Contributions to Journals: Articles
Ovine cervical function and control in non-pregnant ewes
2002 - Published
Robinson, J. J., Williams, L. M. W., Mitchell, S. E., King, M. E., Mylne, M. J. A., Hunton, J. R., McKelvey, W., Dingwall, W. S.
The Journal of Animal Breeding
Contributions to Journals: Articles
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
2000 - Published
Steinhoff, M., Vergnolle, N., Young, S. H., Tognetto, M., Amadesi, S., Ennes, H. S., Trevisani, M., Hollenberg, M. D., Wallace, J. L., Caughey, G. H., Mitchell, S. E., Williams, L., Geppetti, P., Mayer, E. A., Bunnett, N. W.
Nature Medicine, vol. 6, no. 2, pp. 151-158
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/72247
Suppression of leptin during lactation: contribution of the suckling stimulus versus milk production
1999 - Published
Brogan, R. S., Mitchell, S. E., Trayhurn, P., Smith, M. S.
Endocrinology, vol. 140, no. 6, pp. 2621-2627
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1210/endo.140.6.6802
Towards improved reproductive technologies for sheep
1999 - Published
Robinson, J., Williams, L. M., Mitchell, S. E., Mylne, M. J., Mckelvey, W. A. C.
Animal and Food Science Research Report. Scottish Agricultural College, pp. 2-5, 4 pages
Chapters in Books, Reports and Conference Proceedings: Chapters
Nutritional and hormonal regulation of the leptin system
1998 - Published
Trayhurn, P., Hoggard, N., Mitchell, S. E., Rayner, D. V.
Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
ob gene expression and secretion of leptin following differentiation of rat preadipocytes to adipocytes in primary culture
1997 - Published
Mitchell, S. E., Rees, W., Hardie, L. J., Hoggard, N., Tadayyon, M., Arch, J. R., Trayhurn, P.
Biochemical and Biophysical Research Communications, vol. 230, no. 2, pp. 360-364
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1006/bbrc.1996.5964

Refine

Chapters in Books, Reports and Conference Proceedings

Chapters (1)

Conference Proceedings (1)

Contributions to Journals

Abstracts (1)

Articles (60)

Editorials (1)

Update

Biography

Research Overview

Teaching Responsibilities

Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory

Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake

Carbon, nitrogen, and sulfur elemental and isotopic variations in mouse hair and bone collagen during short-term graded calorie restriction

Not feeling the heat?: Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature.

Turmeric shortens lifespan in houseflies

The effects of graded levels of calorie restriction: XX. impact of long term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice

A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation

Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice

The effects of graded levels of calorie restriction XVIII: tissue specific changes in cell size and number in response to calorie restriction

Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes

Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice

Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Limits to sustained energy intake XXVII: trade-offs between first and second litters in lactating mice support the ecological context hypothesis

The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue

Limits to sustained energy intake XXVIII: Beneficial effects of high dietary fat on lactation performance in mice

Energy balance and the sphingosine-1-phosphate/ceramide axis

The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome

The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

The effects of graded levels of calorie restriction: VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

Limits to sustained energy intake XXIV: impact of suckling behaviour on the body temperatures of lactating female mice

The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks

CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction

The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways

The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse

Oxidative costs of reproduction: Oxidative stress in mice fed standard and low antioxidant diets

The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

Mice that are resistant to diet-induced weight loss have greater food anticipatory activity and altered melanocortin-3 receptor (MC3R) and Dopamine receptor 2 (D2) gene expression

The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

Factors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice

Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet-induced obese mice

Limits to sustained energy intake. XXI. Effect of exposing the mother, but not her pups, to a cold environment during lactation in mice

Limits to sustained energy intake. XX. Body temperatures and physical activity of female mice during lactation

Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy

Effects of Chronic Oral Rimonabant Administration on Energy Budgets of Diet-Induced Obese C57BL/6 Mice

Physiological and behavioral responses to intermittent starvation in C57BL/6J mice

Traversing the ovine cervix: a challenge for cryopreserved semen and creative science

Caloric Restriction

The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice

Dietary supplementation with conjugated linoleic acid plus n-3 polyunsatturated fatty acid increases food intake and brown adipose tissue in rats

Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status

The contribution of animal models to the study of obesity

The Lou/C rat is proportionally smaller than the Wistar and not anorexic or hyperactive as previously reported

Animal models of obesity

Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents

Circulating hormones and hypothalamic energy balance: Regulatory gene expression in the Lou/C and Wistar rats

Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis

Proteinase-activated receptors in ovine cervical function

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase

Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin

Interleukin 8 in the cervix of non-pregnant ewes

Ovine cervical function and control in non-pregnant ewes

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

Suppression of leptin during lactation: contribution of the suckling stimulus versus milk production

Towards improved reproductive technologies for sheep

Nutritional and hormonal regulation of the leptin system

ob gene expression and secretion of leptin following differentiation of rat preadipocytes to adipocytes in primary culture

Refine

Chapters in Books, Reports and Conference Proceedings

Contributions to Journals