Professor Claude Wischik | People | The University of Aberdeen

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)
2019 - Published
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G., Klein, J.
ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1021/acschemneuro.8b00274
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12993/1/ACSChemNsci_Konig.pdf
- [ONLINE] View publication in Mendeley
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
2018 - Published
Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2018.08.010
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11249/1/1_s2.0_S0022283618305606_main.pdf
Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development
2018 - Published
Wischik, C. M., Schelter, B. O., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
Journal of Alzheimer's Disease, vol. 62, no. 3, pp. 1287-1303
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170727
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10181/1/Modeling_Prion_Like_Processing_of_Tau_Protein_in_Alzheimer_s_Disease_for_Pharmaceutical_Development.pdf
Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease
2018 - Published
Frahm, S., Melis, V., Horsley, D., Rickard, J., Riedel, G., Fadda, P., Scherma, M., Harrington, C., Wischik, C., Theuring, F., Schwab, K.
Behavioural Brain Research, vol. 339, pp. 153-168
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.bbr.2017.11.025
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9815/1/Alpha_Synuclein_transgenic_mice_h_SynL62_display_Syn_aggregation_and_a_dopaminergic_phenotype_reminiscent_of_Parkinson_s_disease.pdf
A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
2018 - Published
Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.
Frontiers in Molecular Neuroscience, vol. 10, 447
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
2017 - Published
Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457
Contributions to Journals: Articles
- [ONLINE] https://www.j-alz.com/vol61-1
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170560
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9693/1/Potential_of_Low_Dose.pdf
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking
2017 - Published
Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
Journal of Molecular Biology, vol. 429, no. 23, pp. 3650-3665
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2017.09.007
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9614/1/Alzheimer_s_Disease_like_Paired_Helical_Filament_Assembly_from_Truncated_Tau_Protein_Is_Independent_of_Disulfide_Crosslinking.pdf
The effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks
2017 - Published
Shiells, H. C., Thiel, M., Wischik, C., Schelter, B.
Medical Research Archives , vol. 5, no. 9, 1298
Contributions to Journals: Articles
- [ONLINE] http://www.journals.ke-i.org/index.php/mra/article/view/1298
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9406/1/document.pdf
Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes
2017 - Published
Vuksanovic, V., Staff, R., Ahearn, T., Bentham, P., Murray, A. D., Wischik, C. M.
6th Cambridge Neuroscience Symposium
Contributions to Conferences: Abstracts
Method and system for determining network connections
2017 - Published
Sommerlade, L., Schelter, B., Wischik, C.
Patents: Patents

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Research Overview

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

The effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks

Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes

Method and system for determining network connections

Refine

Chapters in Books, Reports and Conference Proceedings

Contributions to Conferences

Contributions to Journals

Patents