Dr Konstantin Shestopaloff

Dr Konstantin Shestopaloff
Dr Konstantin Shestopaloff
Dr Konstantin Shestopaloff

Lecturer

About
Email Address
konstantin.shestopaloff@abdn.ac.uk
Office Address
Polwarth Building
Foresterhill Campus
Foresterhill
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I received my PhD in Biostatistics from the University of Toronto, Canada in 2017, specializing in methods for analysis of microbiome and ecological community data. Subsequently, I worked as a biostatistician in arthritis research, conducting analyses of metabolomic and miRNA signature data, and in population health, where I estimated temporal effects of polygenic risk scores in obesity. From 2020 to 2024 I was the Analytics Lead for the IL-17 project group within the Oxford-Novartis collaboration at the Big Data Institute, University of Oxford. I started as a Lecturer in the Medical Statistics Group within the School of Medicine, Medical Sciences and Nutrition in January 2024.

Qualifications

  • PhD Biostatistics 
    2017 - University of Toronto 

External Memberships

Visiting Researcher, Big Data Institute, University of Oxford, Oxford, United Kingdom

Adjunct Lecturer, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

 

Research

Research Overview

My research focus is on methods development with applications to clinical and biomedical data, particularly methods for addressing sparsity. Some of my previous work includes inference methods for rare species in microbiome data and total species estimators. I have also worked on using nested models for prediction in longitudinal data. My interests in applied statistics focus on biomarker detection using both standard inference methods and machine learning approaches. I've worked extensively in applying data mining for analysing a wide range of omics data and have expertise in statistical genetics.

Research Areas

Applied Health Sciences

Biomedical Sciences

Research Specialisms

  • Applied Statistics
  • Machine Learning
  • Statistical Modelling
  • Medical Statistics
  • Statistics

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Publications

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  • A sequential modeling approach for predicting clinical outcomes with repeated measures

    Shestopaloff, K., Canizares, M., Power, J. D.
    Communications in Statistics - Theory and Methods, vol. 52, no. 20, pp. 7465-7478
    Contributions to Journals: Articles
  • Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background

    Zhang, C., Shestopaloff, K., Hollis, B., Hei Kwok, C., Hon, C., Hartmann, N., Tian, C., Wozniak, M. B., Santos, L., West, D. M., Gardiner, S., Mallon, A., Readie, A., Martin, R., Nichols, T., Beste, M. T., Zierer, J., Ferrero, E., Vandemeulebroecke, M., Jostins-Dean, L.
    American Journal of Human Genetics, vol. 110, no. 10, pp. 1817-1824
    Contributions to Journals: Articles
  • DCMD:: Distance-based classification using mixture distributions on microbiome data

    Shestopaloff, K., Dong, M., Gao, F., Xu, W.
    PLoS Computational Biology , vol. 17, no. 3, e1008799
    Contributions to Journals: Articles
  • Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis

    Ali, S., Gandhi, R., Potla, P., Keshavarzi, S., Espin-Garcia, O., Shestopaloff, K., Pastrello, C., Bethune-Waddell, D., Lively, S., Perruccio, A., Rampersaud, Y., Veillette, C., Rockel, J., Jurisica, I., Appleton, C., Kapoor, M.
    Osteoarthritis and Cartilage, vol. 28, no. 11, pp. 1471-1481
    Contributions to Journals: Articles
  • Effect of autotaxin inhibition in a surgically-induced mouse model of osteoarthritis

    Datta, P., Gandhi, R., Nakamura, S., Lively, S., Rossomacha, E., Potla, P., Shestopaloff, K., Endisha, H., Pastrello, C., Jurisica, I., Rockel, J. S., Kapoor, M.
    Osteoarthritis and Cartilage Open, vol. 2, no. 3, 100080
    Contributions to Journals: Articles
  • Estimating total species using a weighted combination of expected mixture distribution component counts

    Shestopaloff, K., Xu, W., Escobar, M. D.
    Environmental and Ecological Statistics, vol. 27, pp. 447-465
    Contributions to Journals: Articles
  • Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation

    Chahal, J., Gómez-Aristizábal, A., Shestopaloff, K., Bhatt, S., Chaboureau, A., Fazio, A., Chisholm, J., Weston, A., Chiovitti, J., Keating, A., Kapoor, M., Ogilvie-Harris, D. J., Syed, K. A., Gandhi, R., Mahomed, N. N., Marshall, K. W., Sussman, M. S., Naraghi, A. M., Viswanathan, S.
    Stem Cells Translational Medicine, vol. 8, no. 8, pp. 746-757
    Contributions to Journals: Articles
  • Analyzing differences between microbiome communities using mixture distributions

    Shestopaloff, K., Escobar, M. D., Xu, W.
    Statistics in Medicine, vol. 37, no. 27, pp. 4036-4053
    Contributions to Journals: Articles
  • A classification modeling approach for determining metabolite signatures in osteoarthritis

    Rockel, J. S., Zhang, W., Shestopaloff, K., Likhodii, S., Sun, G., Furey, A., Randell, E., Sundararajan, K., Gandhi, R., Zhai, G., Kapoor, M.
    PloS ONE, vol. 13, no. 6, 0199618
    Contributions to Journals: Articles
  • Association of host genome with intestinal microbial composition in a large healthy cohort

    Turpin, W., Espin-Garcia, O., Xu, W., Silverberg, M. S., Kevans, D., Smith, M. I., Guttman, D. S., Griffiths, A., Panaccione, R., Otley, A., Xu, L., Shestopaloff, K., Moreno-Hagelsieb, G., GEM Project Research Consortium, Paterson, A. D., Croitoru, K.
    Nature Genetics, vol. 48, pp. 1413-1417
    Contributions to Journals: Articles
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