![Dr Lynda Constable Dr Lynda Constable](/img/200x200/staffpages/uploads/mmd761/mail.jpg)
BSc (Hons), PhD
Trial Manager
- About
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- Email Address
- l.constable@abdn.ac.uk
- Office Address
Centre for Healthcare Randomised Trials (CHaRT)
Health Services Research Unit
University of Aberdeen
3rd Floor Health Sciences Building
Foresterhill
ABERDEEN AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I joined HSRU as a Trial Manager in 2012 and took up the role of Deputy Senior Trial Manager in 2021.
I am the Lead Trial Manager on the DIAMOND, CATHETER II, VUE, MASTER and ASICA trials.
DIAMOND is an NIHR-HTA funder multi-centre randomised controlled trial (RCT) to compare medical management versus early planned surgery in women with deep endometriosis.
CATHETER II is an NIHR-HTA funded RCT to determine whether or not a weekly prophylactic catheter washout regime improves catheter related complications.
VUE is two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse, funded by the NIHR HTA.
MASTER is an NIHR-HTA funded RCT investigating the surgical treatment of male stress urinary incontinence after prostate surgery.
ASICA is a Cancer Research UK funded pilot RCT investigating the ASICA (Achieving self-directed integrated cancer aftercare) digital intervention for supporting high quality total skin self-examination in those with cutaneous melanoma.
I also coordinate the Institute of Applied Health Sciences seminars.
I gained a BSc in Biosciences and Chemistry and a PhD in Cancer cell and Molecular biology. Prior to joining the unit, I worked as a Research Fellow at Aberdeen University on a range of projects with an emphasis on cancer biomarkers.
Memberships and Affiliations
- Internal Memberships
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IAHS Seminars Coordinator
- External Memberships
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Member of the Education Committee for the Society for Clinical Trials (2013 - 2020)
Chair of the Education Committee for the Society for Clinical Trials (2018-2019)
Co-Chair of the Education Committee for the Society for Clinical Trials (2017-2018)
Chair of the Webinar Committee for the Society for Clinical Trials (2017-2018)
Member of the Board of Directors for the Society for Clinical Trials (2016)
Latest Publications
Male sling is as good as more complex surgery for incontinence after prostate surgery
BMJ (Clinical research ed.), vol. 381, pp. 1179Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.p1179
User Experiences of a Digital Intervention to Support Total-Skin-Self-Examination by Melanoma Survivors: Nested Qualitative Evaluation Embedded in a Randomized Controlled Trial
JMIR Dermatology, vol. 6, e39544Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2196/39544
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20032/1/Reilly_etal_JMIRD_User_Experiences_In_VoR.pdf
- [ONLINE] View publication in Scopus
The Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial
JMIR cancer, vol. 8, no. 3, e37539Contributions to Journals: ArticlesRandomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study
Trials, vol. 23, no. 1, 630Contributions to Journals: ArticlesSynthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT
Health Technology Assessment, vol. 26, no. 36, 184Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/TBFZ0277
- Research
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Research Overview
Clinical trials methodology
Clinical trial management
Research Areas
Applied Health Sciences
Current Research
VUE Trial: Vault or Uterine prolapse surgery evaluation: Two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse.
MASTER Trial: investigating the surgical treatment of male stress incontinence after prostate surgery.
ASICA: Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: A randomised patient-focused trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma
CATHETER II Trial: evaluating the effect of weekly saline or acidic prophylactic catheter washout policies with standard care on catheter related complications.
- Teaching
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Teaching Responsibilities
I have supervised a number of BSc and MSc student research projects, including topics such as understanding patient's decision making to participate in clinical trials; rapid introduction of new cancer therapies; personalised cancer therapies; and investigation of the mode of action novel cancer therapeutics.
- Publications
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Biomarkers for colorectal cancer: identification through proteomics
Current Proteomics, vol. 7, no. 3, pp. 212-221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2174/157016410792928116
Bisnaphthalimidopropyl spermidine induces apoptosis within colon carcinoma cells
Chemico-Biological Interactions, vol. 177, no. 1, pp. 1-6Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.cbi.2008.09.033
Polyamine Analogues and Derivatives as Potential Anticancer Agents
Current Bioactive Compounds, vol. 3, no. 3, pp. 179-191Contributions to Journals: ArticlesThe synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum
Bioorganic & Medicinal Chemistry, vol. 15, no. 1, pp. 541-545Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bmc.2006.09.031
Synthesis and biological activities of bisnaphthalimido polyamines derivatives
Biochemical Pharmacology, vol. 69, no. 1, pp. 19-27Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bcp.2004.09.020