Bioinformatician
- About
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- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Louie van de Lagemaat joined the Centre for Genome-Enabled Biology and Medicine as a bioinformatician in October 2021. He completed his PhD in Genetics at the University of British Columbia, Canada in 2006. Subsequent positions focused on diverse subjects, including molecular neuroscience of the mammalian excitatory synapse and developmental and malignant haematopoiesis. He has used varied analytical methods such as linear and mixed effects models and has broad experience with short-read sequencing technologies including ChIP-seq, bulk and low-cell-count RNA-seq, mRNA splicing, ribosomal profiling (Ribo-seq), transcript methylation (meRIP-seq), poly-A tail length (tail-seq) and transcript half-life (SLAM-seq). He has also performed analysis of survival and loss of HLA allele heterozygosity in cancers.
- Research
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Research Specialisms
- Genomics
- Behavioural Biology
- Bioinformatics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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Page 1 of 4 Results 1 to 10 of 35
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
Nature Communications, vol. 14, 2132Contributions to Journals: ArticlesIntrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis
Open Biology, vol. 11, no. 6, bio059143Contributions to Journals: ArticlesCITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation
Stem Cell Reports, vol. 16, no. 11, pp. 2784-2797Contributions to Journals: ArticlesNANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells
iScience, vol. 24, no. 7, pp. 102762Contributions to Journals: ArticlesThe mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function
Journal of Experimental Medicine, vol. 218, no. 3, e20200829Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1084/jem.20200829
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/21771/1/272592402.pdf
JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells
Blood Advances, vol. 5, no. 3, pp. 889-899Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/bloodadvances.2020002702
Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
Cell stem cell, vol. 25, no. 1, pp. 137-148, e1-.e6Contributions to Journals: ArticlesCpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands.
Epigenetics & Chromatin, vol. 11, 59Contributions to Journals: ArticlesA combinatorial postsynaptic molecular mechanism converts patterns of nerve impulses into the behavioral repertoire
Working Papers: Preprint Papers- [ONLINE] https://www.biorxiv.org/content/early/2018/12/19/500447
- [ONLINE] DOI: https://doi.org/10.1101/500447
Synaptic combinatorial molecular mechanisms generate repertoires of innate and learned behavior
Working Papers: Preprint Papers- [ONLINE] https://www.biorxiv.org/content/early/2018/12/19/500389
- [ONLINE] DOI: https://doi.org/10.1101/500389