Senior Lecturer
- About
-
- Email Address
- i.n.fleming@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438357
- Office Address
Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
- Research
-
Research Overview
Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.
Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.
Current Research
Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis.
Collaborations
Prof Fiona Gilbert, University of Cambridge
Prof Paula Ghaneh, University of Liverpool
Prof David O'Hagan, University of St Andrews
Kemotech, Italy
Funding and Grants
Current Grants:
Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)
18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)
Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)
Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)
Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)
Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)
- Teaching
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Teaching Responsibilities
Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills
Programme coordinator BT5007: Industrial Placement/MSci course
Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease
Course coordinator & lecturer BP5003: Biomedical and other Professional Topics
Lecturer SM2501: Research skills for Medical Sciences
Coordinator of Hotstart programme
- Publications
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Page 1 of 3 Results 1 to 25 of 53
Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
Insights into Imaging, vol. 12, no. 1, 90Contributions to Journals: ArticlesSynthesis, Radiosynthesis and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR
European Journal of Organic Chemistry, vol. 2021, no. 9, pp. 1429-1439Contributions to Journals: ArticlesWidespread tissue hypoxia dysregulates cell and metabolic pathways in SMA
Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593Contributions to Journals: ArticlesHypoxia PET/CT and Colorectal Cancer: A Case Report
Journal of Case Reports and Images in Oncology, vol. 1(1), no. 2-5Contributions to Journals: ArticlesA role for spinal cord hypoxia in neurodegeneration
Cell Death & Disease, vol. 10, 861Contributions to Journals: Review articlesEnzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)
Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/C8OB03150A
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13531/1/Enzymatic_PSMA_manuscript.pdf
- [ONLINE] View publication in Mendeley
Two Years On: How the Core Curriculum has Shaped Pharmacology Courses at the University of Aberdeen
Contributions to Specialist Publications: Featured ArticlesBinding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36Contributions to Journals: ArticlesHigh Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin
ChemMedChem, vol. 12, no. 14, pp. 1142-1151Contributions to Journals: ArticlesKEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation
Hypoxia, vol. 5, pp. 45-59Contributions to Journals: ArticlesDesign and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery
Synlett, vol. 28, no. 20, pp. 2769-2776Contributions to Journals: ArticlesProbing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3
Scientific Reports, vol. 6, 36544Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/srep36544
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7656/1/srep36544.pdf
Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers
Chemistry : a European Journal, vol. 22, no. 31, pp. 10998-11004Contributions to Journals: ArticlesNGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting
Bioconjugate Chemistry, vol. 27, no. 5, pp. 1332-1340Contributions to Journals: ArticlesEnzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase
Organic & Biomolecular Chemistry, vol. 14, no. 11, pp. 3120-3129Contributions to Journals: ArticlesChanges in [18F]Fluoro-2-deoxy-D-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling
Journal of Cancer Research and Clinical Oncology, vol. 141, no. 9, pp. 1523-1532Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00432-015-1909-2
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7402/1/MetforminPaper_CRCO.docx
The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2
Journal of Cancer Research and Clinical Oncology, vol. 141, no. 9, pp. 1575-1583Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00432-015-1921-6
Imaging tumour hypoxia with Positron Emission Tomography
British Journal of Cancer, vol. 112, no. 2, pp. 238-250Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1038/bjc.2014.610
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5427/1/BJC2014_Fleming.pdf
A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography
Chemical Communications, vol. 51, no. 70, pp. 13542-13545Contributions to Journals: ArticlesSynthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone
Tetrahedron, vol. 70, no. 44, pp. 8343-8347Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.tet.2014.09.004
A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions
Angewandte Chemie International Edition, vol. 53, no. 34, pp. 8913-8918Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/anie.201403345
- [ONLINE] View publication in Scopus
Early changes in [18F] FDG incorporation by breast cancer cells treated with trastuzumab in normoxic conditions: Role of the Akt-pathway, glucose transport and HIF-1α
Breast Cancer Research and Treatment, vol. 144, no. 4, pp. 241-248Contributions to Journals: ArticlesMultifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles
Synlett, vol. 25, no. 07, pp. 1019-1025Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1055/s-0033-1340940
Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas
British Journal of Cancer, vol. 110, no. 6, pp. 1525-1534Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2014.45
Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase
Nuclear Medicine and Biology, vol. 40, no. 6, pp. 858-864Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.nucmedbio.2013.05.006
