
BSc MBChB PhD FRCP
Personal Chair (Clinical)
- Email Address
- m.j.macleod@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437842
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Dr Macleod is a Clinical Pharmacologist with a personal chair (Teaching and Research) at the University of Aberdeen and honorary Consultant Physician within NHS Grampian. Her clinical work is largely in the area of acute stroke management, hypertension clinics and primary and secondary cardiovascular prevention. Current research interests include:
Novel imaging markers in stroke and small vessel disease using fast field cycling MRI
Using linked datasets to explore management of stroke including service organisation and secondary prevention
Interactions between stroke and other diseases (e.g. cancer)
Memberships and Affiliations
Chair, Clinical Studies Oversight Group
Chair of Scotland A and B Research Ethics Committees
Honorary Deputy Secretary, British and Irish Association of Stroke Physicians
Trustee SHARP (Scottish Heart and Arterial Disease Prevention)
Latest Publications
Impact of Rurality and Geographical Accessibility on Stroke Care and Outcomes
Turner, M., Dennis, M., Barber, M., Macleod, M.StrokeContributions to Journals: ArticlesField-Cycling Imaging yields repeatable brain R1 dispersion measurement at fields strengths below 0.2 Tesla with optimal fitting routine
Senn, N., Ross, P. J., Ayde, R., Mallikourti, V., Krishna, A., James, C., de Vries, C., Broche, L., Waiter, G., Macleod, M.Magnetic Resonance Materials in Physics, Biology and MedicineContributions to Journals: ArticlesTenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial
Muir, K. W., Ford, G. A., Ford, I., Wardlaw, J. M., McConnachie, A., Greenlaw, N., Mair, G., Sprigg, N., Price, C. I., MacLeod, M. J., Dima, S., Venter, M., Zhang, L., O’Brien, E., Sanyal, R., Reid, J., Sztriha, L. K., Haider, S., Whiteley, W. N., Kennedy, J., Perry, R., Lakshmanan, S., Chakrabarti, A., Hassan, A., Marigold, R., Raghunathan, S., Sims, D., Bhandari, M., Wiggam, I., Rashed, K., Douglass, C., ATTEST-2 InvestigatorsThe Lancet neurology, vol. 23, no. 11, pp. 1087-1096Contributions to Journals: ArticlesField-Cycling MRI for Identifying Minor Ischemic Stroke Below 0.2 T
Ross, J., Mallikourti, V., Maier, O., Guzman Gutierrez, G., Franko, E., Lurie, D., Broche, L., Macleod, M.Radiology, vol. 312, no. 2, e232972Contributions to Journals: ArticlesAcute care, secondary prevention, and outcomes after ischaemic and haemorrhagic stroke in men and women: a data-linkage study
Sterling, K., MacLeod, M., Barber, M., Turner, M.Cerebrovascular DiseasesContributions to Journals: Articles
Teaching Responsibilities
Year 5 MBChB OSCE coordinator
Situational Judgement Test lead
Year 1, 3 and 4 Clinical Pharmacology teaching
MSc Clinical Pharmacology: Pharmacovigilance, Medicines Management
Delivers teaching to MSc Cardiovascular and Diabetes, BSc Neurosciences, BSc Genetics
MRCP PACES examiner
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Magnetic resonance imaging for transient ischaemic attacks and minor strokes: a retrospective cross-sectional study
Varsou, O., Schwarzbauer, C., MacLeod, M. J.UK Stroke Forum 2012 Conference, pp. 61Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/j.1747-4930.2012.00961.x
Scottish stroke care audit: does routine care data confirm benefits of stroke unit admission?
Turner, M. E., MacLeod, M. J., Barber, M. H., Dodds, H., Dennis, M. S., Langhorne, P.International Journal of Stroke, vol. 7, no. Suppl 2, pp. 23Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/j.1747-4930.2012.00961.x
Scottish stroke care audit: can we use routine data to investigate optimal care of stroke patients?
Macleod, M., Turner, M. E., Barber, M. H., Langhorne, P., Dodds, H., Dennis, M. S.International Journal of Stroke, vol. 7, no. 2 supplement, pp. 64Contributions to Journals: AbstractsService redesign: Address the barriers and deliver acute stroke care.
Jacobson, E. U., Bayer, S., MacLeod, M. J.Health Service Journal, vol. 122, no. 6323, pp. 28-29Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Emotion processing and social participation following stroke: study protocol
Scott, C. L., Phillips, L. H., Johnston, M., Whyte, M. M., MacLeod, M. J.BMC Neurology, vol. 12, 56Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2377-12-56
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3856/1/Emotion_processing.pdf
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., Jackson, C. A., Traylor, M., Strange, A., Su, Z., Band, G., Syme, P. D., Malik, R., Pera, J., Norrving, B., Lemmens, R., Freeman, C., Schanz, R., James, T., Poole, D., Murphy, L., Segal, H., Cortellini, L., Cheng, Y., Woo, D., Nalls, M. A., Müller-Myhsok, B., Meisinger, C., Seedorf, U., Ross-Adams, H., Boonen, S., Wloch-Kopec, D., Valant, V., Slark, J., Furie, K., Delavaran, H., Langford, C., Deloukas, P., Edkins, S., Hunt, S., Gray, E., Dronov, S., Peltonen, L., Gretarsdottir, S., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K., Boncoraglio, G. B., Parati, E. A., Macleod, M. J., The International Stroke Genetics Consortium (ISGC), The Wellcome Trust Case Control Consortium 2 (WTCCC2)Nature Genetics, vol. 44, no. 3, pp. 328-333Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1038/ng.1081
Computed tomography and magnetic resonance perfusion imaging in ischemic stroke: definitions and thresholds
Dani, K. A., Thomas, R. G. R., Chappell, F. M., Shuler, K., MacLeod, M. J., Muir, K. W., Wardlaw, J. M., Translational Medicine Research Collaboration Multicentre Acute Stroke Imaging StudyAnnals of Neurology, vol. 70, no. 3, pp. 384-401Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ana.22500
Procedures to evaluate the importance of dietary polyamines
Acheampong, P., Macleod, M. J., Wallace, H. M.Methods in Molecular Medicine, vol. 720, no. 6, pp. 349-364Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-61779-034-8_22
Risk of stroke and cardiovascular events after ischemic stroke or transient ischemic attack in patients with type 2 diabetes or metabolic syndrome: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
Callahan, A., Amarenco, P., Goldstein, L. B., Sillesen, H., Messig, M., Samsa, G. P., Altafullah, I., Ledbetter, L. Y., MacLeod, M. J., Scott, R., Hennerici, M., Zivin, J. A., Welch, K. M. A., SPARCL InvestigatorsArchives of Neurology, vol. 68, no. 10, pp. 1245-1251Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1001/archneurol.2011.146
Improved detection following neuro-eye therapy in patients with post-geniculate brain damage
Sahraie, A., Macleod, M. J., Trevethan, C. T., Robson, S. E., Olson, J. A., Callaghan, P., Yip, B.Experimental Brain Research, vol. 206, no. 1, pp. 25-34Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00221-010-2395-z
Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial
Goldstein, L. B., Amarenco, P., Zivin, J., Messig, M., Altafullah, I., Callahan, A., Hennerici, M., MacLeod, M. J., Sillesen, H., Zweiffler, R., Michael, K., Welch, A., SPARCL InvestigatorsStroke, vol. 40, no. 11, pp. 3526-3531Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1161/STROKEAHA.109.557330
Perceptual Learning in the Blind Field of Hemianopic Patients
Saharie, A., MacLeod, M. J.49th Annual Meeting of the Society-for-Psychophysiological-ResearchContributions to Conferences: AbstractsEvaluation of spermine as a biomarker for clinical research in stroke
Acheampong, P., Wallace, H. M., MacLeod, M. J.Contributions to Conferences: AbstractsPharmacokinetics of blood polyamines after an oral bolus of polyamines
Acheampong, P., MacLeod, M. J., Wallace, H. M.European Association of Clinical Pharmacology and Therapeutics, pp. 122-123Contributions to Conferences: AbstractsRetrospective audit of pre-admission warfarin use in acute stroke patients with pre-existing atrial fibrillation
Elofuke, P., Pickering, G., Shields, L., MacLeod, M. J., Reid, J. M.European Journal of Clinical Pharmacology, vol. 105, pp. 35-35Contributions to Journals: AbstractsWhat is the scale of prescribing errors committed by junior doctors?: A systematic review
Ross, S., Bond, C., Rothnie, H., Thomas, S., MacLeod, M. J.British Journal of Clinical Pharmacology, vol. 67, no. 6, pp. 629-640Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2125.2008.03330.x
Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke
Gschwendtner, A., Bevan, S., Cole, J. W., Plourde, A., Matarin, M., Ross-Adams, H., Meitinger, T., Wichmann, E., Mitchell, B. D., Furie, K., Slowik, A., Rich, S. S., Syme, P. D., MacLeod, M. J., Meschia, J. F., Rosand, J., Kittner, S. J., Markus, H. S., Mueller-Myhsok, B., Dichgans, M., Int Stroke Genetics ConsortiumAnnals of Neurology, vol. 65, no. 5, pp. 531-539Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ana.21590
Neutrophil-Lymphocyte Ratio as a Predictor of Stroke Subtype and Outcome
Acheampong, P., Eduful, B. J., MacLeod, M. J.American-Association-International-Stroke Conference 2009Contributions to Conferences: AbstractsValidation of MAP2K6 as a Novel Stroke Candidate Gene
Ross-Adams, H., Pasdar, A., Mayer, C., MacLeod, M. J.International Stroke Conference 2009, pp. E179Contributions to Journals: AbstractsEmotion perception and activity limitations following stroke: A pilot study
Scott, C. L., Phillips, L. H., Johnston, M., MacLeod, M. J., Whyte, M.Psychology & Health, vol. 23, no. Suppl. 1, pp. 231Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1080/08870440802299543
Temporal properties of spatial channel of processing in hemianopia
Sahraie, A., Trevethan, C. T., MacLeod, M.Neuropsychologia, vol. 46, no. 3, pp. 879-885Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.neuropsychologia.2007.11.008
Validation of stroke candidate genes identified with DNA pools and SNP chips
Ross-Adams, H., Pasdar, A., Mayer, C., MacLeod, M. J.Stroke, vol. 39, no. 2, pp. 630-631Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1161/STROKEAHA.107.100001
Saccadic distractor effect and S-cone processing in normal observers and two cases of hemianopia
Ridgway, N., MacLeod, M. J., Milders, M., Sahraie, A.31st European Conference on Visual Perception, pp. 63Contributions to Journals: AbstractsBlindsight and visual rehabilitation in the cortically blind
Sahraie, A., Trevethan, C. T., MacLeod, M. J., Olson, J., Weiskrantz, L.Perception, vol. 35, pp. 232-232Contributions to Journals: ArticlesIncreased sensitivity after repeated stimulation of residual spatial channels in blindsight
Sahraie, A., Trevethan, C. T., MacLeod, M. J., Murray, A. D., Olson, J. A., Weiskrantz, L.PNAS, vol. 103, no. 40, pp. 14971-14976Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/PNAS.0607073103
Stress, debt and undergraduate medical student performance
Ross, S., Cleland, J. A., MacLeod, M. J.Medical Education, vol. 40, no. 6, pp. 584-589Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2929.2006.02448.x
Study of CETP gene polymophisms and ischaemic stroke in a Scottish population, using pooled DNA samples
Pasdar, A., Ross-Adams, H. E., St Clair, D. M., MacLeod, M. J.Contributions to Conferences: Other ContributionsPoster Presentation - Design and validation of DNA pools in an ischaemic stroke population
Ross-Adams, H. E., Pasdar, A., St Clair, D. M., MacLeod, M. J.Contributions to Conferences: Other ContributionsParaoxonase gene polymorphisms and haplotype analysis in a stroke population
Pasdar, A., Ross-Adams, H., Cumming, A., Cheung, J., Whalley, L., St Clair, D., MacLeod, M. J.BMC Medical Genetics, vol. 7, 28Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2350-7-28
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3929/1/paraoxonase_gene.pdf
Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population
Helgadottir, A., Gretasdottir, S., St Clair, D. M., Maolescu, A., Cheung, J. K. S., Thorleifsson, G., Pasdar, A., Grant, S. F., Whalley, L. J., Hakonarson, H., Thorsteinsdottir, U., Kong, A., Gulcher, J. R., Stefansson, K., MacLeod, M. J.American Journal of Human Genetics, vol. 76, no. 3, pp. 505-509Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1086/428066
ABCA1 gene polymoprhism and lipid profile in a Scottish population
Pasdar, A., Cumming, A. M., St Clair, D. M., MacLeod, M. J.Contributions to Conferences: AbstractsAntihypertensive drug prescribing in Grampian
Ross, S., MacLeod, M. J.British Journal of Clinical Pharmacology, vol. 60, no. 3, pp. 300-305Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2125.2005.02414.x
Timing of aspirin use in acute stroke and use of secondary prevention: stroke unit vs medical unit
Reid, J., MacLeod, M. J., Williams, D.Scottish Medical Journal, vol. 50, pp. 69-72Contributions to Journals: ArticlesPatient compliance in hypertension: role of illness perceptions and treatment beliefs
Ross, S., Walker, A. E., MacLeod, M. J.Journal of Human Hypertension, vol. 18, no. 9, pp. 607-613Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.jhh.1001721
Genotype and haplotype analysis of ABCA1 gene in ischaemic stroke
Pasdar, A., St Clair, D. M., MacLeod, M. J.Stroke, vol. 35, pp. 253-340Contributions to Journals: ArticlesPoster Presentation - Using the TOAST Criteria for Retrospective Classification of Ischemic Stroke Patients
Pasdar, A., St Clair, D. M., MacLeod, M. J.Contributions to Conferences: Other ContributionsSpatial channels of visual processing in cortical blindness
Sahraie, A., Trevethan, C. T., Weiskrantz, L., Olson, J., MacLeod, M. J., Murray, A. D., Dijkhuizen, R. S., Counsell, C. E., Coleman, R.European Journal of Neuroscience, vol. 18, no. 5, pp. 1189-1196Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1460-9568.2003.02853.x
Hypertension in Diabetes: A Perspective from Clinical Pharmacology
Ross, S., MacLeod, M. J.British Journal of Diabetes and Vascular Disease, vol. 3, no. 4, pp. 252-256Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1177/14746514030030040301
Paraoxonase genes (PON1, 2 and 3) polymorphisms and ischaemic stroke in a Scottish population
Pasdar, A., St Clair, D. M., MacLeod, M. J.Contributions to Conferences: AbstractsParaxonase 3 gene (PON3) polymorphism, ischaemic stroke and lipid profile in a Scottish population
Pasdar, A., St Clair, D. M., MacLeod, M. J.Contributions to Conferences: Other ContributionsParaxonase genes (PON1, PON2 and PON3) polymorphisms and lipid profile in a Scottish population
Pasdar, A., MacLeod, M. J., St Clair, D. M., Cumming, A. M.Contributions to Conferences: AbstractsEffects of mailed dissemination of the Royal College of Radiologists' guidelines on general practitioner referrals for radiography: a time series analysis
Matowe, L., Ramsay, C. R., Gilbert, F. J., MacLeod, M. J., Needham, G.Clinical Radiology, vol. 57, no. 7, pp. 575-578Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1053/crad.2001.0894
Genotype and Haplotype Analysis of Paraoxanase Genes (PON 1&2 ) and Ishcaemic Stroke in a Northern Scottish Population
Pasdar, A., MacLeod, M. J., St Clair, D. M.Contributions to Conferences: AbstractsLack of association between apolipoprotein E genotype and ischaemic stroke in a Scottish population
MacLeod, M. J., De Lange, R. P., Breen, G. D., Meiklejohn, D., Lemmon, H., St Clair, D. M.European Journal of Clinical Investigation, vol. 31, no. 7, pp. 570-573Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1365-2362.2001.00851.x
Predicted impact of intravenous thrombolysis
Berwaerts, J., Macleod, M., Johnston, A., Hoffman, J., Jørgensen, H.BMJ, vol. 320, 1006Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1136/bmj.320.7240.1006
- [ONLINE] View publication in Scopus
Pharmacokinetic factors in the modern drug treatment of tuberculosis
Douglas, J. G., Macleod, M.Clinical Pharmacokinetics, vol. 37, no. 2, pp. 127-146Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.2165/00003088-199937020-00003
No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke
MacLeod, M. J., Dahiyat, M. T., Cumming, A., Meiklejohn, D., Shaw, D., St Clair, D.Neurology, vol. 53, pp. 418-420Contributions to Journals: ArticlesDrug Treatment of Hypertension Complicating Diabetes Mellitus
MacLeod, M. J., McLay, J.Drugs, vol. 56, no. 2, pp. 189-202Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2165/00003495-199856020-00003
- [ONLINE] View publication in Scopus
Identification of a common low density lipoprotein receptor mutation (C163Y) in the west of Scotland
Lee, W., Haddad, L., Macleod, M., Dorrance, A., Wilson, D., Gaffney, D., Dominiczak, M., Packard, C., Day, I., Humphries, S., Dominiczak, A.Journal of Medical Genetics, vol. 35, no. 7Contributions to Journals: Articles- [ONLINE] https://jmg.bmj.com/content/35/7/573
- [ONLINE] View publication in Scopus
Renal artery stent placement in renal artery stenosis: Technical and early clinical results
Taylor, A., Sheppard, D., Macleod, M., Harden, P., Baxter, G., Edwards, R., Moss, J.Brain and Language, vol. 52, no. 6, pp. 451-457Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0009-9260(97)80007-4
- [ONLINE] View publication in Scopus