Lecturer
- About
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- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
- Research
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Research Overview
Dr. Quin aims to prevent the pathogenesis of frailty in older adults, providing them with more years of healthy, independent living. Frailty is a state of increased vulnerability to stressors including infections (e.g. pneumonia) and inflammatory diseases (e.g. cardiovascular disease, myelodysplastic syndrome [MDS], diabetes), which develops as a consequence of age-related decline in multiple systems, including the immune system. Using techniques such as flow cytometry, multi-omic approaches and gnotobiotics, Dr. Quin studies mechanisms by which gut microbiota shape the immune and epigenetic landscape to affect the development of frailty and ageing health conditions.
Find out more: https://www.quinlab.co.uk/lab/
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Biomedical Sciences
Accepting PhDsResearch Specialisms
- Gerontology
- Immunology
- Medical Microbiology
- Metabolic Biochemistry
- Bioinformatics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
Major projects in the Quin lab include:
- Understanding the origins of healthy and unhealthy ageing (e.g. frailty)
- Uncovering how the ageing gut microbiome contributes to age-related immune remodeling
- Elucidating how changes in the gut microbiome impact host epigenomics
- Developing novel strategies to prevent age-related conditions (pneumonia, blood cancers, cardiovascular disease)
Past Research
Throughout my academic career, I have been fascinated with factors contributing to health across the life-course. I completed my Ph.D. in Biochemistry and Molecular Biology at the University of British Columbia under the supervision of Dr. Deanna Gibson. My doctoral training focused on how neonatal environmental exposures, such as diet, set up the ageing trajectory and alter systemic inflammation into adulthood through gut-microbe interactions. Here, I gained valuable insights into how different fat types (saturated, monounsaturated etc.) contribute to inflammation directly and through the microbiome. I then joined Dr. Dawn Bowdish’s research group at McMaster University as a postdoctoral researcher. In this position, I addressed important topics in immunology including the impact of the ageing microenvironment on haematopoiesis and epigenetic reprogramming of monocytes, the cellular and molecular mechanisms of impaired anti-pneumococcal immunity with age, and the role of inflammation in immunosenescence.
- Publications
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Page 1 of 1 Results 1 to 19 of 19
Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function
The Journal of Clinical Investigation, vol. 134, no. 11, e171002Contributions to Journals: ArticlesMaternal adaptations in mouse lactation are vulnerable to diet-induced excess adiposity
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.06.30.547298
Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection.
PLoS Pathogens, vol. 17, no. 8, e1009719Contributions to Journals: ArticlesMaternal Intake of Dietary Fat Pre‐Programs Offspring's Gut Ecosystem Altering Colonization Resistance and Immunity to Infectious Colitis in Mice
Molecular Nutrition & Food Research, vol. 65, no. 6, 2000635Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mnfr.202000635
Early life environmental exposures have a minor impact on the gut ecosystem following a natural birth.
Gut Microbes, vol. 13, no. 1, 1875797Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/19490976.2021.1875797
- [ONLINE] https://europepmc.org/articles/PMC7872070
Physical Activity Shapes the Intestinal Microbiome and Immunity of Healthy Mice but Has No Protective Effects against Colitis in MUC2-/- Mice.
mSystems, vol. 5, no. 5Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1128/msystems.00515-20
- [ONLINE] https://europepmc.org/articles/PMC7542559
Human behavior, not race or geography, is the strongest predictor of microbial succession in the gut bacteriome of infants.
Gut Microbes, vol. 11, no. 5, pp. 1143-1171Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1080/19490976.2020.1736973
- [ONLINE] https://europepmc.org/articles/PMC7524360
- [ONLINE] View publication in Scopus
Fish oil supplementation reduces maternal defensive inflammation and predicts a gut bacteriome with reduced immune priming capacity in infants.
The ISME Journal, vol. 14, no. 8, pp. 2090-2104Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41396-020-0672-9
- [ONLINE] https://europepmc.org/articles/PMC7368083
Physical activity shapes the intestinal microbiome and immunity of healthy mice but has no protective effects against colitis in MUC2-/- mice
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2020.05.24.113290
Influence of sulfonated and diet-derived human milk oligosaccharides on the infant microbiome and immune markers.
The Journal of Biological Chemistry, vol. 295, no. 12Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.ra119.011351
- [ONLINE] https://europepmc.org/articles/PMC7086044
Dietary Fatty Acids and Host–Microbial Crosstalk in Neonatal Enteric Infection
Nutrients, vol. 11, no. 9, 2064Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/nu11092064
Gut Mucosal Proteins and Bacteriome Are Shaped by the Saturation Index of Dietary Lipids
Nutrients, vol. 11, no. 2, 418Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/nu11020418
- [ONLINE] http://www.mdpi.com/2072-6643/11/2/418
Effects of Azithromycin on Behavior, Pathologic Signs, and Changes in Cytokines, Chemokines, and Neutrophil Migration in C57BL/6 Mice Exposed to Dextran Sulfate Sodium.
Comparative medicine, vol. 69, no. 1, pp. 4-15Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.30802/aalas-cm-18-000001
- [ONLINE] https://europepmc.org/articles/PMC6382047
Dietary Lipids and Enteric Infection in Rodent Models
The Molecular Nutrition of Fats. Academic Press, pp. 49-64, 16 pagesChapters in Books, Reports and Conference Proceedings: ChaptersProbiotic supplementation and associated infant gut microbiome and health:: a cautionary retrospective clinical comparison.
Scientific Reports, vol. 8, 8283Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41598-018-26423-3
- [ONLINE] https://europepmc.org/articles/PMC5974413
Diet and dysbiosis
The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology. WileyChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)- [ONLINE] DOI: https://doi.org/10.1002/9781118982907.ch29
- [ONLINE] http://dx.doi.org/10.1002/9781118982907.ch29
Omega-3 polyunsaturated fatty acid supplementation during the pre and post-natal period: A meta-analysis and systematic review of randomized and semi-randomized controlled trials
Journal of Nutrition & Intermediary Metabolism, vol. 5, pp. 34-54Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jnim.2016.04.005
Dietary Lipid Type, Rather Than Total Number of Calories, Alters Outcomes of Enteric Infection in Mice.
The journal of infectious diseases, vol. 213, no. 11, pp. 1846-1856Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/infdis/jiw084
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout.
Nature Communications, vol. 5, 5452Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/ncomms6452
- [ONLINE] https://europepmc.org/articles/PMC4263137