Trial Manager
- About
-
- Email Address
- s.breeman@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438169
- Office Address
Health Services Research Unit (HSRU)
3rd Floor, Health Sciences Building
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I joined HSRU in October 2007 as a Trial Manager and work as the Lead Trial Manager on the following trials:
KAT: a multi-centre randomised controlled trial to assess four developments in knee replacement surgery
PROSPECT: a multi-centre randomised controlled trial to measure the clinical and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse.
FUTURE: a multi-centre randomised controlled trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in the managment of women with refractory overactive bladder symptoms
REGAL: multi-centre randomised controlled trial to evaluate the clinical and cost-effectiveness of long-term use of Gonadotrophin Releasing Hormone Analogues (GnRHa) with add-back hormone replacement therapy (HRT) as an alternative treatment to further laparoscopic surgery in women who present with recurrence of pain following previous surgery for endometriosis but wish to retain their fertility.
I am a member of the North of Scotland Research Ethics Committee and faculty member on the Edinburgh Clinical Trial Management course (ECTMC).
I graduated with a BSc in Biochemistry (1994), a PhD in Molecular Biology (1998) and an MSc in Public Health and Health Services Research ()
Prior to joining the HSRU I worked for a biotechnology company called Auvation Limited as a Senior Scientist.
Qualifications
- BSc Biochemistry1994 - University of Aberdeen
- PhD Molecular Biology1998 - University of Aberdeen
- MSc Public Health and Health Services Research2010 - University of Aberdeen
- Research
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Research Overview
Trial management and trial methodology
Current Research
I am currently the Lead Trial Manager on the following trials:
KAT: a multi-centre randomised controlled trial to assess four developments in knee replacement surgery
PROSPECT: a multi-centre randomised controlled trial to measure the clinical and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse
FUTURE: a multi-centre randomised controlled trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in the managment of women with refractory overactive bladder symptoms
REGAL: multi-centre randomised controlled trial to evaluate the clinical and cost-effectiveness of long-term use of Gonadotrophin Releasing Hormone Analogues (GnRHa) with add-back hormone replacement therapy (HRT) as an alternative treatment to further laparoscopic surgery in women who present with recurrence of pain following previous surgery for endometriosis but wish to retain their fertility
Past Research
Since joining the Unit I have worked on a number of trials that have now completed:
HEALTH: a multi-centre randomised controlled trial comparing the clinical and cost effectiveness of laparoscopic supra-cervical hysterectomy (LASH) with second generation endometrial ablation (EA)
UKUFF: a multi-centre randomised controlled trial to measure the clinical and cost effectiveness of different types of management of rotator cuff repairs
PRaCTICaL: a randomised controlled trial comparing a nurse-led ICU follow-up programme versus standard care
- Teaching
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Non-course Teaching Responsibilities
Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC)
- Publications
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Page 2 of 2 Results 11 to 20 of 20
Surgical interventions for uterine prolapse and for vault prolapse: the two VUE RCTs
Health Technology Assessment, vol. 24, no. 13, pp. vii-xxxi, 1-220Contributions to Journals: ArticlesLaparoscopic supracervical hysterectomy versus endometrial ablation for women with heavy menstrual bleeding (HEALTH): a parallel-group, open-label, randomised controlled trial
The Lancet, vol. 394, no. 10207, pp. 1425-1436Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(19)31790-8
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13243/1/Cooper_etal_Lancet_Laparoscopic_supracervical_VOR.pdf
- [ONLINE] https://abdn.pure.elsevier.com/en/en/researchoutput/laparoscopic-supracervical-hysterectomy-versus-endometrial-ablation-for-women-with-heavy-menstrual-bleeding-health(20b3fd84-6e08-4603-beaf-87c88732a17a).html
- [ONLINE] View publication in Scopus
Laparoscopic supracervical hysterectomy compared with second-generation endometrial ablation for heavy menstrual bleeding: the HEALTH RCT
Health Technology Assessment, vol. 23, no. 53, pp. 1-107Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta23530
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13068/1/HTA_REPRT_3030653_VOR.pdf
- [ONLINE] View publication in Scopus
Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)
The Lancet, vol. 389, no. 10067, pp. 381–392Contributions to Journals: ArticlesClinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study
Health Technology Assessment, vol. 20, no. 95, pp. 1-452Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta20950
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8494/1/HTA.pdf
Two parallel, pragmatic, UK multicentre, randomised controlled trials comparing surgical options for upper compartment (vault or uterine) pelvic organ prolapse (the VUE Study): study protocol for a randomised controlled trial
Trials, vol. 17, pp. 1-18Contributions to Journals: ArticlesNormative data for the Hospital Anxiety and Depression Scale
Quality of Life Research, vol. 24, no. 2, pp. 391-398Contributions to Journals: ArticlesA randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT)
Health Technology Assessment, vol. 18, no. 19, pp. 1-235, vii-viiiContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta18190
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3321/1/Murray_2014.pdf
Five-year results of a randomised controlled trial comparing mobile and fixed bearings in total knee replacement
Journal of Bone & Joint Surgery (US Volume), vol. 95-B, no. 4, pp. 486-492Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1302/0301-620X.95B4.29454
The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial
British Medical Journal, vol. 339, b3723Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.b3723