BSc, PhD
Lecturer
- About
-
- Email Address
- dthompson@abdn.ac.uk
- Office Address
office 6.15/lab 2.48
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences,
Foresterhill, Aberdeen
ext: office:7513
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I received my B.Sc Hons in Pharmacology from the University of Aberdeen before obtaining a Ph.D from the University of Strathclyde under the supervision of Prof Susan Pyne, where I studied the enzymes sphingosine kinase and sphingosine-1-phosphate phosphatase. My postdoctoral training began at the Ernest Gallo Clinic and Research Centre (University of California, San Francisco) in the laboratory of Professor Jennifer Whistler, where I investigated the consequences of disrupted GPCR trafficking in health an disease. Specifically, my work focused on the dopamine receptor family and their role in cocaine sensitisation. From here, I moved to the MRC Clinical Sciences Centre at Imperial College London followed by training at the William Harvey Research Centre at Queen Mary London in the laboratory of Profs Mauro Perretti and Roderick Flower where I studied the trafficking properties of the Formylpeptide receptor family (also GPCRs) and their role in innate immunity. I returned to the University of Aberdeen and continued my postdoctoral studies under the supervision of Prof Mirela Delibegovic investigating the role of protein tyrosine phosphatase 1B (PTP1B) in inflammation. In January 2020 I was appointed Lecturer in Medical Sciences.
- Research
-
Research Overview
My research philosophy involves determining processes at the molecular level and translating these into whole animal physiology. My specific focus is G protein-coupled receptor (GPCR) regulation and the molecular mechanisms controlling GPCR endocytosis and post-endocytic fate, how these control cellular function, how disruption of these process alters cell function and ultimately how this leads to disease in the animal.
Research Areas
Biomedical Sciences
Research Specialisms
- Pharmacology
- Neuroscience
- Cell Biology
- Immunology
- Diabetes
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
-
Page 2 of 3 Results 11 to 20 of 30
Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
Scientific Reports, vol. 11, 6949Contributions to Journals: ArticlesDesign, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents
ChemMedChem, vol. 15, no. 16, pp. 1579-1590Contributions to Journals: ArticlesEndocytic Sorting and Downregulation of the M2 Acetylcholine Receptor is Regulated by Ubiquitin and the ESCRT Complex
Neuropharmacology, vol. 162, 107828Contributions to Journals: ArticlesResponse to comment by Moxon et al
Clinical Science, vol. 132, no. 1, pp. 39-41Contributions to Journals: LettersPharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis
Clinical Science, vol. 131, no. 20, pp. 2489-2501Contributions to Journals: ArticlesMyeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Molecular Metabolism, vol. 6, no. 8, pp. 845-853Contributions to Journals: ArticlesNovel G protein-coupled receptors in Pancreatic Beta cells
Experimental Biology, 1052.1Contributions to Journals: AbstractsIdentification of a novel recycling sequence in the C-tail of FPR2/ALX: association with cell protection from apoptosis
The Journal of Biological Chemistry, vol. 289, pp. 36166-36178Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M114.612630
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4240/1/36166.full.pdf
Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses
PNAS, vol. 110, no. 45, pp. 18232-18237Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1308253110
Increased axonal bouton dynamics in the aging mouse cortex
PNAS, vol. 110, no. 16, pp. E1514-E1523Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1218731110
