Louie van de Lagemaat joined the Centre for Genome-Enabled Biology and Medicine as a bioinformatician in October 2021. He completed his PhD in Genetics at the University of British Columbia, Canada in 2006. Subsequent positions focused on diverse subjects, including molecular neuroscience of the mammalian excitatory synapse and developmental and malignant haematopoiesis. He has used varied analytical methods such as linear and mixed effects models and has broad experience with short-read sequencing technologies including ChIP-seq, bulk and low-cell-count RNA-seq, mRNA splicing, ribosomal profiling (Ribo-seq), transcript methylation (meRIP-seq), poly-A tail length (tail-seq) and transcript half-life (SLAM-seq). He has also performed analysis of survival and loss of HLA allele heterozygosity in cancers.
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.
Woodley, K., Dillingh, L., Giotopoulos, G., Madrigal, P., Rattigan, K., Philippe, C., Dembitz, V., Magee, A., Asby, R., van de Lagemaat, L. N., Mapperley, C., James, S., Prehn, J., Tzelepis, K., Rouault-Pierre, K., Vassiliou, G., Kranc, K., Helgason, G. V., Huntly, B., Gallipoli, P.
CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation
Lawson, H., van de Lagemaat, L. N., Barile, M., Tavosanis, A., Durko, J., Villacreces, A., Bellani, A., Mapperley, C., Georges, E., Martins-Costa, C., Sepulveda, C., Allen, L., Campos, J., Campbell, K. J., O'Carroll, D., Göttgens, B., Cory, S., Rodrigues, N. P., Guitart, A. V., Kranc, K. R.
NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells
Codino, A., Turowski, T., van de Lagemaat, L. N., Ivanova, I., Tavosanis, A., Much, C., Auchynnikava, T., Vasiliauskaitė, L., Morgan, M., Rappsilber, J., Allshire, R. C., Kranc, K. R., Tollervey, D., O'Carroll, D.
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function
Mapperley, C., van de Lagemaat, L. N., Lawson, H., Tavosanis, A., Paris, J., Campos, J., Wotherspoon, D., Durko, J., Sarapuu, A., Choe, J., Ivanova, I., Krause, D. S., von Kriegsheim, A., Much, C., Morgan, M., Gregory, R. I., Mead, A. J., O'Carroll, D., Kranc, K. R.
Journal of Experimental Medicine, vol. 218, no. 3, e20200829
JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells
Lawson, H., Sepulveda, C., van de Lagemaat, L. N., Durko, J., Barile, M., Tavosanis, A., Georges, E., Shmakova, A., Timms, P., Carter, R. N., Allen, L., Campos, J., Vukovic, M., Guitart, A. V., Giles, P., O'Shea, M., Vernimmen, D., Morton, N. M., Rodrigues, N. P., Göttgens, B., Schofield, C. J., Lengeling, A., O'Carroll, D., Kranc, K. R.
Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
Paris, J., Morgan, M., Campos, J., Spencer, G. J., Shmakova, A., Ivanova, I., Mapperley, C., Lawson, H., Wotherspoon, D. A., Sepulveda, C., Vukovic, M., Allen, L., Sarapuu, A., Tavosanis, A., Guitart, A. V., Villacreces, A., Much, C., Choe, J., Azar, A., van de Lagemaat, L. N., Vernimmen, D., Nehme, A., Mazurier, F., Somervaille, T. C. P., Gregory, R. I., O'Carroll, D., Kranc, K. R.
Cell stem cell, vol. 25, no. 1, pp. 137-148, e1-.e6
A combinatorial postsynaptic molecular mechanism converts patterns of nerve impulses into the behavioral repertoire
Kopanitsa, M. V., van de Lagemaat, L. N., Afinowi, N. O., Strathdee, D. J., Strathdee, K. E., Fricker, D. G., Tuck, E. J., Elsegood, K. A., Croning, M. D. R., Komiyama, N. H., Grant, S. G. N.
Synaptic combinatorial molecular mechanisms generate repertoires of innate and learned behavior
Komiyama, N. H., van de Lagemaat, L. N., Stanford, L. E., Pettit, C. M., Strathdee, D. J., Strathdee, K. E., Fricker, D. G., Tuck, E. J., Elsegood, K. A., Ryan, T. J., Nithianantharajah, J., Skene, N. G., Croning, M. D. R., Grant, S. G. N.
